Some less known facts about Minoxidil (topical route)

[GreekGenes]

1. You don't actually need to let the minoxidil absorb for 4+ hours as it says on the bottle. I've good it on good authority from 2 derms that more than 50% of the product has basically been absorbed into the hair follicle area after an hour.
> this is especially important for people who hate the sticky look minoxidil can give your hair
> this was also stated by the doctors on the youtube channel "hair loss show", one of the doctors having been involved in the original Minoxidil trials back in the 1980s.

2. Dermarolling + minoxidil does not actually increase cardiac side effects. While dermarolling pokes little holes into your scalp skin, the increased absorption does NOT lead to severe systemic side effects. At least not as long as you keep a reasonably low needle length (0.25-0.5mm). And you do not need to wait for 24 hours after dermarolling to apply minox (defeats the purpose of dermarolling for enhanced absorption, actually, since the mentioned "holes" will have healed)

3. Minoxidil grows hair E-V-E-R-Y-W-H-E-R-E it's applied, as long as hair follicles exist in the area. The crown of your scalp, the temples, everywhere. And it also works for a-n-y kind of body hair.

4. Salicylates, especially orally in the form of Aspirin (acetylsalicylate), counteract minoxidil's efficacy. By inhibiting the Minoxidil Sulfotransferase enzyme* they can render minoxidil (topical AND oral) useless.

*minoxidil sulfotransferase (sult1a1) is the enzyme that converts minoxidil into the necessary form for it to work on your follicles, minoxidil sulfate.

I could add more stuff but it would probably make the thread tl;dr. May add more in later posts in this thread.

 

[Shkreliii]

i like the oily look minox gives.

 

[Shkreliii]

minox made me gain 1 cm of hairs on my temples

 

[FUE Mogger]

1. You don't actually need to let the minoxidil absorb for 4 hours as it says on the bottle. I've good it on good authority from 2 derms that more than 50% of the product has basically been absorbed into the hair follicle area after an hour.

relating this to applying it on Eyebrows, does this mean i should rinse it with water after an hour?

 

[GreekGenes]

Some extra sources:

2. "How long to apply minoxidil after dermarolling?"



4. Low-dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients

Low-dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients - PubMed

Topical minoxidil is the only US FDA approved OTC drug for the treatment of androgenetic alopecia (AGA). Minoxidil is a pro-drug converted into its active form, minoxidil sulfate, by the sulfotransferase enzymes in the outer root sheath of hair follicles. Previously, we demonstrated that...

pubmed.ncbi.nlm.nih.gov

 

[GreekGenes]

relating this to applying it on Eyebrows, does this mean i should rinse it with water after an hour?

Are you applying the foam? The foam is absorbed more than twice as fast as the liquid, so in theory its been absorbed by that point. But the longer you leave it on the better the effects may be.

Just make sure none of the minoxidil gets inside your eyes since it can cause a medical emergency. (thrombosis inside the eye)

 

[AsGoodAsItGets]

Very good thread

 

[starvecell]

Salicylates

Why did i read this a stacylite

 

[MUSTYCOPER]

1. You don't actually need to let the minoxidil absorb for 4+ hours as it says on the bottle. I've good it on good authority from 2 derms that more than 50% of the product has basically been absorbed into the hair follicle area after an hour.
> this is especially important for people who hate the sticky look minoxidil can give your hair
> this was also stated by the doctors on the youtube channel "hair loss show", one of the doctors having been involved in the original Minoxidil trials back in the 1980s.

2. Dermarolling + minoxidil does not actually increase cardiac side effects. While dermarolling pokes little holes into your scalp skin, the increased absorption does NOT lead to severe systemic side effects. At least not as long as you keep a reasonably low needle length (0.25-0.5mm). And you do not need to wait for 24 hours after dermarolling to apply minox (defeats the purpose of dermarolling for enhanced absorption, actually, since the mentioned "holes" will have healed)

3. Minoxidil grows hair E-V-E-R-Y-W-H-E-R-E it's applied, as long as hair follicles exist in the area. The crown of your scalp, the temples, everywhere. And it also works for a-n-y kind of body hair.

4. Salicylates, especially orally in the form of Aspirin (acetylsalicylate), counteract minoxidil's efficacy. By inhibiting the Minoxidil Sulfotransferase enzyme* they can render minoxidil (topical AND oral) useless.

*minoxidil sulfotransferase (sult1a1) is the enzyme that converts minoxidil into the necessary form for it to work on your follicles, minoxidil sulfate.

I could add more stuff but it would probably make the thread tl;dr. May add more in later posts in this thread.

what about drininkin monsters ? I have one every morning but take topical min at night

 

[Deleted member 84544]

Why is it giving me heart palpitations how can I stop this side effect?

 

[averagenormie]

1. You don't actually need to let the minoxidil absorb for 4+ hours as it says on the bottle. I've good it on good authority from 2 derms that more than 50% of the product has basically been absorbed into the hair follicle area after an hour.
> this is especially important for people who hate the sticky look minoxidil can give your hair
> this was also stated by the doctors on the youtube channel "hair loss show", one of the doctors having been involved in the original Minoxidil trials back in the 1980s.

2. Dermarolling + minoxidil does not actually increase cardiac side effects. While dermarolling pokes little holes into your scalp skin, the increased absorption does NOT lead to severe systemic side effects. At least not as long as you keep a reasonably low needle length (0.25-0.5mm). And you do not need to wait for 24 hours after dermarolling to apply minox (defeats the purpose of dermarolling for enhanced absorption, actually, since the mentioned "holes" will have healed)

3. Minoxidil grows hair E-V-E-R-Y-W-H-E-R-E it's applied, as long as hair follicles exist in the area. The crown of your scalp, the temples, everywhere. And it also works for a-n-y kind of body hair.

4. Salicylates, especially orally in the form of Aspirin (acetylsalicylate), counteract minoxidil's efficacy. By inhibiting the Minoxidil Sulfotransferase enzyme* they can render minoxidil (topical AND oral) useless.

*minoxidil sulfotransferase (sult1a1) is the enzyme that converts minoxidil into the necessary form for it to work on your follicles, minoxidil sulfate.

I could add more stuff but it would probably make the thread tl;dr. May add more in later posts in this thread.

How to get the minoxidil sulfotransferase enzyme I heard it only works for 40% because the majority don't have the enzyme on thier hair follicles?

 

[GreekGenes]

How to get the minoxidil sulfotransferase enzyme I heard it only works for 40% because the majority don't have the enzyme on thier hair follicles?

As far as i know there's at least two ways:

1) use a topical retinoid on your scalp (which should upregulate Sult1a1) in combination with minoxidil
2) use ORAL minoxidil

 

[Jonas2k7]

Good thread, post more stuff bhai

 

[halloweed]

4. Salicylates, especially orally in the form of Aspirin (acetylsalicylate), counteract minoxidil's efficacy. By inhibiting the Minoxidil Sulfotransferase enzyme* they can render minoxidil (topical AND oral) useless.

*minoxidil sulfotransferase (sult1a1) is the enzyme that converts minoxidil into the necessary form for it to work on your follicles, minoxidil sulfate.

Never knew this tbh great thread.