Should I take AI once a week or once a day and how much

[rik]

Title

 

[Jonas2k7]

You are good using all AIs e3d (every 3 days).

Exemestan nukes the enzyme itself, which takes around 3 days to be back at baseline. This study showed that the E2 decrease was noninferior to a dosing protocol of once daily.

Efficacy of Alternative Dose Regimens of Exemestane in Postmenopausal Women With Stage 0 to II Estrogen Receptor–Positive Breast Cancer: A Randomized Clinical Trial - PMC

This randomized clinical trial compares exemestane, 25 mg, given once daily, 3 times weekly, and once weekly for the treatment of estrogen receptor–positive breast cancer in postmenopausal women prior to surgery.

pmc.ncbi.nlm.nih.gov

Anastrozole has a half life of around 50 hours.

Pharmacokinetics of third-generation aromatase inhibitors

The latest generation of nonsteroidal aromatase inhibitors (anastrozole and letrozole) has been approved by the US Food and Drug Administration for us…

www.sciencedirect.com

Letrozole has a half life of around 2 days.

Letrozole

@chadisbeingmade @loyolaxavvierretard

 

[rik]

You are good using all AIs e3d (every 3 days).

Exemestan nukes the enzyme itself, which takes around 3 days to be back at baseline. This study showed that the E2 decrease was noninferior to a dosing protocol of once daily.

View attachment 3709052

Efficacy of Alternative Dose Regimens of Exemestane in Postmenopausal Women With Stage 0 to II Estrogen Receptor–Positive Breast Cancer: A Randomized Clinical Trial - PMC

This randomized clinical trial compares exemestane, 25 mg, given once daily, 3 times weekly, and once weekly for the treatment of estrogen receptor–positive breast cancer in postmenopausal women prior to surgery.

pmc.ncbi.nlm.nih.gov

Anastrozole has a half life of around 50 hours.

Pharmacokinetics of third-generation aromatase inhibitors

The latest generation of nonsteroidal aromatase inhibitors (anastrozole and letrozole) has been approved by the US Food and Drug Administration for us…

www.sciencedirect.com

Letrozole has a half life of around 2 days.

Letrozole

@chadisbeingmade @loyolaxavvierretard

Thanks I will switch to letrozol