Nicotine my baby

[Julienmc]

Curious on yalls thoughts, also does not apply to niggas ripping 9+ milly zyns raping their reward system

Cognitive enhancement
∙ Enhances attention, working memory, processing speed via α4β2 and α7 nicotinic receptors in prefrontal cortex and hippocampus
∙ α7 receptor modulates long-term potentiation (cellular basis of learning)
∙ Studied as potential treatment for cognitive deficits in schizophrenia, ADHD, Alzheimer’s
Neurotrophic effects
∙ Upregulates BDNF in hippocampus and cortex
∙ Promotes neurogenesis and synaptic plasticity
∙ Mechanism: calcium influx → CREB-mediated transcription
Neurotransmitter modulation
∙ Triggers release of dopamine, norepinephrine, serotonin, glutamate, GABA, acetylcholine via presynaptic nicotinic receptor activation
Neuroprotection
∙ Reduced Parkinson’s risk in epidemiological data
∙ Proposed mechanisms: reduced oxidative stress, anti-inflammatory effects, nicotinic receptor upregulation supporting neuronal survival
Metabolic effects
∙ Increases metabolic rate, reduces appetite
∙ Improves acute insulin sensitivity
∙ Activates brown adipose tissue thermogenesis
Anti-inflammatory
∙ Activates cholinergic anti-inflammatory pathway via α7 receptors on macrophages
∙ Reduces systemic inflammation and pro-inflammatory cytokines
Mood
∙ Acute anxiolytic effects through GABAergic modulation

 

[Miki]

Nicotine is looksmin my bro

 

[Miki]

do your own research aswell bro

 

[confirmgy]

Curious on yalls thoughts, also does not apply to niggas ripping 9+ milly zyns raping their reward system

Cognitive enhancement
∙ Enhances attention, working memory, processing speed via α4β2 and α7 nicotinic receptors in prefrontal cortex and hippocampus
∙ α7 receptor modulates long-term potentiation (cellular basis of learning)
∙ Studied as potential treatment for cognitive deficits in schizophrenia, ADHD, Alzheimer’s
Neurotrophic effects
∙ Upregulates BDNF in hippocampus and cortex
∙ Promotes neurogenesis and synaptic plasticity
∙ Mechanism: calcium influx → CREB-mediated transcription
Neurotransmitter modulation
∙ Triggers release of dopamine, norepinephrine, serotonin, glutamate, GABA, acetylcholine via presynaptic nicotinic receptor activation
Neuroprotection
∙ Reduced Parkinson’s risk in epidemiological data
∙ Proposed mechanisms: reduced oxidative stress, anti-inflammatory effects, nicotinic receptor upregulation supporting neuronal survival
Metabolic effects
∙ Increases metabolic rate, reduces appetite
∙ Improves acute insulin sensitivity
∙ Activates brown adipose tissue thermogenesis
Anti-inflammatory
∙ Activates cholinergic anti-inflammatory pathway via α7 receptors on macrophages
∙ Reduces systemic inflammation and pro-inflammatory cytokines
Mood
∙ Acute anxiolytic effects through GABAergic modulation

I regularly rip Pablos (50mg zyns) and I am unchanged after half a year pretty much

 

[Julienmc]

View attachment 4455040do your own research aswell bro

Yeah I used ai I don’t need to write allat out myself. I also already knew everything it mentioned just no point in using my brainpower to write ts out. and nicotine is looksmax very effective for leanmaxxing only looksmin is collagen but minimal and you can collagen max urself

 

[Miki]

Yeah I used ai I don’t need to write allat out myself. I also already knew everything it mentioned just no point in using my brainpower to write ts out. and nicotine is looksmax very effective for leanmaxxing only looksmin is collagen but minimal and you can collagen max urself

Its bad for bones as it downregulates bone-forming genes in human osteoblast-like cells. Its looksmin my bro face it

Nicotine modulates bone metabolism-associated gene expression in osteoblast cells - PubMed

Smoking has a broad range of physiological effects, such as being a risk factor in osteoporosis, bone fracture incidence, and increased nonunion rates. Recent studies showed that nicotine has effects at the cellular level in human osteoblast cells. To identify possible mechanisms underlying...

pubmed.ncbi.nlm.nih.gov

 

[pizzaiustin1]

dnrd downsides outweigh the upsides

 

[Julienmc]

Its bad for bones as it downregulates bone-forming genes in human osteoblast-like cells. Its looksmin my bro face it

Nicotine modulates bone metabolism-associated gene expression in osteoblast cells - PubMed

Smoking has a broad range of physiological effects, such as being a risk factor in osteoporosis, bone fracture incidence, and increased nonunion rates. Recent studies showed that nicotine has effects at the cellular level in human osteoblast cells. To identify possible mechanisms underlying...

pubmed.ncbi.nlm.nih.gov

the study explains how low dose nicotine enhances bone metabolism that's crazy what a mogger substance

high dose nicotine impairs bone metabolism as it says. it doesn't make clear what the dosage ranges are but I already said 9+ mg is shit.
The fact that it doesn't even specify what dosages tells me this shit really isn't not gonna change shit towards bone formation. I suggest you start nicotine its a W nootropic dont worry ab this minimal bs.

 

[iheartlebron]

Cognitive enhancement
∙ Enhances attention, working memory, processing speed via α4β2 and α7 nicotinic receptors in prefrontal cortex and hippocampus
∙ α7 receptor modulates long-term potentiation (cellular basis of learning)
∙ Studied as potential treatment for cognitive deficits in schizophrenia, ADHD, Alzheimer’s
Neurotrophic effects
∙ Upregulates BDNF in hippocampus and cortex
∙ Promotes neurogenesis and synaptic plasticity
∙ Mechanism: calcium influx → CREB-mediated transcription
Neurotransmitter modulation
∙ Triggers release of dopamine, norepinephrine, serotonin, glutamate, GABA, acetylcholine via presynaptic nicotinic receptor activation
Neuroprotection
∙ Reduced Parkinson’s risk in epidemiological data
∙ Proposed mechanisms: reduced oxidative stress, anti-inflammatory effects, nicotinic receptor upregulation supporting neuronal survival
Metabolic effects
∙ Increases metabolic rate, reduces appetite
∙ Improves acute insulin sensitivity
∙ Activates brown adipose tissue thermogenesis
Anti-inflammatory
∙ Activates cholinergic anti-inflammatory pathway via α7 receptors on macrophages
∙ Reduces systemic inflammation and pro-inflammatory cytokines
Mood
∙ Acute anxiolytic effects through GABAergic modulation

Yo I just sent this to my parents

 

[BPRoryRory]

Curious on yalls thoughts, also does not apply to niggas ripping 9+ milly zyns raping their reward system

Cognitive enhancement
∙ Enhances attention, working memory, processing speed via α4β2 and α7 nicotinic receptors in prefrontal cortex and hippocampus
∙ α7 receptor modulates long-term potentiation (cellular basis of learning)
∙ Studied as potential treatment for cognitive deficits in schizophrenia, ADHD, Alzheimer’s
Neurotrophic effects
∙ Upregulates BDNF in hippocampus and cortex
∙ Promotes neurogenesis and synaptic plasticity
∙ Mechanism: calcium influx → CREB-mediated transcription
Neurotransmitter modulation
∙ Triggers release of dopamine, norepinephrine, serotonin, glutamate, GABA, acetylcholine via presynaptic nicotinic receptor activation
Neuroprotection
∙ Reduced Parkinson’s risk in epidemiological data
∙ Proposed mechanisms: reduced oxidative stress, anti-inflammatory effects, nicotinic receptor upregulation supporting neuronal survival
Metabolic effects
∙ Increases metabolic rate, reduces appetite
∙ Improves acute insulin sensitivity
∙ Activates brown adipose tissue thermogenesis
Anti-inflammatory
∙ Activates cholinergic anti-inflammatory pathway via α7 receptors on macrophages
∙ Reduces systemic inflammation and pro-inflammatory cytokines
Mood
∙ Acute anxiolytic effects through GABAergic modulation

Dnr, nicotine helped me lean out and suppress my hunger, probs the only benefit imo

 

[Miki]

the study explains how low dose nicotine enhances bone metabolism that's crazy what a mogger substance

high dose nicotine impairs bone metabolism as it says. it doesn't make clear what the dosage ranges are but I already said 9+ mg is shit.
The fact that it doesn't even specify what dosages tells me this shit really isn't not gonna change shit towards bone formation. I suggest you start nicotine its a W nootropic dont worry ab this minimal bs.

The thing is though is that you build a tolerance quite quickly so the nootropic effects won't be there unfortunately. Cons outweigh the pros

 

[mihmaxx]

Looksmin, in my opinion, whenever I personally have any type of nicotine for a prolonged period, it destroys my face.

 

[samgrattlescouilles]

I regularly rip Pablos (50mg zyns) and I am unchanged after half a year pretty much

How do you not die from this i got pablos mint of 15mg and i have to take them out after 5minutes so i dont throw up

 

[ThomasDeutsch]

How do you not die from this i got pablos mint of 15mg and i have to take them out after 5minutes so i dont throw up

My coworker got hospitalized from taking multiple zyns at once
I believe it was one of the strongest zyns

 

[samgrattlescouilles]

My coworker got hospitalized from taking multiple zyns at once
I believe it was one of the strongest zyns

Bc he is a retard jfl nicotine is a poison if you have over 50 iq you dont take multiple strong snus without testing them prior

 

[ThomasDeutsch]

Bc he is a retard jfl nicotine is a poison if you have over 50 iq you dont take multiple strong snus without testing them prior

When i first tried snus i had to lay down for 30 minutes cause i was so sick from it

 

[samgrattlescouilles]

When i first tried snus i had to lay down for 30 minutes cause i was so sick from it

First time i tried snus i took a 15mg pablo mint and had to take it out after 5 min cause the room was genuinly spinning idk how i didnt threw up that day tbh

 

[ThomasDeutsch]

First time i tried snus i took a 15mg pablo mint and had to take it out after 5 min cause the room was genuinly spinning idk how i didnt threw up that day tbh

When i got drunk and took snus i legit threw up my whole room

 

[user2.5]

Curious on yalls thoughts, also does not apply to niggas ripping 9+ milly zyns raping their reward system

Cognitive enhancement
∙ Enhances attention, working memory, processing speed via α4β2 and α7 nicotinic receptors in prefrontal cortex and hippocampus
∙ α7 receptor modulates long-term potentiation (cellular basis of learning)
∙ Studied as potential treatment for cognitive deficits in schizophrenia, ADHD, Alzheimer’s
Neurotrophic effects
∙ Upregulates BDNF in hippocampus and cortex
∙ Promotes neurogenesis and synaptic plasticity
∙ Mechanism: calcium influx → CREB-mediated transcription
Neurotransmitter modulation
∙ Triggers release of dopamine, norepinephrine, serotonin, glutamate, GABA, acetylcholine via presynaptic nicotinic receptor activation
Neuroprotection
∙ Reduced Parkinson’s risk in epidemiological data
∙ Proposed mechanisms: reduced oxidative stress, anti-inflammatory effects, nicotinic receptor upregulation supporting neuronal survival
Metabolic effects
∙ Increases metabolic rate, reduces appetite
∙ Improves acute insulin sensitivity
∙ Activates brown adipose tissue thermogenesis
Anti-inflammatory
∙ Activates cholinergic anti-inflammatory pathway via α7 receptors on macrophages
∙ Reduces systemic inflammation and pro-inflammatory cytokines
Mood
∙ Acute anxiolytic effects through GABAergic modulation

Swear nic during development fucks with ur bm ans structure

 

[egf142]

Nicotine is looksmin my bro

what are the bad effects from it (vaping mostly i dont use snus)