O
Osie
Diamond
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INTRODUCTION
While MSM has always existed on this forum for various uses, it’s been long forgotten for its uses and heightmax (only discussed during Striker and Dyrotic days). Luckily, I was able to find a study showing evidence that MSM can increase IGF-1 and HGH levels and possibly increase longitudinal bone growth by acting like HGH.
EVIDENCE:
What makes MSM special is that it uses the primary signaling pathway that's activated by HGH, which is called JAK-STAT (signal transducer and activator of transcription) pathway. Activation of this pathway by HGH is very important for regulating things like IGF-1 and then by a product activating the IGF-1 receptor.
Now this is very important for bone remodeling and luckily, the non-toxic sulfur can significantly increase GH signaling via this pathway, thereby increasing IGF-1 significantly. As MSM was able to significantly IGF-1R (IGF-1 receptor) and GHR (growth hormone receptor) mRNA expression in osteoblastic cells. MSM induced binding of STAT5 to the IGF-1R and increased IGF-1 and IGF-1R promoter activities.
MSM was also able to significantly promote osteoblast differentiation in MSCs, MSCs are the same thing that can turn into bone cells (osteoblasts) and cartilage cells (chondrocytes), two things that we've established are important. Due to this, it was hypothesized that MSM can affect longitudinal bone growth as it basically replicates what HGH does through its strongest and primary signaling pathway and ultimately helps significantly to decrease bone resorption.
Conclusion:
I would like some people on this forum that are interested in hiehgtmaxxing or currently heightmaxxing to try this supplement out, and after 3 months or so, check to see if there have been any increases in their IGF-1 and Growth hormone levels, as this study makes some pretty bold claims that should theoretically work.