Song of the thread:
Introduction
In this thread, I’ll be taking a closer look at some of the most popular peptides that are getting a lot of attention right now. These compounds are being used for everything from improving general health and boosting performance to helping with skin. Peptides are becoming a go-to in the looksmaxxing space, and this guide will break down what each one does, why people use them, and what the pros and cons are. I am not a doctor and this is not medical advice.
For each peptide, I will include:
-A brief explanation of its primary function
-Two Pros and two Cons
-Its chemical structue for reference
The spreadsheet is designed to offer clear, structured insights to help all of you better understand the unique and potential applications of each peptide.
Let’s begin.
THE SPREADSHEET (I also have a spreadsheet that dives deeper into every singular peptide that is known right now let me know if yall want to see that)
GHK-CU
Category: Skin
Melanotan 1
Category: Skin
-May reduce sunburn risk by boosting melanin.
-Not enough research done and safety isn't completely clear
Melanotan 2
Category: Skin
CJC 1295 no DAC
Category: Skin and Bonemass/Height
TB500
Category: Skin and General Health
MYO
Category: Skin and Health
Epitalon
Category:Skin and General Health
Conclusion
Peptides are quickly becoming one of the most interesting and used tools in looksmaxxing. Whether you're trying to improve your skin, boost recovery, slow down aging, or enhance natural processes like tanning or hormone production—there’s likely a peptide that can help you achieve this goal.
That said, these compounds aren’t magic bullets! They won't make you ascend. Each one comes with its own risks, dosing challenges, and gaps in research—especially in humans. Since most of the research is done on animals. It’s important to do your own research, start low and slow if you decide to experiment, and always prioritize safety. Again, none of this is medical advice—just a breakdown to help all of you guys better understand what’s out there.
If you want the full spreadsheet with every known Ultima peptide, you can PM me and I’ll share it.
Thanks for reading!
@imontheloose
Introduction
In this thread, I’ll be taking a closer look at some of the most popular peptides that are getting a lot of attention right now. These compounds are being used for everything from improving general health and boosting performance to helping with skin. Peptides are becoming a go-to in the looksmaxxing space, and this guide will break down what each one does, why people use them, and what the pros and cons are. I am not a doctor and this is not medical advice.
For each peptide, I will include:
-A brief explanation of its primary function
-Two Pros and two Cons
-Its chemical structue for reference
The spreadsheet is designed to offer clear, structured insights to help all of you better understand the unique and potential applications of each peptide.
Let’s begin.
THE SPREADSHEET (I also have a spreadsheet that dives deeper into every singular peptide that is known right now let me know if yall want to see that)
| Peptide Name | Categories |
| GHK-CU | Skin |
| Melanotan 1 | Skin |
| Melanotan 2 | Skin |
| CJC 1295 No DAC | Skin, Bonemass/Height |
| TB500 | Skin, General Health |
| MYO | Skin |
| NAD+ | Skin, General Health |
| Epitalon | Skin, General Health |
GHK-CU
Category: Skin
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a natural peptide found in the human body. It helps with healing and keeping cells healthy. At age 20, the body has about 200 ng/ml of GHK-Cu in the blood, but this level drops to around 80 ng/ml by age 60.
GHK-Cu supports the repair of many tissues like skin, lungs, bones, liver, and stomach. It increases the production of collagen, elastin, and other important factors in the skin. It also helps new blood vessels and nerves grow, and it supports skin cells called fibroblasts.
This peptide has several protective effects. It can reduce inflammation, fight harmful molecules related to aging, help with pain and anxiety, protect lung cells (for example, in people with COPD), and even support DNA repair. One reason for these many effects is that GHK-Cu can change how many genes work in the body—often making them work in a healthier way.
GHK-Cu supports the repair of many tissues like skin, lungs, bones, liver, and stomach. It increases the production of collagen, elastin, and other important factors in the skin. It also helps new blood vessels and nerves grow, and it supports skin cells called fibroblasts.
This peptide has several protective effects. It can reduce inflammation, fight harmful molecules related to aging, help with pain and anxiety, protect lung cells (for example, in people with COPD), and even support DNA repair. One reason for these many effects is that GHK-Cu can change how many genes work in the body—often making them work in a healthier way.
Pros:
-Helps boost collagen, reduce wrinkles, and improve skin texture. It’s a favorite in anti-aging routines. (Been going viral on TikTok)
-Some users see noticeable improvements in hair thickness and regrowth, especially when combined with other treatments.
Cons:
-Can be pricey – High-quality GHK-CU isn’t cheap, especially if you’re using it regularly or in injectable form.
-While it’s promising, not all benefits (like systemic healing or muscle recovery) are well-studied in humans
-Helps boost collagen, reduce wrinkles, and improve skin texture. It’s a favorite in anti-aging routines. (Been going viral on TikTok)
-Some users see noticeable improvements in hair thickness and regrowth, especially when combined with other treatments.
Cons:
-Can be pricey – High-quality GHK-CU isn’t cheap, especially if you’re using it regularly or in injectable form.
-While it’s promising, not all benefits (like systemic healing or muscle recovery) are well-studied in humans
Melanotan 1
Category: Skin
Afamelanotide, also known as MT-1, is a peptide that works like a natural hormone in the body called α-MSH. This hormone helps the skin produce melanin, which gives it a darker color. Afamelanotide connects to a receptor in the skin called MC1, and this starts the process of skin tanning. It stays active longer than the natural hormone because it doesn't break down quickly in the body.
Although it has a short half-life of about 30 minutes, the drug is given through a small implant under the skin. Most of it is released in the first two days, and 90% is released by day five. By day ten, the drug can no longer be found in the blood. As of 2017, scientists still didn’t fully understand how the body processes or removes it. Studies have shown that afamelanotide can help the skin tan more easily and protect it from sunburn. In one study, most people who used MT-1 tanned more than those who didn’t, and they had about 47% fewer sunburn cells. Other studies showed that the tan lasted longer—up to three weeks more than a normal sun tan—and people needed less sun exposure to get similar results.
Although it has a short half-life of about 30 minutes, the drug is given through a small implant under the skin. Most of it is released in the first two days, and 90% is released by day five. By day ten, the drug can no longer be found in the blood. As of 2017, scientists still didn’t fully understand how the body processes or removes it. Studies have shown that afamelanotide can help the skin tan more easily and protect it from sunburn. In one study, most people who used MT-1 tanned more than those who didn’t, and they had about 47% fewer sunburn cells. Other studies showed that the tan lasted longer—up to three weeks more than a normal sun tan—and people needed less sun exposure to get similar results.
Pros:
-Enhances tanning with less sun exposure.-May reduce sunburn risk by boosting melanin.
Cons:
-Expensive-Not enough research done and safety isn't completely clear
Melanotan 2
Category: Skin
Melanotan II (MT-II) is a peptide version of a natural hormone called α-MSH, which helps the skin produce melanin, causing it to darken. It was developed after Melanotan I and also works by activating the melanocortin 1 receptor to promote tanning. One of its side effects is increased sexual arousal, especially in men.
Although it was originally developed for cosmetic use, the plan was dropped due to regulatory issues and concerns about encouraging suntanning.
Common side effects include nausea, facial flushing, and unwanted erections. It can also temporarily darken moles and freckles. Some cases of melanoma have been reported, but these are usually linked to high UV exposure rather than Melanotan II itself. So far, there is no clear evidence that Melanotan II increases the risk of skin cancer, but more research is needed.
Although it was originally developed for cosmetic use, the plan was dropped due to regulatory issues and concerns about encouraging suntanning.
Common side effects include nausea, facial flushing, and unwanted erections. It can also temporarily darken moles and freckles. Some cases of melanoma have been reported, but these are usually linked to high UV exposure rather than Melanotan II itself. So far, there is no clear evidence that Melanotan II increases the risk of skin cancer, but more research is needed.
Pros:
-Promotes tanning with less sun exposure.
-May boost libido in some users (Low T users GTFIH).
Cons:
-Can cause side effects like nausea, flushing, and unwanted erections
feelskek.
-May darken moles and freckles, raising concerns for people at risk of skin issues. Is associated with skin cancer.
-Promotes tanning with less sun exposure.
-May boost libido in some users (Low T users GTFIH).
Cons:
-Can cause side effects like nausea, flushing, and unwanted erections
feelskek.-May darken moles and freckles, raising concerns for people at risk of skin issues. Is associated with skin cancer.
CJC 1295 no DAC
Category: Skin and Bonemass/Height
CJC-1295 is a synthetic peptide that helps increase the body’s natural production of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). These hormones play important roles in muscle growth, fat metabolism, and overall vitality.
There are two forms of CJC-1295: one with a drug affinity complex (DAC) and one without. The version with DAC stays in the bloodstream much longer—about 6 to 8 days—because it binds to a protein called albumin. This allows GH and IGF-1 levels to stay higher for days or even weeks after a single injection. The form without DAC has a shorter half-life, which means it leaves the body faster and needs more frequent doses. This shorter-acting form can be easier to adjust based on personal needs and may cause fewer side effects.
Why is CJC-1295 good for skin? Growth hormone and IGF-1 help improve skin health by promoting cell regeneration, increasing collagen production, and improving elasticity. This can lead to firmer, more youthful-looking skin and faster repair of damaged tissue.
There are two forms of CJC-1295: one with a drug affinity complex (DAC) and one without. The version with DAC stays in the bloodstream much longer—about 6 to 8 days—because it binds to a protein called albumin. This allows GH and IGF-1 levels to stay higher for days or even weeks after a single injection. The form without DAC has a shorter half-life, which means it leaves the body faster and needs more frequent doses. This shorter-acting form can be easier to adjust based on personal needs and may cause fewer side effects.
Why is CJC-1295 good for skin? Growth hormone and IGF-1 help improve skin health by promoting cell regeneration, increasing collagen production, and improving elasticity. This can lead to firmer, more youthful-looking skin and faster repair of damaged tissue.
Pros:
-Increases GH and IGF-1 levels, which helps with muscle growth, fat loss, and skin regeneration.
-Long-lasting effects (especially with DAC), meaning fewer injections are needed.
Cons:
-Requires multiple doses if using the non-DAC form due to its shorter half-life.
-Possible side effects include water retention (THE BLOAT IS COMING), tiredness, or joint pain in some cases.
-Increases GH and IGF-1 levels, which helps with muscle growth, fat loss, and skin regeneration.
-Long-lasting effects (especially with DAC), meaning fewer injections are needed.
Cons:
-Requires multiple doses if using the non-DAC form due to its shorter half-life.
-Possible side effects include water retention (THE BLOAT IS COMING), tiredness, or joint pain in some cases.
TB500
Category: Skin and General Health
TB 500 is a synthetic version of a natural protein in the body called Thymosin Beta-4. This protein helps the body repair tissues, reduce inflammation, and improve flexibility. Unlike peptides that mainly focus on fat loss or muscle growth, TB 500 is used mostly for healing and recovery.
One important feature of TB 500 is that it moves quickly through muscles, joints, and connective tissues to target injured areas. This makes it helpful for healing sports injuries, joint pain, muscle strains, and even arthritis. It is popular among athletes, doctors, and health enthusiasts for speeding up recovery after injuries or surgery. TB 500 also helps skin by promoting wound healing and new blood vessel growth, which supports faster repair and healthier, more flexible skin. Some studies even suggest it may help with hair regrowth.
One important feature of TB 500 is that it moves quickly through muscles, joints, and connective tissues to target injured areas. This makes it helpful for healing sports injuries, joint pain, muscle strains, and even arthritis. It is popular among athletes, doctors, and health enthusiasts for speeding up recovery after injuries or surgery. TB 500 also helps skin by promoting wound healing and new blood vessel growth, which supports faster repair and healthier, more flexible skin. Some studies even suggest it may help with hair regrowth.
Pros:
-Speeds up healing of muscles, joints, and connective tissues.
-Promotes skin repair and reduces inflammation.
Cons:
-Possible side effects like fatigue or mild irritation in some cases.
-May need frequent dosing due to fast movement through the body.
-Speeds up healing of muscles, joints, and connective tissues.
-Promotes skin repair and reduces inflammation.
Cons:
-Possible side effects like fatigue or mild irritation in some cases.
-May need frequent dosing due to fast movement through the body.
MYO
Category: Skin and Health
Myoinhibiting peptide (MYO) is a small peptide first discovered in insects. It is known for its ability to inhibit muscle contractions, especially in insect muscles, by acting on a specific receptor called the MIP receptor. This peptide has a unique structure with two tryptophan amino acids at one end, which helps it bind to its receptor and produce its effects.
Although MIP was first studied in insects like fruit flies, it belongs to a larger family of peptides that play important roles in regulating muscle activity and other bodily functions. The way MIP controls muscle movement could be useful for relaxing muscles and improving circulation, which in turn might support skin health by enhancing nutrient delivery and promoting skin repair.
Although MIP was first studied in insects like fruit flies, it belongs to a larger family of peptides that play important roles in regulating muscle activity and other bodily functions. The way MIP controls muscle movement could be useful for relaxing muscles and improving circulation, which in turn might support skin health by enhancing nutrient delivery and promoting skin repair.
Pros:
-Helps relax muscles, which can improve blood flow and support skin repair.
-Can reduce muscle spasms.
Cons:
-Effects on humans are not well understood, so more studies are needed.
-Primarily studied in insects, so its full potential and safety in humans are not yet clear.
-Helps relax muscles, which can improve blood flow and support skin repair.
-Can reduce muscle spasms.
Cons:
-Effects on humans are not well understood, so more studies are needed.
-Primarily studied in insects, so its full potential and safety in humans are not yet clear.
Epitalon
Category:Skin and General Health
Epitalon is a synthetic peptide developed in Russia by Professor Vladimir Khavinson. It is known for its potential anti-aging effects and its ability to support cellular health. Epithalon is based on a natural compound from the pineal gland, which helps regulate melatonin and sleep cycles.
This peptide is made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine) and is thought to activate telomerase, an enzyme that helps protect and repair telomeres—the protective ends of chromosomes. Since telomeres shorten as we age, keeping them healthy can help slow down cell aging.
Epithalon may also be good for the skin because healthier, longer-living cells can support better skin regeneration, reduce visible aging, and improve overall skin quality. Unlike regular skincare treatments that work on the surface, Epithalon works at a deeper, cellular level.
This peptide is made of four amino acids (alanine, glutamic acid, aspartic acid, and glycine) and is thought to activate telomerase, an enzyme that helps protect and repair telomeres—the protective ends of chromosomes. Since telomeres shorten as we age, keeping them healthy can help slow down cell aging.
Epithalon may also be good for the skin because healthier, longer-living cells can support better skin regeneration, reduce visible aging, and improve overall skin quality. Unlike regular skincare treatments that work on the surface, Epithalon works at a deeper, cellular level.
Pros:
-May slow down cellular aging by activating telomerase.
-Supports skin regeneration and may improve skin quality from within.
Cons:
-Almost no research and only some from Russian studies.
-Peptide stability and dosing can be hard.
-May slow down cellular aging by activating telomerase.
-Supports skin regeneration and may improve skin quality from within.
Cons:
-Almost no research and only some from Russian studies.
-Peptide stability and dosing can be hard.
Conclusion
Peptides are quickly becoming one of the most interesting and used tools in looksmaxxing. Whether you're trying to improve your skin, boost recovery, slow down aging, or enhance natural processes like tanning or hormone production—there’s likely a peptide that can help you achieve this goal.
That said, these compounds aren’t magic bullets! They won't make you ascend. Each one comes with its own risks, dosing challenges, and gaps in research—especially in humans. Since most of the research is done on animals. It’s important to do your own research, start low and slow if you decide to experiment, and always prioritize safety. Again, none of this is medical advice—just a breakdown to help all of you guys better understand what’s out there.
If you want the full spreadsheet with every known Ultima peptide, you can PM me and I’ll share it.
Thanks for reading!
@imontheloose
