GunnnerW1
Iron
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- Jun 24, 2025
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I’m breaking down why CJC+IPA, whether with DAC or no DAC or pretty much any growth hormone releasing peptide (GHRP) is a dead end if you’re actually chasing height gains. Let’s get to the facts: there’s a total lack of real literature. There are zero clinical studies on CJC+IPA, Ipamorelin, or any GHRP in adolescents. Pediatric growth clinics don’t touch these secretagogues for short stature or height optimization. Everything actually used is recombinant HGH. So, all the claims about gaining height. Is pure theory, no evidence.
If you really want to gain height, you have to use an aromatase inhibitor (AI) to keep the growth plates from closing by preventing estrogen-induced epiphyseal fusion. But HGH doesn’t just crank up IGF-1 and growth speed, it also upregulates aromatase in the growth plates because HGH raises systemic and local IGF-1 levels, and IGF-1 in turn stimulates aromatase gene expression in bone and cartilage cells, including the chondrocytes of the growth plate. That means without an AI, high-dose HGH can actually accelerate growth plate closure, getting you to your genetic max height even faster, but you could lose possible extra inches.
You’re probably asking then why don’t I just use an AI with any growth hormone releasing peptide. But using an AI to lower estrogen in a state where actual height can be gained, around under <10 pg/ml, would lower estrogen enough that the crucial signal that allows the liver to produce IGF-1 efficiently in response to that GH pulse almost cancels out.
In studies with ISS (idiopathic short stature), meaning there is no medical reason like GH deficiency or diseases and having normal proportions basically like a normal person but just short the dosing for HGH is 25–50 mcg/kg/day. So for me, because I am 180 pounds, the minimum dose would be 6.13 IU a day and the high end 12.3 IU a day, which is obviously supraphysiological as a male/female in puberty naturally produces 1.5–2 IU daily. And even with that high of doses such as 12 IU+ for years, height gained isn’t as much as people think, around 1–3 cm on average. GHRPs are going to on average give you a 0.5–1.5 IU boost in GH, so thinking that small of an increase of GH/IGF is going to cause any height growth is insanely dumb, and paired with an AI like Aromasin limiting the amount of natural GH because limited estrogen is going to lower overall GH and IGF levels.
I also want to add that on average, people with ISS, so normal people that are on GH to see a change, are on GH for 4–7 years. This isn’t even possible with GHRP as your pituitary gland becomes desensitized fairly quickly. For example, even in the second week of CJC+IPA, the amount of GH the pituitary gland releases starts to heavily decline and usually becomes fully desensitized to the peptide around 12 weeks.
If you really want to gain height, you have to use an aromatase inhibitor (AI) to keep the growth plates from closing by preventing estrogen-induced epiphyseal fusion. But HGH doesn’t just crank up IGF-1 and growth speed, it also upregulates aromatase in the growth plates because HGH raises systemic and local IGF-1 levels, and IGF-1 in turn stimulates aromatase gene expression in bone and cartilage cells, including the chondrocytes of the growth plate. That means without an AI, high-dose HGH can actually accelerate growth plate closure, getting you to your genetic max height even faster, but you could lose possible extra inches.
You’re probably asking then why don’t I just use an AI with any growth hormone releasing peptide. But using an AI to lower estrogen in a state where actual height can be gained, around under <10 pg/ml, would lower estrogen enough that the crucial signal that allows the liver to produce IGF-1 efficiently in response to that GH pulse almost cancels out.
In studies with ISS (idiopathic short stature), meaning there is no medical reason like GH deficiency or diseases and having normal proportions basically like a normal person but just short the dosing for HGH is 25–50 mcg/kg/day. So for me, because I am 180 pounds, the minimum dose would be 6.13 IU a day and the high end 12.3 IU a day, which is obviously supraphysiological as a male/female in puberty naturally produces 1.5–2 IU daily. And even with that high of doses such as 12 IU+ for years, height gained isn’t as much as people think, around 1–3 cm on average. GHRPs are going to on average give you a 0.5–1.5 IU boost in GH, so thinking that small of an increase of GH/IGF is going to cause any height growth is insanely dumb, and paired with an AI like Aromasin limiting the amount of natural GH because limited estrogen is going to lower overall GH and IGF levels.
I also want to add that on average, people with ISS, so normal people that are on GH to see a change, are on GH for 4–7 years. This isn’t even possible with GHRP as your pituitary gland becomes desensitized fairly quickly. For example, even in the second week of CJC+IPA, the amount of GH the pituitary gland releases starts to heavily decline and usually becomes fully desensitized to the peptide around 12 weeks.
