PFS isn't something to worry about.

[SlayerJonas]

Most individuals will have to use a 5ARi sooner or later to keep their precious hair and skin. Just one pill a day, it's as comfortable as it gets.

5ARis are one of the easiest high ROI softmaxxes and will stop you from looking like William in his early 40s.

Fearmongering regarding side effects is the only logical limiting factor keeping some individuals from improving their lives (via 5ARis).

The most notable fearmongering attempt by society is post-finasteride syndrome (PFS), which only affects <0.1% of humans in the first place.

After acknowledging that this condition is absurdly uncommon, let's proceed further dismantling this cope.

Every brain is individual, consequently some pathways are of higher importance for correct brain function. One of these pathways is the synthesis of allopregnanolone.

This means in <0.1% of individuals PFS can occur, the great thing is that this outcome differs drastically from placebo meaning side effects would manifest noticeably.

In short you only have to cease treatment with the 5ARi of your choice and all side effects resolve, nothing is of permanent nature.

Even better is the fact that we can supplement allopregnanolone exogenously if the affected individual really is one of the <0.1%.

Inb4 "muh needles"

If you want to stay on the safe side test your brain's genotype with finasteride (short half-life of 6-8 hours), meaning it'd clear out of your system within days fully.

After that (if natty) either use a higher dose of finasteride or preferably a low dose of dutasteride. The latter will allow you to maintain your health indicators for life, you can also increase the dose with time.

Sourcing and costs aren't problematic. Where there is a will there's a way.

Spoiler: Tags

@chadisbeingmade @Eltrē @imontheloose @DORIAN @Randomized Shame

 

[idkmanimao]

Most individuals will have to use a 5ARi sooner or later to keep their precious hair and skin. Just one pill a day, it's as comfortable as it gets.

5ARis are one of the easiest high ROI softmaxxes and will stop you from looking like William in his early 40s.

View attachment 3961955

Fearmongering regarding side effects is the only logical limiting factor keeping some individuals from improving their lives (via 5ARis).

The most notable fearmongering attempt by society is post-finasteride syndrome (PFS), which only affects <0.1% of humans in the first place.

After acknowledging that this condition is absurdly uncommon, let's proceed further dismantling this cope.

Every brain is individual, consequently some pathways are of higher importance for correct brain function. One of these pathways is the synthesis of allopregnanolone.

View attachment 3961966

This means in <0.1% of individuals PFS can occur, the great thing is that this outcome differs drastically from placebo meaning side effects would manifest noticeably.

In short you only have to cease treatment with the 5ARi of your choice and all side effects resolve, nothing is of permanent nature.

Even better is the fact that we can supplement allopregnanolone exogenously if the affected individual really is one of the <0.1%.

Inb4 "muh needles"

View attachment 3961979

If you want to stay on the safe side test your brain's genotype with finasteride (short half-life of 6-8 hours), meaning it'd clear out of your system within days fully.

After that (if natty) either use a higher dose of finasteride or preferably a low dose of dutasteride. The latter will allow you to maintain your health indicators for life, you can also increase the dose with time.

Sourcing and costs aren't problematic. Where there is a will there's a way.

Spoiler: Tags

@chadisbeingmade @Eltrē @imontheloose @DORIAN @Randomized Shame

before BOTB thanks bby

 

[ProBono]

thanks for the green letters they are soothing my giganigga headache 1%

 

[MANLETprettyBOY]

Wrote all that when niggas in here dont even take action

 

[Linus1888]

(if natty)

Wyh the if natty part?

 

[Arzenic]

Mirin the effort with ur threads, bookmarked this and gonna look into it

 

[The Homelander]

Finasteride is a tranny drug, balding isn't something to worry about. Bald = high T.

All of the world's greatest leaders are balding/bald

Average Norwooder vs. Average Fin addict

Low T if you care about "muh hair"

@JohnBaza @TheBlackpilledOne @Methylphenidate @2025cel @Toggle9877

 

[Randomized Shame]

Every brain is individual, consequently some pathways are of higher importance for correct brain function. One of these pathways is the synthesis of allopregnanolone.

This means in <0.1% of individuals PFS can occur, the great thing is that this outcome differs drastically from placebo meaning side effects would manifest noticeably.

I think I understand what you're saying here but I'm not fully positive. Are you saying the synthesis of allopregnanolone effects how PFS side effects manifests inside of a person?

 

[6´3 LTN]

Finasteride is a tranny drug, balding isn't something to worry about. Bald = high T.

All of the world's greatest leaders are balding/bald
View attachment 3962105View attachment 3962108


View attachment 3962111

Average Norwooder vs. Average Fin addict
View attachment 3962114

Low T if you care about "muh hair"

@JohnBaza @TheBlackpilledOne @Methylphenidate @2025cel @Toggle9877

Giga cope

 

[The Homelander]

Giga cope

Niggacope.

 

[St. Kentish Gupta]

The Bengalurian prophet back at it again

 

[Toggle9877]

I needed this thanks

 

[SlayerJonas]

Wrote all that when niggas in here dont even take action

Indirectly addressed that problem by reducing mental constructs like the fear of sides.

Wyh the if natty part?

Simplicity. Dutasteride affects the first 5AR isoenzyme which is found in bone tissue to some extent, finasteride only affects the second isoenzyme. You can always directly reduce side effects with other compounds, though for the sake of simplicity I mentioned the use of finasteride in this specific case (natty).

All of the world's greatest leaders are balding/bald

Not this one.

I think I understand what you're saying here but I'm not fully positive. Are you saying the synthesis of allopregnanolone effects how PFS side effects manifests inside of a person?

There is a big genetic variability in how allopregnanolone affects humans, some more, some less. PFS is a condition affecting solely the brain, 5ARis suppress the synthesis of allopregnanolone and neurosteroids, the latter isn't as important. I hope this made my reasoning more clear.

 

[HighIQ ubermensch]

After that (if natty) either use a higher dose of finasteride or preferably a low dose of dutasteride. The latter will allow you to maintain your health indicators for life, you can also increase the dose with time.

hair only
it ain't gonna save the skin

correct me if I'm wrong

 

[Deleted member 180697]

Everyone needs to celebrate their 18th birthday with a bowl of dutasteride. It's better to start inhibiting DHT before you even lose any hair. Hair loss is only apparent when you have already lost 50% of density. You could be balding right now and not even realize it.

 

[Linus1888]

Indirectly addressed that problem by reducing mental constructs like the fear of sides.

Simplicity. Dutasteride affects the first 5AR isoenzyme which is found in bone tissue to some extent, finasteride only affects the second isoenzyme. You can always directly reduce side effects with other compounds, though for the sake of simplicity I mentioned the use of finasteride in this specific case (natty).

Not this one.
View attachment 3962146

There is a big genetic variability in how allopregnanolone affects humans, some more, some less. PFS is a condition affecting solely the brain, 5ARis suppress the synthesis of allopregnanolone and neurosteroids, the latter isn't as important. I hope this made my reasoning more clear.

Kim Jong un is an underrated hairmaxxer. Genetcially keeping Testoserone low to maintain hair, mirin the trade-off

 

[HighIQ ubermensch]

What do you have to say about this?

Long-term use of dutasteride to treat androgenic alopecia in young men may lead to persistent abnormalities in semen parameters - PubMed

Long-term use of dutasteride may lead to male infertility by persistently impairing semen volume and sperm motility.

pubmed.ncbi.nlm.nih.gov

 

[SlayerJonas]

hair only
it ain't gonna save the skin

correct me if I'm wrong

Finasteride negligibly due to the decrease in the serum concentration of DHT because it doesn't inhibit the first isoenzyme of 5AR in skin unlike dutasteride.

The latter option would improve skin short-term via the reduction of sebum production and long-term by preventing the rape of elastin.

Hair loss is only apparent when you have already lost 50% of density. You could be balding right now and not even realize it.

People always fail to realize this. Everyone after reaching full maturity physically should hop on a 5ARi.

What do you have to say about this?

Long-term use of dutasteride to treat androgenic alopecia in young men may lead to persistent abnormalities in semen parameters - PubMed

Long-term use of dutasteride may lead to male infertility by persistently impairing semen volume and sperm motility.

pubmed.ncbi.nlm.nih.gov

Finasteride won't cause any problems spermatogenesis-wise.

CHRONIC TREATMENT WITH FINASTERIDE DAILY DOES NOT AFFECT SPERMATOGENESIS OR SEMEN PRODUCTION IN YOUNG MEN

Finasteride, an oral type 2, 5α-reductase inhibitor, is used in 1 mg. daily doses for the treatment of male pattern hair loss. A dose of 5 mg. finaste…

www.sciencedirect.com

Dutasteride doesn't cause any permanent issues if it does in the first place.

This study demonstrates that the decrease in DHT induced by 5ARIs is associated with mild decreases in semen parameters that appear reversible after discontinuation.

The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men - PubMed

This study demonstrates that the decrease in DHT induced by 5ARIs is associated with mild decreases in semen parameters that appear reversible after discontinuation.

pubmed.ncbi.nlm.nih.gov

That's literally one of the reasons why I specified the use of finasteride for natties. For the sake of simplicity just stick to finasteride if natty.

 

[HighIQ ubermensch]

People always fail to realize this. Everyone after reaching full maturity physically should hop on a 5ARi.

so 16 or 21?

 

[SlayerJonas]

so 16 or 21?

Everyone reaches full maturity at a different age, the answer is something in-between.

Use your tanner stage, bone age and other variables to assess maturity.

Just keep in mind that the norwood reaper doesn't wait until 18.

 

[imontheloose]

You should stop posting this stuff. People do not appreciate the very simple information put forward to them.

 

[repszon]

Pfs affects 0% of users

 

[PSL Accuracy]

Everyone reaches full maturity at a different age, the answer is something in-between.

Use your tanner stage, bone age and other variables to assess maturity.

Just keep in mind that the norwood reaper doesn't wait until 18.

What age would be the best age to hop on dutasteride

 

[Hernan]

Most individuals will have to use a 5ARi sooner or later to keep their precious hair and skin. Just one pill a day, it's as comfortable as it gets.

5ARis are one of the easiest high ROI softmaxxes and will stop you from looking like William in his early 40s.

View attachment 3961955

Fearmongering regarding side effects is the only logical limiting factor keeping some individuals from improving their lives (via 5ARis).

The most notable fearmongering attempt by society is post-finasteride syndrome (PFS), which only affects <0.1% of humans in the first place.

After acknowledging that this condition is absurdly uncommon, let's proceed further dismantling this cope.

Every brain is individual, consequently some pathways are of higher importance for correct brain function. One of these pathways is the synthesis of allopregnanolone.

View attachment 3961966

This means in <0.1% of individuals PFS can occur, the great thing is that this outcome differs drastically from placebo meaning side effects would manifest noticeably.

In short you only have to cease treatment with the 5ARi of your choice and all side effects resolve, nothing is of permanent nature.

Even better is the fact that we can supplement allopregnanolone exogenously if the affected individual really is one of the <0.1%.

Inb4 "muh needles"

View attachment 3961979

If you want to stay on the safe side test your brain's genotype with finasteride (short half-life of 6-8 hours), meaning it'd clear out of your system within days fully.

After that (if natty) either use a higher dose of finasteride or preferably a low dose of dutasteride. The latter will allow you to maintain your health indicators for life, you can also increase the dose with time.

Sourcing and costs aren't problematic. Where there is a will there's a way.

Spoiler: Tags

@chadisbeingmade @Eltrē @imontheloose @DORIAN @Randomized Shame