Retatrutide : The Triple G for Weight & Metabolic Health

4lt.Real

4lt.Real

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Retatrutide
1751278595686

(LY3437943)

What if there was one weekly injection that crushed your appetite, burned fat faster than Ozempic, and reversed liver damage - all in under a year? There is. It’s called Retatrutide. This isn't anything like your typical weight loss drugs. This is a molecule that mogs semaglutide, tirzepatide, and even your expectations.



What is Retatrutide
Retatrutide is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors). (1)
1751281582601




⚙️ Mechanism of Action ⚙️
ReceptorEffectRole
GLP-1Increases insulin, reduces appetiteSuppresses hunger, improves glucose control
GIPEnhances insulin releaseAmplifies GLP-1 and metabolic flexibility
GCGRincreases the amount of energy usedPromotes fat oxidation, thermogenesis, reduces liver fat

Unlike semaglutide (GLP-1 only) or tirzepatide (GLP-1 + GIP), Retatrutide adds glucagon activation for active fat burn rather than passive appetite suppression.

More Info
Retatrutide is currently on phase 3 trials and is not FDA approved yet. You probably have heard about reta by now because it's so good. It’s the strongest fat-loss drug ever studied so far compared to Semaglutide and Tirzepatide (Mounjaro).
DrugAvg Weight LossDuration
🔴Retatrutide~24.2%48 Weeks
🟢Tirzepatide~20.9%72 Weeks
🔵Semaglutide~14.9%68 Weeks

Trial (1), (2), (3)

Most fat-loss drugs just make you eat less. But Retatrutide doesn’t just help you eat less - it can raise your baseline calorie burn, even when you’re doing nothing. That’s because activating the glucagon receptor increases energy expenditure.
the extreme appetite suppression can make you easy to undereat, which mean it can cause nutrient deficiencies or muscle loss if you’re not careful. That’s why you should watch your protein intake and strength training if your'e on reta. Reta isn't only for weight loss, it improves your health too.

Retatrutide Benefits
  1. Fat loss
  2. Appetite Suppression & Cravings Elimination
  3. Increased Energy Expenditure
  4. Blood Sugar & Insulin Optimization
  5. Liver Fat Reduction & MASLD Therapy
  6. Cardiometabolic Health Boost
  7. Cholesterol & Lipid Profile Improvements

Clinical Benefits

Area
Effect
Weight Loss
Up to 24.2% body weight loss in 48 weeks (12mg group, NEJM 2023)
Liver Fat
81–86% liver fat reduction in MASLD patients
Insulin Sensitivity
↑ significantly, even in non-diabetics
Appetite Control
Strong but slightly less "fullness" vs semaglutide
Tolerability
Better than GLP-1s alone, lower dropout in trials



Lipid & Cholesterol Improvements:

Marker
Change
Triglycerides↓ 41.6%
LDL Cholesterol↓ 12–15%
HDL↔ Neutral or slight ↓
Liver Fat ↓ 81-86%
ApoC-III↓ ~48%







💊 Optimal Dosage & Titration Protocol 💊

There is no one size fits all optimal dose.
Instead, use a titration protocol that balances fat loss with tolerability.

The titration protocol is just a step-by-step way to increase the dose of a compound gradually. Think of it like turning up the volume on a speaker. You don’t blast it to max immediately. You increase it slowly until it’s just right.

Dosing Strategy: Start low: 2mg/week.
Increase every 4–6 weeks based on progress and tolerability. Stop when results plateau or sides worsen
Week
Dose (mg/week)
0-4
2.0 mg
4-8
4.0 mg
8-16
8.0 mg
16-36+
12.0 mg
(Sourced from NEJM 2023 Trial: NCT04881760) (1)


Tips
1. Start in Low Dosage and Titrate Slowly
Start with 2 mg per week, and only increase it every 4–6 weeks if your body’s handling it well. Don’t rush to 12 mg just because someone on Reddit did.

Why this matters:
Retatrutide is strong - it hits 3 hormone systems in 1 (GLP-1, GIP, and glucagon). If you take too much too fast, your body might freak out. Nausea, d
iarrhea, and digestive issues.

2. Prioritize High Protein Intake
Eat 1.6–2.4 g/kg bodyweight/day of protein. Retatrutide causes extreme fat loss - up to 24.2% in trials!! - which can also lead to muscle loss if you're under-eating protein. Higher protein intake enhances satiety and thermogenesis, which synergizes with GLP-1 action and enhances GIP signaling.

3. Don't Forget to Eat - Especially Real Food
Retatrutide works so well at suppressing appetite, some people barely eat. It may sound great at first, but if you go weeks under-eating, your body will become deficient in the nutrients it needs to function. Prioritize whole foods like meat, eggs.

4. Track Your Biomarkers
Run blood panels every month or two. Watch your cholesterol, liver enzymes, blood sugar, and kidney function. Retatrutide improves most of these things — but everyone reacts differently. It's important you're not only getting leaner, but healthier as well. Bloodwork keeps you honest. It helps you find problems early, adjust your dosage, and, if necessary, modify your diet.
Focus on

  • Liver function (ALT, AST)
  • Lipids (LDL, HDL, triglycerides)
  • HbA1c / fasting glucose
  • Creatinine / eGFR (kidney)




Side Effects
  1. Nausea (50–60%)
  2. Diarrhea (30–40%)
  3. Constipation
  4. Vomiting
    The side effects are dose-related.



    How to mitigate:
    • Eat smaller meals more frequently.
    • Avoid greasy, spicy, or high-fat meals (this can delay gastric emptying).
    • Make sure you're not under eating (read the tips part)
    • Ginger, peppermint tea, or digestive enzymes may help.



Studies
@inka @Jonasㅤㅤ @chadbeingmade @Orc @Clavicular @Magnum Opus @Sadist @menas
 
Last edited by a moderator:
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Reactions: Randomized Shame, bruhtoobrutal, jeff1234 and 7 others
water
still bookmarked
will read
 
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Ozempic
 
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Reactions: Randomized Shame and aloooeJIEEES
My mom wants to take it but is scared of bone loss, any truth to that? I researched it and the only thing i came about was that too rapid weight loss can reduce bone density
 
  • +1
Reactions: Randomized Shame
My mom wants to take it but is scared of bone loss, any truth to that? I researched it and the only thing i came about was that too rapid weight loss can reduce bone density
If she eats too little or nothing that’ll cause boneloss
2. Prioritize High Protein Intake
 
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Reactions: Randomized Shame, 4lt.Real and Linus1888
mango 67 still water bump
 
  • JFL
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Great way to age max op! We trying to look twice our age💪🏿
 
  • JFL
  • +1
Reactions: Randomized Shame and 4lt.Real
My mom wants to take it but is scared of bone loss, any truth to that? I researched it and the only thing i came about was that too rapid weight loss can reduce bone density
Yeah, weight loss can reduce bone density, but don't worry about it. Just make sure she's eating enough calcium, vitD&K, etc, if she's losing weight.
 
  • +1
Reactions: Randomized Shame and Linus1888

Retatrutide
View attachment 3873648
(LY3437943)

What if there was one weekly injection that crushed your appetite, burned fat faster than Ozempic, and reversed liver damage - all in under a year? There is. It’s called Retatrutide. This isn't anything like your typical weight loss drugs. This is a molecule that mogs semaglutide, tirzepatide, and even your expectations.



What is Retatrutide
Retatrutide is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors). (1)
View attachment 3873731



⚙️ Mechanism of Action ⚙️
ReceptorEffectRole
GLP-1Increases insulin, reduces appetiteSuppresses hunger, improves glucose control
GIPEnhances insulin releaseAmplifies GLP-1 and metabolic flexibility
GCGRincreases the amount of energy usedPromotes fat oxidation, thermogenesis, reduces liver fat

Unlike semaglutide (GLP-1 only) or tirzepatide (GLP-1 + GIP), Retatrutide adds glucagon activation for active fat burn rather than passive appetite suppression.

More Info
Retatrutide is currently on phase 3 trials and is not FDA approved yet. You probably have heard about reta by now because it's so good. It’s the strongest fat-loss drug ever studied so far compared to Semaglutide and Tirzepatide (Mounjaro).
DrugAvg Weight LossDuration
🔴Retatrutide~24.2%48 Weeks
🟢Tirzepatide~20.9%72 Weeks
🔵Semaglutide~14.9%68 Weeks

Trial (1), (2), (3)

Most fat-loss drugs just make you eat less. But Retatrutide doesn’t just help you eat less - it can raise your baseline calorie burn, even when you’re doing nothing. That’s because activating the glucagon receptor increases energy expenditure.
the extreme appetite suppression can make you easy to undereat, which mean it can cause nutrient deficiencies or muscle loss if you’re not careful. That’s why you should watch your protein intake and strength training if your'e on reta. Reta isn't only for weight loss, it improves your health too.


Retatrutide Benefits
  1. Fat loss
  2. Appetite Suppression & Cravings Elimination
  3. Increased Energy Expenditure
  4. Blood Sugar & Insulin Optimization
  5. Liver Fat Reduction & MASLD Therapy
  6. Cardiometabolic Health Boost
  7. Cholesterol & Lipid Profile Improvements

Clinical Benefits
Area
Effect
Weight Loss
Up to 24.2% body weight loss in 48 weeks (12mg group, NEJM 2023)
Liver Fat
81–86% liver fat reduction in MASLD patients
Insulin Sensitivity
↑ significantly, even in non-diabetics
Appetite Control
Strong but slightly less "fullness" vs semaglutide
Tolerability
Better than GLP-1s alone, lower dropout in trials



Lipid & Cholesterol Improvements:

Marker
Change
Triglycerides↓ 41.6%
LDL Cholesterol↓ 12–15%
HDL↔ Neutral or slight ↓
Liver Fat ↓ 81-86%
ApoC-III↓ ~48%







💊 Optimal Dosage & Titration Protocol 💊

There is no one size fits all optimal dose.
Instead, use a titration protocol that balances fat loss with tolerability.

The titration protocol is just a step-by-step way to increase the dose of a compound gradually. Think of it like turning up the volume on a speaker. You don’t blast it to max immediately. You increase it slowly until it’s just right.

Dosing Strategy: Start low: 2mg/week.
Increase every 4–6 weeks based on progress and tolerability. Stop when results plateau or sides worsen
Week
Dose (mg/week)
0-4
2.0 mg
4-8
4.0 mg
8-16
8.0 mg
16-36+
12.0 mg
(Sourced from NEJM 2023 Trial: NCT04881760) (1)


Tips
1. Start in Low Dosage and Titrate Slowly
Start with 2 mg per week, and only increase it every 4–6 weeks if your body’s handling it well. Don’t rush to 12 mg just because someone on Reddit did.

Why this matters:
Retatrutide is strong - it hits 3 hormone systems in 1 (GLP-1, GIP, and glucagon). If you take too much too fast, your body might freak out. Nausea, d
iarrhea, and digestive issues.

2. Prioritize High Protein Intake
Eat 1.6–2.4 g/kg bodyweight/day of protein. Retatrutide causes extreme fat loss - up to 24.2% in trials!! - which can also lead to muscle loss if you're under-eating protein. Higher protein intake enhances satiety and thermogenesis, which synergizes with GLP-1 action and enhances GIP signaling.

3. Don't Forget to Eat - Especially Real Food
Retatrutide works so well at suppressing appetite, some people barely eat. It may sound great at first, but if you go weeks under-eating, your body will become deficient in the nutrients it needs to function. Prioritize whole foods like meat, eggs.

4. Track Your Biomarkers
Run blood panels every month or two. Watch your cholesterol, liver enzymes, blood sugar, and kidney function. Retatrutide improves most of these things — but everyone reacts differently. It's important you're not only getting leaner, but healthier as well. Bloodwork keeps you honest. It helps you find problems early, adjust your dosage, and, if necessary, modify your diet.
Focus on

  • Liver function (ALT, AST)
  • Lipids (LDL, HDL, triglycerides)
  • HbA1c / fasting glucose
  • Creatinine / eGFR (kidney)




Side Effects
  1. Nausea (50–60%)
  2. Diarrhea (30–40%)
  3. Constipation
  4. Vomiting
    The side effects are dose-related.



    How to mitigate:
    • Eat smaller meals more frequently.
    • Avoid greasy, spicy, or high-fat meals (this can delay gastric emptying).
    • Make sure you're not under eating (read the tips part)
    • Ginger, peppermint tea, or digestive enzymes may help.



Studies
@inka @Jonasㅤㅤ @chadbeingmade @Orc @Clavicular @Magnum Opus @Sadist @menas
bookmarked

bump
 
  • +1
Reactions: Randomized Shame and 4lt.Real

Retatrutide
View attachment 3873648
(LY3437943)

What if there was one weekly injection that crushed your appetite, burned fat faster than Ozempic, and reversed liver damage - all in under a year? There is. It’s called Retatrutide. This isn't anything like your typical weight loss drugs. This is a molecule that mogs semaglutide, tirzepatide, and even your expectations.



What is Retatrutide
Retatrutide is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors). (1)
View attachment 3873731



⚙️ Mechanism of Action ⚙️
ReceptorEffectRole
GLP-1Increases insulin, reduces appetiteSuppresses hunger, improves glucose control
GIPEnhances insulin releaseAmplifies GLP-1 and metabolic flexibility
GCGRincreases the amount of energy usedPromotes fat oxidation, thermogenesis, reduces liver fat

Unlike semaglutide (GLP-1 only) or tirzepatide (GLP-1 + GIP), Retatrutide adds glucagon activation for active fat burn rather than passive appetite suppression.

More Info
Retatrutide is currently on phase 3 trials and is not FDA approved yet. You probably have heard about reta by now because it's so good. It’s the strongest fat-loss drug ever studied so far compared to Semaglutide and Tirzepatide (Mounjaro).
DrugAvg Weight LossDuration
🔴Retatrutide~24.2%48 Weeks
🟢Tirzepatide~20.9%72 Weeks
🔵Semaglutide~14.9%68 Weeks

Trial (1), (2), (3)

Most fat-loss drugs just make you eat less. But Retatrutide doesn’t just help you eat less - it can raise your baseline calorie burn, even when you’re doing nothing. That’s because activating the glucagon receptor increases energy expenditure.
the extreme appetite suppression can make you easy to undereat, which mean it can cause nutrient deficiencies or muscle loss if you’re not careful. That’s why you should watch your protein intake and strength training if your'e on reta. Reta isn't only for weight loss, it improves your health too.


Retatrutide Benefits
  1. Fat loss
  2. Appetite Suppression & Cravings Elimination
  3. Increased Energy Expenditure
  4. Blood Sugar & Insulin Optimization
  5. Liver Fat Reduction & MASLD Therapy
  6. Cardiometabolic Health Boost
  7. Cholesterol & Lipid Profile Improvements

Clinical Benefits
Area
Effect
Weight Loss
Up to 24.2% body weight loss in 48 weeks (12mg group, NEJM 2023)
Liver Fat
81–86% liver fat reduction in MASLD patients
Insulin Sensitivity
↑ significantly, even in non-diabetics
Appetite Control
Strong but slightly less "fullness" vs semaglutide
Tolerability
Better than GLP-1s alone, lower dropout in trials



Lipid & Cholesterol Improvements:

Marker
Change
Triglycerides↓ 41.6%
LDL Cholesterol↓ 12–15%
HDL↔ Neutral or slight ↓
Liver Fat ↓ 81-86%
ApoC-III↓ ~48%







💊 Optimal Dosage & Titration Protocol 💊

There is no one size fits all optimal dose.
Instead, use a titration protocol that balances fat loss with tolerability.

The titration protocol is just a step-by-step way to increase the dose of a compound gradually. Think of it like turning up the volume on a speaker. You don’t blast it to max immediately. You increase it slowly until it’s just right.

Dosing Strategy: Start low: 2mg/week.
Increase every 4–6 weeks based on progress and tolerability. Stop when results plateau or sides worsen
Week
Dose (mg/week)
0-4
2.0 mg
4-8
4.0 mg
8-16
8.0 mg
16-36+
12.0 mg
(Sourced from NEJM 2023 Trial: NCT04881760) (1)


Tips
1. Start in Low Dosage and Titrate Slowly
Start with 2 mg per week, and only increase it every 4–6 weeks if your body’s handling it well. Don’t rush to 12 mg just because someone on Reddit did.

Why this matters:
Retatrutide is strong - it hits 3 hormone systems in 1 (GLP-1, GIP, and glucagon). If you take too much too fast, your body might freak out. Nausea, d
iarrhea, and digestive issues.

2. Prioritize High Protein Intake
Eat 1.6–2.4 g/kg bodyweight/day of protein. Retatrutide causes extreme fat loss - up to 24.2% in trials!! - which can also lead to muscle loss if you're under-eating protein. Higher protein intake enhances satiety and thermogenesis, which synergizes with GLP-1 action and enhances GIP signaling.

3. Don't Forget to Eat - Especially Real Food
Retatrutide works so well at suppressing appetite, some people barely eat. It may sound great at first, but if you go weeks under-eating, your body will become deficient in the nutrients it needs to function. Prioritize whole foods like meat, eggs.

4. Track Your Biomarkers
Run blood panels every month or two. Watch your cholesterol, liver enzymes, blood sugar, and kidney function. Retatrutide improves most of these things — but everyone reacts differently. It's important you're not only getting leaner, but healthier as well. Bloodwork keeps you honest. It helps you find problems early, adjust your dosage, and, if necessary, modify your diet.
Focus on

  • Liver function (ALT, AST)
  • Lipids (LDL, HDL, triglycerides)
  • HbA1c / fasting glucose
  • Creatinine / eGFR (kidney)




Side Effects
  1. Nausea (50–60%)
  2. Diarrhea (30–40%)
  3. Constipation
  4. Vomiting
    The side effects are dose-related.



    How to mitigate:
    • Eat smaller meals more frequently.
    • Avoid greasy, spicy, or high-fat meals (this can delay gastric emptying).
    • Make sure you're not under eating (read the tips part)
    • Ginger, peppermint tea, or digestive enzymes may help.



Studies
@inka @Jonasㅤㅤ @chadbeingmade @Orc @Clavicular @Magnum Opus @Sadist @menas
Decent guide but there is already a thread about it on BOTB I think.
 
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Good thread.
 
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