Potential neurosteroidal HRT (finasteridecels GTFIH)

[fluoride1337]

As we all know, the biggest fears people have about Sααr inhibitors is muh watery semens, muuh PFS, and muh neurosteroidinos.

Yesterday I was looking at products from Idealabs, which is a company owned by Haidut, a popular figure from the bioenergetic/Ray Peat sphere.

A hormone that piqued my interest is 3α-DHP, which is a progesterone derivative that shows similar effects on GABA receptors as allopregnanolone. Allopregnanolone is one of the main neurosteroidinos associated with finasteride-induced depression, since it relies on DHT for synthesis.

"Recently, the FDA approved the progesterone derivative allopregnanolone (3α, 5α-tetrahydroprogesterone), commonly known as Allo or AlloP, as a treatment for post-partum depression. In addition, multiple companies are running clinical trials with that steroid for wide range of other conditions including dementia (e.g. Alzheimer Disease), anxiety disorders, autism, psychotic states (e.g. schizophrenia), post-traumatic stress disorder (PTSD), and even direct brain damage states such as traumatic brain injury (TBI) as well as its chronic form known as chronic traumatic encephalopathy (CTE). As of now, the only condition for which AlloP has been approved is postpartum depression with expectations that the steroid will soon be also approved for depression of any origin."

"Interestingly enough, 3α-DHP has been found to have the same affinity and strength as a GABA agonist as allopregnanolone, and the latter is known as the most potent endogenous GABA agonist agent. As such, multiple studies have demonstrated that 3α-DHP has similar anxiolytic, sedative and analgesic effects as allopregnanolone. In addition, levels of 3α-DHP have been found to be low in many conditions where allopregnanolone levels have also been found to be low."

"Unlike the case of most other inhibitory neurosteroids, 3α-DHP production is not blocked by 5α-reductase inhibitors like finasteride."

The idealabs page contains a lot more information and studies regarding 3α-DHP, which I would recommend anyone suffering fin/dut sides to look into.

 

[WifeBeater6⁹]

 

[NZb6Air]

what this nigga, said muh > serious issue

but didn't give me solution,

yo how am i gonna get exo allo easily rn ?

 

[fluoride1337]

what this nigga, said muh > serious issue

but didn't give me solution,

yo how am i gonna get exo allo easily rn ?

I sent you the link to it, I'm not sure if I'm allowed to link it directly in threads

 

[20/04/2008]

Nigga he just copied my thread with gpt i swear to god

Exposing the biggest org fraud that is @piec (balding cell gftih)

Why Finasteride (or dut) is a fraud : So debunking the claim is finasteride dangerous for you yes or no their are some people who get the following effects from just microdosing fin : sexual dysfunction Anhedonia Depression Anxiety Lack of motivation Lack of focus While other seems fine...

looksmax.org

what this nigga, said muh > serious issue

but didn't give me solution,

yo how am i gonna get exo allo easily rn ?

 

[fluoride1337]

Nigga he just copied my thread with gpt i swear to god

Exposing the biggest org fraud that is @piec (balding cell gftih)

Why Finasteride (or dut) is a fraud : So debunking the claim is finasteride dangerous for you yes or no their are some people who get the following effects from just microdosing fin : sexual dysfunction Anhedonia Depression Anxiety Lack of motivation Lack of focus While other seems fine...

looksmax.org

Yea I totally copied your thread recommending peppermint and emu oil for MPB

 

[20/04/2008]

You

Yea I totally copied your thread recommending peppermint and emu oil for MPB

copied the first part

 

[20/04/2008]

“Now lets starts on why finasteride cause all of this sides :

When you use and 5ar inhibitor your not just inhibiting dht but also progesterone and alopregnolone and if you neealycompletely inhibit the enzyme (which you probably will cause most of the 5ar is type 1 and don’t get me started on dut that shit blocks everything) or nearly you have no progesterone and alopregonolone function in your body so back then i thought well you can just take progestene just to come to the conclusion its gonna do nothing for cause you totaly inhibited thw enzyme.

Suggestion : (keep in mind this is not the best approach I’m gonna get to the nest approach later but its still better than the fraud that is piec feel free to insult his ass in the comments)



Now lets talk about the sides :

Remember about the sides i talked about earlier it was due to allo pregnolone who acts as a innate benzo in your system (so basicaly the main inhibotory gaba system in your brain is the gabaergic system related to the hormone you name it “gaba” it has 2 receptors Gaba B fair enough it can be agonized with just phenibut so no need first allopregnolone its not in the sort of communication in the brain anyway (which mean less signaling)

then We have Gaba A

The only critical receptor and guess what the Gaba A receptor is modulated by allopregnolone which if you remember correctly you blocked earlier sp how do i explain it basicaly its like you took a reverse xanax so the average nigga is gonna have anhedonia exept of he is an outlier so now your fucking dependent on benzos who are super dangerous if you don’t wanna feel like shit

(Then some smart ass in the comment gonna write well then why dont you take alopregnolone well it has very short half life and it can’t be stored or kept so unless you want to be taking ng of allopregnolone every 5 minutes you should either feel like shit like that evil piec want you to be or be addicted to benzos for progesterone you can just take transdermal or micronuzed progesterone just make sure to be on hormones cause your at high risk of hypogonadism if you mess up your dosages)



(Also their are other alternatives so 1) way to get allopregnolone which in theory would work not sure 100% is your gonna take your progesterone and agnozed the tsp receptor you’ll end up with more neuro steroidgenisis so you have more alopregnolone just make sure to not get addicted to that shit might write a thread about how to never get addicted to compounds and how to get rid off any addiction but for that ill need you to support me and all insult piec parents for not putting on a rubber that sad night

Getting back to what i was saying their some research that seem mehh like ettyfoxine but that shit is too risky in my opinion

2) alternative is basicaly fuck modulating gaba receptors you just take sodium valproate kt basicaly make your brain a sink of gaba kinda like piec asshole after getting fucked by every dermatologist prescribing him fin

And its a hdac inhibitor so it have epigenetic change keep in mind that shit aint salt that a epilepsy drug and they are reliable 100% cause nigga imagine an epileptic go through withdrawal his gonna fucking die like piec pride after i finish writing this thread)

So to summarize a little :

Erectil dysfunction: is caused by low progesterone abdominal low dht

Anhedhonia : is cause by low alopregnolone levels

Anxiety : is caused because the amygdila have gaba receptors which when inhibited cause the amygdala to start tweaking like piec teading this right now well i hope finasteride would give you trauma and make you hyper vigilant to not with me next time keep in mind if it don’t happen to you it could just mean you had a gabaminergic deficit or your life so

you adapted your the exeption not the rule



Lack of focus : mainly because of low dht and progesterone youll need for that to increase your dopamenergic signaling (supposing you have average serotonorgic signaling) but you can use something like wellbutrin ritalin low dose in the morning 2x per week

(Wellbutrin do have bad effects on cholinergic system but supposing your an average dude and get a lot of choline in your diet your probably fine)”

 

[20/04/2008]

Yea I totally copied your thread recommending peppermint and emu oil for MPB

And the fact you responded immediately that just exposed your ass

 

[20/04/2008]

what this nigga, said muh > serious issue

but didn't give me solution,

yo how am i gonna get exo allo easily rn ?

Nigga he literally just read my thread and copied it using gpt

 

[fluoride1337]

“Now lets starts on why finasteride cause all of this sides :

When you use and 5ar inhibitor your not just inhibiting dht but also progesterone and alopregnolone and if you neealycompletely inhibit the enzyme (which you probably will cause most of the 5ar is type 1 and don’t get me started on dut that shit blocks everything) or nearly you have no progesterone and alopregonolone function in your body so back then i thought well you can just take progestene just to come to the conclusion its gonna do nothing for cause you totaly inhibited thw enzyme.

Suggestion : (keep in mind this is not the best approach I’m gonna get to the nest approach later but its still better than the fraud that is piec feel free to insult his ass in the comments)



Now lets talk about the sides :

Remember about the sides i talked about earlier it was due to allo pregnolone who acts as a innate benzo in your system (so basicaly the main inhibotory gaba system in your brain is the gabaergic system related to the hormone you name it “gaba” it has 2 receptors Gaba B fair enough it can be agonized with just phenibut so no need first allopregnolone its not in the sort of communication in the brain anyway (which mean less signaling)

then We have Gaba A

The only critical receptor and guess what the Gaba A receptor is modulated by allopregnolone which if you remember correctly you blocked earlier sp how do i explain it basicaly its like you took a reverse xanax so the average nigga is gonna have anhedonia exept of he is an outlier so now your fucking dependent on benzos who are super dangerous if you don’t wanna feel like shit

(Then some smart ass in the comment gonna write well then why dont you take alopregnolone well it has very short half life and it can’t be stored or kept so unless you want to be taking ng of allopregnolone every 5 minutes you should either feel like shit like that evil piec want you to be or be addicted to benzos for progesterone you can just take transdermal or micronuzed progesterone just make sure to be on hormones cause your at high risk of hypogonadism if you mess up your dosages)



(Also their are other alternatives so 1) way to get allopregnolone which in theory would work not sure 100% is your gonna take your progesterone and agnozed the tsp receptor you’ll end up with more neuro steroidgenisis so you have more alopregnolone just make sure to not get addicted to that shit might write a thread about how to never get addicted to compounds and how to get rid off any addiction but for that ill need you to support me and all insult piec parents for not putting on a rubber that sad night

Getting back to what i was saying their some research that seem mehh like ettyfoxine but that shit is too risky in my opinion

2) alternative is basicaly fuck modulating gaba receptors you just take sodium valproate kt basicaly make your brain a sink of gaba kinda like piec asshole after getting fucked by every dermatologist prescribing him fin

And its a hdac inhibitor so it have epigenetic change keep in mind that shit aint salt that a epilepsy drug and they are reliable 100% cause nigga imagine an epileptic go through withdrawal his gonna fucking die like piec pride after i finish writing this thread)

So to summarize a little :

Erectil dysfunction: is caused by low progesterone abdominal low dht

Anhedhonia : is cause by low alopregnolone levels

Anxiety : is caused because the amygdila have gaba receptors which when inhibited cause the amygdala to start tweaking like piec teading this right now well i hope finasteride would give you trauma and make you hyper vigilant to not with me next time keep in mind if it don’t happen to you it could just mean you had a gabaminergic deficit or your life so

you adapted your the exeption not the rule



Lack of focus : mainly because of low dht and progesterone youll need for that to increase your dopamenergic signaling (supposing you have average serotonorgic signaling) but you can use something like wellbutrin ritalin low dose in the morning 2x per week

(Wellbutrin do have bad effects on cholinergic system but supposing your an average dude and get a lot of choline in your diet your probably fine)”

dnr

 

[fluoride1337]

Nigga he literally just read my thread and copied it using gpt

nigga thinks he discovered allopregnanolone and I must've copied his thread because I mentioned it

 

[20/04/2008]

nigga thinks he discovered allopregnanolone and I must've copied his thread because I mentioned it

Nigga link me one thread who talked about it before me
Literraly everyone suck the mods (orc and clav dicks) except me

 

[fluoride1337]

Nigga link me one thread who talked about it before me
Literraly everyone suck the mods (orc and clav dicks) except me

I literally never saw your thread and I saw @NZb6Air post about it weeks ago

 

[20/04/2008]

I literally never saw your thread and I saw @NZb6Air post about it weeks ago

If you can send it to me pls
@NZb6Air is it true

 

[20/04/2008]

I literally never saw your thread and I saw @NZb6Air post about it weeks ago

 

[NZb6Air]

@20/04/2008 u typed it wrong lol

 

[20/04/2008]

@20/04/2008 u typed it wrong lol

Did you actually write about it ?