New heightmaxxing method found

[Sociobiology]

Search Indirubin-3'-oxime on Google.

Indirubin-3'-oxime (otherwise called I3'O) seems to be a superior heightmaxxing method to HGH+AI because it upregulates the Wnt/beta-catenin pathway which is crucial new bone formation. If you have manlet genetics and your growth plates will likely be less sensitive to the affects of hgh and will not grow as much, Indirubin-3'-oxime directly targets Wnt/beta-catenin to increase chondrocyte proliferation without the organ and soft tissue growth you see on HGH.

In the past, childhood growth was thought to be regulated by endocrine factors, such as GH, thyroid hormone, estrogen, androgen, vitamin D, and glucocorticoids, entering the circulation. However, recent studies of mutations in human skeletal dysplasias and genetic manipulation have revealed that paracrine factors acting locally in the growth plate and intracellular molecular pathways are important for chondrocyte maturation and longitudinal bone growth.

How I3O compared to other drugs.

The effects of I3O on bone growth seem to be dose dependent as seen by this chart. As a dose of 0.05mg/kg nad 0.5mg/kg of body weight where used in two tests and produced the following results.

0.5mg/kg is very very expensive as 50mg costs like 500USD online. Also I3O was injected into the mice for 2 to 10 week which equates to years of I3O injections in human terms.

It also seems to be a anti-obesity drug and able to prevent cognitive decline but I cba to provide citations for these claims. If true then it's proof for why taller people tend to be more intelligent.

Indirubin-3′-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway - PMC

Researchers have shown increased interest in determining what stimulates height. Currently, many children undergo precocious puberty, resulting in short stature due to premature closure of the growth plate. However, the current approach for height ...

pmc.ncbi.nlm.nih.gov

It has anti-tumor properties and does not seem to be cytotoxic so far, however this article says it can cause mitochondrial dsyfunction.

Spandidos Publications: Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

www.spandidos-publications.com

Any mode of administration may be employed; for example, the administration may be via an oral, rectal or intravenous, intramuscular, subcutaneous, intrauterine, or epidural or intracerebroventricular injection.

WO2015005603A1 - Small molecule, indirubin-3-oxime, for prevention and treatment of bone disease - Google Patents

The present invention provides a composition comprising an indirubin derivative for stimulating longitudinal bone growth. Because the composition for stimulating longitudinal bone growth according to the present invention is shown to be effective in longitudinal bone growth, it may be used not...

patents.google.com

It seems I3O can be administered in a number of ways.

 

[LLcel]

alright nigga link the sources so i can blast why are we wasting time

 

[Sociobiology]

alright nigga link the sources so i can blast why are we wasting time

You're likely not going to be able to afford it.

0.5mg x 70kg = 35mg per dose.
159GBP x 35mg = 5565GBP not including VAT.

here's the link: https://www.scientificlabs.co.uk/product/biomolecules/I0404-1MG
good luck.

 

[LLcel]

You're likely not going to be able to afford it.

0.5mg x 70kg = 35mg per dose.
159GBP x 35mg = 5565GBP not including VAT.

here's the link: https://www.scientificlabs.co.uk/product/biomolecules/I0404-1MG
good luck.

these jews making these unknown ass chems js for no1 to buy em boutta ask for a test sample

 

[Sociobiology]

these jews making these unknown as chems js for no1 to buy em boutta ask for a test sample

Please don't ruin my thread with your choice of words.

 

[Sociobiology]

bump

 

[kamaza247]

Up

 

[Corpuscula]

just inject PTD BDM

 

[Deleted member 118553]

You're likely not going to be able to afford it.

0.5mg x 70kg = 35mg per dose.
159GBP x 35mg = 5565GBP not including VAT.

here's the link: https://www.scientificlabs.co.uk/product/biomolecules/I0404-1MG
good luck.

please stop this stuff is bad it will give you big organs and a heart attack and will kill you stop its not good

 

[Theta]

Search Indirubin-3'-oxime on Google.

Indirubin-3'-oxime (otherwise called I3'O) seems to be a superior heightmaxxing method to HGH+AI because it upregulates the Wnt/beta-catenin pathway which is crucial new bone formation. If you have manlet genetics and your growth plates will likely be less sensitive to the affects of hgh and will not grow as much, Indirubin-3'-oxime directly targets Wnt/beta-catenin to increase chondrocyte proliferation without the organ and soft tissue growth you see on HGH.



How I3O compared to other drugs.
View attachment 3478541

The effects of I3O on bone growth seem to be dose dependent as seen by this chart. As a dose of 0.05mg/kg nad 0.5mg/kg of body weight where used in two tests and produced the following results.
View attachment 3478543

0.5mg/kg is very very expensive as 50mg costs like 500USD online. Also I3O was injected into the mice for 2 to 10 week which equates to years of I3O injections in human terms.

It also seems to be a anti-obesity drug and able to prevent cognitive decline but I cba to provide citations for these claims. If true then it's proof for why taller people tend to be more intelligent.

Indirubin-3′-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway - PMC

Researchers have shown increased interest in determining what stimulates height. Currently, many children undergo precocious puberty, resulting in short stature due to premature closure of the growth plate. However, the current approach for height ...

pmc.ncbi.nlm.nih.gov

It has anti-tumor properties and does not seem to be cytotoxic so far, however this article says it can cause mitochondrial dsyfunction.

Spandidos Publications: Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

www.spandidos-publications.com

WO2015005603A1 - Small molecule, indirubin-3-oxime, for prevention and treatment of bone disease - Google Patents

The present invention provides a composition comprising an indirubin derivative for stimulating longitudinal bone growth. Because the composition for stimulating longitudinal bone growth according to the present invention is shown to be effective in longitudinal bone growth, it may be used not...

patents.google.com

It seems I3O can be administered in a number of ways.

I aint reading all that sum it up

 

[Corpuscula]

please stop this stuff is bad it will give you big organs and a heart attack and will kill you stop its not good

cope

 

[Sociobiology]

I aint reading all that sum it up

I3O makes your growth plates bigger which can theoretically keep your growth plates open forever.

 

[MyDreamIsToBe183CM]

just inject PTD BDM

Are you on it yet?

 

[Deleted member 45092]

I read every single molecule and I will for sure be using it.

 

[MyDreamIsToBe183CM]

read every molecule but ky-19382 probably mogs for upregulation of the wnt/b-catenin signaling pathway

 

[unknownslayer--]

how the fck you are going to pay more than 5k per day for a dose of this

 

[Sociobiology]

how the fck you are going to pay more than 5k per day for a dose of this

absolutely no clue.

 

[mandiblade]

how you are going to pay more than 5k per day for a dose of this

You don't have to pay 5K. You can hop on an hGH secretagogue(aminousa has mk677 cheap) and frequently spike your insulin for higher IGF-1. If you do that, you can lower your dosage, which should make it a lot cheaper, especially with this source.

0.5mg/kg is very very expensive as 50mg costs like 500USD online.

This source has 50mg for $186. https://www.glpbio.com/indirubin-3-039-oxime.html

 

[mandiblade]

It has anti-tumor properties and does not seem to be cytotoxic so far, however this article says it can cause mitochondrial dsyfunction.

Spandidos Publications: Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

www.spandidos-publications.com

The article says that it causes mitochondrial dysfunction in "human neuroblastoma cells," which are neuroblast cancer cancer. You want those things to die.

According to this source:

no significant acute cytotoxicity is observed

 

[mandiblade]

How I3O compared to other drugs.

Know anything about how it compares to its derivatives - like 5'-bromo-5-nitro-indirubin-3'-oxime & 6-bromo-indirubin-3'-oxime - for regulation of the wnt/b-catenin pathway, and specifically about inducing chondrocyte proliferation?

 

[mandiblade]

@MyDreamIsToBe183CM @Sociobiology

Do you guys know how feasible/profitable it is to synthesize I3O and/or its derivatives?

 

[Sociobiology]

Know anything about how it compares to its derivatives - like 5'-bromo-5-nitro-indirubin-3'-oxime & 6-bromo-indirubin-3'-oxime - for regulation of the wnt/b-catenin pathway, and specifically about inducing chondrocyte proliferation?

The drug is so new I could not find anything about it's derivatives.

@MyDreamIsToBe183CM @Sociobiology

Do you guys know how feasible/profitable it is to synthesize I3O and/or its derivatives?

It would be extremely profitable to produce but I have no clue about feasible it is.

 

[MyDreamIsToBe183CM]

@MyDreamIsToBe183CM @Sociobiology

Do you guys know how feasible/profitable it is to synthesize I3O and/or its derivatives?

wdym by "profitable" like producing and selling this shit?

op guessed on a bunch of things, this would not mog the growth hormone signaling pathway. wnt-b catenin pathway is only one of the many pathways that contribute to height. his explanation for why it mogs was sorta dumb too

 

[mandiblade]

The drug is so new I could not find anything about it's derivatives.

I found out a bit. Google AI isn't that useless anymore. Gave me a few names and I just had to google them further.

- [Upregulating Wnt Signaling with I3'MO Derivatives](https://pubmed.ncbi.nlm.nih.gov/35176556/)
- [Inverse Binding Indr Derivatives Improve Selectivity for DYRK Kinases](https://pubs.acs.org/doi/10.1021/ml300207a)
- [5,5′-Substituted Indirubin-3′-oxime Derivatives as Potent CDK Inhibitors](https://pubs.acs.org/doi/abs/10.1021/jm100080z)
- [Synthesis and Anti-osteoporosis Potential of 2 New I3'O Derivatives](https://applbiolchem.springeropen.com/counter/pdf/10.3839/jksabc.2010.004.pdf)
- [7-Bromoindirubin-3'-oxime induces caspase-independent cell death](https://pubmed.ncbi.nlm.nih.gov/16702956/)
- [7-Bromo-5'-Carboxyindirubin-3'-oxime](https://www.google.com/search?cs=1&sca_esv=2db17c2fd44c4b31&q=7-Bromo-5%27-carboxyindirubin-3%27-oxime)
- [6BIO Review](https://www.nature.com/articles/s41598-017-11662-7)

EDIT: You might want to google "indirubin derivative e804" too
EDIT 2: You do not. It is an IGF1r antagonist, not agonist

wdym by "profitable" like producing and selling this

Not exactly. I meant to ask if producing it would be cheaper than buying it. No way it costs 35 bucks to make 5 milligrams. That glpinfo site I linked also had insane inflation for the same compound($45/mg) on another page, for the exact same compound. I doubt it costs $7/mg to make. Aminousa has 750mg of Ibutamoren for $50.


Side note: searching for this gave me a lot more raw data to research. Haven't looked into the ky-<buncha numbers> drug yet. Should do that soon.

Side side note: I have a few sources saved for I3'O(not its derivatives) synthesis. Ask in this thread if you want them.

 

[mandiblade]

Side side side note: How on planet earth do you guys discover this stuff randomly.

 

[MyDreamIsToBe183CM]

I found out a bit. Google AI isn't that useless anymore. Gave me a few names and I just had to google them further.

- [Upregulating Wnt Signaling with I3'MO Derivatives](https://pubmed.ncbi.nlm.nih.gov/35176556/)
- [Inverse Binding Indr Derivatives Improve Selectivity for DYRK Kinases](https://pubs.acs.org/doi/10.1021/ml300207a)
- [5,5′-Substituted Indirubin-3′-oxime Derivatives as Potent CDK Inhibitors](https://pubs.acs.org/doi/abs/10.1021/jm100080z)
- [Synthesis and Anti-osteoporosis Potential of 2 New I3'O Derivatives](https://applbiolchem.springeropen.com/counter/pdf/10.3839/jksabc.2010.004.pdf)
- [7-Bromoindirubin-3'-oxime induces caspase-independent cell death](https://pubmed.ncbi.nlm.nih.gov/16702956/)
- [7-Bromo-5'-Carboxyindirubin-3'-oxime](https://www.google.com/search?cs=1&sca_esv=2db17c2fd44c4b31&q=7-Bromo-5%27-carboxyindirubin-3%27-oxime)
- [6BIO Review](https://www.nature.com/articles/s41598-017-11662-7)

EDIT: You might want to google "indirubin derivative e804" too
EDIT 2: You do not. It is an IGF1r antagonist, not agonist


Not exactly. I meant to ask if producing it would be cheaper than buying it. No way it costs 35 bucks to make 5 milligrams. That glpinfo site I linked also had insane inflation for the same compound($45/mg) on another page, for the exact same compound. I doubt it costs $7/mg to make. Aminousa has 750mg of Ibutamoren for $50.


Side note: searching for this gave me a lot more raw data to research. Haven't looked into the ky-<buncha numbers> drug yet. Should do that soon.

Side side note: I have a few sources saved for I3'O(not its derivatives) synthesis. Ask in this thread if you want them.

don’t know about this compound but ky-19382 does the same thing and is cheaper

 

[Sociobiology]

Side side side note: How on planet earth do you guys discover this stuff randomly.

I asked consensus.app for heightmaxxing drugs.

 

[unknownslayer--]

You don't have to pay 5K. You can hop on an hGH secretagogue(aminousa has mk677 cheap) and frequently spike your insulin for higher IGF-1. If you do that, you can lower your dosage, which should make it a lot cheaper, especially with this source.


This source has 50mg for $186. https://www.glpbio.com/indirubin-3-039-oxime.html

increasing gh and spike insulin at the same time is free insulin resistance

 

[mandiblade]

increasing gh and spike insulin at the same time is free insulin resistance

I haven't researched hGH and secretagogues in months. Sorry. That was irresponsible of me. I'll edit that out.

EDIT: I can't edit old posts? Hope no one followed that advice

 

[Orthognathic]

You're likely not going to be able to afford it.

0.5mg x 70kg = 35mg per dose.
159GBP x 35mg = 5565GBP not including VAT.

here's the link: https://www.scientificlabs.co.uk/product/biomolecules/I0404-1MG
good luck.

holy fuck