Wtf aromasin permanently deactivated aromatase enzymes

[Willmogulater]

Irreversible steroidal inhibitors, such as exemestane (Aromasin), forms a permanent and deactivating bond with the aromatase enzyme. Nonsteroidal inhibitors, such as the triazoles anastrozole (Arimidex) and letrozole (Femara), inhibit the synthesis of estrogen via reversible competition.

Does it mean even after stopping exemestane the enzymes won't get active I will try it to nuke my gyno

 

[Hernan]

i think its like a 0,2% permanent deactivation thing, not significant. letrozole here i come.

 

[Willmogulater]

i think its like a 0,2% permanent deactivation thing, not significant. letrozole here i come.

Not letrozole it says exemestane

 

[Hernan]

Not letrozole it says exemestane

do you know why?

 

[Willmogulater]

Idk

do you know why?

 

[Hernan]

Idk

@lestoa @org3cel.RR @Acromegaly_Chad @Orc ?

 

[Jason Voorhees]

i think its like a 0,2% permanent deactivation thing, not significant. letrozole here i come.

Why do u guys want to nuke your estrogen?

 

[Willmogulater]

Why do u guys want to nuke your estrogen?

I want to reduce gyno I am thinking of taking tamoxifen

 

[Hernan]

Why do u guys want to nuke your estrogen?

height stack nigga, now speak up.

 

[psychomandible]

Why do u guys want to nuke your estrogen?

.2 isn't really nuking it

 

[Mainlander]

It will come back
but it will take some time

 

[Willmogulater]

It will come back
but it will take some time

Should I take tamoxifen instead

 

[Mainlander]

Should I take tamoxifen instead

if you are taking it for gyno I would say yes

 

[Willmogulater]

if you are taking it for gyno I would say yes

The gyno is been there for some years I am thinking of taking 20 mg everyday 10 mg morning 10 mg night

 

[Jason Voorhees]

I want to reduce gyno I am thinking of taking tamoxifen

.2 isn't really nuking it

height stack nigga, now speak up.

There are better ways of stopping your growth plates from closing than using lestrol like Tamoxifen, Ralox even hgh Secretagogue can help

 

[Willmogulater]

There are better ways of stopping your growth plates from closing than using lestrol like Tamoxifen, Ralox even hgh Secretagogue can help

I tried ralox for gyno for a month didn't worked

 

[Jonasㅤㅤ]

There are better ways of stopping your growth plates from closing than using lestrol like Tamoxifen, Ralox even hgh Secretagogue can help

SERMs will nuke your growth plates. They literally bind selectively to the ER in certain tissues like growth plates.

@psychomandible @PsychoH @Willmogulater

 

[Hernan]

There are better ways of stopping your growth plates from closing than using lestrol like Tamoxifen, Ralox even hgh Secretagogue can help

@org3cel.RR ??

 

[Hernan]

SERMs will nuke your growth plates. They literally bind selectively to the ER in certain tissues like growth plates.

@psychomandible @PsychoH @Willmogulater

so stick to letro?

 

[Jonasㅤㅤ]

so stick to letro?

Nope, Exemestan is superior to manage E2 levels. I wouldn't nuke my E2 personally as that can cause many problems. Just microdose Exemestan and you're good.

 

[Jason Voorhees]

SERMs will nuke your growth plates. They literally bind selectively to the ER in certain tissues like growth plates.

@psychomandible @PsychoH @Willmogulater

Yes but still better than letro. Aromasin is the best but it is expensive

 

[TsarTsar444]

That just means the enzyme which make estrogen are permanently inhibited but not new enzymes that are going to be made in the body. If you stop the drug it would take 15 days to fully saturate your body with functional enzymes, its not permanent. Irreversible MAOIs also work this way

 

[Hernan]

Nope, Exemestan is superior to manage E2 levels. I wouldn't nuke my E2 personally as that can cause many problems. Just microdose Exemestan and you're good.

for max height growth and open plate time?
are you sure?

 

[org3cel.RR]

@lestoa @org3cel.RR @Acromegaly_Chad @Orc ?

Its a good thing dont worry

 

[org3cel.RR]

@lestoa @org3cel.RR @Acromegaly_Chad @Orc ?

It can have a longer “tail effect” compared to reversible inhibitors.
Estrogen levels typically recover over weeks to months once the drug is discontinued depending on your dose, metabolism, and overall health.

 

[org3cel.RR]

@org3cel.RR ??

Yes @Jason Voorhees is right, theres better ways of stopping growth plates from closing other then using an aromasin
Stronger stuff like letro, gh secragogues etc

 

[org3cel.RR]

@Jonas2k7 what did I say that was wrong

 

[Jonasㅤㅤ]

@Jonas2k7 what did I say that was wrong

Not helping anymore publicly unless I feel like doing so, PM me if you or @PsychoH want to know stuff.

 

[org3cel.RR]

Not helping anymore publicly unless I feel like doing so, PM me if you or @PsychoH want to know stuff.

Your dms are blocked, pm me

 

[Hitlerstopguy05]

Irreversible steroidal inhibitors, such as exemestane (Aromasin), forms a permanent and deactivating bond with the aromatase enzyme. Nonsteroidal inhibitors, such as the triazoles anastrozole (Arimidex) and letrozole (Femara), inhibit the synthesis of estrogen via reversible competition.

Does it mean even after stopping exemestane the enzymes won't get active I will try it to nuke my gyno

The body will just make other enzymes