Sociobiology
Fuchsia
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Search Indirubin-3'-oxime on Google.
Indirubin-3'-oxime (otherwise called I3'O) seems to be a superior heightmaxxing method to HGH+AI because it upregulates the Wnt/beta-catenin pathway which is crucial new bone formation. If you have manlet genetics and your growth plates will likely be less sensitive to the affects of hgh and will not grow as much, Indirubin-3'-oxime directly targets Wnt/beta-catenin to increase chondrocyte proliferation without the organ and soft tissue growth you see on HGH.
How I3O compared to other drugs.
The effects of I3O on bone growth seem to be dose dependent as seen by this chart. As a dose of 0.05mg/kg nad 0.5mg/kg of body weight where used in two tests and produced the following results.
0.5mg/kg is very very expensive as 50mg costs like 500USD online. Also I3O was injected into the mice for 2 to 10 week which equates to years of I3O injections in human terms.
It also seems to be a anti-obesity drug and able to prevent cognitive decline but I cba to provide citations for these claims. If true then it's proof for why taller people tend to be more intelligent.
pmc.ncbi.nlm.nih.gov
It has anti-tumor properties and does not seem to be cytotoxic so far, however this article says it can cause mitochondrial dsyfunction.
It seems I3O can be administered in a number of ways.
Indirubin-3'-oxime (otherwise called I3'O) seems to be a superior heightmaxxing method to HGH+AI because it upregulates the Wnt/beta-catenin pathway which is crucial new bone formation. If you have manlet genetics and your growth plates will likely be less sensitive to the affects of hgh and will not grow as much, Indirubin-3'-oxime directly targets Wnt/beta-catenin to increase chondrocyte proliferation without the organ and soft tissue growth you see on HGH.
How I3O compared to other drugs.
The effects of I3O on bone growth seem to be dose dependent as seen by this chart. As a dose of 0.05mg/kg nad 0.5mg/kg of body weight where used in two tests and produced the following results.
0.5mg/kg is very very expensive as 50mg costs like 500USD online. Also I3O was injected into the mice for 2 to 10 week which equates to years of I3O injections in human terms.
It also seems to be a anti-obesity drug and able to prevent cognitive decline but I cba to provide citations for these claims. If true then it's proof for why taller people tend to be more intelligent.
Indirubin-3′-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway - PMC
Researchers have shown increased interest in determining what stimulates height. Currently, many children undergo precocious puberty, resulting in short stature due to premature closure of the growth plate. However, the current approach for height ...
pmc.ncbi.nlm.nih.gov
It has anti-tumor properties and does not seem to be cytotoxic so far, however this article says it can cause mitochondrial dsyfunction.
Indirubin-3'-oxime induces mitochondrial dysfunction and triggers growth inhibition and cell cycle arrest in human neuroblastoma cells
Neuroblastoma is the most common extracranial solid tumor found in infancy and childhood. Current multimodal therapies such as surgery, chemotherapy, radiotherapy and stem cell transplantation often cause inevitable severe side-effects, therefore, it is necessary to develop novel drugs with...
www.spandidos-publications.com
WO2015005603A1 - Small molecule, indirubin-3-oxime, for prevention and treatment of bone disease - Google Patents
The present invention provides a composition comprising an indirubin derivative for stimulating longitudinal bone growth. Because the composition for stimulating longitudinal bone growth according to the present invention is shown to be effective in longitudinal bone growth, it may be used not...
patents.google.com
