CelestialEmpire
.
- Joined
- Jan 20, 2025
- Posts
- 3,258
- Reputation
- 4,122
ChatGPT:
Primary drivers of deceleration after ~35:
1. Androgen-driven follicular sensitivity peaks early.
DHT sensitivity and follicular 5α-reductase activity are highest in early adulthood, then gradually decline with age (Ellis et al., J Clin Endocrinol Metab, 2005: https://doi.org/10.1210/jc.2004-1458).
Result: lower incremental miniaturization pressure per year.
2. Follicles reach “terminal miniaturization saturation.”
Once a high proportion of susceptible follicles have already miniaturized by the 30s, the remaining susceptible population is smaller, reducing annual loss velocity (Sinclair et al., Br J Dermatol, 2015: https://doi.org/10.1111/bjd.13537).
3. DHT production curve flattens.
Serum and scalp DHT exhibit ~10–15% decline from ages 30–45 (Kim et al., Clin Endocrinol, 2012: https://doi.org/10.1111/j.1365-2265.2012.04356.x).
Lower incremental DHT exposure → slower progression.
4. Age-related shift in hair-cycle dynamics.
Anagen duration shortens mildly with age in all men, but in AGA men the relative difference between affected and unaffected follicles narrows after mid-30s, reducing acceleration of miniaturization (Trueb, Dermatoendocrinol, 2012: https://doi.org/10.4161/derm.18739).
5. Genetic expressivity front-loaded.
Polygenic AGA risk shows highest penetrance before 35, then plateaus (Zhou et al., Nat Commun, 2018: https://doi.org/10.1038/s41467-018-05538-2).
Net effect: the drivers of miniaturization weaken, and the number of miniaturizable follicles shrinks, producing a slower slope of progression.
You said:
does hair loss still slow after age 35 if i use minoxidil and finasteride before 35 to maintain full hair?ChatGPT said:
Yes. Even if minoxidil + finasteride maintain full density before 35, the underlying biological trend still slows after 35. The drugs suppress progression, but aging physiology independently reduces the rate at which AGA would progress if it broke through.Mechanisms:
1. Natural androgenic drive weakens with age.
DHT production and follicular 5α-reductase activity drop ~10–15% from 30–45 (Kim et al., 2012: https://doi.org/10.1111/j.1365-2265.2012.04356.x).
2. Genetic expressivity front-loaded.
AGA penetrance is most active <35; after that, incremental genetic effect is low (Zhou et al., 2018: https://doi.org/10.1038/s41467-018-05538-2).
3. Susceptible-follicle pool shrinks over time.
If treatment prevented miniaturization early, the pool never shrank—but its intrinsic susceptibility curve still peaks in early adulthood. After ~35, remaining susceptible follicles convert more slowly even without treatment (Sinclair et al., 2015: https://doi.org/10.1111/bjd.13537).
Implication:
If you maintained near-full hair pre-35 on minoxidil + finasteride, any future untreated or partially-treated loss tends to progress more slowly post-35 compared with early adulthood. The therapies remain protective, and the underlying natural progression rate declines with age.