aids
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Sup fuckers.
I'm off an amphetamine (legal) right now and it's the weekend so I'm going to make a quick thread on a very interesting new treatment I found; Tirbanibulin (ATC code: D06BX03), a drug classed as a microtubule inhibitor sold under the brand name "Klisyri".
It is also known as KX2-391 or Onakta.
I don't really care for getting all of the information on this out immediately, but I want to at least introduce it to looksmaxxing discourse.
I will experiment on myself with this and update you all with results and more information on the drug. Yes, that includes pictures (probably).
Tirbanibulin is a topical medication, used in treating actinic keratosis (AK) on the face and/or the scalp.
AK is a precancerous lesion, described as a "rough, scaly patch on the skin... often found on the face, lips, ears, forearms, scalp, neck or back of the hands."
AK is also known as a solar keratosis.
Attached below are a few examples of how AK looks. It is more common on elderly people, as it develops consequent to years of sun exposure.
Effectively, actinic keratoses (plural) develop over time, usually appearing in people over 40.
Untreated, these patches can (not will) develop into a form of skin cancer, known as "squamous cell carcinoma".
Hence, people with AK may use Klisyri to prevent it from developing into skin cancer.
Good question, I have no idea.
Tirbanibulin has recently been used off-label by people for its potent skin rejuvenation effects. Consequently, there's basically no literature on how this drug can help younger patients looking solely to improve their skin quality.
It's worth noting that if you're still very young (i.e., early-to-mid teens), Klisyri may be redundant for you to use, unless you already have existing sun damage on your skin.
This is NOT a replacement product for retinoids, copper peptides, etc., it has a different use case.
Tirbanibulin targets rapidly-dividing abnormal skin cells, through two main mechanisms:
Microtubule inhibition
For on-label use, Klisyri is only applied to AK, so less of the wrong cells are affected, but we will want to be applying it to our whole face (since we want to get rid of sun damage, not AK, which you presumably do NOT have).
Now, Tirbanibulin is not selective, i.e., it does not specifically target only these abnormal (precancerous) cells. However, given healthy cells divide much slower, they are relatively unaffected even if Klisyri is applied to them.
Using Klisyri for longer than 5 days (the treatment period which I will go into below), however, may affect healthy cells, so DON'T DO IT!
The treatment duration for Klisyri is extremely quick; only five days. So you can expect to see results quickly.
Klisyri comes in packets (see below) of wipes which are rubbed over the affected area to induce the aforementioned effects.
Off-label users of Klisyri noted crusting and redness as side effects post-use, that quickly subsided upon conclusion of their treatment.
This dude uses acetone and microneedling (0.25mm depth) before some of his applications for superior absorption of Klisyri. I will likely try microneedling before I use it on certain days, and let you all know the results. It took only a few days after conclusion of his treatment for his skin quality to return to normal/the effects to show.
Obviously, this dude has already good skin, having mentioned some other clinical treatments (e.g., CO2 Laser, likely Fraxel) he's undergone, in this video, but he still saw pretty crazy results, especially for only a few days.
In theory, this treatment could help to reverse sun damage consequent to UV exposure we likely all have from when we use MT1 or MT2.
Hopefully this shit interests some of you, I will source it and let you know all how my experience is. I might add more information to this thread later.
If you have any suggestions for what I should do with Klisyri, put them below.
I'm off an amphetamine (legal) right now and it's the weekend so I'm going to make a quick thread on a very interesting new treatment I found; Tirbanibulin (ATC code: D06BX03), a drug classed as a microtubule inhibitor sold under the brand name "Klisyri".
It is also known as KX2-391 or Onakta.
I don't really care for getting all of the information on this out immediately, but I want to at least introduce it to looksmaxxing discourse.
I will experiment on myself with this and update you all with results and more information on the drug. Yes, that includes pictures (probably).
So, briefly, what is Tirbanibulin?
Tirbanibulin is a topical medication, used in treating actinic keratosis (AK) on the face and/or the scalp.
You're probably asking, what the fuck is actinic keratosis?
AK is a precancerous lesion, described as a "rough, scaly patch on the skin... often found on the face, lips, ears, forearms, scalp, neck or back of the hands."
AK is also known as a solar keratosis.
Attached below are a few examples of how AK looks. It is more common on elderly people, as it develops consequent to years of sun exposure.
Effectively, actinic keratoses (plural) develop over time, usually appearing in people over 40.
Untreated, these patches can (not will) develop into a form of skin cancer, known as "squamous cell carcinoma".
Hence, people with AK may use Klisyri to prevent it from developing into skin cancer.
aids, I'm literally a child, why the FUCK do I need this stuff?
Good question, I have no idea.
Just kidding. I have some idea. I mean fuck bro, do you really think I'd make this thread if I didn't?
Tirbanibulin has recently been used off-label by people for its potent skin rejuvenation effects. Consequently, there's basically no literature on how this drug can help younger patients looking solely to improve their skin quality.
It's worth noting that if you're still very young (i.e., early-to-mid teens), Klisyri may be redundant for you to use, unless you already have existing sun damage on your skin.
This is NOT a replacement product for retinoids, copper peptides, etc., it has a different use case.
Do we at least know how it (Tirbanibulin) works?
Tirbanibulin targets rapidly-dividing abnormal skin cells, through two main mechanisms:
Microtubule inhibition
- Microtubules are tiny, hollow "scaffolding" inside cells. In layman's terms, they help to keep the shape of cells, move materials, and pull DNA apart when cells divide (i.e., undergo mitosis).
- However, abnormal cells (those in sun-damaged skin) rely heavily on microtubules to split and multiply. By blocking microtubules in these abnormal cells, we are stopping these abnormal cells from dividing, causing them to die off, while still allowing relatively slower-dividing healthy cells to split and multiply normally.
- c-Src is a protein, a type of enzyme called tyrosine kinase, that acts like that of an "on switch" for cells to grow.
- However, in abnormal/precancerous cells (like that of an AK), c-Src is overactive, helping these abnormal cells to grow continuously, instead of dying (what we want). Inhibiting c-Src takes away this "on switch" from these *bad* cells, so they can die.
For on-label use, Klisyri is only applied to AK, so less of the wrong cells are affected, but we will want to be applying it to our whole face (since we want to get rid of sun damage, not AK, which you presumably do NOT have).
Now, Tirbanibulin is not selective, i.e., it does not specifically target only these abnormal (precancerous) cells. However, given healthy cells divide much slower, they are relatively unaffected even if Klisyri is applied to them.
Using Klisyri for longer than 5 days (the treatment period which I will go into below), however, may affect healthy cells, so DON'T DO IT!
How does treatment work?
The treatment duration for Klisyri is extremely quick; only five days. So you can expect to see results quickly.
Klisyri comes in packets (see below) of wipes which are rubbed over the affected area to induce the aforementioned effects.
Off-label users of Klisyri noted crusting and redness as side effects post-use, that quickly subsided upon conclusion of their treatment.
This dude uses acetone and microneedling (0.25mm depth) before some of his applications for superior absorption of Klisyri. I will likely try microneedling before I use it on certain days, and let you all know the results. It took only a few days after conclusion of his treatment for his skin quality to return to normal/the effects to show.
Obviously, this dude has already good skin, having mentioned some other clinical treatments (e.g., CO2 Laser, likely Fraxel) he's undergone, in this video, but he still saw pretty crazy results, especially for only a few days.
In theory, this treatment could help to reverse sun damage consequent to UV exposure we likely all have from when we use MT1 or MT2.
Hopefully this shit interests some of you, I will source it and let you know all how my experience is. I might add more information to this thread later.
If you have any suggestions for what I should do with Klisyri, put them below.
Last edited:
she should have died at the start
