People get muh "androgen receptor sensitivity" wrong.

[Donkeyballs]

TLDR: Androgen receptor sensitivity DOES NOT refer to the intrinsic sensitivity of each individual receptor (which is determined by genetics).
It refers to the regulation (upregulation/downregulation) of these receptors.

Nobody can explain what androgen receptor sensitivity actually is because it dosent exist in the way they are talking about it, they just talk about how muh important and how to "increase sensitivity."
The individual androgen receptors THEMSELVES don't have varying sensitivity, only upregulation and downregulation of said receptor.
The only factors that actually influence the androgen receptor sensitivity ITSELF are genetic factors like CAG repeats and co-regulators which come from gene transcription, like DNA methylation and histone modifications, basically epigenetic regulators.

Actual terminology of androgen receptor sensitivity refers to the upregulation and downregulation, because of factors like androgen receptor density. (# of receptors)
Usually, the more androgen receptors the more androgen receptor upregulation. Of course it also depends on total and free androgens and antagonists like estrogen, xenostrogens and etc.

We can increase this androgen receptor sensitivity by increasing the number of receptors (AR density, which little people mention LOLLOL)
rather than a change in the intrinsic sensitivity of each individual receptor, because thats only determined by genetics.
L-cartinine for example increases androgen receptor density, and overall the androgen receptor sensitivity, but not because the actual
androgen receptors themselves get more sensitive, it's just the increased number of these receptors.

 

[Deleted member 23558]

actually there are transcriptional genomic effects from things like say t3 and DHT that actually intrinsically modify it to be more sensitive to the effects of androgens. For eg phosophorylation of the receptor may be faster the next time an androgen attaches to the receptor because it was made more sensitive by DHT, but for most purposes probably increasing AR density is what leads to better "sensitization" of these hormones.

 

[ShawarmaFilth]

TLDR: Androgen receptor sensitivity DOES NOT refer to the intrinsic sensitivity of each individual receptor (which is determined by genetics).
It refers to the regulation (upregulation/downregulation) of these receptors.

Nobody can explain what androgen receptor sensitivity actually is because it dosent exist in the way they are talking about it, they just talk about how muh important and how to "increase sensitivity."
The individual androgen receptors THEMSELVES don't have varying sensitivity, only upregulation and downregulation of said receptor.
The only factors that actually influence the androgen receptor sensitivity ITSELF are genetic factors like CAG repeats and co-regulators which come from gene transcription, like DNA methylation and histone modifications, basically epigenetic regulators.

Actual terminology of androgen receptor sensitivity refers to the upregulation and downregulation, because of factors like androgen receptor density. (# of receptors)
Usually, the more androgen receptors the more androgen receptor upregulation. Of course it also depends on total and free androgens and antagonists like estrogen, xenostrogens and etc.

We can increase this androgen receptor sensitivity by increasing the number of receptors (AR density, which little people mention LOLLOL)
rather than a change in the intrinsic sensitivity of each individual receptor, because thats only determined by genetics.
L-cartinine for example increases androgen receptor density, and overall the androgen receptor sensitivity, but not because the actual
androgen receptors themselves get more sensitive, it's just the increased number of these receptors.

actually there are transcriptional genomic effects from things like say t3 and DHT that actually intrinsically modify it to be more sensitive to the effects of androgens. For eg phosophorylation of the receptor may be faster the next time an androgen attaches to the receptor because it was made more sensitive by DHT, but for most purposes probably increasing AR density is what leads to better "sensitization" of these hormones.

give tdlr

Is l cartinine worth it or fake?

 

[TechnoBoss]

TLDR: Androgen receptor sensitivity DOES NOT refer to the intrinsic sensitivity of each individual receptor (which is determined by genetics).
It refers to the regulation (upregulation/downregulation) of these receptors.

Nobody can explain what androgen receptor sensitivity actually is because it dosent exist in the way they are talking about it, they just talk about how muh important and how to "increase sensitivity."
The individual androgen receptors THEMSELVES don't have varying sensitivity, only upregulation and downregulation of said receptor.
The only factors that actually influence the androgen receptor sensitivity ITSELF are genetic factors like CAG repeats and co-regulators which come from gene transcription, like DNA methylation and histone modifications, basically epigenetic regulators.

Actual terminology of androgen receptor sensitivity refers to the upregulation and downregulation, because of factors like androgen receptor density. (# of receptors)
Usually, the more androgen receptors the more androgen receptor upregulation. Of course it also depends on total and free androgens and antagonists like estrogen, xenostrogens and etc.

We can increase this androgen receptor sensitivity by increasing the number of receptors (AR density, which little people mention LOLLOL)
rather than a change in the intrinsic sensitivity of each individual receptor, because thats only determined by genetics.
L-cartinine for example increases androgen receptor density, and overall the androgen receptor sensitivity, but not because the actual
androgen receptors themselves get more sensitive, it's just the increased number of these receptors.

So basically it means the same thing as what you're saying? Androgen sensitivity just sounds like an easy thing to say. Maybe people get the explanation wrong but the usual explanation people give is basically in practice the same thing as what you're talking about. Correct?

 

[Donkeyballs]

So basically it means the same thing as what you're saying? Androgen sensitivity just sounds like an easy thing to say. Maybe people get the explanation wrong but the usual explanation people give is basically in practice the same thing as what you're talking about. Correct?

When talking about the this terminology of androgen sensitivity (what they are actually referring to) by increasing upregulation but not actual sensitivity, then pretty much yeah.

However the factors that intrinsically affect the androgen receptors are different from factors that upregulate and increase androgen receptors and it's important to separate this.
Because factors that increase the actual sensitivity are genetic, affected by epigenetics, which are affected by these epigenetic regulators, like DNA methylation, histone modifications.
I mentioned this here

like DNA methylation and histone modifications, basically epigenetic regulators.

And for example, phosphorylation affects these epigenetic regulators like BrahminBoss mentioned

For eg phosophorylation

And phosphorylation is influenced by factors like DHT which BrahminBoss mentioned. All of this is transcriptional activity in which androgen receptor sensitivity changes, influenced by the former. So basically:

AR sensitivity <-- Genetic <--- Epigenetics (influences and controls genetic transcriptions) <--- Epigenetic regulators <--- (various other factor, etc etc.)

 

[Donkeyballs]

give tdlr

Is l cartinine worth it or fake?

L-cartinitne ---> Increases androgen receptor density ---> More androgen receptor upregulation.
So yeah, it's not fake

 

[ShawarmaFilth]

H

L-cartinitne ---> Increases androgen receptor density ---> More androgen receptor upregulation.
So yeah, it's not fake

ow much? I’m taking 3000 but prolly gonna up to 4000

 

[Donkeyballs]

H

ow much? I’m taking 3000 but prolly gonna up to 4000

yeah 4000mg is fine, you should avoid small doses of oral l-cartinine because the bioavailability is low.

After oral doses of 1-6g, the absolute bioavailability is 5-18%.

According to this: https://pubmed.ncbi.nlm.nih.gov/129...f 1-6g, the absolute bioavailability is 5-18%.

In contrast, the bioavailability of dietary L-carnitine may be as high as 75%.
So also try to eat important foods

 

[ShawarmaFilth]

yeah 4000mg is fine, you should avoid small doses of oral l-cartinine because the bioavailability is low.

After oral doses of 1-6g, the absolute bioavailability is 5-18%.

According to this: https://pubmed.ncbi.nlm.nih.gov/12908852/#:~:text=After oral doses of 1-6g, the absolute bioavailability is 5-18%.

In contrast, the bioavailability of dietary L-carnitine may be as high as 75%.
So also try to eat important foods

I eat a ton of meat like a pound a day what should i put into my diet

 

[MA_ascender]

actually there are transcriptional genomic effects from things like say t3 and DHT that actually intrinsically modify it to be more sensitive to the effects of androgens. For eg phosophorylation of the receptor may be faster the next time an androgen attaches to the receptor because it was made more sensitive by DHT, but for most purposes probably increasing AR density is what leads to better "sensitization" of these hormones.

so thyroid hormone gives you more bang for your buck on your androgens? explain bhai im regarded

 

[Deleted member 23558]

so thyroid hormone gives you more bang for your buck on your androgens? explain bhai im regarded

you can say that, t3 prevents muscle loss on a cut and t3 is ESSENTIAL for producing the sex hormones in the first place. Bodybuilders dose it like retards which is they end up losing muscle

 

[MA_ascender]

you can say that, t3 prevents muscle loss on a cut and t3 is ESSENTIAL for producing the sex hormones in the first place. Bodybuilders dose it like retards which is they end up losing muscle

bhai i wanna heightmaxx im on 0.25 mg anastrozole should i take 100 mcg t4 per day? to boost growth and androgens

 

[Deleted member 23558]

bhai i wanna heightmaxx im on 0.25 mg anastrozole should i take 100 mcg t4 per day? to boost growth and androgens

no take iodine but if u really want to increase then take t3

 

[MA_ascender]

no take iodine but if u really want to increase then take t3

t3 is banned and impossible to find where i live. is t4 + selenium not good? gets converted anyway, plus i see height studies with t4 only. they say t4 also boosts hgh secretion and expression

 

[Deleted member 23558]

t3 is banned and impossible to find where i live. is t4 + selenium not good? gets converted anyway, plus i see height studies with t4 only. they say t4 also boosts hgh secretion and expression

t4 i think is risky, for some it works some it doesnt u can never know. why would t3 be banned? try sourcing it from some other place if ur country doesnt have it. Iodine will reliably increase ur thyroid in the long run, coffee also stimulates the thyroid gland. reduce estrogen with progesterone also leads to thyroid working more efficiently

 

[MA_ascender]

t4 i think is risky, for some it works some it doesnt u can never know. why would t3 be banned? try sourcing it from some other place if ur country doesnt have it. Iodine will reliably increase ur thyroid in the long run, coffee also stimulates the thyroid gland. reduce estrogen with progesterone also leads to thyroid working more efficiently

i have 10 tubs of progestogel you sure this wont give me fatass hips like a woman ? im being fr bhai. t4 is my only option how bad is it reallyN

 

[Deleted member 23558]

i have 10 tubs of progestogel

dosage?

 

[MA_ascender]

dosage?

hold on ill get it

 

[MA_ascender]

dosage?

80 grams of gel 1 gram of progesterone

 

[Deleted member 23558]

View attachment 2995896 80 grams of gel 1 gram of progesterone

idk about topical absorption, i take 50 mg oral , if topical absorption is as good as oral try the same dose. once or twice a week is enough

 

[MA_ascender]

idk about topical absorption, i take 50 mg oral , if topical absorption is as good as oral try the same dose. once or twice a week is enough

isnt this a tranny buttsex drug tho? what about t4 why is it inferior

 

[MA_ascender]

idk about topical absorption, i take 50 mg oral , if topical absorption is as good as oral try the same dose. once or twice a week is enough

nigger wtf is this why do you want to turn me trans @Sapieeen

 

[Rigged]

TLDR: Androgen receptor sensitivity DOES NOT refer to the intrinsic sensitivity of each individual receptor (which is determined by genetics).
It refers to the regulation (upregulation/downregulation) of these receptors.

Nobody can explain what androgen receptor sensitivity actually is because it dosent exist in the way they are talking about it, they just talk about how muh important and how to "increase sensitivity."
The individual androgen receptors THEMSELVES don't have varying sensitivity, only upregulation and downregulation of said receptor.
The only factors that actually influence the androgen receptor sensitivity ITSELF are genetic factors like CAG repeats and co-regulators which come from gene transcription, like DNA methylation and histone modifications, basically epigenetic regulators.

Actual terminology of androgen receptor sensitivity refers to the upregulation and downregulation, because of factors like androgen receptor density. (# of receptors)
Usually, the more androgen receptors the more androgen receptor upregulation. Of course it also depends on total and free androgens and antagonists like estrogen, xenostrogens and etc.

We can increase this androgen receptor sensitivity by increasing the number of receptors (AR density, which little people mention LOLLOL)
rather than a change in the intrinsic sensitivity of each individual receptor, because thats only determined by genetics.
L-cartinine for example increases androgen receptor density, and overall the androgen receptor sensitivity, but not because the actual
androgen receptors themselves get more sensitive, it's just the increased number of these receptors.

High IQ yap, just inject Progesterone