Question about vit B6 methylation ageing

[Deleted member 48352]

I ask : would vit B6 supp potentially accelerate DNA methylation ageing cuz of the methyl group ?

DNA methylation ageing changes according to Steve horvath’s multispecies clock shows that the majority of changes r methylation percentage gain …

 

[Deleted member 48352]

@arabcelxxx

 

[Deleted member 48352]

@noodlelover

 

[Deleted member 15778]

What reason would you have to supplement with B6?

 

[Deleted member 48352]

What reason would you have to supplement with B6?

It’s just included in this timed release melatonin my mom got at store … idk if I should take it

 

[Deleted member 15778]

It’s just included in this timed release melatonin my mom got at store … idk if I should take it

I don't know anything about methylation.

My go to is to lookup studies associated with all-cause mortality, because of how complex and non-linear the mechanisms of the human body are. It's too easy to make narratives that make anything seem good or bad, based on mechanisms in the human body. Some things that seem like they would hurt us, actually reduce our all cause mortality.

Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort - PubMed

The evidence regarding the intake of dietary folate, vitamin B6, and vitamin B12 in relation to mortality in the general population is limited. This study aimed to examine the relationship between dietary intakes of folate, vitamin B6, and vitamin B12 in relation to all-cause and cause-specific...

pubmed.ncbi.nlm.nih.gov

Vit B6 is inversely associated with all cause mortality. So it's probably fine.

I'd stop taking it if it makes you feel worse.

 

[Deleted member 48352]

I don't know anything about methylation.

My go to is to lookup studies associated with all-cause mortality, because of how complex and non-linear the mechanisms of the human body are. It's too easy to make narratives that make anything seem good or bad, based on mechanisms in the human body. Some things that seem like they would hurt us, actually reduce our all cause mortality.

Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort - PubMed

The evidence regarding the intake of dietary folate, vitamin B6, and vitamin B12 in relation to mortality in the general population is limited. This study aimed to examine the relationship between dietary intakes of folate, vitamin B6, and vitamin B12 in relation to all-cause and cause-specific...

pubmed.ncbi.nlm.nih.gov

Vit B6 is inversely associated with all cause mortality. So it's probably fine.

I'd stop taking it if it makes you feel worse.

Good answer but I’m still unsure lol

This supp has like 6x the recommended daily

 

[Deleted member 15778]

Good answer but I’m still unsure lol

This supp has like 6x the recommended daily

I usually don't take supplements unless there's a really strong case for it. Our bodies are evolved to take in things in certain combinations that occur in plants, animals, seeds, nuts. Some things we do well with in a pure state like Vit-C, but it's not guaranteed for a random thing like B6 unless there's good evidence for it, and some things like Vit-E actually increase all cause mortality when taken as a supplement.

If you're concerned about sleep quality, in addition to what I already mentioned, I recently discovered if I stay more awake and alert during the day (not relaxing sunbathing for example) I have much higher quality sleep, after about two weeks of doing this.

You could try this.

 

[Rigged]

I ask : would vit B6 supp potentially accelerate DNA methylation ageing cuz of the methyl group ?

Hey fed nigga
Yes PLP boosts one carbon paths they synthesize SAM b6 helps their generation which increase dna methyl

DNA methylation ageing changes according to Steve horvath’s multispecies clock shows that the majority of changes r methylation percentage gain …

From increase in CpG sites it predicts adds of methyl groups to 5’ position of cytosine rings in CpG dinucleotides causes gene expression modulation thru transcriptional repression/activation

 

[Deleted member 48352]

I usually don't take supplements unless there's a really strong case for it. Our bodies are evolved to take in things in certain combinations that occur in plants, animals, seeds, nuts. Some things we do well with in a pure state like Vit-C, but it's not guaranteed for a random thing like B6 unless there's good evidence for it, and some things like Vit-E actually increase all cause mortality when taken as a supplement.

If you're concerned about sleep quality, in addition to what I already mentioned, I recently discovered if I stay more awake and alert during the day (not relaxing sunbathing for example) I have much higher quality sleep, after about two weeks of doing this.

You could try this.

I’m not takeing melatonin for sleep but for separate reasons . I still take it b4 sleeping but the purpose isn’t sleepmaxxing

 

[Deleted member 48352]

Hey fed nigga
Yes PLP boosts one carbon paths they synthesize SAM b6 helps their generation which increase dna methyl

From increase in CpG sites it predicts adds of methyl groups to 5’ position of cytosine rings in CpG dinucleotides causes gene expression modulation thru transcriptional repression/activation

U seem like a nerdcel

Do u want to join

you's SERIOUS discord server has been made

this is very specific server , so like almost no one here could actually join , but i do need some people to join . PM if interested , ill give the purpose of the server : serious high IQ people to anti age to live as long as possible & strategize time for progress

looksmax.org

 

[Rigged]

U seem like a nerdcel

Do u want to join

you's SERIOUS discord server has been made

this is very specific server , so like almost no one here could actually join , but i do need some people to join . PM if interested , ill give the purpose of the server : serious high IQ people to anti age to live as long as possible & strategize time for progress

looksmax.org

Sure

 

[Aladin]

and some things like Vit-E actually increase all cause mortality when taken as a supplement.

Sauce?

 

[Deleted member 15778]

Sauce?

No.

It would take you about four seconds to google and find multiple studies all coming to the same conclusion.

 

[(In)CelibatePsycho2]

I don't know anything about methylation.

My go to is to lookup studies associated with all-cause mortality, because of how complex and non-linear the mechanisms of the human body are. It's too easy to make narratives that make anything seem good or bad, based on mechanisms in the human body. Some things that seem like they would hurt us, actually reduce our all cause mortality.

Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort - PubMed

The evidence regarding the intake of dietary folate, vitamin B6, and vitamin B12 in relation to mortality in the general population is limited. This study aimed to examine the relationship between dietary intakes of folate, vitamin B6, and vitamin B12 in relation to all-cause and cause-specific...

pubmed.ncbi.nlm.nih.gov

Vit B6 is inversely associated with all cause mortality. So it's probably fine.

I'd stop taking it if it makes you feel worse.

Associations aren’t very relatable. Something can be bad for you and still have positive “associations” because the average person who takes it is just healthier than the average person who doesn’t take it for unrelated reasons

 

[Aladin]

No.

It would take you about four seconds to google and find multiple studies all coming to the same conclusion.

The studies focus on alpha tocopherol:

Vitamin E might increase risk of death - PMC

pmc.ncbi.nlm.nih.gov

Approximately 22% of adults use vitamin E, usually in the form of alpha-tocopherol, at 400 IU daily.6

 

[Deleted member 15778]

.

 

[Deleted member 15778]

Associations aren’t very relatable. Something can be bad for you and still have positive “associations” because the average person who takes it is just healthier than the average person who doesn’t take it for unrelated reasons

True.

The studies focus on alpha tocopherol:

Vitamin E might increase risk of death - PMC

pmc.ncbi.nlm.nih.gov

The most common form of Vit-E, most used in the body, and most supplemented with.

Dosage matters. But my point wasn't about Vit-E, that was just an example that taking some vitamins can increase all cause mortality. In double blind placebo controlled studies, multivitamins also increase all cause mortality.

The bigger point is, that we shouldn't assume ingesting anything is safe by default, we should weigh all of the evidence, ideally.

 

[Aladin]

The most common form of Vit-E, most used in the body, and most supplemented with.

Taking alpha tocopherol only is bad. The whole complex is needed. Thus it can only be concluded that vitamin E in just the alpha tocopherol form is bad in large enough doses.