Questions For a Thread on PTH Analogues and HDACi

[Zagro]

Ask me anything you would like to know about them and I’ll include it in my guide (similar to my HGH guide) on them and i can’t think of many myself so just ask anything. Been researching on these 2 topics for like a month or two now.

Also if theres a topic you would want me to make a guide about please do tell.

 

[vincentzygo]

Brutal avi descension bro...

Just go back to the old one....

 

[Bitchwhipper2]

Whats your opinion on hdaci

Do you believe theyre applicable to bone formation

 

[vincentzygo]

Brutal avi descension bro...

Just go back to the old one....

yay its back

 

[Zagro]

Whats your opinion on hdaci

Do you believe they work?

Seems like total garbage but I’m still looking into it. Selective HDAC inhibitors are the best possible choice as most HDACs are essential for bone growth apart from HDAC7 and somewhat HDAC6 which you can use MS-275/Entinostat and Tubastatin A for but seems like its impossible to source.

 

[Zagro]

yay its back

I was going to change it yesterday but I’m travelling rn so my wifi is shitty so it wouldn’t load.

 

[Bitchwhipper2]

Seems like total garbage but I’m still looking into it. Selective HDAC inhibitors are the best possible choice as most HDACs are essential for bone growth apart from HDAC7 and somewhat HDAC6 which you can use MS-275/Entinostat and Tubastatin A for but seems like its impossible to source.

Thats the thing.

Theres all kinds of experimental wonderdrugs for bone formation.

Its not about whether bonemaxxing is possible. Its more about whether it can be done realistically on a normal budget

 

[vincentzygo]

Really just an overhaul on the topic is needed

Niggas be mentioning muh pth muh hdaci but theres no solid thread on them

 

[Zagro]

Thats the thing.

Theres all kinds of experimental wonderdrugs for bone formation.

Its not about whether bonemaxxing is possible. Its more about whether it can be done realistically on a normal budget

Very true brah and this may be the reason people opt for HDACi like vorinostat for the sake of saving money but it does more damage than good, so using HDACi appropriately is not realistic if you aren’t a richcel with good connections.

 

[Bitchwhipper2]

Really just an overhaul on the topic is needed

Niggas be mentioning muh pth muh hdaci but theres no solid thread on them

Pth is genuinely good.

Hdaci has some promising aspects, but really is a complete crapshoot given that we just dont know how it works im vivo humans.

Especially given that valproic acid is related to lower bone density in those prescribed and vorinostat shows resorbative capacity in rodent models at higher doses

 

[Bitchwhipper2]

Very true brah and this may be the reason people opt for HDACi like vorinostat for the sake of saving money but it does more damage than good, so using HDACi appropriately is not realistic if you aren’t a richcel with good connections.

Tbh. Vorinostat is the one hdaci that I actually think shows promise.

Iirc vorinostat treated cancer patients showed faster tracebular bone recovery after cancer treatment.

This would somewhat demonstrate its proposed ability to both expand and proliferate msc resivouirs

 

[KeepCopingLads]

Go over how shit on paper may sound good but in reality won't work or something along those lines

 

[Zagro]

Go over how shit on paper may sound good but in reality won't work or something along those lines

Will do brah but I’m looking for some particular questions about them really its hard to come up with

 

[KeepCopingLads]

Will do brah but I’m looking for some particular questions about them really its hard to come up with

Maybe how if it works, is the bone growth actually that significant to have noticeable changes
And where does most of the bone growth go to or if it's equally distributed

 

[Sachlichkeit]

Hdacis are to loosen the chromatin around genes allowing for more genetic expression.

then you do androgens and their effects are temporarily amplified.

vstat is both viable and attainable.

Yes longterm use has negative impacts on bone. Also cytotoxic. It’s a Cancer drug lol

PTH analogs when used correctly promote osteogenesis over bone resorption. Meaning, if you pair it with HGH you will get more bone growth.

Maybe 40% of growth is dictated by genes that can ((now)) be temporarily altered through the use of drugs if you are willing to take the risk of epigentic damage.

I’m gatekeeping a lot of it and personally hope org writes it off as cope

 

[Zagro]

Hdacis are to loosen the chromatin around genes allowing for more genetic expression.

then you do androgens and their effects are temporarily amplified.

vstat is both viable and attainable.

Yes longterm use has negative impacts on bone. Also cytotoxic. It’s a Cancer drug lol

PTH analogs when used correctly promote osteogenesis over bone resorption. Meaning, if you pair it with HGH you will get more bone growth.

Maybe 40% of growth is dictated by genes that can ((now)) be temporarily altered through the use of drugs if you are willing to take the risk of epigentic damage.

I’m gatekeeping a lot of it and personally hope org writes it off as cope

HDACi is not realistic bro have fun using Pan-HDAC inhibitors, vstat mainly inhibits class I HDACs which will just do harm for height goals and partially inhibits class IIa hdacs to make it even worse, only pro of vstat would be inhibiting class IIb which is like HDAC6.

@Bitchwhipper2 this is why i don’t like vstat ^


PTH analogues are pretty good nothing wrong about them and the ones in clinical use are all great. Using PTH analogues correctly is just not overdosing on them and focusing on intermittent signaling with once-daily injections, just don’t fuck up the dosing theory.

Theres no personal gain in gatekeeping as people would have to take the risks involved with these type of drugs and use androgens and peptides as a base. The only reason i would gatekeep is so that retards don’t randomly use this shit.

 

[Zagro]

@ZerefDragnee1l any other topics i should cover? I’m working on PTH analogues and HDACi right now but more is always better

 

[ZerefDragnee1l]

@ZerefDragnee1l any other topics i should cover? I’m working on PTH analogues and HDACi right now but more is always better

sure i have some questions actually, for PTH analogs (teriparatide/abaloparatide) what do we actually know about effects on craniofacial bones i mean is it really working on face is thefe any evidence? also is it safe? do you have a safety stack for risk management? and is there a local stimulu test? o you think mechanical/local stimuli meaningfully amplify a PTH pulse for site-specific remodeling? if yes what frequency/intensity and dosage would you pair with the PTh window to ride the anabolic phase without tipping into resorption? If HDAC inhibition is useful which isoform selectivity matters most here i mean do you see any realistic accesible options that show a net-positive bone phenotype or is it basically “only the selective ones (entinostat/tubastatin) make sense, but they’re impractical”?


also sry for bad english you know im from turkey

these are my questions

 

[Zagro]

sure i have some questions actually, for PTH analogs (teriparatide/abaloparatide) what do we actually know about effects on craniofacial bones i mean is it really working on face is thefe any evidence? also is it safe? do you have a safety stack for risk management? and is there a local stimulu test? o you think mechanical/local stimuli meaningfully amplify a PTH pulse for site-specific remodeling? if yes what frequency/intensity and dosage would you pair with the PTh window to ride the anabolic phase without tipping into resorption? If HDAC inhibition is useful which isoform selectivity matters most here i mean do you see any realistic accesible options that show a net-positive bone phenotype or is it basically “only the selective ones (entinostat/tubastatin) make sense, but they’re impractical”?


also sry for bad english you know im from turkey

these are my questions

Perfect bro thank you so much you asked about topics i wouldn’t have thought about . Threads coming out soon I’ll tag ya

 

[Zagro]

Bump, i also just lost all the progress i had on the threads so it will take longer to finish the threads now. Any other questions please this is all i have now:

Do PTH analogues effect craniofacial bones? Is there any evidence on it and are the changes worth it? -ZerefDragnee1l

Where does most of the bone growth occur and are the changes symmetrical? -KeepCopingLads

 

[keife]

Bump high iq

 

[org3cel.RR]

Ask me anything you would like to know about them and I’ll include it in my guide (similar to my HGH guide) on them and i can’t think of many myself so just ask anything. Been researching on these 2 topics for like a month or two now.

Also if theres a topic you would want me to make a guide about please do tell.

What do you intend to gain with PTH analogs and HDCAH inhibitors?

 

[Zagro]

What do you intend to gain with PTH analogs and HDCAH inhibitors?

A more potent approach on height growth via different pathways to achieve a positive remodeling balance and inhibit the detrimental pathways for bone growth and improve the beneficial ones. I just want to do anything i possibly can so that i can atleast claim that I’ve tried everything for height, and i see potential in it as ive saw growth on my last stack.