smartfoiddestroyer2
seroquel
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RUNX2, the gene that controls the production of osteoblasts
RUNX2 is the gene that acts as the master switch for bones
It's the gatekeeper of your MSCs, think of these cells as a fork in the road
They can either become osteoblasts (the good stuff)
Or they turn into Adipocytes (the bad stuff)
RUNX2 is the leader that forces your cells down to the bones
It is the primary gene responsible for intramembranous ossification
which is the biological process that builds the entire skeleton
The RUNX2 dictates the density and thickness of the browridge
the projection of the zygos
and the robustness of your mandible
It is also the main gene responsible for the lateral growth of the clavicles
High expression of it is linked to a wide clavicle
Lower expression is ofc linked to a narrow clavicle
RUNX2 Regulates chondrocyte hypertrophy within the growth plates
It acts as a pacemaker for height
a deficiency in RUNX2
which is called
Cleidocranial Dysplasia
Example:
Gaten Matarazzo, the actor mainly known for Stranger Things, has this condition
He is 5'5 and severely underdeveloped
due to being deficient in RUNX2 (which is rare)
How to maximize RUNX2
To maximize RUNX2, you need to target the
Wnt/b-catenin
and BMP signaling pathways
The way to do this is achieved with
HDAC inhibitors
Nespirin-1 stabilization
Teriparatide
BMP-2
HGH
IGF-1
HDAC inhibitors
HDACS specifically HDAC4 and HDAC5
Are the brakes on RUNX2
They bind to RUNX2 and suppress its ability to do its work
RUNX2 is the gene that acts as the master switch for bones
It's the gatekeeper of your MSCs, think of these cells as a fork in the road
They can either become osteoblasts (the good stuff)
Or they turn into Adipocytes (the bad stuff)
RUNX2 is the leader that forces your cells down to the bones
It is the primary gene responsible for intramembranous ossification
which is the biological process that builds the entire skeleton
The RUNX2 dictates the density and thickness of the browridge
the projection of the zygos
and the robustness of your mandible
It is also the main gene responsible for the lateral growth of the clavicles
High expression of it is linked to a wide clavicle
Lower expression is ofc linked to a narrow clavicle
RUNX2 Regulates chondrocyte hypertrophy within the growth plates
It acts as a pacemaker for height
a deficiency in RUNX2
which is called
Cleidocranial Dysplasia
Example:
Gaten Matarazzo, the actor mainly known for Stranger Things, has this condition
He is 5'5 and severely underdeveloped
due to being deficient in RUNX2 (which is rare)How to maximize RUNX2
To maximize RUNX2, you need to target the
Wnt/b-catenin
and BMP signaling pathways
The way to do this is achieved with
HDAC inhibitors
Nespirin-1 stabilization
Teriparatide
BMP-2
HGH
IGF-1
HDAC inhibitors
HDACS specifically HDAC4 and HDAC5
Are the brakes on RUNX2
They bind to RUNX2 and suppress its ability to do its work
LMK-235
LMK-235 is a highly potent inhibitor
Research shows LMK-235 directly promotes osteoblasts
TMP195
TMP195 is an inhibitor that modulates the myeloid environment and
enhances osteogenic response
TASQUINIMOD
TASQUINIMOD targets the HDAC4 pathway to shift the bone marrow environment
towards bone formation and increased trabecular volume
QUISINOSTAT
QUISINOSTAT is hands down one of the most potent pan-HDAC inhibitors
It forces massive upregulation of the RUNX2
Teriparatide
Teriparatide is one of the most powerful bone anabolics
It creates a massive anabolic window for RUNX2 growth
BMP-2
BMP-2 forces stem cells to become bone very quickly, which is very good
HGH
HGH stimulates cartilage cells to divide
Once the new IGF-1 cells are created, hGH stimulates them to mature
RUNX2 steps in and turns that final stage into bone
IGF-1
IGF-1 prevents cell death
which means the cells created by RUNX2 survive longer
BONESMASHING
Everyone knows what bone smashing is
But when you're on anything that promotes RUNX2, bone smashing becomes 100x more efficient and real
Because the impact creates Fluid shear stress, this triggers MAPK/ERK pathways
This pathway travels to the nucleus and phosphorylates
. This is the switch that tells RUNX2 where to work. Without this, RUNX2 is less efficient
WHAT LOWERS RUNX2
CHRONIC CORTISOL
Chronic cortisol directly binds to the RUNX2 promoter gene and mutes it
Cortisol is often high due to
Poor sleep
Excessive caffeine
And a poor diet
ALCOHOL
Alcohol suppresses RUNX2 and simultaneously activates PPAR-gamma
It forces your stem cells to turn into fat instead of osteoblasts
HIGH SUGAR INTAKE
High sugar spikes create AGEs
AGEs bind to the RAGE receptor on your osteoblast and trigger oxidative stress that degrades RUNX2
HIGH ESTROGEN
Excessive can lead to premature exhaustion of the RUNX2 in the growth plates
It forces the plates to close earlier
and it also causes gyno
Thanks to anyone who took this seriously and actually read this
Teriparatide
Teriparatide is one of the most powerful bone anabolics
It creates a massive anabolic window for RUNX2 growth
BMP-2
BMP-2 forces stem cells to become bone very quickly, which is very good
HGH
HGH stimulates cartilage cells to divide
Once the new IGF-1 cells are created, hGH stimulates them to mature
RUNX2 steps in and turns that final stage into bone
IGF-1
IGF-1 prevents cell death
which means the cells created by RUNX2 survive longer
BONESMASHING
Everyone knows what bone smashing is
But when you're on anything that promotes RUNX2, bone smashing becomes 100x more efficient and real
Because the impact creates Fluid shear stress, this triggers MAPK/ERK pathways
This pathway travels to the nucleus and phosphorylates
. This is the switch that tells RUNX2 where to work. Without this, RUNX2 is less efficient
WHAT LOWERS RUNX2
CHRONIC CORTISOL
Chronic cortisol directly binds to the RUNX2 promoter gene and mutes it
Cortisol is often high due to
Poor sleep
Excessive caffeine
And a poor diet
ALCOHOL
Alcohol suppresses RUNX2 and simultaneously activates PPAR-gamma
It forces your stem cells to turn into fat instead of osteoblasts
HIGH SUGAR INTAKE
High sugar spikes create AGEs
AGEs bind to the RAGE receptor on your osteoblast and trigger oxidative stress that degrades RUNX2
HIGH ESTROGEN
Excessive can lead to premature exhaustion of the RUNX2 in the growth plates
It forces the plates to close earlier
and it also causes gyno
Thanks to anyone who took this seriously and actually read this
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