The Science Behind: STRŌMA

Alexanderr

Alexanderr

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Introduction
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Throughout history, eye color has fascinated us, sparking tales of mystique and beauty. While blue contacts let you play pretend, the dream of actually changing your eye color seemed as likely as growing wings. But science has been busy, and that far-fetched idea? It's here. Well, almost.

This thread will be a deep dive into the science & technicalities behind laser eye color change/iris depigmentation.
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We'll examine the anatomy of the iris, and delve into the role of stromal pigment – the target of this laser procedure, and a lot more.

To accomplish this, I've primarily relied on patents recently released by Stroma but broader contextual & critical info will be from external sources.

P.S. I don't know when this will be commercially available.

The Anatomy of Eye Color
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As I've established earlier, the iris holds the key to our unique eye color. But before telling you how this laser technology can be used to modify pigment within the iris, we'll need to understand its structure.

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The iris is a thin, circular structure that controls the amount of light entering the eye. It's composed of multiple layers, each contributing to its overall appearance.
  • Anterior Border Layer
    • This outermost layer is responsible for the iris's intricate texture and patterns. Think of it as the "fingerprint" of your eye. It's relatively transparent and doesn't play a significant role in determining eye color.
  • Stroma
    • This middle layer is the heart of eye color determination. It houses specialized cells called melanocytes, which produce the pigment melanin. Melanin comes in two main forms:
      • Eumelanin: A brown-black pigment responsible for darker eye colors.
      • Pheomelanin: A reddish-yellow pigment contributing to lighter shades like amber, green, and hazel.
It's the density and distribution of eumelanin within the stroma that primarily dictates whether an eye appears brown, blue, green, or hazel.
  • Posterior Iris Pigment Epithelium (IPE)
    • This innermost layer, densely packed with pigment, acts sorta like a "dark curtain" behind the stroma. It absorbs excess light entering the eye, prevents it from scattering, and ensures a clear image on the retina.

Stroma - The Target
But here's the key: Most people are born with blue or green eyes because they have minimal stromal pigment. Think about it: Most babies have bright, piercing blue eyes.
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As we age, melanocytes in the stroma of some individuals produce more eumelanin, causing their eyes to turn brown.

>So all of us can become a part of the blue-eyed master race? :chad:
>Yes. :feelsez:


This laser eye color change procedure targets the stromal eumelanin in brown eyes. By selectively disrupting the melanosomes (pigment granules within the melanocytes), the procedure triggers a natural process of pigment removal by the body.

This allows the underlying blue or green color to become more visible, resulting in a lighter eye color.

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Important here is that this procedure doesn't introduce a new pigment; it just alters the existing pigment composition of the stroma.

This is a key difference from colored contact lenses, which merely cover the iris with a colored layer, or iris implants, which involve inserting a foreign object into the eye.

The Laser Technology​

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Before those with special needs try to DIY this shit - it isn't just about any laser. It's a specialized system designed for precise and controlled interaction with the iris.

This system is specifically engineered to target the stromal pigment responsible for brown eye color, disrupting its structure while minimizing risk to surrounding tissues.

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The system typically includes several key components:

The Laser Head
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This is the powerhouse that generates the laser beam. For this procedure, a specialized laser is required, often a Nd:YAG (neodymium-doped yttrium aluminum garnet) laser. These lasers are known for their precision and reliability, generating a concentrated beam of light.

Laser Specifications
To ensure both effectiveness and safety, the laser system controls three key parameters:
  1. Wavelength: Typically 532nm (green), ideal for melanin absorption in the stroma.
  2. Pulse Width: Measured in nanoseconds, controls energy delivery and minimizes heat spread.
  3. Repetition Rate: Measured in kilohertz, determines treatment speed and intensity.
In essence: Green light targets melanin, short bursts prevent damage, and zap frequency fine-tunes the effect.

The Gaussian Beam Profile
The laser beam is shaped to create a Gaussian beam profile.
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But, what the fuck does this mean? Well, it means the beam converges to a focal point and then diverges. This shape is very important for achieving the desired outcome. Here's why:
  • High Energy at Iris
    • The beam's peak energy is concentrated at the focal point, directly targeting the stromal pigment in the iris. This maximizes the odds of disrupting the melanosomes (pigment granules) within those cells, triggering the body's natural pigment removal process.
  • Lower Energy at Retina
    • As the beam diverges, the energy density decreases, protecting the sensitive structures of the retina from damage.
In short, focused zap on iris color, spreads out to avoid frying your retina...

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Safety Considerations
The first thing anyone probably thinks when hearing someone say "Let's point a laser in your eyes, and burn them to change your eye color" is probably "Are you fucking retarded?" And they'd be right.

So, to ensure you don't end up looking like a confused cyclops, the laser wizards follow these rules.
  • MPE (Maximum Permissible Exposure)
    • Self-explanatory. This critical parameter represents the maximum amount of laser energy that can be safely delivered to the retina without causing damage. This is a fundamental safety guideline in ophthalmology, btw.
  • MRE (Minimum Required Exposure)
    • This parameter is just as important as the MPE. It represents the minimum amount of laser energy needed to effectively disrupt the stromal pigment in the iris while remaining within the MPE for retinal safety.
In other words, we need enough energy to achieve the desired effect but not so much that it risks damaging the delicate retinal tissue.

The Treatment Process​

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So, now that we understand the principles behind the laser system, let's explore how it's actually used to change eye color.

Off the bat, it isn't a single, quick fix; it's a multi-step process that requires careful planning, precise targeting, and continuous monitoring.

Again, DIY attempts are not recommended...

Scanning Patterns and Treatment Zones
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The laser beam doesn't simply blast the entire iris; it's carefully scanned across specific regions. Here, the iris is typically divided into two concentric (circular) treatment zones.
First, the inner ring (zone 1). It's the area right around the pupil, like the first ring on a dartboard. This is where the action starts. Second, the outer ring (zone 2). It covers everything from the edge of your iris (where the white of your eye begins) inward until it meets Zone 1.

The very center (the pupil) is off-limits - that's the black dot in the middle of the diagram.

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The laser moves in a spiral pattern, starting from the outer edge and working its way in. It treats the inner ring (Zone 1) first, spinning inward sorta like a corkscrew. Once that's done, it moves to the outer ring (Zone 2) and does the same thing.

This spiral dance ensures every part of the iris gets zapped evenly, without missing spots or overdoing it in others.

Multiple Treatment Sessions and a Staged Approach
Sadly, changing eye color isn't a one-and-done procedure. The process of stromal pigment disruption and removal is a gradual one.

Therefore, multiple treatment sessions, spaced several weeks apart, are typically required. :feelsrope:

(((Supposedly))), this staged approach is designed to:
  • Minimize Risk
  • Maximize Efficacy
  • Individualize Treatment
and NOT to empty your pockets... 🕎

Importance of Precise Targeting and Eye Tracking
Achieving the desired eye color change depends on pinpoint accuracy in directing the laser beam to the target stromal pigment. I cannot overstate the importance of this.

So, this is where sophisticated tech, like eye-tracking systems, comes into play.
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Eye-tracking systems use specialized sensors to constantly monitor the position and movement of the eye during the procedure. Helps ensure that the laser beam stays on target since even the slightest movement of the eye can throw off the laser beam's trajectory. Also, since the treatment area is precisely defined, eye tracking allows for real-time adjustments of the laser beam's position, ensuring it stays focused on the target zone.

Positioning and Support Systems​

To ensure safe and effective treatment, you've gotta be positioned and supported in a way that minimizes movement.

You are your worst enemy here.

Again, even small, involuntary movements of the head or eye can disrupt the precise targeting of the laser beam, leading to uneven treatment or damage to other parts of your eye.

This is where specialized patient support systems come into play. These systems are designed to immobilize you (yep, you're stuck), maintain proper alignment (to make sure your eye is aligned with the laser beam), and enhance comfort via features like reclining portions, leg supports, or, even possible head-cooling systems.
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Neck Muscle Disengagement
By now you know, movement = bad. Still, something that might be easily overlooked is the importance of disengaging the neck muscles. When your neck muscles are actively engaged, they naturally make small, involuntary movements of the head and eye...and you know the rest.

So, the laser wizards claim these support systems are designed to support your head in a way that allows the neck muscles to relax and remain disengaged. This should result in a more stable and comfortable experience, ultimately contributing to the precision of the treatment.

Despite all of that, you'll inevitably shift, slightly, but that's why they've got...

Rangefinding and Precision Targeting​

I want you to imagine trying to hit a moving target with a laser beam, but the target is as small as the iris of the eye, and it's constantly shifting slightly.

This is the problem STROMA and other companies face when delivering laser treatment for eye color change. Overcoming it requires some advanced technology to ensure accuracy & safety.
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Rangefinding Tech
Rangefinders measure the exact distance between the laser and your eye. They're crucial for focusing the beam precisely on the iris pigment. Here are some types used:
  • Triangulation
    • Involves projecting a laser beam onto the iris and measuring the angle at which it's reflected back to a sensor. By knowing the distance between the laser and the sensor, the system can calculate the precise distance to the iris.
  • Time-of-Flight
    • Involves sending a pulse of laser light or ultrasound to the iris and measuring the time it takes for the pulse to return. The speed of light or sound is known, so the system can calculate the distance based on the travel time.
  • Optical Coherence Tomography (OCT)
    • This imaging technique creates a detailed, three-dimensional image of the eye's internal structures, including the iris. OCT provides extremely precise measurements of distances within the eye, making it an important tool for accurate targeting.
TLDR: Rangefinders use different tricks to measure eye-to-laser distance. Some bounce light and do math, others time light-speed races, and the fancy ones take 3D eye selfies.

Coarse vs. Fine Adjustments
Course adjustment
vs.
Fine adjustment

The system uses these measurements for both coarse and fine adjustments, ensuring the laser remains focused on the target area throughout the procedure. Coarse adjustments position the patient, while fine adjustments, often computer-controlled, ensure pinpoint accuracy.

Additionally, autofocusing mechanisms allow for real-time adjustments as the eye moves or changes shape during treatment.

Monitoring and Control Systems​

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To ensure safety and effectiveness, several monitoring systems are employed:

Real-time Temperature Monitoring
  • Tracks iris temperature to prevent damage to surrounding tissues
  • Ensures temperature remains within safe limits

Microbubble Detection
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  • Monitors formation of tiny gas pockets on stromal pigment surface
  • Indicates effective laser energy and guides treatment adjustments
Physician and Technician Consoles

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  • Separate but connected consoles for coordinated operation
  • Physician console displays patient info and treatment plans
  • Technician console controls laser system and manages treatment process
  • Allows real-time communication and improved accuracy

Challenges and Limitations​

Okay, we're almost done, I promise...

Now, as you likely know already, STROMA hasn't released a commercial product. So while laser eye color depigmentation technology shows tremendous promise, it currently still faces big questions and limitations.

Consistency Across Different Eye Types and Pigmentation Levels
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One of the biggest hurdles is ensuring consistent results across different individuals. The human eye, much like our skin, comes in a wide range of colors and pigment densities. The amount and type of melanin present in the stroma can vary dramatically from person to person. This variability means:
  • Treatment parameters might need adjustment for each individual
  • Predicting outcomes can be challenging
Long-term Stability Concerns
Now, there's one big question, still unanswered. Will the color last?

Short answer: Maybe..? :feelswat:

The long-term stability of laser-induced eye color change is still unknown. While initial results might be promising, it's unclear whether the body's natural pigment production processes will attempt to restore the original eye color over time.

Regulatory Hurdles
  • The procedure is still experimental and not approved for widespread cosmetic use
  • Strict regulations require extensive testing and clinical trials - these take a long time
  • Limited access until regulatory approval is granted

I won't elaborate on other companies that supposedly offer various alternative laser eye color change procedures.

Conclusion​

Laser eye color change technology represents the future of looksmaxing. Old chains, broken. New paradigms set, yada yada yada— you get the point.

However, as we've explored, significant challenges remain:
  1. Ensuring consistent results across diverse eye types
  2. Establishing long-term stability of the color change
  3. Navigating complex regulatory hurdles
These obstacles have me think that widespread availability is unlikely within this decade. Yet, the progress made thus far is undeniably impressive.

At the end of the day, laser eye color change represents more than just a cosmetic procedure.

It's a glimpse into a future where the line between our innate characteristics and chosen attributes blur. Promising some exciting, but weird possibilities as we inch closer to this new frontier of human enhancement.

 
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  • Woah
  • JFL
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Think that's it, guys, no more high-effort threads from me this year. God, this shit costs me so much time...
 
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  • So Sad
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This isn't a shitpost thread, btw, for those who can't manage anything else but those
 
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DNR the whole thing but how much do you think this would cost
 
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DNR the whole thing but how much do you think this would cost
Depends on the number of treatments until your desired eye color. The costs will be higher, initially, so I'll guess anything from € 5K-10K in total.
 
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Reactions: TechnoBoss
Depends on the number of treatments until your desired eye color. The costs will be higher, initially, so I'll guess anything from € 5K-10K in total.
So worth it. Going from curry subhuman brown to green thanks
 
Eye color is giga important, good thread.
 
It is quite good but better if you make a thread of the science of eyelid pulling
 
  • JFL
Reactions: DarkAscender
High iq thread, gonna start saving money for Stroma
 
Now, there's one big question, still unanswered. Will the color last?

Short answer: Maybe..? :feelswat:

The long-term stability of laser-induced eye color change is still unknown. While initial results might be promising, it's unclear whether the body's natural pigment production processes will attempt to restore the original eye color over time.


The reason that eye color changing drops don't work is that they only prevent new melanin formation in the eyes while not doing anything about the preexisting melanin, but it could work well here if you want to make sure that the results last precisely for this reason.
 
I'll never understand jerks who pray for blue eyes
It looks like you're sick of something, moreover, dark-eyes turn blue in old age anyway, so it's also a sign of aging.
Blue eyes should be considered ugly
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Reactions: 5'7 zoomer
3350226 IMG 0701

@ascension @ReadBooksEveryday
 
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I should larp a10 eyes with contacts for all videos on my route to attaining gigastatus then within 7 or 8 years get this treatment for permanent results and nobody will be any the wiser 🤓
 
I should larp a10 eyes with contacts for all videos on my route to attaining gigastatus then within 7 or 8 years get this treatment for permanent results and nobody will be any the wiser 🤓
What's your current color
 
BOTB, great thread.

Even though I dont plan on this still read every molecule, I like reading about anatomy.
 
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Reactions: Alexanderr
BOTB, great thread.

Even though I dont plan on this still read every molecule, I like reading about anatomy.
I'll probably update the thread and update the iris anatomy section because whilst the pigment in the iris does matter a lot as to which color you end up having, it's not everything.
 

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