Vorinostat pulses

[hamiwts]

@Sachlichkeit so I’m following some of your threads
Doing a 50mg vorinostat pulse for 5 days 30 days off , but I don’t know what’s the max amount of times I can do this. What do you recommend. I’m also doing tren ace 50mg ed during the pulses but I’m not sure if that’s a one time thing for only one pulse. Do you have a side effect risk mitigation protocol? because obviously with the benefits of locking in pro osteogenic benefits you also risk locking in side effects and downsides of everything in the stack.

 

[jeoyw9192]

@Sachlichkeit so I’m following some of your threads
Doing a 50mg vorinostat pulse for 5 days 30 days off , but I don’t know what’s the max amount of times I can do this. What do you recommend. I’m also doing tren ace 50mg ed during the pulses but I’m not sure if that’s a one time thing for only one pulse. Do you have a side effect risk mitigation protocol? because obviously with the benefits of locking in pro osteogenic benefits you also risk locking in side effects and downsides of everything in the stack.

What is ur full stack?

 

[Sachlichkeit]

What is ur full stack?

>

 

[hamiwts]

What is ur full stack?

Test 500mg weekly

8iu Growth Hormone daily

Abaloparatide 120 mcg daily

Vorinostat 50mg 5 days on 30 days off

Tren Ace 50mg ED during vstat pulses

100mcg of T4( I’m hypo)

 

[Sachlichkeit]

@Sachlichkeit so I’m following some of your threads
Doing a 50mg vorinostat pulse for 5 days 30 days off , but I don’t know what’s the max amount of times I can do this. What do you recommend. I’m also doing tren ace 50mg ed during the pulses but I’m not sure if that’s a one time thing for only one pulse. Do you have a side effect risk mitigation protocol? because obviously with the benefits of locking in pro osteogenic benefits you also risk locking in side effects and downsides of everything in the stack.

Risk accumulates with chronic exposure, idk we are in research chemical territory boys nobody is pulsing offlabel vorinostat its cancer medication intended for people with cancer (medical doses 400mg ED) until toxicity or recession of the disease. Its used until the body can't stand it anymore or the disease is eradicated lmao

We are still massively below medical limit by pulsing it and using 12-25% of medical doses. The 30 day split is because we only need it for short term gene transcription and not the cytotoxicity (killing of cells) its intended for. If you want to be conservative, you can take 2-3mos off every 3 months. That is, a 3 cycles, then a 60-90 day break.

Obv theres a point where chronic repeated exposure (even if cycled) the body begins to adjust to the effects and the negative side effects begin to outperform the results, but theres no medical reference point. Repeated exposure will both signal more side effects and more positive effects

Do you have a side effect risk mitigation protocol?

Yea but not relating to offtarget HDACi upregulation just in general, for ex. Tren causes hairloss without the use of DHT (primary cause for hairloss in men) because of how androgenic it is (5-7x) more than testosterone so topical anti androgen like RU58841 to prevent raping of hair from both supraphysiological levels of DHT (downstream of testosterone) and tren is good idea. Tren should always be ran with a test base. Whether using it during vstat will genetically prevent androgens at the scalp idk.

50mg x 7 = 350mg/wk x 5 thats almost 2 grams (1.7grams) equivalent of testosterone.

Tren is different animal, there are bodybuilders that refuse to touch it cbum comes to mind. Side effect profile high though something like trensomnia or gyno can't really be permanently upregulated like androgen receptors or osteoblasts can via HDACi

I wrote tren A which is the harsher of the two, because I needed something fast acting, Test I think peaks in 2-4 weeks cant remember, I wanted my androgen signaling to be kickstarted which testosterone won't do. even then my ideal doses were only 125-150mg/week not 350mg/wk

 

[hamiwts]

Risk accumulates with chronic exposure, idk we are in research chemical territory boys nobody is pulsing offlabel vorinostat its cancer medication intended for people with cancer (medical doses 400mg ED) until toxicity or recession of the disease. Its used until the body can't stand it anymore or the disease is eradicated lmao

We are still massively below medical limit by pulsing it and using 12-25% of medical doses. The 30 day split is because we only need it for short term gene transcription and not the cytotoxicity (killing of cells) its intended for. If you want to be conservative, you can take 2-3mos off every 3 months. That is, a 3 cycles, then a 60-90 day break.

Obv theres a point where chronic repeated exposure (even if cycled) the body begins to adjust to the effects and the negative side effects begin to outperform the results, but theres no medical reference point. Repeated exposure will both signal more side effects and more positive effects



Yea but not relating to offtarget HDACi upregulation just in general, for ex. Tren causes hairloss without the use of DHT (primary cause for hairloss in men) because of how androgenic it is (5-7x) more than testosterone so topical anti androgen like RU58841 to prevent raping of hair from both supraphysiological levels of DHT (downstream of testosterone) and tren is good idea. Tren should always be ran with a test base. Whether using it during vstat will genetically prevent androgens at the scalp idk.

50mg x 7 = 350mg/wk x 5 thats almost 2 grams (1.7grams) equivalent of testosterone.

Tren is different animal, there are bodybuilders that refuse to touch it cbum comes to mind. Side effect profile high though something like trensomnia or gyno can't really be permanently upregulated like androgen receptors or osteoblasts can via HDACi

I wrote tren A which is the harsher of the two, because I needed something fast acting, Test I think peaks in 2-4 weeks cant remember, I wanted my androgen signaling to be kickstarted which testosterone won't do. even then my ideal doses were only 125-150mg/week not 350mg/wk

yeah but honestly I don’t think tren for 5 days is too bad tbh, with proper mitigation I think it’s doable. The main question is that would this be a constant during vstat pulses or a one time thing?

 

[Sachlichkeit]

yeah but honestly I don’t think tren for 5 days is too bad tbh, with proper mitigation I think it’s doable. The main question is that would this be a constant during vstat pulses or a one time thing?

That’s up 2 u man