D
Deleted member 439
what would jordan do?
- Joined
- Oct 20, 2018
- Posts
- 3,304
- Reputation
- 6,474
This is my approach to developing long term, successful looksmaxing and lifemaxing success. The most important and crucial thing you need is a healthy functioning mind. A healthy mind and reward system is crucial for long term success. Most problems you face in your life are a result of a fucked up mind, they are symptoms of the problem not the problem itself.
The functional Brain vs The unfunctional Brain
Healthy:
Dopamine is created from the amino acids phenylalanine and tyrosine using iron and vitamin B6 as cofactors.
Phenylalanine ⇒ (phenylalanine hydroxylase) ⇒ Tyrosine ⇒ (tyrosine hydroxylase) ⇒ L-dopa ⇒ (dopa decarboxylase) ⇒ Dopamine
Dopamine then acts on two receptors namely D1 and D2. D1 promotes the release of cAMP and D2 reduces cAMP levels. D2 is also the dopamine autoreceptor, which means that, when dopamine binds to it, it reduces dopamine synthesis, thus controlling dopamine levels.
People with functional brain reward systems are wired to work hard and achieve their goals. The brain rewards actions such as sex with dopamine.
Dysfunctional:
When you have chronically low dopamine, your brain forces you to do small tasks to temporarily raise dopamine. These actions are things like fapping, overeating, ect. However, these short term dopamine spikes will keep becoming less and less.
"Addiction has always been thought to be driven by dopamine, but it’s been found that it’s dopamine hypo-activity that leads to addiction. People with addiction usually have low dopamine or less D2 receptors, thus they require more dopamine releasing substances just to feel “normal” again. A lack of dopamine and/or an excess of serotonin (serotonin also suppresses dopamine release (R)) causes anhedonia; the lack of pleasure."
As dopamine drops, due to chronic stress or serotonin, less D2 is activated and this may lead to elevated glutamatergic signalling which may contribute to addiction (R). Additionally, low striatal D1 receptor availability leads to more risk-seeking behavior, a character trait known to be associated with an increased risk of addiction (R). Again, low dopamine and/or dopamine receptors lead to addiction.
Do you have a healthy brain?
If you have these symptoms, you probably have a dysfunctional reward system. With the lifestyle many of you live, its exteremely likely that you suffer from this
Two things:
1. Its Impossible to ascend with a brain like this. Ascension requires committment, motivation, and hard work.
2. Problems in your brain cause a huge amount of problems
Dopamine and serotonin for Erections:
Serotonin
Up to 80% of people, in young patients in particular, on SSRI drugs report sexual dysfunction as one of the most relevant side effects (R, R). That is exactly why up to 90% of people discontinue SSRI therapy. SSRIS inhibits the reabsorption of serotonin by neurons, so increasing the availability of serotonin as a neurotransmitter.
the serotonin receptor 5-HT4 might also be anti-erection, and blocking it can have pro-erection effects (R). Lysine is a natural amino acid with Spotent 5-HT4 antagonistic properties and could aid in erections.
Dopamine:
Dopamine is a major modulator of sexual function and is the primary prolactin antagonist. Prolactin lowers testosterone levels, inhibits DHT formation and reduces libido and erections. Prolactin, similar to serotonin, is also able to modulate dopaminergic function in specific brain regions and inhibit dopamine control in the hypothalamus (R). More on prolactin in part 2.
Dopamine is thought to regulate erection by acting on oxytocin containing neurons in the paraventricular nucleus of the hypothalamus, where prolactin has an inhibitory effect (R).
Dopamine agonist treatment in Parkinson’s disease is frequently accompanied by the clinical observation of hypersexuality (R).
Some of the safer dopaminergic drugs that can have the best effect on erections include lisuride, metergoline, amantadine and selegiline (R, R)
Dopamine can even induce an erection in the presence of a NOS inhibitor (R).
Effects of High serotonin
More evidence on the importance
High serotonin:
Depressed, sadness, feeling down, reduced desire to do other things like go out and have fun, social anxiety and withdrawal, etc. (R, R, R)
Effects of Dopamine:
Low histamine and dopamine leads to excess fatigue during the day, slow mental function, hypo-activity (not very active during the day), constant munchies, anxiety, etc. Antagonizing the H3 receptor increases histamine and dopamine, which as a result improves energy during the day, sleep at night and also boosts mental function and reduces appetite.
The difference between histamine and dopamine is that dopamine mostly promotes exploration of things outside the comfort-zone, whereas histamine mostly promotes exploration inside the comfort-zone and makes you prone to forming habits.
High dopamine promotes a creative, socially comfortable (pro-social, no anxiety), more fluid and flexible personality (R, R). Dopamine is also involved in learning – what to avoid that might put you in danger – but uncomfortable situations might rather be seen as opportunities instead of difficulties.
To those serious about looksmaxing and improving your life: There are NO quick fixes. Everything is connected, and being healthy should be everyone first priority. Men are naturally driven by success and motivated, It should come naturally. Men should be risk takers, optmistic, with high libido.
IF you constantly feel tired, lethargic, unmotivated, no libido you NEED to fix this. It is not a normal way to live. Life should be enjoyable and easy, If its not something is wrong. If you notice so many symptoms its all connected to this. ED drugs, study pills, alcohol to relax, sarms to build muscle are all ignoring the underlying issue. @Seth Walsh was right all along
The next thread will be about how to change your diet, lifestyle, sleep, and supplements to restore a healthy brain. After we built the foundation which allows us to be happy and motivated, I will make more detailed threads about specific topics. If you want to be tagged please comment it.
The functional Brain vs The unfunctional Brain
Healthy:
Dopamine is created from the amino acids phenylalanine and tyrosine using iron and vitamin B6 as cofactors.
Phenylalanine ⇒ (phenylalanine hydroxylase) ⇒ Tyrosine ⇒ (tyrosine hydroxylase) ⇒ L-dopa ⇒ (dopa decarboxylase) ⇒ Dopamine
Dopamine then acts on two receptors namely D1 and D2. D1 promotes the release of cAMP and D2 reduces cAMP levels. D2 is also the dopamine autoreceptor, which means that, when dopamine binds to it, it reduces dopamine synthesis, thus controlling dopamine levels.
People with functional brain reward systems are wired to work hard and achieve their goals. The brain rewards actions such as sex with dopamine.
Dysfunctional:
When you have chronically low dopamine, your brain forces you to do small tasks to temporarily raise dopamine. These actions are things like fapping, overeating, ect. However, these short term dopamine spikes will keep becoming less and less.
"Addiction has always been thought to be driven by dopamine, but it’s been found that it’s dopamine hypo-activity that leads to addiction. People with addiction usually have low dopamine or less D2 receptors, thus they require more dopamine releasing substances just to feel “normal” again. A lack of dopamine and/or an excess of serotonin (serotonin also suppresses dopamine release (R)) causes anhedonia; the lack of pleasure."
As dopamine drops, due to chronic stress or serotonin, less D2 is activated and this may lead to elevated glutamatergic signalling which may contribute to addiction (R). Additionally, low striatal D1 receptor availability leads to more risk-seeking behavior, a character trait known to be associated with an increased risk of addiction (R). Again, low dopamine and/or dopamine receptors lead to addiction.
Do you have a healthy brain?
If you have these symptoms, you probably have a dysfunctional reward system. With the lifestyle many of you live, its exteremely likely that you suffer from this
- Lack of motivation, no goal setting or ambition, lack of self-grooming
- No creativity, brain fog, low problem solving ability
- Don’t want to explore, not curious, closed minded
- Anhedonia, lack of pleasure, don’t enjoy much, negativity (rarely happy), no humor, disconnected
- Diminished ability or just don’t want to connect with people
- Lack of content, no purpose or beauty in life
- Anti-social / social anxiety, fearful, nervous, anxious
- Attention deficit, short term memory loss, etc…
- Low appetite (because of elevated serotonin)
- High prolactin
- Might increase dependence of stimulants
Two things:
1. Its Impossible to ascend with a brain like this. Ascension requires committment, motivation, and hard work.
2. Problems in your brain cause a huge amount of problems
Dopamine and serotonin for Erections:
Serotonin
Up to 80% of people, in young patients in particular, on SSRI drugs report sexual dysfunction as one of the most relevant side effects (R, R). That is exactly why up to 90% of people discontinue SSRI therapy. SSRIS inhibits the reabsorption of serotonin by neurons, so increasing the availability of serotonin as a neurotransmitter.
- inhibiting nitric oxide synthesis (R)
- lowering dopamine release
- increasing prolactin
- increasing renin (which promotes vasoconstriction and inflammation)
- stimulating the adrenal axis (CRH, ACTH and cortisol) through activation of the 5-HT2A receptor (R, R).
the serotonin receptor 5-HT4 might also be anti-erection, and blocking it can have pro-erection effects (R). Lysine is a natural amino acid with Spotent 5-HT4 antagonistic properties and could aid in erections.
Dopamine:
Dopamine is a major modulator of sexual function and is the primary prolactin antagonist. Prolactin lowers testosterone levels, inhibits DHT formation and reduces libido and erections. Prolactin, similar to serotonin, is also able to modulate dopaminergic function in specific brain regions and inhibit dopamine control in the hypothalamus (R). More on prolactin in part 2.
Dopamine is thought to regulate erection by acting on oxytocin containing neurons in the paraventricular nucleus of the hypothalamus, where prolactin has an inhibitory effect (R).
Dopamine agonist treatment in Parkinson’s disease is frequently accompanied by the clinical observation of hypersexuality (R).
Some of the safer dopaminergic drugs that can have the best effect on erections include lisuride, metergoline, amantadine and selegiline (R, R)
Dopamine can even induce an erection in the presence of a NOS inhibitor (R).
Effects of High serotonin
- Increases aldosterone (aldosterone increases blood pressure and causes water retention)
- Increases prolactin release (mainly through 5-HT2A) (R),
- Activates the adrenal axis, by increasing CRH, glucocorticoids & ACTH (mainly through 5-HT2C) as well as glucocorticoid receptors via the 5-HT7 receptor (R)
- Increases estrogen receptors (through 5-HT4) (R)
- inhibits testosterone synthesis
- inhibits dopamine release in frontal cortex (through 5-HT1B and 5-HT2C)
More evidence on the importance
High serotonin:
Depressed, sadness, feeling down, reduced desire to do other things like go out and have fun, social anxiety and withdrawal, etc. (R, R, R)
- Reduced cognitive function (not necessarily lack of knowledge, but intuitive thinking) (R). However, they might think they are smart and have all the answers in a very authoritative way.
- Narcissistic (R) – delusions of grandeur, fantasize about power, exaggerated sense of self-importance, requiring constant admiration, etc.
- Reduced senses (sensory perception) – anhedonia, apathy, reduced smell, hearing, taste, sensation, euphoria to music, etc. (R, R)
Effects of Dopamine:
Low histamine and dopamine leads to excess fatigue during the day, slow mental function, hypo-activity (not very active during the day), constant munchies, anxiety, etc. Antagonizing the H3 receptor increases histamine and dopamine, which as a result improves energy during the day, sleep at night and also boosts mental function and reduces appetite.
The difference between histamine and dopamine is that dopamine mostly promotes exploration of things outside the comfort-zone, whereas histamine mostly promotes exploration inside the comfort-zone and makes you prone to forming habits.
High dopamine promotes a creative, socially comfortable (pro-social, no anxiety), more fluid and flexible personality (R, R). Dopamine is also involved in learning – what to avoid that might put you in danger – but uncomfortable situations might rather be seen as opportunities instead of difficulties.
To those serious about looksmaxing and improving your life: There are NO quick fixes. Everything is connected, and being healthy should be everyone first priority. Men are naturally driven by success and motivated, It should come naturally. Men should be risk takers, optmistic, with high libido.
IF you constantly feel tired, lethargic, unmotivated, no libido you NEED to fix this. It is not a normal way to live. Life should be enjoyable and easy, If its not something is wrong. If you notice so many symptoms its all connected to this. ED drugs, study pills, alcohol to relax, sarms to build muscle are all ignoring the underlying issue. @Seth Walsh was right all along
The next thread will be about how to change your diet, lifestyle, sleep, and supplements to restore a healthy brain. After we built the foundation which allows us to be happy and motivated, I will make more detailed threads about specific topics. If you want to be tagged please comment it.
