SERMs/Nolvadex effect on growth plates

[clavicel]

Been looking into the effects of SERMs on growth plate closure, and I keep finding conflicting info. Here I have linked some studies about the effects of tamoxifen (nolvadex) on bone growth that appear to have opposite conclusions.

"[Tamoxifen] caused a dose-dependent growth retardation of cultured metatarsal bones. No catch-up growth was observed after [tamoxifen] was removed from the culture medium. Detailed analysis of sectioned growth plate cartilage revealed increased apoptosis of chondrocytes within the resting and hypertrophic zones." - https://pubmed.ncbi.nlm.nih.gov/17293177/
And here's an in vivo follow-up confirming the results: https://www.researchgate.net/publication/5503175

"As expected, E2 was found to suppress longitudinal bone growth, but in contrast, this parameter was stimulated by tamoxifen. We conclude that tamoxifen acts as an agonist with respect to estrogen’s stimulatory action on bone formation but as an antagonist in terms of estrogen’s inhibition of longitudinal growth, suggesting that the protective effect of SERMs on the skeleton is partly mediated by stimulation of osteoblast activity." - https://academic.oup.com/endo/article/146/3/1060/2500135
Here's another one (which I don't fully understand) that seems to describe the same effect: https://pubmed.ncbi.nlm.nih.gov/11983487/

This one done on actual boys in puberty says it has no effect: https://www.degruyter.com/view/journals/jpem/29/1/article-p77.xml

So which is it? This is quite important for any pubertymaxxers wanting to cycle as they will have to PCT somehow.

 

[Deleted member 4430]

 

[sandcelmuttcel]

tldr

 

[Deleted member 2621]

well, serms have, as the name suggests, mild estrogenic effects on bone.
This means osteoblasts are going to be lowered, osteoclasts too though. Also the plates will close a little sooner compared to no estrogen, because serms occupate e receptors, but later compared to high e.


I know it sounds all very confusing but unless you have a degree in endocrinology I wouldnt use them for that purpose lol

 

[clavicel]

well, serms have, as the name suggests, mild estrogenic effects on bone.
This means osteoblasts are going to be lowered, osteoclasts too though. Also the plates will close a little sooner compared to no estrogen, because serms occupate e receptors, but later compared to high e.


I know it sounds all very confusing but unless you have a degree in endocrinology I wouldnt use them for that purpose lol

SERMs have antagonistic effects in some tissues (tamoxifen is antiestrogenic in breast tissue which is why it's used for gyno) and act as agonists in others. The question is how it affects the growth plates in particular.

 

[Gaia262]

SERMs have antagonistic effects in some tissues (tamoxifen is antiestrogenic in breast tissue which is why it's used for gyno) and act as agonists in others. The question is how it affects the growth plates in particular.

Bro you ain't going to get a good answer from this forum.

Try a steroid forum, they tend to have high IQ SERM users and doctors that understand SERMs on their that might help.

Try this place.

I took 20mg nolvadex as part of my PCT this morning but know nothing on its effect on growth plates for teens etc.

MESO-Rx Anabolic Steroids Info

The most credible source for anabolic steroids information with performance-enhancing drug profiles and a massive community of steroid users.

thinksteroids.com

 

[clavicel]

Bro you ain't going to get a good answer from this forum.

Try a steroid forum, they tend to have high IQ SERM users and doctors that understand SERMs on their that might help.

Try this place.

I took 20mg nolvadex as part of my PCT this morning but know nothing on its effect on growth plates for teens etc.

MESO-Rx Anabolic Steroids Info

The most credible source for anabolic steroids information with performance-enhancing drug profiles and a massive community of steroid users.

thinksteroids.com

I would think that steroid users don't really give a fuck about growth plates, since they all have closed plates. I know this place has very low average IQ but I was hoping maybe someone would know. Will do some searching on there as well I suppose.

 

[MentalistKebab]

>Pubertymaxxer
>Cycling

Choose one bro