There Is NO Proof That Minoxidil Ages You

[Deleted member 1100]

Effects of Minoxidil Gel on Burn Wound Healing in Rats

Minoxidil has been reported to inhibit in-vitro fibroblast proliferation and lysyl hydroxylase activity, a key enzyme in collagen biosynthesis. These in-vitro effects proposed minoxidil to be a potential antifibrotic agent. The present study aimed to ...

www.ncbi.nlm.nih.gov

I didn't bother reading the full article yet, but:

In conclusion, although topical minoxidil improved the process of wound healing, our results did not support the proposed idea of minoxidil usage as an anti-fibrotic agent, because it did not alter the collagen content or tensile strength of burned area of the skin. However, in order to reject the possible effects of minoxidil as an anti-fibrotic agent, more objective animal models, e.g. hypertrophic scar model should be developed and studied.

Minoxidil, Collagen and Facial Aging: Where are we at? — Donovan Hair Clinic

Minoxidil and Facial Aging: Yes or No, …or we don’t know? There is currently a great buzz on the internet world that topical minoxidil affects collagen synthesis and affects facial skin by promoting facial aging. To date, there is no good evidence in the medical literature that minoxidil promotes

donovanmedical.com

Everyone saying it does is basing it on an 80s article that was In-VITRO, not In-Vivo




The only real problem so far is that for it to work it's needed a shit ton of alcohol in the composition, and alcohol does age you skin, BUT from what I know it ages only near the place you applied, not your whole skin like some people here say that minox does.

 

[Deleted member 773]

It definitely aged me bro

 

[Deleted member 2634]

nasolabialfolds guy 2

 

[Ekeoma_The_BBC]

Jfl at using minoxidil in 2019

 

[Deleted member 1100]

It definitely aged me bro

It wasn't mixodil, I'll prove it on my next video

 

[Deleted member 773]

It wasn't mixodil, I'll prove it on my next video

Yes it was retard.

Stops fibroblast cells from dividing

https://iovs.arvojournals.org/data/journals/iovs/933397/567.pdf

Less fibroblasts = less collagen production

Here it is on HUMAN SKIN FIBROBLASTS (literally the fibroblasts that produce 99% of your collagen): Same effect

Effects of minoxidil on cultured human skin fibroblasts - PubMed

Two important findings related to the effect of minoxidil on human skin fibroblasts in culture are reviewed. Treatment of cells with minoxidil is associated with a specific loss of lysyl hydroxylase activity; this loss occurs gradually and is reversed by removing minoxidil from the culture...

www.ncbi.nlm.nih.gov

It was definitely the minoxidil brah I'm 82 days off that bitch and my skin still looks like shit. I've put alchohol on my skin before it's definitely not that.

 

[x30001]

Yes it was retard.

Stops fibroblast cells from dividing

https://iovs.arvojournals.org/data/journals/iovs/933397/567.pdf

Less fibroblasts = less collagen production

Here it is on HUMAN SKIN FIBROBLASTS (literally the fibroblasts that produce 99% of your collagen): Same effect

Effects of minoxidil on cultured human skin fibroblasts - PubMed

Two important findings related to the effect of minoxidil on human skin fibroblasts in culture are reviewed. Treatment of cells with minoxidil is associated with a specific loss of lysyl hydroxylase activity; this loss occurs gradually and is reversed by removing minoxidil from the culture...

www.ncbi.nlm.nih.gov

It was definitely the minoxidil brah I'm 82 days off that bitch and my skin still looks like shit. I've put alchohol on my skin before it's definitely not that.

Kills the fibroblasts, doesn't just put them into senescence or stop them from dividing.

 

[Deleted member 773]

Kills the fibroblasts, doesn't just put them into senescence or stop them from dividing.

If it killed the fibroblasts wouldn't your body recycle them quickly?

Also the study on Ocular Fibroblasts says that Minoxidil isn't cytotoxic to cells and has a "truly antiproliferative effect"

> In this study, minoxidil (1-5 mM) decreased the number of proliferating cells and had no effect on the number of hRPE and hTCF made quiescent at high cell density, indicating that minoxidil exerts a truly antiproliferative effect without being cytotoxic

 

[Deleted member 502]

It aged me. I made this empirical observation by looking in the fucking mirror,

 

[Deleted member 2275]

It definitely aged me bro

You're so fucking retarded and you couldn't even give a rebuttal when I shit down the throat of both you and the "studies" you linked.

EDIT: AHAHAHA YOURE LINKING THE SAME FUCKING STUDY THAT IS OVER 30 YEARS OLD AND STILL PRETENDING LIKE IT'S VALID LMAOOOO

"Administration of minoxidil (500 microM), which specifically decreases LH activity without affecting PH activity or collagen biosynthesis in skin fibroblasts"

Please kill yourself, and next time stop being a poor faggot and purchase the minox liquid instead of the foam, that way you get less alcohol on your skin

 

[Deleted member 1100]

You're so fucking retarded and you couldn't even give a rebuttal when I shit down the throat of both you and the "studies" you linked.

EDIT: AHAHAHA YOURE LINKING THE SAME FUCKING STUDY THAT IS OVER 30 YEARS OLD AND STILL PRETENDING LIKE IT'S VALID LMAOOOO

"Administration of minoxidil (500 microM), which specifically decreases LH activity without affecting PH activity or collagen biosynthesis in skin fibroblasts"

Please kill yourself, and next time stop being a poor faggot and purchase the minox liquid instead of the foam, that way you get less alcohol on your skin

Fuck, why didn't I pay more attention to the chemistry classes in hs?! So many chemical names, it will take me hours to read this article and understand it

 

[OCDMaxxing]

"It aged me" is a brainlet argument. NO! You aged and you think it was minoxidil, while in reality it was TIME.

Studies > Brainlet anecdotes

 

[Brandon10]

It's really one's fault to follow any type of advice for health/cosmetic reasons posted here. I can't believe people over 18 take seriously some crazy shit posted here like "you're going to grow a vulva if you're on minox", "implants erode your bonez" , "I know better than all the researchers, doctors that have dedicated their lives to the medical science and have years of experience, they're all cucks" etc.

With maybe one or two exceptions, PSL theorists are fucking cesspit.

 

[elfmaxx]

I've seen people I know get agepilled by it.
better to be an oldcel than a baldcel tho

 

[Deleted member 773]

Reminder these people will look you in the eyes and say this is normal aging

 

[Rimcel]

A lot of minoxidil brands do not mix it with alcohol

 

[Deleted member 1100]

A lot of minoxidil brands do not mix it with alcohol

You need alcohol (either ethanol or propylene glycol) otherwise it won't penetrate the skin

 

[Deleted member 1862]

I can't believe people over 18 take seriously some crazy shit posted here like "you're going to grow a vulva if you're on minox", "implants erode your bonez"

With maybe one or two exceptions, PSL theorists are fucking cesspit.

you're an exact replica of the people you think you're so much better than. Implants, especially when not fixated to the underlying bone, can cause erosion. If that doesn't intuitively make sense to you then I'm incredibly sorry for your loss.

I know better than all the researchers, doctors that have dedicated their lives to the medical science and have years of experience

No one worth listening to thinks they're better than the pioneers or high fliers in any given field. The funny thing is, genius, that most people are not the best in their field.

You realise no two practitioners in any profession are equal in their skills & knowledge? You sound like a child who's never had to be independent and is now too afraid/ poorly equipped to start. This "just listen to da dawktr idiot" bs is you coping with your inadequacy & lack of ability to take things into your own hands, therefore you just spew nonsense to make yourself feel as though you're actually in the right.

Do you know how many doctors give incorrect/rushed/cookie cutter diagnoses?
How many lousy mechanics do shitty repair jobs on cars?
How many impatient teachers fail to get their point across?

Skills are not black & white, I can't believe I even have to clarify that. Furthermore, in this day & age anyone can learn pretty much anything given enough time.

What you've said basically boils down to "just let someone do it for you". A sentiment that I'm sure you're very familiar with.

 

[Deleted member 2275]

If that doesn't intuitively

"muh intuition bro"

No one worth listening to thinks they're better than the pioneers or high fliers in any given field. The funny thing is, genius, that most people are not the best in their field.

You realise no two practitioners in any profession are equal in their skills & knowledge? You sound like a child who's never had to be independent and is now too afraid/ poorly equipped to start. This "just listen to da dawktr idiot" bs is you coping with your inadequacy & lack of ability to take things into your own hands, therefore you just spew nonsense to make yourself feel as though you're actually in the right.

Do you know how many doctors give incorrect/rushed/cookie cutter diagnoses?
How many lousy mechanics do shitty repair jobs on cars?
How many impatient teachers fail to get their point across?

Skills are not black & white, I can't believe I even have to clarify that. Furthermore, in this day & age anyone can learn pretty much anything given enough time.

What you've said basically boils down to "just let someone do it for you". A sentiment that I'm sure you're very familiar with.

You're retarded

 

[Brandon10]

you're an exact replica of the people you think you're so much better than. Implants, especially when not fixated to the underlying bone, can cause erosion. If that doesn't intuitively make sense to you then I'm incredibly sorry for your loss.

Don't try to act like you don't know the way is this shit spewed here. Ofc there's a degree of errosion, this is in chin implants mostly btw, but what fools think here and I'm kind of sure is the same thing you subscibe to is that implants will eat your bones out which is fucking stupid.

You realise no two practitioners in any profession are equal in their skills & knowledge? You sound like a child who's never had to be independent and is now afraid/ poorly equipped to start. This "just listen to da dawktr idiot" bs is you coping with your inadequacy & lack of ability to take things into your own hands, therefore you just spew nonsense to make yourself feel as though you're actually in the right.

Do you know how many doctors give incorrect/rushed/cookie cutter diagnoses?
How many lousy mechanics do shitty repair jobs on cars?
How many impatient teachers fail to get their point across?

Skills are not black & white, I can't believe I even have to clarify that. Furthermore, in this day & age anyone can learn pretty much anything given enough time.

First of all, just fuckin lol at confusing medical research with medical practice. This wasn't even the point of the thread.

What I objected to was that some posters here think that the anecdata, not even their own personal experience, they're gathering from mostly lunatics in various forums is more valid than results of peer reviewed, carefully planned and controlled studies. You can't take someone seriously when they say that e.g. over 20-30% of people in finasteride grow gyno cause that's what their forum friends said, when in fact MANY studies have concluded to a much, much less probability of this side effect occuring.

By the way, if you don't do research effectively aka the equivalent of bad medical practice in science, no one will take you or your group seriously and you'll just be disregarded by the whole scientific community. There's a good reason Mike Mew is a literal no-namer amongst the medical community and is surprisingly popular here.

Which is what people on the opposite side of "just listen to the doc" are doing: thinking that the Big-Pharma are trying to silence them and only care about maximizing their revenues disregarding the patient's health.

Now on the part of how do you choose the right doctor/lawyer/car mechanic. For obvious reasons I will prioritize the importance of the first one.

It has become harder to find a skilled surgeon and trust your body to them, I'll give you that. And this is because many people aren't putting a lot of effort on most aspects of their life and end up half-assing everything: their degree, hobbies, bills etc. This includes MDs as well. They may not kill their patients but they may happen to do some serious wrong-doing in their practice that could end their careers, whether it's due to inexperience or anything else. I did not deny there are incompetent doctors.

Remember that I said It has become harder to find a skilled surgeon and trust your body to them ? Well there's some good news. And it's called the Internet, reviews, before and afters etc. Considering that we take away any potentially paid reviews or photoshopped before/afters (either of which is extremely risky for a doc to do btw, they won't risk fucking up their careers over it) there is a VERY good chance you'll find a competent doctor if you have some common sense and do your research well. Needless to say that if you research a bit more the operations you suspect the Dr. is going to suggest beforehand aka the ones you think you need, you're pretty much done.

But even if we suppose the average person doesn't have the time to go through journals and PSL posts on various surgeries, no one right on their mind will consult with only one doctor for plastic surgery. Which is why even the dr. you're consulting with encourages you to get a second, third, ... , nth opinion. Unless you think that all doctors are idiots and Surgerycel4ever suggesting you BSSO + LF III + Facial Bipartition is the route to go. Nothing can save you from fucking up yourself then.

P.S. : I bet you know at least of a group of people that are radically opposed to the idea of "listening to the Dr." are also against a specific practice that Drs. are URGED by the law to do, thinking that it will make their children autistic. I think I gave it away.

 

[Deleted member 1862]

Don't try to act like you don't know the way is this shit spewed here. Ofc there's a degree of errosion, this is in chin implants mostly btw, but what fools think here and I'm kind of sure is the same thing you subscibe to is that implants will eat your bones out which is fucking stupid.


First of all, just fuckin lol at confusing medical research with medical practice. This wasn't even the point of the thread.

What I objected to was that some posters here think that the anecdata, not even their own personal experience, they're gathering from mostly lunatics in various forums is more valid than results of peer reviewed, carefully planned and controlled studies. You can't take someone seriously when they say that e.g. over 20-30% of people in finasteride grow gyno cause that's what they gathered from their forum friends, when in fact MANY studies have concluded to a much, much less probability of this side effect occuring.

By the way, if you don't do research effectively aka the equivalent of bad medical practice in science, no one will take you or your group seriously and you'll just be disregarded by the whole scientific community.

Which is what people on the opposite side of "just listen to the doc" are doing: thinking that the Big-Pharma are trying to silence them and only care about maximizing their revenues disregarding the patient's health.

Now on the part of how do you choose the right doctor/lawyer/car mechanic. For obvious reasons I will prioritize the importance of the first one.

It has become harder to find a skilled surgeon and trust your body to them, I'll give you that. And this is because many people aren't putting a lot of effort on most aspects of their life and end up half-assing everything: their degree, hobbies, bills etc. This includes MDs as well. They may not kill their patients but they may happen to do some serious wrong-doing in their practice that could end their careers, whether it's due to inexperience or anything else. I did not deny there are incompetent doctors.

Remember that I said It has become harder to find a skilled surgeon and trust your body to them ? Well there's some good news. And it's called the Internet, reviews, before and afters etc. Considering that we take away any potentially paid reviews or photoshopped before/afters (either of which is extremely risky for a doc to do btw, they won't fuck up their careers over it) there is a VERY good chance you'll find a competent doctor if you have some common sense and do your research well. Needless to say that if you research a bit more the operations you suspect the Dr. is going to suggest beforehand, you're pretty much done.

But even if we suppose the average person doesn't have the time to go through journals and PSL posts on various surgeries, no one right on their mind will consult with only one doctor for plastic surgery. Which is why even the dr. you're consulting with encourages you to get a second, third, ... , nth opinion. Unless you think that all doctors are idiots and Surgerycel4ever suggesting you BSSO + LF III + Facial Bipartition is the route to go. Nothing can save you from fucking up yourself then.

P.S. : I bet you know at least of a group of people that are radically opposed to the idea of "listening to the Dr." are also against a specific practice that Drs. are URGED by the law to do, thinking that it will make their children autistic. I think I gave it away.

tbh, not what I expected your response to be. Well put. Your original post wasn't as articulate so I misjudged.

Anecdotal evidence has value though, it's just limited.