I
Inosebreathonly
Iron
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- Aug 20, 2023
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First of all let's see how growth plates expand and then turn into bones which leads to height growth:
Chondrocytes first undergo a proliferative phase where they multiply in their number.
Then they get hypertrophied which leads to their expansion into 10-20x their previous size.
Then minerals start to accumulate and the ossification occurs which seals the growth plates and finishes growth window.
And unless proven otherwise, in humans this process goes in only one direction.
Obviously the timing and duration of these processes may differ from growth plate to growth plate and it could also be different in different chondrocytes that are in the same growth plate hence why we see height growth over a long period and not just at once..
For maximum height gains the best strategy is to prevent premature hypertrophy and ossification in the early puberty stages so you can maximize the proliferation of chondrocytes in their early proliferative stages.
When you are in later stages of puberty where majority of chondrocytes finished their proliferative phases and started getting into hypertrophic stages you want to maximize their hypertrophy.
And delaying chondrocyte ossification regardless of where you are at your puberty will lead to extension the growing window and higher final height.
This may differ from person to person but generally the primary driver of growth plate ossification is the activation of ER-α in bones and growth plates.
And more free testosterone means higher estradiol levels which leads to higher activation of ER-α, everybody knows that and this is why people use estradiol receptor antagonists like tamoxifen and aromatase inhibitors like aromasin, arimidex etc.
But even if we ignore estradiol one of the other main drivers of chondrocyte ossification is androgen receptor activation in bones and growth plates. (Regardless of estradiol)
Androgen receptor activation leads to increases in bone formation, mineralization and lateral growth of bones.
Excessive bone formation rates may also lead to mineralization and premature ossification of chondrocytes.
This is why adolescents with high androgen levels may experience earlier and more accelerated growth but also earlier closure of growth plates.
And earlier closure of growth plates will almost always lead to shorter final height.
This may also be the reason why countries with the highest testosterone levels like Mongolia, Uzbekistan, Ethiopia, Nigeria, Egypt, Azerbaijan etc. are also among the shortest
Androgenic hormone's are anabolic but not pro-proliferative like hgh and igf-1.
Androgen receptor activation in chondrocytes will mainly cause expansion/hypertrophy in chondrocytes. And this may be bad if you are in earlier stages of puberty because it may cause premature hypertrophy and this will lead to lower count of chondrocytes and lead to lower height growth potential in the later stages and overall shorter final height.
Also again too much hypertrophy stimuli from androgens may cause apoptosis or premature ossification of chondrocytes.
So what's the optimal strategy? How could we utilize androgenic hormones' anabolic and masculinization effects without limiting height growth potential?
I suggest keeping both estrogens and androgens and their receptor's activation low in earlier stages of puberty this could be done by taking low dose AI, estrogen receptor blockers, androgen receptor blockers, 5-AR blockers, high dose melatonin supplementation etc. while maximizing growth hormones and factors so you can reach your genetic potential of maximum chondrocyte proliferation.
And then once the majority of chondrocytes are out of their proliferative phase and are expanding/getting hypertrophied you can use SARMS, steroids etc. this will maximize the hypertrophy of chondrocytes and then with the ossification starting to occur your growth window will end but my maximizing both
chondrocyte proliferation and hypertrophy you will almost reach your maximum potential.
This will lead to a sudden grow/glow up both in height and dimorphism/striking features so you can surprise your crush at your school
Maybe there could be some strategies to still limit the ossification like using AI, using high dose vitamin K2 and magnesium to direct the calcium away from soft tissues to bones which will limit excess mineralization-induced ossification, upregulating WNT/B-catenin pathway etc. but once both proliferation and hypertrophy are maximized I don't think keeping growth plates open will lead to significantly more height growth..
Idk tell me your thoughts
Chondrocytes first undergo a proliferative phase where they multiply in their number.
Then they get hypertrophied which leads to their expansion into 10-20x their previous size.
Then minerals start to accumulate and the ossification occurs which seals the growth plates and finishes growth window.
And unless proven otherwise, in humans this process goes in only one direction.
Obviously the timing and duration of these processes may differ from growth plate to growth plate and it could also be different in different chondrocytes that are in the same growth plate hence why we see height growth over a long period and not just at once..
For maximum height gains the best strategy is to prevent premature hypertrophy and ossification in the early puberty stages so you can maximize the proliferation of chondrocytes in their early proliferative stages.
When you are in later stages of puberty where majority of chondrocytes finished their proliferative phases and started getting into hypertrophic stages you want to maximize their hypertrophy.
And delaying chondrocyte ossification regardless of where you are at your puberty will lead to extension the growing window and higher final height.
This may differ from person to person but generally the primary driver of growth plate ossification is the activation of ER-α in bones and growth plates.
And more free testosterone means higher estradiol levels which leads to higher activation of ER-α, everybody knows that and this is why people use estradiol receptor antagonists like tamoxifen and aromatase inhibitors like aromasin, arimidex etc.
But even if we ignore estradiol one of the other main drivers of chondrocyte ossification is androgen receptor activation in bones and growth plates. (Regardless of estradiol)
Androgen receptor activation leads to increases in bone formation, mineralization and lateral growth of bones.
Excessive bone formation rates may also lead to mineralization and premature ossification of chondrocytes.
This is why adolescents with high androgen levels may experience earlier and more accelerated growth but also earlier closure of growth plates.
And earlier closure of growth plates will almost always lead to shorter final height.
This may also be the reason why countries with the highest testosterone levels like Mongolia, Uzbekistan, Ethiopia, Nigeria, Egypt, Azerbaijan etc. are also among the shortest
Androgenic hormone's are anabolic but not pro-proliferative like hgh and igf-1.
Androgen receptor activation in chondrocytes will mainly cause expansion/hypertrophy in chondrocytes. And this may be bad if you are in earlier stages of puberty because it may cause premature hypertrophy and this will lead to lower count of chondrocytes and lead to lower height growth potential in the later stages and overall shorter final height.
Also again too much hypertrophy stimuli from androgens may cause apoptosis or premature ossification of chondrocytes.
So what's the optimal strategy? How could we utilize androgenic hormones' anabolic and masculinization effects without limiting height growth potential?
I suggest keeping both estrogens and androgens and their receptor's activation low in earlier stages of puberty this could be done by taking low dose AI, estrogen receptor blockers, androgen receptor blockers, 5-AR blockers, high dose melatonin supplementation etc. while maximizing growth hormones and factors so you can reach your genetic potential of maximum chondrocyte proliferation.
And then once the majority of chondrocytes are out of their proliferative phase and are expanding/getting hypertrophied you can use SARMS, steroids etc. this will maximize the hypertrophy of chondrocytes and then with the ossification starting to occur your growth window will end but my maximizing both
chondrocyte proliferation and hypertrophy you will almost reach your maximum potential.
This will lead to a sudden grow/glow up both in height and dimorphism/striking features so you can surprise your crush at your school
Maybe there could be some strategies to still limit the ossification like using AI, using high dose vitamin K2 and magnesium to direct the calcium away from soft tissues to bones which will limit excess mineralization-induced ossification, upregulating WNT/B-catenin pathway etc. but once both proliferation and hypertrophy are maximized I don't think keeping growth plates open will lead to significantly more height growth..
Idk tell me your thoughts
