You guys are sleeping on selegelline (the ultimate nootropic)

[william_wallace]

Selegiline is an irreversible MAO-B inhibitor that remains highly selective for the MAO-B enzyme at standard oral doses below 10 mg per day. Because it binds irreversibly, the enzyme it attaches to is essentially taken out of commission until the body synthesizes new MAO-B — a process that generally takes 10–14 days. MAO-B’s main job in the brain is to break down dopamine. When selegiline blocks it, less dopamine is metabolized and more dopamine remains available. By preventing dopamine from being broken down, selegiline effectively enhances dopaminergic signaling in the brain. With more dopamine remaining available in synapses for longer, dopaminergic neurons can maintain stronger and more sustained communication. This boost in dopamine tone supports motor function and other dopamine-dependent processes without directly forcing dopamine release. It works purely by preserving the dopamine that’s already there.

When dopamine is broken down by MAO-B, the process produces several potentially toxic by-products, including hydrogen peroxide and DOPAL. These oxidative metabolites can contribute to oxidative stress and cellular damage, especially in dopamine-rich areas of the brain. By inhibiting MAO-B, selegiline not only keeps dopamine around longer but also reduces the formation of these oxidative by-products, which is one of the reasons it has been explored for possible neuroprotective effects.

Because selegiline increases the availability of dopamine, many of its effects in humans stem from this enhanced dopaminergic signalling. In clinical contexts, supporting dopamine pathways can help improve motivation, initiative, mood, and cognitive drive, since dopamine plays a key role in reward, goal-directed behaviour, and mental energy. Some individuals also report improvements in libido or overall interest and engagement in daily activities, which aligns with dopamine’s involvement in pleasure, desire, and reinforcement.

With doses below 10mg orally per day it remains largely selective for mao B inhibiting nearly 100% of the enzyme at this dose. Some minor MAO A inhibition may occur at this dose but not irreversibly and only by a small amount. At doses below 10mg daily tyramine diet restriction is not required but may be wise to avoid food sources exceptionally high in tyramine. Combining selgelline and stimulants should be approached with caution as selegelline will potentiate any dopaminergic drug even nicotine or caffeine. If your taking other substances please ensure its safe to combine with selegeline. Also other dosing routes such as sublingual or transdermal can result in higher bioavailability meaning loss of selectivity for MAO-B could occur at lower doses. Let me know what you guys think. I have personally been taking selegeline for months now and have noticed a huge increase in focus, motivation, libido and overall mood. It has been a game changer for me

 

[alexias]

Posted first in offtopic

 

[william_wallace]

I wasnt sure which thread to post in tbh. I can remove original

 

[jeoyw9192]

Selegiline is an irreversible MAO-B inhibitor that remains highly selective for the MAO-B enzyme at standard oral doses below 10 mg per day. Because it binds irreversibly, the enzyme it attaches to is essentially taken out of commission until the body synthesizes new MAO-B — a process that generally takes 10–14 days. MAO-B’s main job in the brain is to break down dopamine. When selegiline blocks it, less dopamine is metabolized and more dopamine remains available. By preventing dopamine from being broken down, selegiline effectively enhances dopaminergic signaling in the brain. With more dopamine remaining available in synapses for longer, dopaminergic neurons can maintain stronger and more sustained communication. This boost in dopamine tone supports motor function and other dopamine-dependent processes without directly forcing dopamine release. It works purely by preserving the dopamine that’s already there.

When dopamine is broken down by MAO-B, the process produces several potentially toxic by-products, including hydrogen peroxide and DOPAL. These oxidative metabolites can contribute to oxidative stress and cellular damage, especially in dopamine-rich areas of the brain. By inhibiting MAO-B, selegiline not only keeps dopamine around longer but also reduces the formation of these oxidative by-products, which is one of the reasons it has been explored for possible neuroprotective effects.

Because selegiline increases the availability of dopamine, many of its effects in humans stem from this enhanced dopaminergic signalling. In clinical contexts, supporting dopamine pathways can help improve motivation, initiative, mood, and cognitive drive, since dopamine plays a key role in reward, goal-directed behaviour, and mental energy. Some individuals also report improvements in libido or overall interest and engagement in daily activities, which aligns with dopamine’s involvement in pleasure, desire, and reinforcement.

With doses below 10mg orally per day it remains largely selective for mao B inhibiting nearly 100% of the enzyme at this dose. Some minor MAO A inhibition may occur at this dose but not irreversibly and only by a small amount. At doses below 10mg daily tyramine diet restriction is not required but may be wise to avoid food sources exceptionally high in tyramine. Combining selgelline and stimulants should be approached with caution as selegelline will potentiate any dopaminergic drug even nicotine or caffeine. If your taking other substances please ensure its safe to combine with selegeline. Also other dosing routes such as sublingual or transdermal can result in higher bioavailability meaning loss of selectivity for MAO-B could occur at lower doses. Let me know what you guys think. I have personally been taking selegeline for months now and have noticed a huge increase in focus, motivation, libido and overall mood. It has been a game changer for me

Thoughts @hej1377

 

[hej1377]

Thoughts @hej1377

Ive actuslly been at the moment looking into mao-b inhibitors and they seem pretty good

I think the natural comparison is between them and buprupione and it kinda seems as if selegiline is cleaner while buprupione is more dopamine focused, i might try them as ive been using low dose buprupione(75-100mg) and see how they compare but it seems like at this point atleast in my research buprupione is better for me as im not full out adhd/add but im still leaning towards some add symptoms and that dopamine is highly needed for maximized focus

I think tho maybe at some point if i get a job or in uni and i need to focus for longer amounts of time ill switch to mao-b inhib+adderal/modafinil to be gentler on my brain and not be overstimulated or get raped by neural adaptation long term

 

[william_wallace]

Ive actuslly been at the moment looking into mao-b inhibitors and they seem pretty good

I think the natural comparison is between them and buprupione and it kinda seems as if selegiline is cleaner while buprupione is more dopamine focused, i might try them as ive been using low dose buprupione(75-100mg) and see how they compare but it seems like at this point atleast in my research buprupione is better for me as im not full out adhd/add but im still leaning towards some add symptoms and that dopamine is highly needed for maximized focus

I think tho maybe at some point if i get a job or in uni and i need to focus for longer amounts of time ill switch to mao-b inhib+adderal/modafinil to be gentler on my brain and not be overstimulated or get raped by neural adaptation long term

The metabolites of oral selegelline are levo amphetamine/levo methamphetamine. I feel they add something to the experience at 10mg daily

 

[hej1377]

The metabolites of oral selegelline are levo amphetamine/levo methamphetamine. I feel they add something to the experience at 10mg daily

Yeah but its l-isomers that are pretty weak

 

[william_wallace]

Yeah but its l-isomers that are pretty weak

They are. But i still feel at the 10mg dose they add something to the experience

 

[dudebroguy]

I wonder how this would go paired with TRT as this also increases dopamine in the brain I think. I'm going to look into this one, it sounds fun.

 

[failed normie]

I experimented with 2,5 -5mg sublingual dosages but it didn't do anything for me

 

[william_wallace]

I experimented with 2,5 -5mg sublingual dosages but it didn't do anything for me

How long did you take it for? Also did you use the sublingual formulation? Because crushing up a tablet and placing it under your tongue is not nearly as effective as a sublingual formulation. You likely didnt absorb much this way

 

[failed normie]

How long did you take it for? Also did you use the sublingual formulation? Because crushing up a tablet and placing it under your tongue is not nearly as effective as a sublingual formulation. You likely didnt absorb much this way

nope its expilcitly stated that you should take it orally so thats probably an issue. I tried it on 2 seperate ocassions for 3 days always in the morning on empty stomach: 1st time frame: 5mg orally, 2,5mg sublingually, 5mg sublingually; 2nd time frame: 2,5mg sublingually every day. it did not do anything for me and when i asked ai it said that you can feel the effects within a few minutes

 

[william_wallace]

nope its expilcitly stated that you should take it orally so thats probably an issue. I tried it on 2 seperate ocassions for 3 days always in the morning on empty stomach: 1st time frame: 5mg orally, 2,5mg sublingually, 5mg sublingually; 2nd time frame: 2,5mg sublingually every day. it did not do anything for me and when i asked ai it said that you can feel the effects within a few minutes

3 days.. you realise this stuff takes weeks to start working?

 

[failed normie]

3 days.. you realise this stuff takes weeks to start working?

i have a few pills left how much do you recommend daily? and for how long should i take it until i notice the first effects?

 

[Julienmc]

where do you get it?

 

[Hans88]

Selegiline is an irreversible MAO-B inhibitor that remains highly selective for the MAO-B enzyme at standard oral doses below 10 mg per day. Because it binds irreversibly, the enzyme it attaches to is essentially taken out of commission until the body synthesizes new MAO-B — a process that generally takes 10–14 days. MAO-B’s main job in the brain is to break down dopamine. When selegiline blocks it, less dopamine is metabolized and more dopamine remains available. By preventing dopamine from being broken down, selegiline effectively enhances dopaminergic signaling in the brain. With more dopamine remaining available in synapses for longer, dopaminergic neurons can maintain stronger and more sustained communication. This boost in dopamine tone supports motor function and other dopamine-dependent processes without directly forcing dopamine release. It works purely by preserving the dopamine that’s already there.

When dopamine is broken down by MAO-B, the process produces several potentially toxic by-products, including hydrogen peroxide and DOPAL. These oxidative metabolites can contribute to oxidative stress and cellular damage, especially in dopamine-rich areas of the brain. By inhibiting MAO-B, selegiline not only keeps dopamine around longer but also reduces the formation of these oxidative by-products, which is one of the reasons it has been explored for possible neuroprotective effects.

Because selegiline increases the availability of dopamine, many of its effects in humans stem from this enhanced dopaminergic signalling. In clinical contexts, supporting dopamine pathways can help improve motivation, initiative, mood, and cognitive drive, since dopamine plays a key role in reward, goal-directed behaviour, and mental energy. Some individuals also report improvements in libido or overall interest and engagement in daily activities, which aligns with dopamine’s involvement in pleasure, desire, and reinforcement.

With doses below 10mg orally per day it remains largely selective for mao B inhibiting nearly 100% of the enzyme at this dose. Some minor MAO A inhibition may occur at this dose but not irreversibly and only by a small amount. At doses below 10mg daily tyramine diet restriction is not required but may be wise to avoid food sources exceptionally high in tyramine. Combining selgelline and stimulants should be approached with caution as selegelline will potentiate any dopaminergic drug even nicotine or caffeine. If your taking other substances please ensure its safe to combine with selegeline. Also other dosing routes such as sublingual or transdermal can result in higher bioavailability meaning loss of selectivity for MAO-B could occur at lower doses. Let me know what you guys think. I have personally been taking selegeline for months now and have noticed a huge increase in focus, motivation, libido and overall mood. It has been a game changer for me

Ngl, good thread. Interested in implementing something like that into my stimulant cycling. I have a few questions, how much time does it take for it to start working, and how much time does it take to be completely out of your system so you can start taking other stimulants again? Also, did you notice any appetite suppression from it, and if you did, how strong is it?