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Alcohol is a powerful social lubricant, something you would really need when having subhuman acne. While the temporary escape from reality alcohol can give you would be welcomed, as well as the low inhibness, it's still really important to not give in to the temptations. In this thread I'll explain why.
Key points:
There's more and more evidence to show that treatment with Isotretinoin causes these ALDH enzymes to downregulate. This isn't surprising as negative feedback loops are often used throughout the body in an attempt to achieve homeostasis. The excessive retinoic acid signalling that occurs during Accutane treatment likely triggers a repression of the enzymes involved in the natural synthesis of retinoic acid, including ALDH. By marking ALDH enzymes for repression, Isotretinoin boosts the presence of Reactive Oxygen Species (ROS). This makes it a remarkably useful conjunctive in treating cancer, by enhancing the toxic effects of chemo drugs. Whilst Reactive Oxygen Species are harmful to cancers, they are also harmful for healthy tissue too.
If you can't quit alcohol, then I suggest an ALDH2 inhibitor, like Disulfiram. This way ALDH2 doesn't metabolize the toxic aldehydes after drinking alcohol, and the hangovers will be far worse. This encourages you quitting alcohol.
Tldr: don't drink alcohol on accutane cause your ALDH2 enzymes got better things to do than metabolize alcohol.
link.springer.com
www.nature.com
jpet.aspetjournals.org
Key points:
- Isotretinoin is a slightly modified version of retinoic acid which is naturally produced by the body using enzymes including ALDHs.
- By administering Isotretinoin, which converts into retinoic acid, the enzymes the body uses to naturally synthesise retinoic acid become downregulated.
- This is likely on account of a negative feedback loop to counter the excessive retinoic acid signalling that during treatment with the acne drug.
- This is likely on account of a negative feedback loop to counter the excessive retinoic acid signalling that during treatment with the acne drug.
- Acetaldehyde is the cause of hangover and many of the side effects of Alcohol consumption.
- By downregulating these detoxifying enzymes, Accutane puts us in a compromised position, so alcohol should be strictly prohibited during the treatment.
- Isotretinoin is a retinoid, which means it is related to Vitamin A. It essentially works as a pro-drug for the main metabolite of Vitamin A called Retinoic Acid. Isotretinoin is simply a modified version of retinoic acid, which can be easily converted to retinoic within cells. In fact, Isotretinoin avoids stimulating a response from the enzymes (P450) that would other metabolise high doses of retinoic acid if administered directly. This simple process bypasses all the enzymes that the body uses to naturally synthesise retinoic acid from dietary sources of retinol.
- Retinoic Acid is typically produced in the body in a two-stage process. First retinol is converted to retinal with enzymes called Alcohol/retinol dehydrogenases (ADH/RDH), and then retinal is oxidised to retinoic acid with the different Aldehyde Dehydrogenase (ALDH) isoforms expressed in different tissues. It's these ALDH enzymes that are so critical for understanding the effect of alcohol consumption during Accutane treatment.** They are a diverse family of enzymes with a broad spectrum of roles outside of the production of retinoic acid from maintaining vision to generating neurosteroids.
- The function of ALDH enzymes which is perhaps best well known is in their de-toxifying effect, breaking down reactive aldehydes to much less harmful metabolites. Specifically, ALDH2, which oxidises acetaldehyde into the much less harmful acetic acid. Acetaldehyde is the toxic product of alcohol consumption which contributes to the negative symptoms of hangover.
There's more and more evidence to show that treatment with Isotretinoin causes these ALDH enzymes to downregulate. This isn't surprising as negative feedback loops are often used throughout the body in an attempt to achieve homeostasis. The excessive retinoic acid signalling that occurs during Accutane treatment likely triggers a repression of the enzymes involved in the natural synthesis of retinoic acid, including ALDH. By marking ALDH enzymes for repression, Isotretinoin boosts the presence of Reactive Oxygen Species (ROS). This makes it a remarkably useful conjunctive in treating cancer, by enhancing the toxic effects of chemo drugs. Whilst Reactive Oxygen Species are harmful to cancers, they are also harmful for healthy tissue too.
If you can't quit alcohol, then I suggest an ALDH2 inhibitor, like Disulfiram. This way ALDH2 doesn't metabolize the toxic aldehydes after drinking alcohol, and the hangovers will be far worse. This encourages you quitting alcohol.
Tldr: don't drink alcohol on accutane cause your ALDH2 enzymes got better things to do than metabolize alcohol.
Use of retinoic acid/aldehyde dehydrogenase pathway as potential targeted therapy against cancer stem cells - Cancer Chemotherapy and Pharmacology
A large number of studies have investigated possible drug resistance mechanisms of cancer cells and suggested strategies to overcome it. In this review, we outline the role and function of aldehyde dehydrogenase (ALDH) activity in multiple cellular functions and in cancer stem cells (CSCs) and...
link.springer.com
Aldehyde dehydrogenase 2 is associated with cognitive functions in patients with Parkinson’s disease - Scientific Reports
Neurotransmitter degradation has been proposed to cause the accumulation of neurotoxic metabolites. The metabolism of these metabolites involves aldehyde dehydrogenase 2 (ALDH2). The Asian-specific single nucleotide polymorphism rs671 causes reduced enzyme activity. This study aims to explore...
www.nature.com
Retinoic Acid Down-Regulates Aldehyde Dehydrogenase and Increases Cytotoxicity of 4-Hydroperoxycyclophosphamide and Acetaldehyde
Multiple prior studies have identified aldehyde dehydrogenases (ALDH) that are capable of oxidizing retinal to retinoic acid. In this study, we test the hypothesis that the accumulation of intracellular retinoic acid may lead to the suppression of ALDH expression and thus increase cytotoxicity...
