Neuroenhancement Protocol Let’s define the line together

[FutureSlayer]

The time has come to stop wandering aimlessly through nootropic fluff and build a proper BlackPill guideline (like those doctors use but in our optics lmao) for pharmacological use, both long-term and short-term


I’m calling in the three main voices in this field @Cope @Alexanderr @AscendingHero to finally synthesize a serious, layered approach. We need a framework that addresses:

-Chronic use substances that are sustainable and actually work
- Acute use compounds for specific high stakes situations (social dominance, verbal fluency, mental stillness, job interviews, exams, dates)
-Risk/reward mapping (long term health profile, hair, libido, cortisol, etc.)


CANDIDATES:

Long-Term Core Stack (Baseline Mental Edge):

Noradrenaline α2-agonist
-Clonidine 0.05–0.2 mg/day

MAO-A/B inhibitor
-Nardil (Phenelzine) 60 mg/day

Histone Deacetylase (HDAC) inhibitor
-Vorinostat 50 mg/day (PERMANENT changes after a while, crazy stuff)

Dopaminergic
-Bromantane 50–100 mg/day

Neurotrophic peptide mix
-Cerebrolysin 10 mg/week, cycles of 10–20 days

Anxiety sweating/primary hyperhidrosis/scialorrea
-Glycopirrolate 2mg/day


Short-Term Kill Mode for special events
(To add to the previous stack):

Dopamine/norepinephrine reuptake inhibitor
-Ritalin (Methylphenidate) 10–20 mg IR / 36–54 mg XR

α2δ-subunit modulator
-Lyrica (Pregabalin) 450 mg (or should have been put in the baseline stack paired with 10mg memantine to counteract tolerance? or maybe in a grey zone which we can cycle it on and off for a period like cerebrolysin?)

GABA-B receptor agonist
-Baclofen 50 mg

β-adrenergic blocker
-Propranolol 40 mg



Still researching this stack by @Cope and trying to figure out which of those would be beneficial in the guideline
Anti-Glutamatergic Stack -

• Riluzole: Inhibits glutamate release and enhances reuptake.
• Lamotrigine: Blocks sodium channels, reducing glutamate release.
• Oxcarbazepine: Stabilizes neuronal membranes and dampens excitatory firing.
• Pregabalin: Inhibits calcium influx to reduce neurotransmitter release.
• Baclofen (optional): Activates GABA-B
  receptors to indirectly suppress glutamate.

What should we address further? Any pathway I am missing? I get at the day this is probably a trial-end-error approach as our physiologies are different and can not me synthetized in a simple guideline but it’s still worth a try at least to emphasize pros and cons

Spoiler: tags

@Clavicular @thecel @Jason Voorhees @AlexBrown84 @CalulArgintiu59 @Clqs @Boyoshutup @Bitterschön @LLcel

 

[ru58841]

bookmarked will research this, im still grey with this topic

 

[A_Ron_Kool_Aid]

Niggas will learn all this just to waste it on .org Dawg go into the medical field

 

[FutureSlayer]

bookmarked will research this, im still grey with this topic

Can’t believe in never delved the topic in all these years as well, very interesting stuff

 

[ru58841]

Can’t believe in never delved the topic in all these years as well, very interesting stuff

i dont really see much nootropics guides on here, only saw one on botb that barely explains it, someone should make a botb thread on it

 

[FutureSlayer]

i dont really see much nootropics guides on here, only saw one on botb that barely explains it, someone should make a botb thread on it

This is an attempt

 

[FutureSlayer]

Spoiler: tags

@incelmogger @crosshold @androgenic @Amnesia
@chadisbeingmade @flambria @Oreone @jeff1234 @2414763h @6ft4 @Akatlyn @AscensionMan98 @AstroSky @autistic_tendencies @BigJimsWornOutTires @Cuervo @distance decay @dreamcake1mo @Gaygymmaxx @HarrierDuBois @Hernan @looks>books @Michelangelo @NegativeNorwood @Niklaus Mikaelson @NZb6Air @OldRooster @PeakIncels @PseudoMaxxer @Reformed @Saint Casanova @schizowillascend @Slayer @snowbunnypolice @superpsycho @Tabula Rasa @Zagro @Zenis @lestoa @Orc @WrathOfOlives @Gengar @ReadBooksEveryday @enchanted_elixir @Gargantuan

 

[FutureSlayer]

Spoiler

@emeraldglass @Willmogulater @ranierean @dimorphism @St.TikTokcel @roping3264 @Roping Subhuman @superpsycho @sigma boii @asdvek
@Never Get Up @anthony111553 @Blackgymmax @Debetro @VV62 @The Homelander
@PsychoDsk @Weresobackbased @Jonasㅤㅤ @Randomized Shame @aids @Whirr22222
@trenace450 @imontheloose

 

[chadhamed]

I love italians

 

[FutureSlayer]

I love italians

pizzacels reciprocate

 

[FutureSlayer]

Bump

 

[FutureSlayer]

@iabsolvejordan @NorwoodAscender

 

[FutureSlayer]

b

 

[CD34]

Neuroprotection and Recovery


ARA-290: Enhances nerve fiber growth, reduces pain in various diseases.
BPC-157: Repairs dopaminergic neurons, increases Nitric oxide.
Cortagen: Aids posttraumatic recovery of peripheral nerve tissue.
Cerebrolysin, N-PEP-12: Provides essential neurotrophic factors, enhances brain oxygen delivery.
Cerluten: Regulates CNS, acts as antioxidant and adaptogen.
Cortexin: Balances cortisol, boosts serotonin, GABA, and dopamine regulation.
Dihexa: Stimulates synapse generation, potentially improving memory and motor functions.
DNSP-5 & 11: Protects dopaminergic neurons, enhances motor performance.
Glutathione: Combats oxidative stress in Parkinson’s disease.
HAYED (5): Reduces oxidative damage in cells and brain.
Humanin: Protects against neurotoxins, enhances neurological insulin sensitivity.
Melanotan 1 & 2: Reduces neural inflammation, improves astrocyte function.
Pinealon: Repairs neurologic and pituitary damage, improves circadian rhythms.
Thymosin alpha-1, Thymosin Beta 4: Supports neuron growth and connectivity, reduces inflammation.
WRW-4: Protects brain from amyloid β42 impairment.

Neurogenesis and Cognitive Enhancement


FGLL/HA-FGL: Stimulates neurite outgrowth, reduces oxidative stress-induced neuronal death.
GHK-Cu: Enhances angiogenesis and nerve growth, reduces CNS inflammation.
IGF-2: Involved in myelinogenesis, neuronal growth, and memory improvement.
P21: Mimics LIF, inhibits tau hyperphosphorylation, enhances neurogenesis.
Rubiscolin-6, Semax: Stimulates memory consolidation, induces neurotrophic factors.
Tesamorelin: Increases NAAG levels, potentially enhancing cognitive function.

Regulatory and Signaling Pathways


Epitalon (Epithalamin): Increases stress resistance, acts as antioxidant.
Fermented rice peptide (FRP): Regulates ERK/CREB/BDNF signaling, memory function.
GLP-1: Protects neurons, stimulates neurite outgrowth, reduces amyloid-beta levels.
Gly-Pro-Glu (GPE): Modulates signaling pathways, facilitates dopamine release.
Gonadorelin: Modulates testosterone levels, affecting neuroprotection.
Mots-C: Sensitizes endothelial cells to signaling molecules.
Noopept: Affects NGF and BDNF expression, enhances adaptation to environmental stress.
Orexin-A: Improves memory tasks performance in sleep-deprived subjects.
Phoenixin: Involved in regulation of memory, anxiety, and reproductive function.
VGVAPG (pal-VGVAPG): Modulates astrocyte and neuroblastoma cell functions.
VIP: Neuroprotective against inflammatory conditions, promotes repair and BDNF production.

Specialized Functions and Conditions


Thyrotropin TRH: Facilitates motor learning, decreases ataxia in degenerative diseases.


Full list


ARA-290 increases the number of small nerve fibers and reduces pain significantly, offering effective treatment for nerve damage seen in diseases like sarcoidosis, diabetes, thyroid dysfunction, celiac disease, HIV, and more. Dr. Daniel Culver states, "ARA 290 offers new hope for patients suffering debilitating pain and severe dysautonomia."
BPC-157 repairs dopaminergic neurons and raises Nitric oxide levels.
Cortagen demonstrated a pronounced therapeutic effect upon the structural and functional posttraumatic recovery of peripheral nerve tissue.
Cerebrolysin (to a weaker extent N-PEP-12) contains GDNF, NGF, BDNF, CTNF, and many essential amino acids, encouraging more oxygen delivery into the brain.
Cerluten helps regulate the CNS and cortex, acting as a neural antioxidant and perhaps as an adaptogen.
Cortexin comprises BDNF and NGF peptides, reduces excessive levels of cortisol, and enhances serotonin and GABA production. Stimulates dopamine liberation and suppresses dopamine action on receptors.
Dihexa is a hepatocyte growth factor agonist that stimulates nerve synapse generation, potentially overcoming memory and motor dysfunctions.
DNSP-5 & 11 increase tyrosine hydroxylase positive neuronal sparing, enhance motor performance, and induce neurological GDNF(?), protecting dopaminergic neurons.
Epitalon (A.K.A. Epithalamin) increases resistance to emotional stress and acts as an antioxidant.
Fermented rice peptide (FRP) prevents memory impairment through regulation of the ERK/CREB/BDNF signaling pathway, decreasing acetylcholine levels and increasing acetylcholinesterase activity.
FGLL/HA-FGL activates NCAM–FGFR signaling pathways, resulting in increased neurite outgrowth and survival, effects in memory, and decreased oxidative stress-induced neuronal cell death.
GHK-Cu improves angiogenesis in the nervous system, boosts nerve outgrowth, and reduces inflammation in the central nervous system.
GLP-1 protects against excitotoxic neuron damage and stimulates neurite outgrowth, reducing levels of amyloid-beta and the beta-amyloid precursor protein.
Glutathione may combat oxidative stress that damages dopamine neurons in Parkinson’s disease.
Gly-Pro-Glu (GPE) is neuroprotective, modulating calcium and GSK-3β signaling, facilitating dopamine release through NMDA receptor interaction.
Gonadorelin raises LH, converting into testosterone, which contains neuroprotective effects against Dementia. Continuous use requires cycling due to natural testosterone shutdown.
HAYED (5) decreases iron and radical levels, preventing cell and brain damage.
Humanin protects the brain from neurotoxins like amyloid β, improves neurological insulin sensitivity, regulates IRS-1/mTOR signaling, and acts like an antioxidant to excitotoxins.
IGF-2 plays a role in myelinogenesis, regulating growth, differentiation, survival of neurons, calcium homeostasis, and acetylcholinesterase enhancement.
Melanotan 1 & 2 assist with neural inflammation and improve astrocyte functioning by increasing levels of BDNF.
Mots-C sensitizes endothelial cells to effects of other signaling molecules like acetylcholine.
Noopept positively affects psychological components for rapid climate adaptation, expression of NGF and BDNF mRNA, and increases DNA-binding activity of HIF-1.
Orexin-A significantly improves performance in sleep-deprived subjects on short-term memory tasks.
P21 is a LIF mimetic, inhibiting tau abnormal hyperphosphorylation, enhancing adult hippocampal progenitors proliferation and differentiation, and improving cognition.
Phoenixin plays a role in reproductive function, memory, and anxiety regulation in the brain and periphery.
Pinealon mends dopaminergic/serotonergic and pituitary damage caused by aging, may improve circadian rhythm disorders, and limits excitotoxic effects of NMDA activity.
Rubiscolin-6 had an analgesic effect and stimulated memory consolidation.
Semax, induces BDNF in the CNS, and improves gene expression for the hippocampus and frontal cortex, preventing long-term potentiation impairment.
Tesamorelin raises NAAG levels.
Thymosin alpha-1 advances neuron growth and development connections between neurons, protective for inflammation and neuron dysfunction.
Thymosin Beta 4 might improve spinal cord wounds, promoting angiogenesis, neurogenesis, synaptogenesis, and oligodendrogenesis.
Thyrotropin TRH enhances motor learning speed via exogenous administration, active in the cerebellum, and decreases ataxia in cerebellar degenerative disease models.
VIP has a neuroprotective effect on inflammatory conditions, inhibiting production of microglia-derived proinflammatory factors and promoting axonal regrowth and BDNF production through the VPAC2 receptor.
VGVAPG (sold as pal-VGVAPG) decreases secretion of P4 by astrocytes and SH-SY5Y Neuroblastoma cells proliferation, which is prevented by ROS scavenger N-acetyl-L-cysteine.
WRW-4 protests the brain from amyloid β42 impairment, acting as a FPR2 antagonist

 

[CD34]

Acetylcholine Enhancement


CDP Choline
1000 mg orally with a meal twice daily
Alternatives: IM injections to avoid TMAO
Alpha GPC
100-300 mg for cognitively taxing tasks
Re-dose: 3-4 hours later
Tips:
Move around in mouth for better absorption
Consider cycling: 1 day off per week
Donepezil
5-20 mg upon rising daily
Uridine Monophosphate
500 mg for cognitively taxing tasks
Piracetam/Noopept
Piracetam: 1000-2000 mg, re-dose 1000 mg 3-4 hours later, max 5 days/week
Alternative: 10-30 mg Noopept
Tip: Combine CDP-choline and Alpha-GPC

Dopamine Regulation


L-Tyrosine
1000 mg upon rising
Enhances Adderall effects when taken on an empty stomach
Adderall
5-10 mg for taxing tasks, max 5x/week
Alternatives
Safinamide, methylphenidate, or modafinil
Low-dose Selegiline
For dopamine boost

Adrenaline Management


Propranolol
10-40 mg in stressful circumstances

GABA Regulation


Diazepam
2.5-5 mg for important social events, max 1x/week

Neuroplasticity Enhancement


Fluvoxamine/Amitriptyline
Fluvoxamine: Up to 50 mg before bed if genetics allow
Amitriptyline: Up to 25 mg otherwise
Cerebrolysin
5ml once a week if needed

Neuroinflammation Control


Low Dose Naltrexone
5-10 mg upon rising
Supplements
Butyric acid, EPA, NAC, TUDCA: 3x/day
Tips: Fasting for liver enzymes, Creatine and Betaine

Circadian Rhythms Optimization


Growth Hormone
2-3 IU before bed
Melatonin
2.5-10 mg short release before bed
SR9009
Injections upon rising, especially when traveling

Exercise Recommendations


Routine
30 min aerobic + 20 min sauna, 4x/week
Tips: Morning cardio, Incorporate HIIT

Dietary Guidelines


Eating Window
Restrict to 6 hours daily
Macronutrients
150-200g protein, low carb
Foods to Prioritize
Vegetables, fruits, nuts, beef liver, eggs
Genetic Considerations


BDNF Val66Met and 5-HTTLPR
Affect response to SSRIs
MTHFR Polymorphisms
Implications for folate metabolism

 

[FutureSlayer]

b

 

[FutureSlayer]

Any high iq recommendations to target Gaba-A receptors?

 

[FutureSlayer]

b