There is no reliable way to cause depression in people not prone to it

[High Cortisol Chad]

It's often beneficial to think in reverse like that to understand the causes of X condition. Just like there's no reliable way to cause dementia in people not prone to it. You have people who get dementia at the age of 38 with healthy lifestyles and you also have 90-year-olds who have drunk and smoked their whole lives and have sharp minds with no signs of dementia.

Lowering serotonin does not reliably cause depression
Abusing alcohol does not reliably cause depression
Childhood trauma does not reliably cause depression
Being an incel does not reliably cause depression
Being thrown in a concentration camp does not reliably cause depression
Malnutrition does not reliably cause depression


The most reliable (all tho still quite unreliable) ways to cause depression in people not prone to it are:
1) opioid withdrawal
2) strong, chronic stress
3) Rimonabant (anti-obesity drug which has been withdrawn from the market due to psychiatric problems), is an endocannabinoid receptor (CB1) antagonist which indirectly activates fatty acid amide hydrolase

 

[ambi]

showing random people this forum could probably cause depression in most