*theoretical* usage of BNP and PTH analogues for framecels

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The typical frame & heightmaxxing stack has been HGH, an AI & steroids/sarms whatever. This is out of date, there are new drugs. We are aiming for skeletal growth so drugs that impact muscle mass are not necessary. If you think blasting HGH & gear is going to give you loox tier bonemass, it won't.

PTH ANALOGUES

>explain it to me like im 5

>GPT answer

🦴 What is PTH?​

PTH (Parathyroid Hormone) is like a construction boss for your bones. It tells the bone workers when to:
  • Build more bone (like making your jaw stronger or your cheeks wider)
  • Or take bone away (if needed)

🧪 What are PTH Analogues?​

PTH analogues are medicine copies of that bone boss. They help wake up your bone builders, even if you’re an adult. Think of them like a magic whistle that makes your bones a little more like clay again — not squishy, but a little easier to shape.
  • Boys usually have bigger jaws, strong cheekbones, and wider shoulders.
If you're an adult and want to look more like a strong male shape, these PTH analogues can help:
  • Tell your bones to grow in those areas
  • Work better if you also give them tools like testosterone, growth hormones, and good food (like IGF-1, MK-677, etc.)

There are TWO clinically approved PTH analogues we are interested in.

1. Teriparatide and its lyophilized powder UGL form (PTH-134.) This is the strongest, (and clinically approved) PTH analogue
2. Abaloparatide which is a weaker and safer PTH analogue.

A Teriparatide cycle typically lasts 6-12months at 20MCG first thing in the morning on an empty stomach. You will then need to take 70mg of alendronate weekly post cycle for a year to mitigate bone resorption (losing your gains.)

Side effects:
Injection site reactionsPain, redness, swelling where you inject
NauseaFeeling sick, mild stomach upset
HeadacheMild to moderate headaches
DizzinessFeeling lightheaded or faint
Leg crampsMuscle cramps or spasms, especially in legs
HypercalcemiaToo much calcium in the blood (can cause fatigue, weakness, thirst)
Joint pain or muscle painMild discomfort in joints or muscles
FatigueFeeling tired or low energy

Sourcing PTH is not easy. When reconstituted it decays in 48 hours at room temperature so shipping pharma pens are not an option. If you want to take the risk of using new drugs and also experiment with injecting the expired version of it be my guest but im not interested. The realistic standard is the UGL lyophilized form with either a COA (certificate of approval) confirming the purity of the batch or third party lab verification. You could order it bulk from Madeinchina for probably like $50 shipping included but I wouldn't use it without having a third party lab test it which is probably at least a couple hundred dollars.

Reconstituting and storing is also a pain so im not going to type it out. I get my analogues in july (in mincraft.), when I start pinning I will make a video and show you how to store it.

So PTH analogues and masculinizing drugs as ancillaries for an increased frame, but what about height?

BNP ANALOGUES

>
GPT

What is BNP?​

BNP is like a special helper that tells your bones to grow longer — like making your legs and arms grow taller.

What are BNP analogues?​

  • They are like magic copies of that helper, telling your bones:
    “Hey! Keep growing taller!”

How does it help with looking more like a boy or girl?​

  • Boys and girls sometimes have different heights. BNP analogues help bones grow longer, so you can get taller.
  • But they don’t really make your jaw bigger or your face wider — just longer bones like legs or arms.

So:​

If you want to grow taller, BNP analogues are good helpers.

1. Vosoritide (BMN 111) FDA approved for height increase in dwarf kids with open epiphyseal plates.
2. TransCon CNP. Longer half life, so theoretically better for height increase. still in clinical trials.

Side EffectDescription
Injection site reactionsPain, redness, or swelling where the shot is given
Vomiting or nauseaEspecially when starting treatment
Low blood pressure (hypotension)Dizziness or fainting, especially after standing up
HeadacheMild to moderate, due to vascular changes
FeverLow-grade fevers may happen in the beginning
Muscle or joint painAs bones grow, some discomfort can occur
Flushing or warmthBlood vessel dilation from CNP/BNP action

Partial closure & delayed fusion in young adults.

Late teens, early 20s, some plates in your body probably open to a very minor extent though you wont see any height increase because it takes elevated levels of GH to result in growth. Vosoritide isn't approved for use in adults but if midget children are using it you can probably get away with it.

Sourcing BNP: idk

Puberty 2

Standard .org incel stack

300mg/test minimum weekly
AI
HGH or something cheaper and worse
miscellaneous steroids
supplemental ancillaries

Combine this synergistically with BNP/PTH analogues with proper diet & mechanical tension on bones via high intensity exercise. If you are widening the body focus on chest, clavs, shoulders, etc. For length in legs its more tricky. Mechanical tension is necessary and the most efficient way to stimulate growth in bones is through low volume, high intensity. Squat rack or something like calve raises probably stimulates bone remodeling to a very minor degree but your gains in height are lost by gravity + weight compressing the microfractures in your legs. High seat stationary cycling sounds promising but it doesn't follow the high intensity rule. SO you need to find a way to damage your tibia and femur, then reduce the pressure of your own weight & gravity to allow the bones to remodel vertically.

Me personally, I am going to jump down a flight of stairs.
 
Last edited:
  • +1
Reactions: Neurotypicalnow and AverageCurryEnjoyer
BUMP. Meant to say CNP analogue, not BMP. Whoopsie
 
I thought Abaloparatide
was stronger than Teriparatide
but I heard from many that Abalop.. is stronger though
 
  • +1
Reactions: Deleted member 28209
I thought Abaloparatide
was stronger than Teriparatide
but I heard from many that Abalop.. is stronger though
if you compare it mcg per mcg teriparatide is stronger
 
  • Hmm...
Reactions: flambria
if you compare it mcg per mcg teriparatide is stronger
but then more importantly how much and how long could you take before severe side effects, negating strength per mcg
 
brooo no one is getting a cnp analogue, maybe a fgfr3 inhibitor for rn
 
  • +1
Reactions: flambria
clinical cycle is 6-12mos
 
but then more importantly how much and how long could you take before severe side effects, negating strength per mcg
clinical cycle is 6-12mos 20mcg ed
 
brooo no one is getting a cnp analogue, maybe a fgfr3 inhibitor for rn
I have a source 100mg (100 days) for $550 split the difference with me rn and ill send u half
 
  • +1
Reactions: Deleted member 28209
Has anyone even tried this ?
 
I have a source 100mg (100 days) for $550 split the difference with me rn and ill send u half
source for what? i order VPA and lith carbonate from BGpharma and im wating for it rn
 
source for what? i order VPA and lith carbonate from BGpharma and im wating for it rn
Vosoritide which is CNP analogue. L carbonate and VPA are Hdac inhibitors, gene expression related.
 
  • +1
Reactions: Deleted member 28209
Vosoritide which is CNP analogue. L carbonate and VPA are Hdac inhibitors, gene expression related.
I already have lith carbo and valproic acid shipping from bg, dm me the vosortide link
 
Vosoritide which is CNP analogue. L carbonate and VPA are Hdac inhibitors, gene expression related.
Holy shit tho near $600 for 3 month cycle practically?
 
Isn't a guy in the jhp doing an abaloparatide group buy rn?
 
The typical frame & heightmaxxing stack has been HGH, an AI & steroids/sarms whatever. This is out of date, there are new drugs. We are aiming for skeletal growth so drugs that impact muscle mass are not necessary. If you think blasting HGH & gear is going to give you loox tier bonemass, it won't.

PTH ANALOGUES

>explain it to me like im 5

>GPT answer

🦴 What is PTH?​

PTH (Parathyroid Hormone) is like a construction boss for your bones. It tells the bone workers when to:
  • Build more bone (like making your jaw stronger or your cheeks wider)
  • Or take bone away (if needed)

🧪 What are PTH Analogues?​

PTH analogues are medicine copies of that bone boss. They help wake up your bone builders, even if you’re an adult. Think of them like a magic whistle that makes your bones a little more like clay again — not squishy, but a little easier to shape.
  • Boys usually have bigger jaws, strong cheekbones, and wider shoulders.
If you're an adult and want to look more like a strong male shape, these PTH analogues can help:
  • Tell your bones to grow in those areas
  • Work better if you also give them tools like testosterone, growth hormones, and good food (like IGF-1, MK-677, etc.)

There are TWO clinically approved PTH analogues we are interested in.

1. Teriparatide and its lyophilized powder UGL form (PTH-134.) This is the strongest, (and clinically approved) PTH analogue
2. Abaloparatide which is a weaker and safer PTH analogue.

A Teriparatide cycle typically lasts 6-12months at 20MCG first thing in the morning on an empty stomach. You will then need to take 70mg of alendronate weekly post cycle for a year to mitigate bone resorption (losing your gains.)

Side effects:
Injection site reactionsPain, redness, swelling where you inject
NauseaFeeling sick, mild stomach upset
HeadacheMild to moderate headaches
DizzinessFeeling lightheaded or faint
Leg crampsMuscle cramps or spasms, especially in legs
HypercalcemiaToo much calcium in the blood (can cause fatigue, weakness, thirst)
Joint pain or muscle painMild discomfort in joints or muscles
FatigueFeeling tired or low energy

Sourcing PTH is not easy. When reconstituted it decays in 48 hours at room temperature so shipping pharma pens are not an option. If you want to take the risk of using new drugs and also experiment with injecting the expired version of it be my guest but im not interested. The realistic standard is the UGL lyophilized form with either a COA (certificate of approval) confirming the purity of the batch or third party lab verification. You could order it bulk from Madeinchina for probably like $50 shipping included but I wouldn't use it without having a third party lab test it which is probably at least a couple hundred dollars.

Reconstituting and storing is also a pain so im not going to type it out. I get my analogues in july (in mincraft.), when I start pinning I will make a video and show you how to store it.

So PTH analogues and masculinizing drugs as ancillaries for an increased frame, but what about height?

BNP ANALOGUES

>
GPT

What is BNP?​

BNP is like a special helper that tells your bones to grow longer — like making your legs and arms grow taller.

What are BNP analogues?​

  • They are like magic copies of that helper, telling your bones:
    “Hey! Keep growing taller!”

How does it help with looking more like a boy or girl?​

  • Boys and girls sometimes have different heights. BNP analogues help bones grow longer, so you can get taller.
  • But they don’t really make your jaw bigger or your face wider — just longer bones like legs or arms.

So:​

If you want to grow taller, BNP analogues are good helpers.

1. Vosoritide (BMN 111) FDA approved for height increase in dwarf kids with open epiphyseal plates.
2. TransCon CNP. Longer half life, so theoretically better for height increase. still in clinical trials.

Side EffectDescription
Injection site reactionsPain, redness, or swelling where the shot is given
Vomiting or nauseaEspecially when starting treatment
Low blood pressure (hypotension)Dizziness or fainting, especially after standing up
HeadacheMild to moderate, due to vascular changes
FeverLow-grade fevers may happen in the beginning
Muscle or joint painAs bones grow, some discomfort can occur
Flushing or warmthBlood vessel dilation from CNP/BNP action

Partial closure & delayed fusion in young adults.

Late teens, early 20s, some plates in your body probably open to a very minor extent though you wont see any height increase because it takes elevated levels of GH to result in growth. Vosoritide isn't approved for use in adults but if midget children are using it you can probably get away with it.

Sourcing BNP: idk

Puberty 2

Standard .org incel stack

300mg/test minimum weekly
AI
HGH or something cheaper and worse
miscellaneous steroids
supplemental ancillaries

Combine this synergistically with BNP/PTH analogues with proper diet & mechanical tension on bones via high intensity exercise. If you are widening the body focus on chest, clavs, shoulders, etc. For length in legs its more tricky. Mechanical tension is necessary and the most efficient way to stimulate growth in bones is through low volume, high intensity. Squat rack or something like calve raises probably stimulates bone remodeling to a very minor degree but your gains in height are lost by gravity + weight compressing the microfractures in your legs. High seat stationary cycling sounds promising but it doesn't follow the high intensity rule. SO you need to find a way to damage your tibia and femur, then reduce the pressure of your own weight & gravity to allow the bones to remodel vertically.

Me personally, I am going to jump down a flight of stairs.
CNP is for dwarves who have overexpressed FGFR3 and still only gives 1-3cm/year. If this is your genius idea and really think this is worth it compared to running GH and letrozole, you’re stupid. Only teriparatide is worth it 2 months on 1 month off.
 
CNP is for dwarves who have overexpressed FGFR3 and still only gives 1-3cm/year. If this is your genius idea and really think this is worth it compared to running GH and letrozole, you’re stupid. Only teriparatide is worth it 2 months on 1 month off.
Achondroplasia is primarily driven by fgfr3 inhibition not CNP deficiency. A CNP analogue would theoretically be more effective in somebody with normal development than an FGFR3 inhibitor.

Fgfr inhibition alone resulted an increase of height velocity from 3.03cm-2.50cm in dwarf kids.

CNP analogues had a lower measured increase

IGF-1 is the primary pathway for driving longitudinal growth but it’s not the only relevant one.

Excess GH for height increase in normal teens is not as effective as you think. Height is still regulated by things like genes and bone age. Not just the closing of plates from estrogen

If you can properly target the relevant growth pathways during development I think you could upregulate genetic height peotential by ~60%. Whereas just using AIs and GH something like 30%.

Pth-134 doesn’t need to be cycled 2mo on 1mo off . It’s used for minimum 6mo spans. It also has nothing to do with longitudinal growth.

I’d post more about framecel things but ngl I stopped caring. Waste of time. I’ve found more effective things than GH and AI though.

Also the type of AI you use (aside from exemestane) doesn’t matter. If you do AIs but don’t get a blood test your levels could be above or below the necessary reference range and you would never know.
 
Achondroplasia is primarily driven by fgfr3 inhibition not CNP deficiency. A CNP analogue would theoretically be more effective in somebody with normal development than an FGFR3 inhibitor.

Fgfr inhibition alone resulted an increase of height velocity from 3.03cm-2.50cm in dwarf kids.

CNP analogues had a lower measured increase

IGF-1 is the primary pathway for driving longitudinal growth but it’s not the only relevant one.

Excess GH for height increase in normal teens is not as effective as you think. Height is still regulated by things like genes and bone age. Not just the closing of plates from estrogen

If you can properly target the relevant growth pathways during development I think you could upregulate genetic height peotential by ~60%. Whereas just using AIs and GH something like 30%.

Pth-134 doesn’t need to be cycled 2mo on 1mo off . It’s used for minimum 6mo spans. It also has nothing to do with longitudinal growth.

I’d post more about framecel things but ngl I stopped caring. Waste of time. I’ve found more effective things than GH and AI though.

Also the type of AI you use (aside from exemestane) doesn’t matter. If you do AIs but don’t get a blood test your levels could be above or below the necessary reference range and you would never know.
PTH definitely has to be cycled 2 months on 1 month off if you’re taking it everyday. If you don’t you’re osteoblasts will become overstimulated which could lead to them burning out or even become apoptotic. Additionally, if you don’t reset for 1 month, the PTH1R receptor can easily become desensitized and this prevents that. Additionally, if you keep running teripararide non stop, it could easily become catabolic and break bone down. Safety is #1 when running height protocols. And the AI you use does matter. If it’s suicidal like letrozole, then it’s good. Why I always preach about letrozole is because letrozole is the only AI that preserves hippocampal estrogen making it crucial for brain health as a teenager(which most people running this stuff are). One think I noticed you don’t consider whatsoever is MSC stem cell preservation and exhaustion. Only because there is another height growth pathway DOES NOT make it better. Additionally, alternative pathways to height growth often have many things that you must look out for because it’s more experimental. Additionally, in my mind I was talking about GH efficiency when running extreme steroids which increase GH receptors and completely override your genetic limit. 6IU GH/a day is not overkill or excess and you’re acting like GH doesn’t convert to IGF-1. If you really want to go overkill, you can just inject micro dosed IGF-1 lr3 subq and you’re good. And I have no clue what you’re saying in the first part. CNP analogues by definition downregulate FGFR3 as that’s their main function.
 
Achondroplasia is primarily driven by fgfr3 inhibition not CNP deficiency. A CNP analogue would theoretically be more effective in somebody with normal development than an FGFR3 inhibitor.

Fgfr inhibition alone resulted an increase of height velocity from 3.03cm-2.50cm in dwarf kids.

CNP analogues had a lower measured increase

IGF-1 is the primary pathway for driving longitudinal growth but it’s not the only relevant one.

Excess GH for height increase in normal teens is not as effective as you think. Height is still regulated by things like genes and bone age. Not just the closing of plates from estrogen

If you can properly target the relevant growth pathways during development I think you could upregulate genetic height peotential by ~60%. Whereas just using AIs and GH something like 30%.

Pth-134 doesn’t need to be cycled 2mo on 1mo off . It’s used for minimum 6mo spans. It also has nothing to do with longitudinal growth.

I’d post more about framecel things but ngl I stopped caring. Waste of time. I’ve found more effective things than GH and AI though.

Also the type of AI you use (aside from exemestane) doesn’t matter. If you do AIs but don’t get a blood test your levels could be above or below the necessary reference range and you would never know.
And also you’re bringing up the use of teriparatide in 6 month periods in the context for people with osteoporosis and in the dosage needed to run it for heightmaxxing + our goals, it’s simply unwise. Longer periods ≠ better. Safe periods = guaranteed growth.
 
PTH definitely has to be cycled 2 months on 1 month off if you’re taking it everyday. If you don’t you’re osteoblasts will become overstimulated which could lead to them burning out or even become apoptotic. Additionally, if you don’t reset for 1 month, the PTH1R receptor can easily become desensitized and this prevents that. Additionally, if you keep running teripararide non stop, it could easily become catabolic and break bone down. Safety is #1 when running height protocols. And the AI you use does matter. If it’s suicidal like letrozole, then it’s good. Why I always preach about letrozole is because letrozole is the only AI that preserves hippocampal estrogen making it crucial for brain health as a teenager(which most people running this stuff are). One think I noticed you don’t consider whatsoever is MSC stem cell preservation and exhaustion. Only because there is another height growth pathway DOES NOT make it better. Additionally, alternative pathways to height growth often have many things that you must look out for because it’s more experimental. Additionally, in my mind I was talking about GH efficiency when running extreme steroids which increase GH receptors and completely override your genetic limit. 6IU GH/a day is not overkill or excess and you’re acting like GH doesn’t convert to IGF-1. If you really want to go overkill, you can just inject micro dosed IGF-1 lr3 subq and you’re good. And I have no clue what you’re saying in the first part. CNP analogues by definition downregulate FGFR3 as that’s their main function.
Didn’t read
 
And also you’re bringing up the use of teriparatide in 6 month periods in the context for people with osteoporosis and in the dosage needed to run it for heightmaxxing + our goals, it’s simply unwise. Longer periods ≠ better. Safe periods = guaranteed growth.
Teriparatide had a 9-13% increase in bonemass over 12 months if u cycle for 2 months nothing is going to happen lol
 
Teriparatide had a 9-13% increase in bonemass over 12 months if u cycle for 2 months nothing is going to happen lol
If you’re not going to read my full thing, please don’t reply to a comment meant to add on to it. Thanks.
 
PTH definitely has to be cycled 2 months on 1 month off if you’re taking it everyday. If you don’t you’re osteoblasts will become overstimulated which could lead to them burning out or even become apoptotic. Additionally, if you don’t reset for 1 month, the PTH1R receptor can easily become desensitized and this prevents that. Additionally, if you keep running teripararide non stop, it could easily become catabolic and break bone down. Safety is #1 when running height protocols. And the AI you use does matter. If it’s suicidal like letrozole, then it’s good. Why I always preach about letrozole is because letrozole is the only AI that preserves hippocampal estrogen making it crucial for brain health as a teenager(which most people running this stuff are). One think I noticed you don’t consider whatsoever is MSC stem cell preservation and exhaustion. Only because there is another height growth pathway DOES NOT make it better. Additionally, alternative pathways to height growth often have many things that you must look out for because it’s more experimental. Additionally, in my mind I was talking about GH efficiency when running extreme steroids which increase GH receptors and completely override your genetic limit. 6IU GH/a day is not overkill or excess and you’re acting like GH doesn’t convert to IGF-1. If you really want to go overkill, you can just inject micro dosed IGF-1 lr3 subq and you’re good. And I have no clue what you’re saying in the first part. CNP analogues by definition downregulate FGFR3 as that’s their main function.
why 2 months on 1 month off?

osteoporosis treament lasts 18-24 months with daily injections

it becomes desensitized after way longer
 
Any1 wanna do a group buy and Share the shipping costs for pth-134 or teriparatide
 

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