Why you shouldn't drink alcohol while on Accutane

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Deleted member 65576

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Alcohol is a powerful social lubricant, something you would really need when having subhuman acne. While the temporary escape from reality alcohol can give you would be welcomed, as well as the low inhibness, it's still really important to not give in to the temptations. In this thread I'll explain why.

Key points:

  • Isotretinoin is a slightly modified version of retinoic acid which is naturally produced by the body using enzymes including ALDHs.
  • By administering Isotretinoin, which converts into retinoic acid, the enzymes the body uses to naturally synthesise retinoic acid become downregulated.
  • This is likely on account of a negative feedback loop to counter the excessive retinoic acid signalling that during treatment with the acne drug.
  • This is likely on account of a negative feedback loop to counter the excessive retinoic acid signalling that during treatment with the acne drug.
  • Acetaldehyde is the cause of hangover and many of the side effects of Alcohol consumption.
  • By downregulating these detoxifying enzymes, Accutane puts us in a compromised position, so alcohol should be strictly prohibited during the treatment.
ALDH is needed for Alcohol metabolism
  • Isotretinoin is a retinoid, which means it is related to Vitamin A. It essentially works as a pro-drug for the main metabolite of Vitamin A called Retinoic Acid. Isotretinoin is simply a modified version of retinoic acid, which can be easily converted to retinoic within cells. In fact, Isotretinoin avoids stimulating a response from the enzymes (P450) that would other metabolise high doses of retinoic acid if administered directly. This simple process bypasses all the enzymes that the body uses to naturally synthesise retinoic acid from dietary sources of retinol.
  • Retinoic Acid is typically produced in the body in a two-stage process. First retinol is converted to retinal with enzymes called Alcohol/retinol dehydrogenases (ADH/RDH), and then retinal is oxidised to retinoic acid with the different Aldehyde Dehydrogenase (ALDH) isoforms expressed in different tissues. It's these ALDH enzymes that are so critical for understanding the effect of alcohol consumption during Accutane treatment.** They are a diverse family of enzymes with a broad spectrum of roles outside of the production of retinoic acid from maintaining vision to generating neurosteroids.
  • The function of ALDH enzymes which is perhaps best well known is in their de-toxifying effect, breaking down reactive aldehydes to much less harmful metabolites. Specifically, ALDH2, which oxidises acetaldehyde into the much less harmful acetic acid. Acetaldehyde is the toxic product of alcohol consumption which contributes to the negative symptoms of hangover.
Accutane downregulates ALDH
There's more and more evidence to show that treatment with Isotretinoin causes these ALDH enzymes to downregulate. This isn't surprising as negative feedback loops are often used throughout the body in an attempt to achieve homeostasis. The excessive retinoic acid signalling that occurs during Accutane treatment likely triggers a repression of the enzymes involved in the natural synthesis of retinoic acid, including ALDH. By marking ALDH enzymes for repression, Isotretinoin boosts the presence of Reactive Oxygen Species (ROS). This makes it a remarkably useful conjunctive in treating cancer, by enhancing the toxic effects of chemo drugs. Whilst Reactive Oxygen Species are harmful to cancers, they are also harmful for healthy tissue too.

If you can't quit alcohol, then I suggest an ALDH2 inhibitor, like Disulfiram. This way ALDH2 doesn't metabolize the toxic aldehydes after drinking alcohol, and the hangovers will be far worse. This encourages you quitting alcohol.
Tldr: don't drink alcohol on accutane cause your ALDH2 enzymes got better things to do than metabolize alcohol.

 
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good
 
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@Gaygymmaxx @AySab
 
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good thread
 
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is accutane even safe ? thats the bigger question
 
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you shouldnt drink alcohol anyways. Alcohol is a huge looksmin
 
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is accutane even safe ? thats the bigger question
Not gonna cause anything life threatening otherwise it wouldn't be approved to use, don't believe the fearmongerers with the 'lifelong lasting side effects'.

On the other hand is better to not take it obviously, but some of use don't have a choice.
 
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you shouldnt drink alcohol anyways. Alcohol is a huge looksmin
Drinking in general at public settings is okay.
But on this drug it's better not to.
 
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Alcohol is a powerful social lubricant, something you would really need when having subhuman acne. While the temporary escape from reality alcohol can give you would be welcomed, as well as the low inhibness, it's still really important to not give in to the temptations. In this thread I'll explain why.

Key points:

  • Isotretinoin is a slightly modified version of retinoic acid which is naturally produced by the body using enzymes including ALDHs.
  • By administering Isotretinoin, which converts into retinoic acid, the enzymes the body uses to naturally synthesise retinoic acid become downregulated.
  • This is likely on account of a negative feedback loop to counter the excessive retinoic acid signalling that during treatment with the acne drug.
  • This is likely on account of a negative feedback loop to counter the excessive retinoic acid signalling that during treatment with the acne drug.
  • Acetaldehyde is the cause of hangover and many of the side effects of Alcohol consumption.
  • By downregulating these detoxifying enzymes, Accutane puts us in a compromised position, so alcohol should be strictly prohibited during the treatment.
ALDH is needed for Alcohol metabolism
  • Isotretinoin is a retinoid, which means it is related to Vitamin A. It essentially works as a pro-drug for the main metabolite of Vitamin A called Retinoic Acid. Isotretinoin is simply a modified version of retinoic acid, which can be easily converted to retinoic within cells. In fact, Isotretinoin avoids stimulating a response from the enzymes (P450) that would other metabolise high doses of retinoic acid if administered directly. This simple process bypasses all the enzymes that the body uses to naturally synthesise retinoic acid from dietary sources of retinol.
  • Retinoic Acid is typically produced in the body in a two-stage process. First retinol is converted to retinal with enzymes called Alcohol/retinol dehydrogenases (ADH/RDH), and then retinal is oxidised to retinoic acid with the different Aldehyde Dehydrogenase (ALDH) isoforms expressed in different tissues. It's these ALDH enzymes that are so critical for understanding the effect of alcohol consumption during Accutane treatment.** They are a diverse family of enzymes with a broad spectrum of roles outside of the production of retinoic acid from maintaining vision to generating neurosteroids.
  • The function of ALDH enzymes which is perhaps best well known is in their de-toxifying effect, breaking down reactive aldehydes to much less harmful metabolites. Specifically, ALDH2, which oxidises acetaldehyde into the much less harmful acetic acid. Acetaldehyde is the toxic product of alcohol consumption which contributes to the negative symptoms of hangover.
Accutane downregulates ALDH
There's more and more evidence to show that treatment with Isotretinoin causes these ALDH enzymes to downregulate. This isn't surprising as negative feedback loops are often used throughout the body in an attempt to achieve homeostasis. The excessive retinoic acid signalling that occurs during Accutane treatment likely triggers a repression of the enzymes involved in the natural synthesis of retinoic acid, including ALDH. By marking ALDH enzymes for repression, Isotretinoin boosts the presence of Reactive Oxygen Species (ROS). This makes it a remarkably useful conjunctive in treating cancer, by enhancing the toxic effects of chemo drugs. Whilst Reactive Oxygen Species are harmful to cancers, they are also harmful for healthy tissue too.

If you can't quit alcohol, then I suggest an ALDH2 inhibitor, like Disulfiram. This way ALDH2 doesn't metabolize the toxic aldehydes after drinking alcohol, and the hangovers will be far worse. This encourages you quitting alcohol.
Tldr: don't drink alcohol on accutane cause your ALDH2 enzymes got better things to do than metabolize alcohol.

looks like ai maxxed
 
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JFL at anyone who drinks alcohol in general major looksmin
 
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I drank enough to get my bac to at least .08 under normal conditions on accutane multiple times and I was completely fine.

Even back to back nights
 
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This thread is beyond water tbh
 
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pls dont be an autist like i was at ur age and go drink with ur friends.

staying home/going out sober will ruin you in the long run.
 
  • JFL
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Alcohol is a powerful social lubricant, something you would really need when having subhuman acne. While the temporary escape from reality alcohol can give you would be welcomed, as well as the low inhibness, it's still really important to not give in to the temptations. In this thread I'll explain why.

Key points:

  • Isotretinoin is a slightly modified version of retinoic acid which is naturally produced by the body using enzymes including ALDHs.
  • By administering Isotretinoin, which converts into retinoic acid, the enzymes the body uses to naturally synthesise retinoic acid become downregulated.
  • This is likely on account of a negative feedback loop to counter the excessive retinoic acid signalling that during treatment with the acne drug.
  • This is likely on account of a negative feedback loop to counter the excessive retinoic acid signalling that during treatment with the acne drug.
  • Acetaldehyde is the cause of hangover and many of the side effects of Alcohol consumption.
  • By downregulating these detoxifying enzymes, Accutane puts us in a compromised position, so alcohol should be strictly prohibited during the treatment.
ALDH is needed for Alcohol metabolism
  • Isotretinoin is a retinoid, which means it is related to Vitamin A. It essentially works as a pro-drug for the main metabolite of Vitamin A called Retinoic Acid. Isotretinoin is simply a modified version of retinoic acid, which can be easily converted to retinoic within cells. In fact, Isotretinoin avoids stimulating a response from the enzymes (P450) that would other metabolise high doses of retinoic acid if administered directly. This simple process bypasses all the enzymes that the body uses to naturally synthesise retinoic acid from dietary sources of retinol.
  • Retinoic Acid is typically produced in the body in a two-stage process. First retinol is converted to retinal with enzymes called Alcohol/retinol dehydrogenases (ADH/RDH), and then retinal is oxidised to retinoic acid with the different Aldehyde Dehydrogenase (ALDH) isoforms expressed in different tissues. It's these ALDH enzymes that are so critical for understanding the effect of alcohol consumption during Accutane treatment.** They are a diverse family of enzymes with a broad spectrum of roles outside of the production of retinoic acid from maintaining vision to generating neurosteroids.
  • The function of ALDH enzymes which is perhaps best well known is in their de-toxifying effect, breaking down reactive aldehydes to much less harmful metabolites. Specifically, ALDH2, which oxidises acetaldehyde into the much less harmful acetic acid. Acetaldehyde is the toxic product of alcohol consumption which contributes to the negative symptoms of hangover.
Accutane downregulates ALDH
There's more and more evidence to show that treatment with Isotretinoin causes these ALDH enzymes to downregulate. This isn't surprising as negative feedback loops are often used throughout the body in an attempt to achieve homeostasis. The excessive retinoic acid signalling that occurs during Accutane treatment likely triggers a repression of the enzymes involved in the natural synthesis of retinoic acid, including ALDH. By marking ALDH enzymes for repression, Isotretinoin boosts the presence of Reactive Oxygen Species (ROS). This makes it a remarkably useful conjunctive in treating cancer, by enhancing the toxic effects of chemo drugs. Whilst Reactive Oxygen Species are harmful to cancers, they are also harmful for healthy tissue too.

If you can't quit alcohol, then I suggest an ALDH2 inhibitor, like Disulfiram. This way ALDH2 doesn't metabolize the toxic aldehydes after drinking alcohol, and the hangovers will be far worse. This encourages you quitting alcohol.
Tldr: don't drink alcohol on accutane cause your ALDH2 enzymes got better things to do than metabolize alcohol.

alcohol just sucks, shouldn’t be drinking it in the first place.
 
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  • JFL
Reactions: Deleted member 23558, Deleted member 27550 and Deleted member 65576
pls dont be an autist like i was at ur age and go drink with ur friends.

staying home/going out sober will ruin you in the long run.
??? We the same age?
 
  • JFL
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it should be common sense to limit alcohol consumption when looksmaxxing in general. You will fuck up ur looks with that shit
 
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it should be common sense to limit alcohol consumption when looksmaxxing in general. You will fuck up ur looks with that shit
Obviously. But on accutane it has way worse effects, so the people who only drink when going out, shouldn't drink even then.
 
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Shit thread

0/10
 
Jk man good thread
 
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Obviously. But on accutane it has way worse effects, so the people who only drink when going out, shouldn't drink even then.
Yes same with oral roids
 
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Yes same with oral roids
On accutane you shouldn't do anything really. Just thug it out until the acne is gone. Roids are especially bad cause most of them cause acne, so it's pretty counterproductive.
 
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