Things you didn't know about DXM cough syrup

[High Cortisol Chad]

1) It works as an antidepressant with a completely different mechanism of action (similar to ketamine) than SSRI's and is already a part of FDA approved drug for depression Auvelity​

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2) It can get you high af​

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3) Chronic DXM use is associated with a reduced risk of dementia​

https://journals.sagepub.com/doi/full/10.1177/15333175221124952

Dextromethorphan (DXM) has been reported to reduce neuronal damage and neurodegeneration in animal and human models
We used a Cox regression hazard model to identify risk factors of dementia during 16 years of follow-up, and the results indicate that a significantly lower percentage of subjects with DXM use (P < .001) developed dementia compared with those without DXM use (11.38%, 4541/39 895 vs 18.66%, 29 785/159 580). After adjustment for age and other variables [adjusted hazard ratio: .567 (95% confidence interval: .413-.678, P < .001)], this study also demonstrated that DXM use appeared to reduce the risk of developing dementia. DXM use may potentially provide a protective effect against dementia.

Furthermore, there is a dose dependent pattern, where higher dosage of DXM relates with a lower risk of dementia.

Hazard ratio for no DXM use 1 (reference)

Hazard ratio for 1-30mg a day 0.754

Hazard ratio for 31-90mg a day 0.563

Hazard ratio for ≥91mg a day 0.442




4) DXM use is associated with a reduced risk of hearing loss

In human study, we used a Cox regression hazard model to indicate that a significantly lower percentage individuals developed SNHL compared with and without DXM use (0.44%, 175/39,895 vs. 1.05%, 1675/159,580, p < 0.001). After adjustment for age and other variables [adjusted hazard ratio: 0.725 (95% confidence interval: 0.624-0.803, p < 0.001)], this study also demonstrated that DXM use appeared to reduce the risk of developing SNHL. This animal study demonstrated that DXM significantly attenuated noise-induced hearing loss. In human study, DXM use may have a protective effect against SNHL.

https://pubmed.ncbi.nlm.nih.gov/32878128/



5) It has profound anti-inflammatory, anti-arthritic, and Immunomodulatory effects

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595833/

 

[High Cortisol Chad]

B

 

[Matthias8272]

I bought pills then never touched them