Theoretical Approach to Retrognathism(Young overbitecels GTFIH)

Dylan The Enigma

Dylan The Enigma

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The above diagram shows the bone remodeling process, our main focal point is on osteoblasts which actually create the new structure. The process of producing development through osteoblasts is utilized in bone smashing, however, we won't be diving into Wolff's law. Instead, we'll look at the natural processes, particularly the elements that could lead to retrognathism.
Biology:
In vertebrates, the maxilla and mandible, like most of the other craniofacial bones, are derived from cranial neural crest cells (CNCCs). These cells are known for their multipotency and their extensive migration through the embryo. During early development, CNCCs migrate out from the hindbrain (rhombomere segments r1–r7), traveling along the dorsal-ventral as loosely connected streams that ultimately come to populate the pharyngeal arches. Shortly after first pharyngeal arch (PA1) patterning, a group of mesenchymal cells condenses and develops into Meckel’s cartilage (MC).
...
Meanwhile, lateral to the MC, mandibular bone starts to form. In the maxilla, the ossification process begins slightly later than in the mandible. At the cellular level, condensed mesenchymal cells undergo differentiation into osteoblasts with the guidance of a series of osteogenic transcriptional regulators, such as Dlx5, Runx2, and Osterix
(https://pmc.ncbi.nlm.nih.gov/articles/PMC6986348/)
(You can look more in depth into the article, but this outlines what's important for the theory)
Theory:
The single nucleotide polymorphism rs3825393 showed a statistically significant association with mandibular retrognathism.
(https://www.ajodo.org/article/S0889-5406(15)01460-2/abstract)

What does this mean? It connects the MYO1H gene to retrognathism. MYO1H encodes information for the myosin-1H protein, which plays a role in signaling the production of mesenchymal cells, which explained above are what are differentiated into osteoblasts. While the MYO1H connection to mesenchymal cells isn't fully elucidated, it's role suggests how it is connected to retrognathism.

Other factors that may lead to retrognathism are epigenetic factors. Mainly mechanical forces, which mesenchymal cells are reactive to. Research shows thumb-sucking can lead to retrognathism via epigenetic changes directly, as well as muscular changes which further mechanically influence jaw development.

Malnutrition is another culprit. Malnutrition can lead to insufficient mesenchymal stem cells which could lead to a lack of particular mesenchymal cells such as ones for the jaw. Additionally, a lack of certain nutrients like Vitamin D, calcium, protein, and zinc can disrupt the pathways, which could lead to epigenetic changes. High oxidative stress, which can result from malnutrition, can impair bone growth. Reduced IGF-1, which can result from malnutrition, could cause epigenetic changes to certain genes like RUNX2 which is important for osteoblast differentiation. HGH is additionally important for bone development.

It is likely theoretically possible to fix retrognathism during adolescence and puberty. To do so would require the following:
1. Cause mechanical force that would influence proper development.
2. Ensure maximal nutrition and a good amount of IGF-1 and HGH.
3. Adequate enough amount of time after intervention to correct retrognathism while still in development.
Methods:
Basics: proper tongue posture, proper chewing, proper breathing, adequate chewing.
Advanced: Myofunctional therapy(builds off the basics), orthodontic and orthotropic applications(palate expanders, twin block, herbst appliance, etc)
Theoretical: any of the insane stuff on this thread(jfl), face pulling, molar clenching, or anything that in theory applies mechanical force(important to recognize we aren't trying to correct it directly with the force, we're just using the force to epigenetically influence further correct development)
Nutrition: just low carbs, low plant, high fatty meat, maybe organs, maybe dairy, maybe fruits.
 
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this is actually a really good hq thread tbf
 
So its all genetics
 
So what’s best way to fix overbite post puberty
Honestly, just surgery, afaik you can't get any more growth(especially not significant enough to add several millimeters) after puberty, and being able to obtain mandible growth is what this is contingent on. Most of the bones fuse early, during late puberty you can still achieve growth, but post puberty is just what you are, it's the culmination of 18 years of health.
 
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no. The position need to be kept for too much time for those to be effective.
Probably yeah. The ideal scenario would be catching it pre-puberty and going through myofunctional therapy and orthodontics/orthotropics for the duration of puberty, but I am still curious about the potential theoretical potential of more unorthodox methods such as those, as well as their potential results from starting in early puberty as well as in late puberty.
 
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