Taking AI only once a week?

[Crazzen8]

Obviously, as we all know taking aromatase inhibitors can delay the fusion of growth plates thus helping in gaining height.

The question I have here is that I'm currently running a stack of 2.5mg letrozole and now 5iu's of HGH. The problem I'm having is that letrozole leads to a lot of negative side effects one of the biggest ones being hair loss/thinning, so I'd like to know if instead of taking 2.5mg on a daily basis I started dosing it weekly. Obviously this will be way less effective but would it still help in delaying growth plate fusion or is it negligible at that point.

Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism

Objective Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E2) production and E2-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can reverse this process. This study evaluates...

eje.bioscientifica.com

The study I linked above put obese men on a dose of 2.5mg letrozole per week for 6 months, and this resulted in lower Estrogen levels as well as increased Test levels.

just to recap I'd like to continue using letrozole but dose it only once a week is this even worth it?

 

[Deleted member 5521]

then take a lower dose everyday because the half life is one day (2 for letrozole) so for the other 6 days your bones will start fusing which is no good

 

[Crazzen8]

then take a lower dose everyday because the half life is one day (2 for letrozole) so for the other 6 days your bones will start fusing which is no good

Actually according to this study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740217/

"The half-life for letrozole is 3–4 days [15] suggesting that daily dosing may lead to increased drug accumulation and toxicity and that non-daily dosing may effectively suppress estrogen." I think your referring to Letrozole's terminal elimination which has a half-life of 2 days.

So should I try and take it around its half life?

"In this study, no differences were observed in the AE profiles between the 0.5 mg and 2.5 mg daily dosing groups [14]." apparently higher dosing didn't have major changes in effects as well


"Earlier studies have shown that serum estrogen suppression of greater than 72 hours was maintained with a single dose of 0.1 or 0.5 mg letrozole; and estrogen suppression was maintained for 7 days with a single 2.5 mg dose" also estrogen suppression is maintained for 7 days with a single dose.

 

[Deleted member 5521]

Actually according to this study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740217/

"The half-life for letrozole is 3–4 days [15] suggesting that daily dosing may lead to increased drug accumulation and toxicity and that non-daily dosing may effectively suppress estrogen." I think your referring to Letrozole's terminal elimination which has a half-life of 2 days.

So should I try and take it around its half life?

"In this study, no differences were observed in the AE profiles between the 0.5 mg and 2.5 mg daily dosing groups [14]." apparently higher dosing didn't have major changes in effects as well


"Earlier studies have shown that serum estrogen suppression of greater than 72 hours was maintained with a single dose of 0.1 or 0.5 mg letrozole; and estrogen suppression was maintained for 7 days with a single 2.5 mg dose" also estrogen suppression is maintained for 7 days with a single dose.

Yea I was thinking about the half life of aromasin when i wrote that, if you want less side effects then probably just take a dose every half life so every 3-4 days so you still suppress the estrogen

 

[rax1337]

you're better off not taking them, because of the e2 rebound effect.

 

[PubertyMaxxer]

you're better off not taking them, because of the e2 rebound effect.

Aromasin has no rebound though

 

[Piro]

Take a low dose of a suicidal AI every time it finishes its half life
Not every AI have a rebound effect so you might have to dig a bit deeper
Just make sure that you aren’t crashing your e2 but keeping them on the lower end

 

[Alexanderr]

Take a low dose of a suicidal AI every time it finishes its half life
Not every AI have a rebound effect so you might have to dig a bit deeper
Just make sure that you aren’t crashing your e2 but keeping them on the lower end

I plan on taking 10mg of aromasin every other day to be on the safe side but its half life is 24 hours.

 

[rax1337]

Aromasin has no rebound though

Hes talking about letrozole

 

[KingOfRome]

might as well not take it at all lol

 

[Crazzen8]

might as well not take it at all lol

lol idk if u can read but the studies clearly found that it still suppresses estrogen when taken once a week.