why does no one here research gene expression

[lifelesschud764]

its actually a really good method

 

[Gobnull]

Why would anyone research gene expression here?

 

[Loukas7]

its actually a really good method

cause it’s too much work

 

[birthdefect]

its actually a really good method

elaborate on what youve discovered
how would you modulate gene expression in your favour

 

[lifelesschud764]

Why would anyone research gene expression here?

for genes that express bone growth for example

 

[lifelesschud764]

t

elaborate on what youve discovered
how would you modulate gene expression in your favour

there are multiple factors that could inhibit the expression of specific genes

 

[Gobnull]

for genes that express bone growth for example

You mean study them and discover something to influence those genes?

 

[birthdefect]

t

there are multiple factors that could inhibit the expression of specific genes

yea like tell me them

 

[ascendtocl122]

yea like tell me them

grey ramblings he dosent even know what a gene is. gene for ‘bone growth’ jfl

 

[lifelesschud764]

grey ramblings he dosent even know what a gene is. gene for ‘bone growth’ jfl

there are literally genes that inhibit osteoblasts??

 

[lifelesschud764]

yea like tell me them

for genes Like OPG, RUNX2, SP7

 

[ascendtocl122]

there are literally genes that inhibit osteoblasts??

more bone mass dosent equal better projection you ogre loving retard

 

[Ch1gga]

its actually a really good method

 

[lifelesschud764]

more bone mass dosent equal better projection you ogre loving retard

alright but more bone mass development by osteoblast differentiation can possibly maximize genetic height potential

 

[lifelesschud764]

View attachment 4700436

proof that it isnt?

 

[birthdefect]

for genes Like OPG, RUNX2, SP7

i know the genes themselves i want you to elaborate on how you would modulate them
cus the kind of gene modulation that you might be thinking of rn is literally how every single medication works

there are literally genes that inhibit osteoblasts??

you know a negative regulator of osteoblasts? sclerostin(sost)
we inhibit it with romosozumab, which is not a gene modulator
gene modulation involves viral vectors to change the actual dna strands within the nucleus, and doing all that isnt necessary for most purposes

 

[birthdefect]

alright but more bone mass development by osteoblast differentiation can possibly maximize genetic height potential

osteoblasts have fuck all to do with height
the growth plate is cartilage, not bone
its about chondrocyte proliferation and hypertrophy

 

[lifelesschud764]

i know the genes themselves i want you to elaborate on how you would modulate them
cus the kind of gene modulation that you might be thinking of rn is literally how every single medication works

you know a negative regulator of osteoblasts? sclerostin(sost)
we inhibit it with romosozumab, which is not a gene modulator
gene modulation involves viral vectors to change the actual dna strands within the nucleus, and doing all that isnt necessary for most purposes

no you can specifically target the development of multple genes such as GDF5 and ACAN which will express cartillage development at growth plates with would later minerlaize into bone

 

[lifelesschud764]

osteoblasts have fuck all to do with height
the growth plate is cartilage, not bone
its about chondrocyte proliferation and hypertrophy

yes but osteoblast differentiation mineralizes cartillage at growth plates

 

[eeaghost]

its actually a really good method

u really think this degenerate corner of the internet has lots of research oriented people?

 

[hotdoggy]

for genes that express bone growth for example

Humans take too long and expensive to grow to see certain phenotypes (Huntingtons disease, for example, appears after someone ages), too many variables to see certain phenotypes, and ethics prevent controlled research from happening.

 

[lifelesschud764]

u really think this degenerate corner of the internet has lots of research oriented people?

idk

 

[birthdefect]

no you can specifically target the development of multple genes such as GDF5 and ACAN which will express cartillage development at growth plates with would later minerlaize into bone

how would you do this practically?

 

[lifelesschud764]

Humans take too long and expensive to grow to see certain phenotypes (Huntingtons disease, for example, appears after someone ages), too many variables to see certain phenotypes, and ethics prevent controlled research from happening.

?? elaborate because im not talking about phenotypes

 

[lifelesschud764]

how would you do this practically?

general nutrtion and further more specific nutrtional needs for example stuff like polyphenols has been seen to express genes that affect cartillage production such as ACAN

 

[birthdefect]

general nutrtion and further more specific nutrtional needs for example stuff like polyphenols has been seen to express genes that affect cartillage production such as ACAN

nutrition isnt enough
dietary stuff isnt enough
you need pharmaceuticals, i thought you were gonna mention some niche modulators of these genes

 

[Veridic]

its actually a really good method

"Method" and it's just regular physiology

 

[hotdoggy]

?? elaborate because im not talking about phenotypes

You are though. Phenotypes are how the genes that someone has are expressed. It is the stuff that gives you your bone density, your height, your facial features. Even then, each of those traits are so complex with their own genes and then it gets added on to how it interacts with different parts of the body (also having their own traits, genes, and interactions).

 

[lifelesschud764]

nutrition isnt enough
dietary stuff isnt enough
you need pharmaceuticals, i thought you were gonna mention some niche modulators of these genes

i mean i just started researching but if youd like to tell me youre welcome

 

[lifelesschud764]

You are though. Phenotypes are how the genes that someone has are expressed. It is the stuff that gives you your bone density, your height, your facial features. Even then, each of those traits are so complex with their own genes and then it gets added on to how it interacts with different parts of the body (also having their own traits, genes, and interactions).

the phenos you mentioned in your first reply are different than helping the expression of your already dominant genes

 

[birthdefect]

i mean i just started researching but if youd like to tell me youre welcome

i mean i dont have much to say on this tbh
only gene modulators i know are hdaci, ezhi, and dnmti

 

[lifelesschud764]

i mean i dont have much to say on this tbh
only gene modulators i know are hdaci, ezhi, and dnmti

personally i lean more onto softmaxxes so if i were to publish anything related to gene expression and such i wouldnt put much (if any) pharmacueticals since i consider them hardmaxxes and im also lf for stuff which is easy to find

 

[lifelesschud764]

also

i mean i dont have much to say on this tbh
only gene modulators i know are hdaci, ezhi, and dnmti

also HDACI is expensive asf

and is also prescription only

 

[birthdefect]

personally i lean more onto softmaxxes so if i were to publish anything related to gene expression and such i wouldnt put much (if any) pharmacueticals since i consider them hardmaxxes and im also lf for stuff which is easy to find

why do you consider pharmaceuticals as hardmaxxes, they most definitely are not

also

also HDACI is expensive asf View attachment 4700484 and is also prescription only

dont have to source legitimately

 

[lifelesschud764]

why do you consider pharmaceuticals as hardmaxxes, they most definitely are not

dont have to source legitimately

personally just dont wanna get random china chems

 

[birthdefect]

personally just dont wanna get random china chems

what else can you do tbh

 

[enzymepilled]

are you retarded, we can kinda manage genetic maniplation of bacteria, what the fuck are you gonna do with gene expression, you cant change it, go study for your ap bio test and stop being an idiot

 

[lifelesschud764]

are you retarded, we can kinda manage genetic maniplation of bacteria, what the fuck are you gonna do with gene expression, you cant change it, go study for your ap bio test and stop being an idiot

can u tell me more about the bacteria point id like to research it also why you so angry calm down in theory evrything i said is slightly effective

 

[enzymepilled]

can u tell me more about the bacteria point id like to research it also why you so angry calm down in theory evrything i said is slightly effective

we can alter bacterial dna, like prokaryotes, its easy since they can take up outside DNA, or we can use more complex methods that im not gonna get into, thats how we produce many medicines just make the bacteria make it, im mad because youre being retarded, dont be retarded, if youre gonna be lame you at least gotta be not retarded or you will be lame forever, to not be retarded go do research

 

[enzymepilled]

can u tell me more about the bacteria point id like to research it also why you so angry calm down in theory evrything i said is slightly effective

think about it if you wanna alter gene expression you gotta change those genes, all of those cells need to be changed, if we could do that then there wouldnt be cancer or genetic conditions

 

[India lover 52]

because its pointless unless you have acess to a CRISPR

 

[Boosie’s_Build]

It would be cool if follistatin gene therapy were cheap and actually real.

 

[AtrophicPyra]

osteoblasts have fuck all to do with height
the growth plate is cartilage, not bone
its about chondrocyte proliferation and hypertrophy

honestly just test and hgh tb500 and bpc157 during puberty, UC, aqualyx, neck curls

this is all you need

 

[birthdefect]

honestly just test and hgh tb500 and bpc157 during puberty, UC, aqualyx, neck curls

this is all you need

why the tb and bpc?
gh receptor sensitivity?
androgens already sensitise gh receptors and vice versa

 

[AtrophicPyra]

why the tb and bpc?
gh receptor sensitivity?
androgens already sensitise gh receptors and vice versa

osteoblast promoters that are affordable and work well, help skin, gut, everything, overall make u feel fantastic and healthy.

but what do u think abt the stack? u got any sleeper builds to add?

 

[birthdefect]

osteoblast promoters that are affordable and work well, help skin, gut, everything, overall make u feel fantastic and healthy.

but what do u think abt the stack? u got any sleeper builds to add?

honestly i just thought bpc and tb upregulate collagen and fibroblast production idk much about them
depending on age i would add the classic anti aging compounds like rapamycin, epitalon, dut, alfatradiol, maybe melatonin

if during puberty for height i would add an ai, pth/pthrp analogue to manage chondrocyte hypertrophy