Truth about Melanotan II

[Mendible]

What is melanotan II?​

Melanotan II is an unlicensed and largely untested form of alpha-melanocyte

-stimulating hormone, which causes pigmentation (tanning) of human skin. Melanotan II is a variant of melanotan I (afamelanotide), a drug used in the treatment of erythropoietic protoporphyria.


Melanotan II is not approved for the treatment of any medical conditions currently. It has been reported to cause a wide range of potentially serious side effects. Warnings against its use have been issued from the US, UK and several other countries.

How does melanotan II work?​

Melanotan II non-selectively mimics the action of melanocortin peptides.

These are natural hormones involved with pigmentation, energy homeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system. Much like melanotan I (afamelanotide), melanotan II stimulates the production of eumelanin, causing the skin to go darker (tanning).


Melanotan II is usually administered as an injection of liquid underneath the skin, commonly every second day. Trials have shown that the tanning effect can occur within 5 doses.

Side effects of melanotan II​

Short term side effects after administration include:

• Facial flushing
• Reduced appetite, nausea and vomiting
• In males, spontaneous erections 1-5 hours after administration (priapism), associated with yawning and stretching complex

Long term, there is concern that melanotan II may increase the risk of:

• Melanoma – a potentially serious form of skin cancer
• Deepening of the colour of moles, new moles and atypical melanocytic naevi
• Melanonychia – brown to black discolouration of one or more nails
• Rhabdomyolysis – potentially fatal destruction of muscle cells
• Encephalopathy syndrome

There is also concern about possible side effects due to contamination or lack of sterility if melanotan II is prepared incorrectly or needles are shared.

Sexual dysfunction​

During clinic trials for its use as a tanning agent, melanotan II was found to be a potent stimulator of male erections. A new drug based on melanotan II, bremelanotide, was developed to take advantage of this property. It has been noted across several studies to increase rigidity and duration of male erection, as well as male sexual desire. It has also been shown to increase female sexual desire in patients with sexual arousal disorder.

 

[Bajio]

What is melanotan II?​

Melanotan II is an unlicensed and largely untested form of alpha-melanocyte

-stimulating hormone, which causes pigmentation (tanning) of human skin. Melanotan II is a variant of melanotan I (afamelanotide), a drug used in the treatment of erythropoietic protoporphyria.


Melanotan II is not approved for the treatment of any medical conditions currently. It has been reported to cause a wide range of potentially serious side effects. Warnings against its use have been issued from the US, UK and several other countries.

How does melanotan II work?​

Melanotan II non-selectively mimics the action of melanocortin peptides.

These are natural hormones involved with pigmentation, energy homeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system. Much like melanotan I (afamelanotide), melanotan II stimulates the production of eumelanin, causing the skin to go darker (tanning).


Melanotan II is usually administered as an injection of liquid underneath the skin, commonly every second day. Trials have shown that the tanning effect can occur within 5 doses.

Side effects of melanotan II​

Short term side effects after administration include:

• Facial flushing
• Reduced appetite, nausea and vomiting
• In males, spontaneous erections 1-5 hours after administration (priapism), associated with yawning and stretching complex

Long term, there is concern that melanotan II may increase the risk of:

• Melanoma – a potentially serious form of skin cancer
• Deepening of the colour of moles, new moles and atypical melanocytic naevi
• Melanonychia – brown to black discolouration of one or more nails
• Rhabdomyolysis – potentially fatal destruction of muscle cells
• Encephalopathy syndrome

There is also concern about possible side effects due to contamination or lack of sterility if melanotan II is prepared incorrectly or needles are shared.

Sexual dysfunction​

During clinic trials for its use as a tanning agent, melanotan II was found to be a potent stimulator of male erections. A new drug based on melanotan II, bremelanotide, was developed to take advantage of this property. It has been noted across several studies to increase rigidity and duration of male erection, as well as male sexual desire. It has also been shown to increase female sexual desire in patients with sexual arousal disorder.

yea this is a w thread

 

[Napoleon1800]

thank you for copy pasting basic info from chatgpt

 

[aids]

Long term, there is concern that melanotan II may increase the risk of:

• Melanoma – a potentially serious form of skin cancer
• Deepening of the colour of moles, new moles and atypical melanocytic naevi
• Melanonychia – brown to black discolouration of one or more nails
• Rhabdomyolysis – potentially fatal destruction of muscle cells
• Encephalopathy syndrome

There is no evidence MC1R agonism causes an increased likelihood of melanoma. MT1 (which agonises MC1R also) is used to decrease likelihood of melanoma. I don't know where the opposing conclusion has came from.
Darker moles (just get laser if you care so much).
Melanonychia is not serious and nor is there any confirmed association with MT1/MT2 use.
Rhabdo from MT2, JFL.
Encephalopathy has nothing to do with MT2 and everything to do with sterility.

Besides the fact that this is a shit GPT thread, the information is all actually wrong, or a no shit. Who could guess that exposure to endotoxins through non-sterile peptide preparation would cause endotoxin-related effects on the body?

 

[slaters]

I’m tan and I mog u brah

 

[Mendible]

thank you for copy pasting basic info from chatgpt

There is no evidence MC1R agonism causes an increased likelihood of melanoma. MT1 (which agonises MC1R also) is used to decrease likelihood of melanoma. I don't know where the opposing conclusion has came from.
Darker moles (just get laser if you care so much).
Melanonychia is not serious and nor is there any confirmed association with MT1/MT2 use.
Rhabdo from MT2, JFL.
Encephalopathy has nothing to do with MT2 and everything to do with sterility.

Besides the fact that this is a shit GPT thread, the information is all actually wrong, or a no shit. Who could guess that exposure to endotoxins through non-sterile peptide preparation would cause endotoxin-related effects on the body?

its not chatgpt thread buddy https://dermnetnz.org/topics/melanotan-ii

 

[aids]

its not chatgpt thread buddy https://dermnetnz.org/topics/melanotan-ii

The author was a final year med student with likely no knowledge outside of the superficial research they did for the paper they wrote.
Regardless, it's inaccurate.

 

[Mendible]

The author was a final year med student with likely no knowledge outside of the superficial research they did for the paper they wrote.
Regardless, it's inaccurate.

Melanoma associated with the use of melanotan-II - PubMed

This observation brings attention to the potential risks related to the use of the cyclic α-melanocyte-stimulating hormone analogue MT-II. There are several hazardous aspects of the possible widespread use of MT-II. As the drug is unlicensed and incompletely tested, the extent and types of...

pubmed.ncbi.nlm.nih.gov

An unhealthy glow? A review of melanotan use and associated clinical outcomes

Socio-cultural emphasis on having a tan has led to blackmarket diversion of synthetic-tanning products Melanotan I and II. This review of literature o…

www.sciencedirect.com

https://www.tga.gov.au/news/blog/dont-risk-using-tanning-products-containing-melanotan

 

[Mezialix]

What is melanotan II?​

Melanotan II is an unlicensed and largely untested form of alpha-melanocyte

-stimulating hormone, which causes pigmentation (tanning) of human skin. Melanotan II is a variant of melanotan I (afamelanotide), a drug used in the treatment of erythropoietic protoporphyria.


Melanotan II is not approved for the treatment of any medical conditions currently. It has been reported to cause a wide range of potentially serious side effects. Warnings against its use have been issued from the US, UK and several other countries.

How does melanotan II work?​

Melanotan II non-selectively mimics the action of melanocortin peptides.

These are natural hormones involved with pigmentation, energy homeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system. Much like melanotan I (afamelanotide), melanotan II stimulates the production of eumelanin, causing the skin to go darker (tanning).


Melanotan II is usually administered as an injection of liquid underneath the skin, commonly every second day. Trials have shown that the tanning effect can occur within 5 doses.

Side effects of melanotan II​

Short term side effects after administration include:

• Facial flushing
• Reduced appetite, nausea and vomiting
• In males, spontaneous erections 1-5 hours after administration (priapism), associated with yawning and stretching complex

Long term, there is concern that melanotan II may increase the risk of:

• Melanoma – a potentially serious form of skin cancer
• Deepening of the colour of moles, new moles and atypical melanocytic naevi
• Melanonychia – brown to black discolouration of one or more nails
• Rhabdomyolysis – potentially fatal destruction of muscle cells
• Encephalopathy syndrome

There is also concern about possible side effects due to contamination or lack of sterility if melanotan II is prepared incorrectly or needles are shared.

Sexual dysfunction​

During clinic trials for its use as a tanning agent, melanotan II was found to be a potent stimulator of male erections. A new drug based on melanotan II, bremelanotide, was developed to take advantage of this property. It has been noted across several studies to increase rigidity and duration of male erection, as well as male sexual desire. It has also been shown to increase female sexual desire in patients with sexual arousal disorder.

This could be good for dihmaxxing

 

[aids]

Melanoma associated with the use of melanotan-II - PubMed

This observation brings attention to the potential risks related to the use of the cyclic α-melanocyte-stimulating hormone analogue MT-II. There are several hazardous aspects of the possible widespread use of MT-II. As the drug is unlicensed and incompletely tested, the extent and types of...

pubmed.ncbi.nlm.nih.gov

This is a case report.
Weakest form of evidence.

An unhealthy glow? A review of melanotan use and associated clinical outcomes

Socio-cultural emphasis on having a tan has led to blackmarket diversion of synthetic-tanning products Melanotan I and II. This review of literature o…

www.sciencedirect.com

https://www.tga.gov.au/news/blog/dont-risk-using-tanning-products-containing-melanotan

This is directly from the TGA... do you think a fucking Government body is going to be without bias?
Ffs.

READ THE SHIT YOU SHARE BEFORE YOU SHARE IT.