TOP 3 GROWTH FACTORS FOR HEIGHTMAXXING

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wannabemogger

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1. PTH 1-34 (Teriparatide)


Mechanism:
An anabolic bone agent that stimulates osteoblast activity and increases bone remodeling. Mimics parathyroid hormone—intermittent dosing leads to bone formation, not resorption.


Target Zone:
Growth plates (epiphyseal regions of long bones: femur, tibia).


Injection Type:


  • Subperiosteal (under the periosteum near tibial epiphysis).
  • 27–30G insulin syringe.
  • Angle: ~30°, just under the skin, sliding toward the bone.

Dosage:


  • 20 µg/day or split into 10 µg AM/PM
  • 5 days on / 2 days off

Pros:


  • Proven to increase bone density and formation
  • Synergistic with IGF-1 and BMP-2
  • Readily available as Forteo or biosimilars

Cons:
− Long-term use may cause desensitization
− Mild nausea or hypercalcemia risk
− Expensive without insurance




2. BMP-2 (Bone Morphogenetic Protein-2)


Mechanism:
BMP-2 triggers mesenchymal stem cell differentiation into osteoblasts, catalyzing new bone growth via endochondral ossification. It's what your body uses after fractures.


Target Zone:
Tibial shaft, spinal processes, or femur near growth-active zones.


Injection Type:


  • Subperiosteal + Hydrogel scaffold
  • BMP-2 must be mixed into a sterile hydrogel (like GelMA, PEG-based, or HA-based) for localized delivery.
  • Inject directly against bone beneath the periosteum with a 1 mL syringe, 27G needle.

Dosage:


  • 2–10 µg per site
  • Frequency: 1–2x/week
  • Rotate limbs to prevent saturation/osteolysis

Pros:


  • Direct bone mass and length gains
  • Triggers natural bone morphogenesis
  • Synergizes with PTH, VEGF-A165

Cons:
− Risk of ectopic bone if misplaced
− Osteolysis if overdosed
− Needs a proper scaffold for efficacy




3. VEGF-A165 (Vascular Endothelial Growth Factor A)


Mechanism:
Drives angiogenesis, blood vessel growth into growth plates and periosteum. Enhances nutrient delivery and speeds up endochondral ossification. Helps vascularize BMP-2 sites.


Target Zone:
Same as BMP-2—epiphyseal regions and periosteal zones of tibia or femur.


Injection Type:


  • Subperiosteal or intradermal over bone zones
  • 27–31G insulin syringe
  • Combine with BMP-2 or IGF-1 DES for max effect

Dosage:


  • 2–5 µg/site
  • 2–3x/week, alternate sites

Pros:


  • Increases BMP-2 and IGF-1 response
  • Improves vascularization of graft zones
  • Good for stacking with growth factors

Cons:
− Must be dosed carefully to avoid aberrant angiogenesis
− May cause edema if overdosed




Final Notes:


  • Cycle example: 8–12 weeks on, 4 weeks off
  • Ideal stack: PTH 1-34 (daily), BMP-2 (weekly), VEGF-A165 (3x/week)
  • Recovery support: BPC-157, MSC exosomes
  • Avoid training 2–4 hours after injections for osteogenesis window.
I accidentally deleted 1hr worth of thread so this is my reboot jfl...
 
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@lurker999
 
Copy pasted from GPT
 
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"speeds up endochondral ossification", jfl that's literally not even close to what you want for height growth my god
 
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"speeds up endochondral ossification", jfl that's literally not even close to what you want for height growth my god
Yeah this sounds a little silly. Wouldn’t chondrocyte proliferation be most important here?
 
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you want chrondogenesis when youre doing LL :eek::eek::eek:
or when you want to get taller
Endochondral ossification is responsible for the initial bone development from cartilage in utero and infants and the longitudinal growth of long bones in the epiphyseal plate. The plate's chondrocytes are under constant division by mitosis. These daughter cellsstack facing the epiphysis while the older cells are pushed towards the diaphysis. As the older chondrocytes degenerate, osteoblasts ossify the remains to form new bone. In puberty increasing levels of estrogen, in both females and males, leads to increased apoptosis of chondrocytes in the epiphyseal plate.[6] Depletion of chondrocytes due to apoptosis leads to less ossification and growth slows down and later stops when the entire cartilage have become replaced by bone, leaving only a thin epiphyseal scar which later disappears
 

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