Your first cycle guide. A deep dive into roids, sarms, HGH and more. The truth about how to start your first guide

Aryan Incel

Aryan Incel

Platinum
Joined
Apr 30, 2025
Posts
1,075
Reputation
1,374
Your first cycle guide. A deep dive into roids, sarms, HGH and more. The truth about how to start your first guide

IMG 7566

This thread will go over the best way to do a cycle and will go over copes, sarms, AAS and more.

Most of the info has been found through lurking through @Zagro @SlayerJonas @chadisbeingmade threads

In 1998, researchers discovered a new class of non-steroidal compounds, the SARMs. These compounds selectively stimulate the androgen receptor, offering potent effects on bone and muscle to increase bone density and lean body mass while having minimal impact on reproductive tissues.
IMG 7564


Rad 140



Dosing 10mg per day



Rating (as a SARM) 5/10



How it works:

It specifically affects ARs in muscles and bones, activating them for muscle protein synthesis and cell growth. Its structure optimizes interactions, ends up leading to positive changes in gene expression related to muscle development and satellite cell proliferation.



A strong sarm with very good muscle gaining ability. And giving mostly dry muscle gains.



However Very strong hair loss is common with it putting big strain on your cardiovascular system and liver.



All in all rad 140 upsides do not outweigh the downsides, as many other sarms have similar upsides with nowhere near as bad downsides



S23



How it works:

S-23 activates ARs in muscles, stimulating protein synthesis and satellite cell activation, with some androgenic effects on reproductive tissues.



Dosing 10 mg per day



Rating 6/10



It’s the most powerful sarm

And you get the most amount of gains on this sarm. However it completely test shutdown you’ll need to get a proper test base and probably TRT. It also will fuck up your liver and your hair



I would not recommend S23 especially for beginners as there aren’t really much more benefits than the others and at this point you’d be better to do AAS instead



Lgd 4033



Its targeting of ARs in muscles and bones is caused by its molecular structure. This interaction prompts changes in the receptor, influencing gene expression for muscle growth and bons .



Dosing 10mg every day



Rating 9/10



My personal favorite sarm, and the one I think mogs all the others



Muscle gains are similar to rad but usually not full dry mass (some water weight)



Only 1-2% experience balding on this sarm(dut should be taken as well for preventative measures)



https://muscleandbrawn.com/sarms/sarms-hair-loss/



However it is toxic to the liver but less so than Rad 140 and you can get a LGD flu but it passes after a week



To conclude I’d recommend Lgd 4033 to all beginners or people doing a Sarms cycle



MK677 (not a sarm but I’m including anyway as people might use them)



Rating 0/10



How it works

it stimulates the growth hormone secretagogue receptor (GHSR), releasing growth hormone (GH) and insulin-like growth factor 1



Very mid gains and it will basically only make you bloated.
Your SARM cycle should last 8 weeks with a PCT of Enclo ED (12.5 mg) starting for 2 weeks before (boost to 25 mg for the days prior) and 2 weeks after. Remember to take 20 mg of accutane and 2.5 mg of Dutasteride while on the cycle.
Some sarms are useful and should be used as a stepping stone to AAS, but they get brutally mogged by AAS and shouldn’t be anymore than just your first cycle

Testosterone was isolated in the 1930s, and numerous synthetic androgens were quickly developed thereafter. Athletes soon discovered the dramatic anabolic effects of these hormones, and AAS spread rapidly through elite athletics and bodybuilding from the 1950s through the 1970s
Anavar



Dosing 20 mg every day



Rating (as a AAS) 4/10



How it works



is a synthetic anabolic steroid that works primarily by binding to androgen receptors inside muscle cells. Once activated, these receptors increase protein synthesis, promote lean muscle growth, and enhance nitrogen retention.



Some positives are you take pill so no injection which some can be scared of jfl. decent muscle growth mogs SARMS but not as good as test. The downside is it pretty much has the same downsides as test but is worse at muscle gains.



Test E



Dosing 500mg- 1g per week



Rating 8/10



How it works



works by acting as a long-lasting reservoir of testosterone in the body. When injected, the enanthate ester is slowly released from an oil depot, then broken down by enzymes to release free testosterone. This restores the body's testosterone levels, producing anabolic effects like increased muscle mass and bone density.



Mogger AAS and the best imo. Extremely good muscle gain with a very good rep. However bloat on it is fairly common so make sure to use over 200 mg of Epleronone to counter it. Some downsides are lower fertility, hairloss and acne. But all can be easily countered if done correctly.


Masterone



Rating 0/10



How it works



It Binds Strongly to Androgen Receptors (AR), Masteron is a highly androgenic compound, meaning it directly activates androgen receptors in muscle tissue and fat cells.



Some positives are it Hardens Muscles & Reduces Softness, Masteron’s DHT-like effects make muscles feel solid, dense, and dry. It pulls water from under the skin, which makes veins pop more and muscle striations stand out.



However it should never be taken under any circumstance as it heavily ages you
First have your estrogen checked and if youre estrogen is too high use an Aromatase inhibitor.

Next your cycle should last 20 weeks and look like this-



AAS of choice

5 IU’s of HGH (I’ll explain in the HGH section)

20 mg of accutane

2.5 mg of Dutasteride

AI of your choice if needed



After the cycle you should go on TRT use test e and dose 100 mg 2 times a week (e.g Wednesday and Sunday)

Most of the info about this section came from @Zagro thread
Human growth hormone (HGH) is a peptide hormone crucial for growth and metabolism in humans. Its discovery traces back to the 1920s, with significant advancements made in the mid-20th century when researchers like Choh Hao Li isolated growth hormones from various species, including humans.
Biggest reason why you should take it from a roiders perspective is it allows more lean mass to be gained on bulls rather than fat



Some cons are:



Bloat : Bloat on HGH happens mainly because HGH increases water retention by boosting sodium retention and raising levels of a hormone called aldosterone, leading to fluid buildup in the skin and tissues.

Study: https://pubmed.ncbi.nlm.nih.gov/11932310/



Cartilage Growth : This happens because of higher IGF-1 levels and cartilage in for example the nose and the ears are very sensitive to IGF-1 and are the first bones to show noticeable effect this and grow in size due to this.



Drains Thyroid : HGH increases the conversion of T4 to T3, making the thyroid work harder and eventually causing it to slow down if not supported.

Study: https://pubmed.ncbi.nlm.nih.gov/34012834/



Hyperglycemia : HGH lowers insulin sensitivity, so you need carbs to prevent low blood sugar. 10-15 grams of carbs per IU keeps your blood sugar stableand avoids symptoms like shakiness and dizziness.



But they are really very rare on lowish doses (<10 IU).
6-8 IU every day
Taking HGH will real help you gym maxxing as it’s not risky and has great benefits

Contrary to popular belief it isnt quite a simple as calories in calories out and there’s much simpler ways. I got most of this section from @chadisbeingmade
What is it?

To put it as simply as possible, it's just an apatite suppressant. It is a GLP-1 receptor agonist medication used to treat type 2 diabetes and obesity. It works by mimicking the natural hormone GLP-1. Semaglutide is a single agonist. It only effects GLP-1R (GLP-1 receptors). It has the highest affinity for its target site. Semaglutide is about 94% identical to human produced GLP-1. GLP-1 has multiple effects. To mention a few it decreased hunger and food noise, delayed gastric emptying, increased satiety, decreased glucagon secretion, increased pancreatic beta cell function.



Effects on muscle mass

Out of the 3 main GLP-1 Agonists, Semaglutide has the worst muscle wastage to fat loss ratio compared to the other agonists. This is because it doesn't have the other methods of action that will help to relieve side effects and improve nutrient partitioning (amongst other things) to preserve lean mass. The muscle mass loss can be mitigated to a large degree by making sure you continue to have a high protein diet (which may be hard if you want to puke every time you eat), and continue weight training. The drug itself is not muscle wasting like some people seem to believe. The muscle loss is a direct cause of the aggressive deficit.



The side effects of Semaglutide

The most common would be Nausea which is experienced by around 43.9% of users on this highest dosage of Semaglutide (2.4mg). Vomiting, Diarrhoea, Abdominal pain and constipation are amongst the most common side effects. You may feel sick every time you think about eating, which is a large reason why it works, but obviously this is not ideal. Semaglutide has the harshest side effects out of the 3
What is it?

Tirzepatide isn’t actually GLP-1. It’s actually a 39 amino acid modified GIP molecule that has GLP-1 activity added to the molecule. That is why we call it a dual agonist. It’s having an effect on two incretin receptors. That means Tirzepatide is binding to the native GIP-R (GIP receptor) with essentially equal affinity as our body’s own GIP molecule. However, the GLP-1 binding is about 5 times weaker than what our body creates. It is an imbalanced dual agonist with preferential activity at GIP over GLP-1. This means that mg for mg, compared to Semaglutide, it will reduce apatite to a much greater degree than Tirzepatide since the drug is a full agonist of GIP-R, and only a partial agonist of GLP-1R. That partial agonist effect means you’re not fully saturating the receptor site, which means you don’t get the full effect.



The benefits of being a GIP Agonist

There are multiple benefits to GIP (glucose-dependent insulinotropic polypeptide) Agonism that Semaglutide don't produce. GIP is another hormone involved in glucose metabolism. It has an anti-emetic/anti-nausea effect which explain why some people experience less side effects. Like GLP-1, it promotes insulin secretion in response to high blood glucose levels. However, GIP has also been shown to have effects on fat metabolism and energy balance. It also has other effects, it is neuroprotective, increases bone formation, decreases stomach acid secretion, increases insulin release.



Effects on muscle mass and bodyweight

In a study comparing the weight loss effects of Semaglutide and Tirzepatide, it was found that a larger proportion of patients on Tirzepatide achieved significant weight loss.

Spoiler

In terms of lean mass preservation Tirzepatide does seem to preserve more than Semaglutide users.



The side effect of Tirzepatide

The side effect profile is very much the same as Semaglutide. The side effects are typically less severe than Semaglutide allowing it to be a much more sustainable to run long term. The main side effects still are Nausea, Vomiting, Diarrhoea, Abdominal pain and constipation.



Who should run Tirzepatide?

Well, in my opinion no one, due to the existence of Retatutide (which I will explain next) which makes Tirzepatide redundant. There is a reason I do not say that Semaglutide is redundant which I will get into later on in this thread, since it can be utilised well in specific scenarios. The only reason one could consider retatrutide is due to cost issues and it being less costly than Retatrutide. But with proper sourcing you can a year supply of the superior drug for very cheap. If your are going to a run a GLP-1 year round and you cannot get your hands on retatrutide for whatever reason, Tirzepatide is your best bet.



Tirzepatide dosage protocol

4925991_1746446291418.png
What is it?

Retatrutide's a triple agonist, acting on GLP-1R, GIP-R and glucagon receptors (GCGR). Structurally, it is nearly identical to Tirzepatide. It is also a 39 amino acid modified GIP molecule but with changes to the amino acid structure to allow for activity at the GCGR site as well. It is also an imbalanced agonist. It is 8.9 fold more potent at GIP-R than human GIP. So this drug is way more potent than Tirzepatide at GIP-R agonism which means it further enhances any of the GIP-R effects and the GLP-1 effects in a synergistic manner.



Who should use Retatrutide?

Everyone. Everyone should use it. Even if you have already reached your goal body fat I would (and am currently) run Retatrutide year round to improve lipids and all your healthy blood markers and allow you to effortlessly maintain your current level of leanness.



Retatrutide dosage protocol

I would recommend starting at 1mg and titrating your way up as necessary. High dose Retatrutide can have it's benefits such as burning a few extra hundred calories through other mechanisms of lipolysis. If you want to use high dose Retatrutide, I would recommend between 5-10mg every week.
How DNP works

DNP works by increasing metabolism through inhibiting the mitochondria from making adenosine triphosphate (ATP), which results in heat being produced instead of ATP. So put that simply in the most basic way possible, it prevents energy from being stored as fat burning it as heat instead.



DNP side effect profile

You will be sweating.

You will experience facial bloating on cycle that will resolve 1 week after your cycle ends.

You may experience a slight rash on cycle. Sometimes you'll get it, sometimes you won't. It is harmless. Use anti-histamine if you want.

Your thyroid will be tanked for 1-2 weeks after your cycle, so keep calories low for those 2 weeks to not regain fat is a good idea. (T3 replacement can also be run with the cycle).

Your apatite will go crazy, and you will mainly crave carbohydrates (solution below)



DNP effects on muscle mass

DNP is protein sparing. It only uses fats and carbs for energy. Your strength will decrease on cycle, that is because you are completely glycogen depleted and your cells are essential in overdrive. Once you carb up and DNP leaves your system you will regain your strength.



How much does DNP increase your TDEE?

DNP increases your TDEE, not your BMR. This means it acts as a multiplicator for any activity that you do. DNP powder will increase your TDEE by ~15% and crystal will increase your TDEE by ~11% for every 100mg consumed after the DNP has built up in your system which is after about 5-6 days unless you front load it, which I would not recommend due to the fact that dealers may miss dose the DNP and you could be consuming more than you think, which can be fatal if you are at high dosages.



DNP dosage protocol

Always start low and titrate DNP up for the reason I just mentioned. 200mg will give help you out, but 400mg mogs everything to oblivion. Do not exceed 600mg, ESPECIALLY after you have reached peak DNP concentration of a certain dose at around day 5. If you are looking for good steady weight loss 200mg is a perfect dosage that will give you all the benefits with minimal heat and side effects.



The best way to run DNP

DNP solo is great, it does what it says. The only problem is that DNP will ramp up your apatite to another level. You will feel orgasmic whilst eating an apple. This can lead to you uncountably eating. To combat this using a GLP-1 Agonist is ideal. The GLP-1 Agonist as discussed above will nuke your apatite and the DNP will ramp up your metabolism. I would recommend using either Semaglutide or Tirzepatide due to the fact they are just more potent apatite suppressors than Retatutide. We do not really care for the increased metabolic effects that Retatutude would give, since we have given that job to DNP, we just need the apatite to be gone.



Benefits of running DNP

At the end of the cycle, with DNP and GLP-1 Agonists you will be left disgustingly insulin sensitive since DNP sensitizes insulin

Obviously you will become dick skin shredded

DNP releases releases a tonne of PUFA

DNP is neurogenic

DNP is anti-catabolic

DNP removes visceral fat first

Some DNP studies show that is may have protective effects on mitochondria
Run DNP with either Tirzepatide or Semaglutide and run Reta for once you reach your ideal bf (<10%)

Do a sarms cycle as your first cycle,

Then do a AAS cycle for the rest

Remember to add HGH, Reta, Epleronone, Dutasteride and Accutane for best results

And run DNP with either Tirzepatide or Semaglutide if you’re cutting

And then just do TRT and chill

@edodalic29 @Copercel @SlayerJonas @chadisbeingmade @Iplamephiltrum @Orc
@enchanted_elixir @Gengar @Stacyslayerᛉ @FlotPSL @iblamegenetics7681 @BigBallsLarry @Lars2 @FutureExoticChad @MaracasMogs
 
Last edited:
  • +1
  • Love it
Reactions: placeholde_r, Sadist, FutureExoticChad and 11 others
dr. good thread :feelsokman:
 
  • +1
  • Love it
Reactions: FutureExoticChad, MaracasMogs, Luca_. and 4 others
Dnr

Looks high effort :feelsyay:
 
  • +1
  • Love it
Reactions: MaracasMogs, Luca_., Zagro and 2 others
Your first cycle guide. A deep dive into roids, sarms, HGH and more. The truth about how to start your first guide

View attachment 4121947
This thread will go over the best way to do a cycle and will go over copes, sarms, AAS and more.

Most of the info has been found through lurking through @Zagro @SlayerJonas @chadisbeingmade threads

In 1998, researchers discovered a new class of non-steroidal compounds, the SARMs. These compounds selectively stimulate the androgen receptor, offering potent effects on bone and muscle to increase bone density and lean body mass while having minimal impact on reproductive tissues.
View attachment 4121892

Rad 140



Dosing 10mg per day



Rating (as a SARM) 5/10



How it works:

It specifically affects ARs in muscles and bones, activating them for muscle protein synthesis and cell growth. Its structure optimizes interactions, ends up leading to positive changes in gene expression related to muscle development and satellite cell proliferation.



A strong sarm with very good muscle gaining ability. And giving mostly dry muscle gains.



However Very strong hair loss is common with it putting big strain on your cardiovascular system and liver.



All in all rad 140 upsides do not outweigh the downsides, as many other sarms have similar upsides with nowhere near as bad downsides



S23



How it works:

S-23 activates ARs in muscles, stimulating protein synthesis and satellite cell activation, with some androgenic effects on reproductive tissues.



Dosing 10 mg per day



Rating 6/10



It’s the most powerful sarm

And you get the most amount of gains on this sarm. However it completely test shutdown you’ll need to get a proper test base and probably TRT. It also will fuck up your liver and your hair



I would not recommend S23 especially for beginners as there aren’t really much more benefits than the others and at this point you’d be better to do AAS instead



Lgd 4033



Its targeting of ARs in muscles and bones is caused by its molecular structure. This interaction prompts changes in the receptor, influencing gene expression for muscle growth and bons .



Dosing 10mg every day



Rating 9/10



My personal favorite sarm, and the one I think mogs all the others



Muscle gains are similar to rad but usually not full dry mass (some water weight)



Only 1-2% experience balding on this sarm(dut should be taken as well for preventative measures)



https://muscleandbrawn.com/sarms/sarms-hair-loss/



However it is toxic to the liver but less so than Rad 140 and you can get a LGD flu but it passes after a week



To conclude I’d recommend Lgd 4033 to all beginners or people doing a Sarms cycle



MK677 (not a sarm but I’m including anyway as people might use them)



Rating 0/10



How it works

it stimulates the growth hormone secretagogue receptor (GHSR), releasing growth hormone (GH) and insulin-like growth factor 1



Very mid gains and it will basically only make you bloated.
Your SARM cycle should last 8 weeks with a PCT of Enclo ED (12.5 mg) starting for 2 weeks before (boost to 25 mg for the days prior) and 2 weeks after. Remember to take 20 mg of accutane and 2.5 mg of Dutasteride while on the cycle.
Some sarms are useful and should be used as a stepping stone to AAS, but they get brutally mogged by AAS and shouldn’t be anymore than just your first cycle

Testosterone was isolated in the 1930s, and numerous synthetic androgens were quickly developed thereafter. Athletes soon discovered the dramatic anabolic effects of these hormones, and AAS spread rapidly through elite athletics and bodybuilding from the 1950s through the 1970s
Anavar



Dosing 20 mg every day



Rating (as a AAS) 4/10



How it works



is a synthetic anabolic steroid that works primarily by binding to androgen receptors inside muscle cells. Once activated, these receptors increase protein synthesis, promote lean muscle growth, and enhance nitrogen retention.



Some positives are you take pill so no injection which some can be scared of jfl. decent muscle growth mogs SARMS but not as good as test. The downside is it pretty much has the same downsides as test but is worse at muscle gains.



Test E



Dosing 500mg- 1g per week



Rating 8/10



How it works



works by acting as a long-lasting reservoir of testosterone in the body. When injected, the enanthate ester is slowly released from an oil depot, then broken down by enzymes to release free testosterone. This restores the body's testosterone levels, producing anabolic effects like increased muscle mass and bone density.



Mogger AAS and the best imo. Extremely good muscle gain with a very good rep. However bloat on it is fairly common so make sure to use over 200 mg of Epleronone to counter it. Some downsides are lower fertility, hairloss and acne. But all can be easily countered if done correctly.



Test P



Dosing 500 mg per wek



Rating 6/10



Worse gains and shorter half life than test e but less bloat. I think test e mogs but if you’re really scared of the bloat it’s a potential option



Masterone



Rating 0/10



How it works



It Binds Strongly to Androgen Receptors (AR), Masteron is a highly androgenic compound, meaning it directly activates androgen receptors in muscle tissue and fat cells.



Some positives are it Hardens Muscles & Reduces Softness, Masteron’s DHT-like effects make muscles feel solid, dense, and dry. It pulls water from under the skin, which makes veins pop more and muscle striations stand out.



However it should never be taken under any circumstance as it heavily ages you
First have your estrogen checked and if youre estrogen is too high use an Aromatase inhibitor.

Next your cycle should last 20 weeks and look like this-



AAS of choice

5 IU’s of HGH (I’ll explain in the HGH section)

20 mg of accutane

2.5 mg of Dutasteride

AI of your choice if needed



After the cycle you should go on TRT use test e and dose 100 mg 2 times a week (e.g Wednesday and Sunday)

Most of the info about this section came from @Zagro thread
Human growth hormone (HGH) is a peptide hormone crucial for growth and metabolism in humans. Its discovery traces back to the 1920s, with significant advancements made in the mid-20th century when researchers like Choh Hao Li isolated growth hormones from various species, including humans.
Biggest reason why you should take it from a roiders perspective is it allows more lean mass to be gained on bulls rather than fat



Some cons are:



Bloat : Bloat on HGH happens mainly because HGH increases water retention by boosting sodium retention and raising levels of a hormone called aldosterone, leading to fluid buildup in the skin and tissues.

Study: https://pubmed.ncbi.nlm.nih.gov/11932310/



Cartilage Growth : This happens because of higher IGF-1 levels and cartilage in for example the nose and the ears are very sensitive to IGF-1 and are the first bones to show noticeable effect this and grow in size due to this.



Drains Thyroid : HGH increases the conversion of T4 to T3, making the thyroid work harder and eventually causing it to slow down if not supported.

Study: https://pubmed.ncbi.nlm.nih.gov/34012834/



Hypoglycemia : HGH lowers insulin sensitivity, so you need carbs to prevent low blood sugar. 10-15 grams of carbs per IU keeps your blood sugar stableand avoids symptoms like shakiness and dizziness.



But they are really very rare on lowish doses (<10 IU).
6-8 IU every day
Taking HGH will real help you gym maxxing as it’s not risky and has great benefits

Contrary to popular belief it isnt quite a simple as calories in calories out and there’s much simpler ways. I got most of this section from @chadisbeingmade
What is it?

To put it as simply as possible, it's just an apatite suppressant. It is a GLP-1 receptor agonist medication used to treat type 2 diabetes and obesity. It works by mimicking the natural hormone GLP-1. Semaglutide is a single agonist. It only effects GLP-1R (GLP-1 receptors). It has the highest affinity for its target site. Semaglutide is about 94% identical to human produced GLP-1. GLP-1 has multiple effects. To mention a few it decreased hunger and food noise, delayed gastric emptying, increased satiety, decreased glucagon secretion, increased pancreatic beta cell function.



Effects on muscle mass

Out of the 3 main GLP-1 Agonists, Semaglutide has the worst muscle wastage to fat loss ratio compared to the other agonists. This is because it doesn't have the other methods of action that will help to relieve side effects and improve nutrient partitioning (amongst other things) to preserve lean mass. The muscle mass loss can be mitigated to a large degree by making sure you continue to have a high protein diet (which may be hard if you want to puke every time you eat), and continue weight training. The drug itself is not muscle wasting like some people seem to believe. The muscle loss is a direct cause of the aggressive deficit.



The side effects of Semaglutide

The most common would be Nausea which is experienced by around 43.9% of users on this highest dosage of Semaglutide (2.4mg). Vomiting, Diarrhoea, Abdominal pain and constipation are amongst the most common side effects. You may feel sick every time you think about eating, which is a large reason why it works, but obviously this is not ideal. Semaglutide has the harshest side effects out of the 3
What is it?

Tirzepatide isn’t actually GLP-1. It’s actually a 39 amino acid modified GIP molecule that has GLP-1 activity added to the molecule. That is why we call it a dual agonist. It’s having an effect on two incretin receptors. That means Tirzepatide is binding to the native GIP-R (GIP receptor) with essentially equal affinity as our body’s own GIP molecule. However, the GLP-1 binding is about 5 times weaker than what our body creates. It is an imbalanced dual agonist with preferential activity at GIP over GLP-1. This means that mg for mg, compared to Semaglutide, it will reduce apatite to a much greater degree than Tirzepatide since the drug is a full agonist of GIP-R, and only a partial agonist of GLP-1R. That partial agonist effect means you’re not fully saturating the receptor site, which means you don’t get the full effect.



The benefits of being a GIP Agonist

There are multiple benefits to GIP (glucose-dependent insulinotropic polypeptide) Agonism that Semaglutide don't produce. GIP is another hormone involved in glucose metabolism. It has an anti-emetic/anti-nausea effect which explain why some people experience less side effects. Like GLP-1, it promotes insulin secretion in response to high blood glucose levels. However, GIP has also been shown to have effects on fat metabolism and energy balance. It also has other effects, it is neuroprotective, increases bone formation, decreases stomach acid secretion, increases insulin release.



Effects on muscle mass and bodyweight

In a study comparing the weight loss effects of Semaglutide and Tirzepatide, it was found that a larger proportion of patients on Tirzepatide achieved significant weight loss.

Spoiler

In terms of lean mass preservation Tirzepatide does seem to preserve more than Semaglutide users.



The side effect of Tirzepatide

The side effect profile is very much the same as Semaglutide. The side effects are typically less severe than Semaglutide allowing it to be a much more sustainable to run long term. The main side effects still are Nausea, Vomiting, Diarrhoea, Abdominal pain and constipation.



Who should run Tirzepatide?

Well, in my opinion no one, due to the existence of Retatutide (which I will explain next) which makes Tirzepatide redundant. There is a reason I do not say that Semaglutide is redundant which I will get into later on in this thread, since it can be utilised well in specific scenarios. The only reason one could consider retatrutide is due to cost issues and it being less costly than Retatrutide. But with proper sourcing you can a year supply of the superior drug for very cheap. If your are going to a run a GLP-1 year round and you cannot get your hands on retatrutide for whatever reason, Tirzepatide is your best bet.



Tirzepatide dosage protocol

View attachment 4121925
What is it?

Retatrutide's a triple agonist, acting on GLP-1R, GIP-R and glucagon receptors (GCGR). Structurally, it is nearly identical to Tirzepatide. It is also a 39 amino acid modified GIP molecule but with changes to the amino acid structure to allow for activity at the GCGR site as well. It is also an imbalanced agonist. It is 8.9 fold more potent at GIP-R than human GIP. So this drug is way more potent than Tirzepatide at GIP-R agonism which means it further enhances any of the GIP-R effects and the GLP-1 effects in a synergistic manner.



Who should use Retatrutide?

Everyone. Everyone should use it. Even if you have already reached your goal body fat I would (and am currently) run Retatrutide year round to improve lipids and all your healthy blood markers and allow you to effortlessly maintain your current level of leanness.



Retatrutide dosage protocol

I would recommend starting at 1mg and titrating your way up as necessary. High dose Retatrutide can have it's benefits such as burning a few extra hundred calories through other mechanisms of lipolysis. If you want to use high dose Retatrutide, I would recommend between 5-10mg every week.
How DNP works

DNP works by increasing metabolism through inhibiting the mitochondria from making adenosine triphosphate (ATP), which results in heat being produced instead of ATP. So put that simply in the most basic way possible, it prevents energy from being stored as fat burning it as heat instead.



DNP side effect profile

You will be sweating.

You will experience facial bloating on cycle that will resolve 1 week after your cycle ends.

You may experience a slight rash on cycle. Sometimes you'll get it, sometimes you won't. It is harmless. Use anti-histamine if you want.

Your thyroid will be tanked for 1-2 weeks after your cycle, so keep calories low for those 2 weeks to not regain fat is a good idea. (T3 replacement can also be run with the cycle).

Your apatite will go crazy, and you will mainly crave carbohydrates (solution below)



DNP effects on muscle mass

DNP is protein sparing. It only uses fats and carbs for energy. Your strength will decrease on cycle, that is because you are completely glycogen depleted and your cells are essential in overdrive. Once you carb up and DNP leaves your system you will regain your strength.



How much does DNP increase your TDEE?

DNP increases your TDEE, not your BMR. This means it acts as a multiplicator for any activity that you do. DNP powder will increase your TDEE by ~15% and crystal will increase your TDEE by ~11% for every 100mg consumed after the DNP has built up in your system which is after about 5-6 days unless you front load it, which I would not recommend due to the fact that dealers may miss dose the DNP and you could be consuming more than you think, which can be fatal if you are at high dosages.



DNP dosage protocol

Always start low and titrate DNP up for the reason I just mentioned. 200mg will give help you out, but 400mg mogs everything to oblivion. Do not exceed 600mg, ESPECIALLY after you have reached peak DNP concentration of a certain dose at around day 5. If you are looking for good steady weight loss 200mg is a perfect dosage that will give you all the benefits with minimal heat and side effects.



The best way to run DNP

DNP solo is great, it does what it says. The only problem is that DNP will ramp up your apatite to another level. You will feel orgasmic whilst eating an apple. This can lead to you uncountably eating. To combat this using a GLP-1 Agonist is ideal. The GLP-1 Agonist as discussed above will nuke your apatite and the DNP will ramp up your metabolism. I would recommend using either Semaglutide or Tirzepatide due to the fact they are just more potent apatite suppressors than Retatutide. We do not really care for the increased metabolic effects that Retatutude would give, since we have given that job to DNP, we just need the apatite to be gone.



Benefits of running DNP

At the end of the cycle, with DNP and GLP-1 Agonists you will be left disgustingly insulin sensitive since DNP sensitizes insulin

Obviously you will become dick skin shredded

DNP releases releases a tonne of PUFA

DNP is neurogenic

DNP is anti-catabolic

DNP removes visceral fat first

Some DNP studies show that is may have protective effects on mitochondria
Run DNP with either Tirzepatide or Semaglutide and run Reta for once you reach your ideal bf (<10%)

Do a sarms cycle as your first cycle,

Then do a AAS cycle for the rest

Remember to add HGH, Reta, Epleronone, Dutasteride and Accutane for best results

And run DNP with either Tirzepatide or Semaglutide if you’re cutting

And then just do TRT and chill

@edodalic29 @Copercel @SlayerJonas @chadisbeingmade @Iplamephiltrum @Orc
@enchanted_elixir @Gengar @Stacyslayerᛉ @FlotPSL @iblamegenetics7681 @BigBallsLarry @Lars2 @FutureExoticChad @MaracasMogs
High Five Napoleon Dynamite GIF by MOODMAN

nice thread
 
  • +1
  • Love it
Reactions: MaracasMogs, Luca_., Mike456 and 3 others
tag me next time sir :cry:
 
  • +1
Reactions: MaracasMogs, Luca_., Zagro and 2 others
Your first cycle guide. A deep dive into roids, sarms, HGH and more. The truth about how to start your first guide

View attachment 4121947
This thread will go over the best way to do a cycle and will go over copes, sarms, AAS and more.

Most of the info has been found through lurking through @Zagro @SlayerJonas @chadisbeingmade threads

In 1998, researchers discovered a new class of non-steroidal compounds, the SARMs. These compounds selectively stimulate the androgen receptor, offering potent effects on bone and muscle to increase bone density and lean body mass while having minimal impact on reproductive tissues.
View attachment 4121892

Rad 140



Dosing 10mg per day



Rating (as a SARM) 5/10



How it works:

It specifically affects ARs in muscles and bones, activating them for muscle protein synthesis and cell growth. Its structure optimizes interactions, ends up leading to positive changes in gene expression related to muscle development and satellite cell proliferation.



A strong sarm with very good muscle gaining ability. And giving mostly dry muscle gains.



However Very strong hair loss is common with it putting big strain on your cardiovascular system and liver.



All in all rad 140 upsides do not outweigh the downsides, as many other sarms have similar upsides with nowhere near as bad downsides



S23



How it works:

S-23 activates ARs in muscles, stimulating protein synthesis and satellite cell activation, with some androgenic effects on reproductive tissues.



Dosing 10 mg per day



Rating 6/10



It’s the most powerful sarm

And you get the most amount of gains on this sarm. However it completely test shutdown you’ll need to get a proper test base and probably TRT. It also will fuck up your liver and your hair



I would not recommend S23 especially for beginners as there aren’t really much more benefits than the others and at this point you’d be better to do AAS instead



Lgd 4033



Its targeting of ARs in muscles and bones is caused by its molecular structure. This interaction prompts changes in the receptor, influencing gene expression for muscle growth and bons .



Dosing 10mg every day



Rating 9/10



My personal favorite sarm, and the one I think mogs all the others



Muscle gains are similar to rad but usually not full dry mass (some water weight)



Only 1-2% experience balding on this sarm(dut should be taken as well for preventative measures)



https://muscleandbrawn.com/sarms/sarms-hair-loss/



However it is toxic to the liver but less so than Rad 140 and you can get a LGD flu but it passes after a week



To conclude I’d recommend Lgd 4033 to all beginners or people doing a Sarms cycle



MK677 (not a sarm but I’m including anyway as people might use them)



Rating 0/10



How it works

it stimulates the growth hormone secretagogue receptor (GHSR), releasing growth hormone (GH) and insulin-like growth factor 1



Very mid gains and it will basically only make you bloated.
Your SARM cycle should last 8 weeks with a PCT of Enclo ED (12.5 mg) starting for 2 weeks before (boost to 25 mg for the days prior) and 2 weeks after. Remember to take 20 mg of accutane and 2.5 mg of Dutasteride while on the cycle.
Some sarms are useful and should be used as a stepping stone to AAS, but they get brutally mogged by AAS and shouldn’t be anymore than just your first cycle

Testosterone was isolated in the 1930s, and numerous synthetic androgens were quickly developed thereafter. Athletes soon discovered the dramatic anabolic effects of these hormones, and AAS spread rapidly through elite athletics and bodybuilding from the 1950s through the 1970s
Anavar



Dosing 20 mg every day



Rating (as a AAS) 4/10



How it works



is a synthetic anabolic steroid that works primarily by binding to androgen receptors inside muscle cells. Once activated, these receptors increase protein synthesis, promote lean muscle growth, and enhance nitrogen retention.



Some positives are you take pill so no injection which some can be scared of jfl. decent muscle growth mogs SARMS but not as good as test. The downside is it pretty much has the same downsides as test but is worse at muscle gains.



Test E



Dosing 500mg- 1g per week



Rating 8/10



How it works



works by acting as a long-lasting reservoir of testosterone in the body. When injected, the enanthate ester is slowly released from an oil depot, then broken down by enzymes to release free testosterone. This restores the body's testosterone levels, producing anabolic effects like increased muscle mass and bone density.



Mogger AAS and the best imo. Extremely good muscle gain with a very good rep. However bloat on it is fairly common so make sure to use over 200 mg of Epleronone to counter it. Some downsides are lower fertility, hairloss and acne. But all can be easily countered if done correctly.



Test P



Dosing 500 mg per wek



Rating 6/10



Worse gains and shorter half life than test e but less bloat. I think test e mogs but if you’re really scared of the bloat it’s a potential option



Masterone



Rating 0/10



How it works



It Binds Strongly to Androgen Receptors (AR), Masteron is a highly androgenic compound, meaning it directly activates androgen receptors in muscle tissue and fat cells.



Some positives are it Hardens Muscles & Reduces Softness, Masteron’s DHT-like effects make muscles feel solid, dense, and dry. It pulls water from under the skin, which makes veins pop more and muscle striations stand out.



However it should never be taken under any circumstance as it heavily ages you
First have your estrogen checked and if youre estrogen is too high use an Aromatase inhibitor.

Next your cycle should last 20 weeks and look like this-



AAS of choice

5 IU’s of HGH (I’ll explain in the HGH section)

20 mg of accutane

2.5 mg of Dutasteride

AI of your choice if needed



After the cycle you should go on TRT use test e and dose 100 mg 2 times a week (e.g Wednesday and Sunday)

Most of the info about this section came from @Zagro thread
Human growth hormone (HGH) is a peptide hormone crucial for growth and metabolism in humans. Its discovery traces back to the 1920s, with significant advancements made in the mid-20th century when researchers like Choh Hao Li isolated growth hormones from various species, including humans.
Biggest reason why you should take it from a roiders perspective is it allows more lean mass to be gained on bulls rather than fat



Some cons are:



Bloat : Bloat on HGH happens mainly because HGH increases water retention by boosting sodium retention and raising levels of a hormone called aldosterone, leading to fluid buildup in the skin and tissues.

Study: https://pubmed.ncbi.nlm.nih.gov/11932310/



Cartilage Growth : This happens because of higher IGF-1 levels and cartilage in for example the nose and the ears are very sensitive to IGF-1 and are the first bones to show noticeable effect this and grow in size due to this.



Drains Thyroid : HGH increases the conversion of T4 to T3, making the thyroid work harder and eventually causing it to slow down if not supported.

Study: https://pubmed.ncbi.nlm.nih.gov/34012834/



Hypoglycemia : HGH lowers insulin sensitivity, so you need carbs to prevent low blood sugar. 10-15 grams of carbs per IU keeps your blood sugar stableand avoids symptoms like shakiness and dizziness.



But they are really very rare on lowish doses (<10 IU).
6-8 IU every day
Taking HGH will real help you gym maxxing as it’s not risky and has great benefits

Contrary to popular belief it isnt quite a simple as calories in calories out and there’s much simpler ways. I got most of this section from @chadisbeingmade
What is it?

To put it as simply as possible, it's just an apatite suppressant. It is a GLP-1 receptor agonist medication used to treat type 2 diabetes and obesity. It works by mimicking the natural hormone GLP-1. Semaglutide is a single agonist. It only effects GLP-1R (GLP-1 receptors). It has the highest affinity for its target site. Semaglutide is about 94% identical to human produced GLP-1. GLP-1 has multiple effects. To mention a few it decreased hunger and food noise, delayed gastric emptying, increased satiety, decreased glucagon secretion, increased pancreatic beta cell function.



Effects on muscle mass

Out of the 3 main GLP-1 Agonists, Semaglutide has the worst muscle wastage to fat loss ratio compared to the other agonists. This is because it doesn't have the other methods of action that will help to relieve side effects and improve nutrient partitioning (amongst other things) to preserve lean mass. The muscle mass loss can be mitigated to a large degree by making sure you continue to have a high protein diet (which may be hard if you want to puke every time you eat), and continue weight training. The drug itself is not muscle wasting like some people seem to believe. The muscle loss is a direct cause of the aggressive deficit.



The side effects of Semaglutide

The most common would be Nausea which is experienced by around 43.9% of users on this highest dosage of Semaglutide (2.4mg). Vomiting, Diarrhoea, Abdominal pain and constipation are amongst the most common side effects. You may feel sick every time you think about eating, which is a large reason why it works, but obviously this is not ideal. Semaglutide has the harshest side effects out of the 3
What is it?

Tirzepatide isn’t actually GLP-1. It’s actually a 39 amino acid modified GIP molecule that has GLP-1 activity added to the molecule. That is why we call it a dual agonist. It’s having an effect on two incretin receptors. That means Tirzepatide is binding to the native GIP-R (GIP receptor) with essentially equal affinity as our body’s own GIP molecule. However, the GLP-1 binding is about 5 times weaker than what our body creates. It is an imbalanced dual agonist with preferential activity at GIP over GLP-1. This means that mg for mg, compared to Semaglutide, it will reduce apatite to a much greater degree than Tirzepatide since the drug is a full agonist of GIP-R, and only a partial agonist of GLP-1R. That partial agonist effect means you’re not fully saturating the receptor site, which means you don’t get the full effect.



The benefits of being a GIP Agonist

There are multiple benefits to GIP (glucose-dependent insulinotropic polypeptide) Agonism that Semaglutide don't produce. GIP is another hormone involved in glucose metabolism. It has an anti-emetic/anti-nausea effect which explain why some people experience less side effects. Like GLP-1, it promotes insulin secretion in response to high blood glucose levels. However, GIP has also been shown to have effects on fat metabolism and energy balance. It also has other effects, it is neuroprotective, increases bone formation, decreases stomach acid secretion, increases insulin release.



Effects on muscle mass and bodyweight

In a study comparing the weight loss effects of Semaglutide and Tirzepatide, it was found that a larger proportion of patients on Tirzepatide achieved significant weight loss.

Spoiler

In terms of lean mass preservation Tirzepatide does seem to preserve more than Semaglutide users.



The side effect of Tirzepatide

The side effect profile is very much the same as Semaglutide. The side effects are typically less severe than Semaglutide allowing it to be a much more sustainable to run long term. The main side effects still are Nausea, Vomiting, Diarrhoea, Abdominal pain and constipation.



Who should run Tirzepatide?

Well, in my opinion no one, due to the existence of Retatutide (which I will explain next) which makes Tirzepatide redundant. There is a reason I do not say that Semaglutide is redundant which I will get into later on in this thread, since it can be utilised well in specific scenarios. The only reason one could consider retatrutide is due to cost issues and it being less costly than Retatrutide. But with proper sourcing you can a year supply of the superior drug for very cheap. If your are going to a run a GLP-1 year round and you cannot get your hands on retatrutide for whatever reason, Tirzepatide is your best bet.



Tirzepatide dosage protocol

View attachment 4121925
What is it?

Retatrutide's a triple agonist, acting on GLP-1R, GIP-R and glucagon receptors (GCGR). Structurally, it is nearly identical to Tirzepatide. It is also a 39 amino acid modified GIP molecule but with changes to the amino acid structure to allow for activity at the GCGR site as well. It is also an imbalanced agonist. It is 8.9 fold more potent at GIP-R than human GIP. So this drug is way more potent than Tirzepatide at GIP-R agonism which means it further enhances any of the GIP-R effects and the GLP-1 effects in a synergistic manner.



Who should use Retatrutide?

Everyone. Everyone should use it. Even if you have already reached your goal body fat I would (and am currently) run Retatrutide year round to improve lipids and all your healthy blood markers and allow you to effortlessly maintain your current level of leanness.



Retatrutide dosage protocol

I would recommend starting at 1mg and titrating your way up as necessary. High dose Retatrutide can have it's benefits such as burning a few extra hundred calories through other mechanisms of lipolysis. If you want to use high dose Retatrutide, I would recommend between 5-10mg every week.
How DNP works

DNP works by increasing metabolism through inhibiting the mitochondria from making adenosine triphosphate (ATP), which results in heat being produced instead of ATP. So put that simply in the most basic way possible, it prevents energy from being stored as fat burning it as heat instead.



DNP side effect profile

You will be sweating.

You will experience facial bloating on cycle that will resolve 1 week after your cycle ends.

You may experience a slight rash on cycle. Sometimes you'll get it, sometimes you won't. It is harmless. Use anti-histamine if you want.

Your thyroid will be tanked for 1-2 weeks after your cycle, so keep calories low for those 2 weeks to not regain fat is a good idea. (T3 replacement can also be run with the cycle).

Your apatite will go crazy, and you will mainly crave carbohydrates (solution below)



DNP effects on muscle mass

DNP is protein sparing. It only uses fats and carbs for energy. Your strength will decrease on cycle, that is because you are completely glycogen depleted and your cells are essential in overdrive. Once you carb up and DNP leaves your system you will regain your strength.



How much does DNP increase your TDEE?

DNP increases your TDEE, not your BMR. This means it acts as a multiplicator for any activity that you do. DNP powder will increase your TDEE by ~15% and crystal will increase your TDEE by ~11% for every 100mg consumed after the DNP has built up in your system which is after about 5-6 days unless you front load it, which I would not recommend due to the fact that dealers may miss dose the DNP and you could be consuming more than you think, which can be fatal if you are at high dosages.



DNP dosage protocol

Always start low and titrate DNP up for the reason I just mentioned. 200mg will give help you out, but 400mg mogs everything to oblivion. Do not exceed 600mg, ESPECIALLY after you have reached peak DNP concentration of a certain dose at around day 5. If you are looking for good steady weight loss 200mg is a perfect dosage that will give you all the benefits with minimal heat and side effects.



The best way to run DNP

DNP solo is great, it does what it says. The only problem is that DNP will ramp up your apatite to another level. You will feel orgasmic whilst eating an apple. This can lead to you uncountably eating. To combat this using a GLP-1 Agonist is ideal. The GLP-1 Agonist as discussed above will nuke your apatite and the DNP will ramp up your metabolism. I would recommend using either Semaglutide or Tirzepatide due to the fact they are just more potent apatite suppressors than Retatutide. We do not really care for the increased metabolic effects that Retatutude would give, since we have given that job to DNP, we just need the apatite to be gone.



Benefits of running DNP

At the end of the cycle, with DNP and GLP-1 Agonists you will be left disgustingly insulin sensitive since DNP sensitizes insulin

Obviously you will become dick skin shredded

DNP releases releases a tonne of PUFA

DNP is neurogenic

DNP is anti-catabolic

DNP removes visceral fat first

Some DNP studies show that is may have protective effects on mitochondria
Run DNP with either Tirzepatide or Semaglutide and run Reta for once you reach your ideal bf (<10%)

Do a sarms cycle as your first cycle,

Then do a AAS cycle for the rest

Remember to add HGH, Reta, Epleronone, Dutasteride and Accutane for best results

And run DNP with either Tirzepatide or Semaglutide if you’re cutting

And then just do TRT and chill

@edodalic29 @Copercel @SlayerJonas @chadisbeingmade @Iplamephiltrum @Orc
@enchanted_elixir @Gengar @Stacyslayerᛉ @FlotPSL @iblamegenetics7681 @BigBallsLarry @Lars2 @FutureExoticChad @MaracasMogs
BOTB
 
  • +1
  • Love it
Reactions: Luca_., Zagro, heightmax and 1 other person
This info didn’t come from us.

I stopped reading at Test P causes less gains. No idea where you got that from, if anything it’s the opposite.
 
  • +1
Reactions: Luca_., unon, m0ss26 and 2 others
The hypoglycaemia part is wrong pretty sure that was a mistake in my thread, it actually may cause hyperglycaemia rather than hypoglycaemia.
 
  • +1
Reactions: Luca_. and Aryan Incel
Stop recommend the 2x a week pin shit its so fucking ass
If you actually want to be optimal you stop being a pussy and pin your gear daily, less sides and more stable blood levels
And masteron is the safest injectable after test (no it doesnt rape your hair)
I’m not biased i dont even run mast
 
  • +1
Reactions: Luca_. and Zagro
Your first cycle guide. A deep dive into roids, sarms, HGH and more. The truth about how to start your first guide

View attachment 4121947
This thread will go over the best way to do a cycle and will go over copes, sarms, AAS and more.

Most of the info has been found through lurking through @Zagro @SlayerJonas @chadisbeingmade threads

In 1998, researchers discovered a new class of non-steroidal compounds, the SARMs. These compounds selectively stimulate the androgen receptor, offering potent effects on bone and muscle to increase bone density and lean body mass while having minimal impact on reproductive tissues.
View attachment 4121892

Rad 140



Dosing 10mg per day



Rating (as a SARM) 5/10



How it works:

It specifically affects ARs in muscles and bones, activating them for muscle protein synthesis and cell growth. Its structure optimizes interactions, ends up leading to positive changes in gene expression related to muscle development and satellite cell proliferation.



A strong sarm with very good muscle gaining ability. And giving mostly dry muscle gains.



However Very strong hair loss is common with it putting big strain on your cardiovascular system and liver.



All in all rad 140 upsides do not outweigh the downsides, as many other sarms have similar upsides with nowhere near as bad downsides



S23



How it works:

S-23 activates ARs in muscles, stimulating protein synthesis and satellite cell activation, with some androgenic effects on reproductive tissues.



Dosing 10 mg per day



Rating 6/10



It’s the most powerful sarm

And you get the most amount of gains on this sarm. However it completely test shutdown you’ll need to get a proper test base and probably TRT. It also will fuck up your liver and your hair



I would not recommend S23 especially for beginners as there aren’t really much more benefits than the others and at this point you’d be better to do AAS instead



Lgd 4033



Its targeting of ARs in muscles and bones is caused by its molecular structure. This interaction prompts changes in the receptor, influencing gene expression for muscle growth and bons .



Dosing 10mg every day



Rating 9/10



My personal favorite sarm, and the one I think mogs all the others



Muscle gains are similar to rad but usually not full dry mass (some water weight)



Only 1-2% experience balding on this sarm(dut should be taken as well for preventative measures)



https://muscleandbrawn.com/sarms/sarms-hair-loss/



However it is toxic to the liver but less so than Rad 140 and you can get a LGD flu but it passes after a week



To conclude I’d recommend Lgd 4033 to all beginners or people doing a Sarms cycle



MK677 (not a sarm but I’m including anyway as people might use them)



Rating 0/10



How it works

it stimulates the growth hormone secretagogue receptor (GHSR), releasing growth hormone (GH) and insulin-like growth factor 1



Very mid gains and it will basically only make you bloated.
Your SARM cycle should last 8 weeks with a PCT of Enclo ED (12.5 mg) starting for 2 weeks before (boost to 25 mg for the days prior) and 2 weeks after. Remember to take 20 mg of accutane and 2.5 mg of Dutasteride while on the cycle.
Some sarms are useful and should be used as a stepping stone to AAS, but they get brutally mogged by AAS and shouldn’t be anymore than just your first cycle

Testosterone was isolated in the 1930s, and numerous synthetic androgens were quickly developed thereafter. Athletes soon discovered the dramatic anabolic effects of these hormones, and AAS spread rapidly through elite athletics and bodybuilding from the 1950s through the 1970s
Anavar



Dosing 20 mg every day



Rating (as a AAS) 4/10



How it works



is a synthetic anabolic steroid that works primarily by binding to androgen receptors inside muscle cells. Once activated, these receptors increase protein synthesis, promote lean muscle growth, and enhance nitrogen retention.



Some positives are you take pill so no injection which some can be scared of jfl. decent muscle growth mogs SARMS but not as good as test. The downside is it pretty much has the same downsides as test but is worse at muscle gains.



Test E



Dosing 500mg- 1g per week



Rating 8/10



How it works



works by acting as a long-lasting reservoir of testosterone in the body. When injected, the enanthate ester is slowly released from an oil depot, then broken down by enzymes to release free testosterone. This restores the body's testosterone levels, producing anabolic effects like increased muscle mass and bone density.



Mogger AAS and the best imo. Extremely good muscle gain with a very good rep. However bloat on it is fairly common so make sure to use over 200 mg of Epleronone to counter it. Some downsides are lower fertility, hairloss and acne. But all can be easily countered if done correctly.



Test P



Dosing 500 mg per wek



Rating 6/10



Worse gains and shorter half life than test e but less bloat. I think test e mogs but if you’re really scared of the bloat it’s a potential option



Masterone



Rating 0/10



How it works



It Binds Strongly to Androgen Receptors (AR), Masteron is a highly androgenic compound, meaning it directly activates androgen receptors in muscle tissue and fat cells.



Some positives are it Hardens Muscles & Reduces Softness, Masteron’s DHT-like effects make muscles feel solid, dense, and dry. It pulls water from under the skin, which makes veins pop more and muscle striations stand out.



However it should never be taken under any circumstance as it heavily ages you
First have your estrogen checked and if youre estrogen is too high use an Aromatase inhibitor.

Next your cycle should last 20 weeks and look like this-



AAS of choice

5 IU’s of HGH (I’ll explain in the HGH section)

20 mg of accutane

2.5 mg of Dutasteride

AI of your choice if needed



After the cycle you should go on TRT use test e and dose 100 mg 2 times a week (e.g Wednesday and Sunday)

Most of the info about this section came from @Zagro thread
Human growth hormone (HGH) is a peptide hormone crucial for growth and metabolism in humans. Its discovery traces back to the 1920s, with significant advancements made in the mid-20th century when researchers like Choh Hao Li isolated growth hormones from various species, including humans.
Biggest reason why you should take it from a roiders perspective is it allows more lean mass to be gained on bulls rather than fat



Some cons are:



Bloat : Bloat on HGH happens mainly because HGH increases water retention by boosting sodium retention and raising levels of a hormone called aldosterone, leading to fluid buildup in the skin and tissues.

Study: https://pubmed.ncbi.nlm.nih.gov/11932310/



Cartilage Growth : This happens because of higher IGF-1 levels and cartilage in for example the nose and the ears are very sensitive to IGF-1 and are the first bones to show noticeable effect this and grow in size due to this.



Drains Thyroid : HGH increases the conversion of T4 to T3, making the thyroid work harder and eventually causing it to slow down if not supported.

Study: https://pubmed.ncbi.nlm.nih.gov/34012834/



Hypoglycemia : HGH lowers insulin sensitivity, so you need carbs to prevent low blood sugar. 10-15 grams of carbs per IU keeps your blood sugar stableand avoids symptoms like shakiness and dizziness.



But they are really very rare on lowish doses (<10 IU).
6-8 IU every day
Taking HGH will real help you gym maxxing as it’s not risky and has great benefits

Contrary to popular belief it isnt quite a simple as calories in calories out and there’s much simpler ways. I got most of this section from @chadisbeingmade
What is it?

To put it as simply as possible, it's just an apatite suppressant. It is a GLP-1 receptor agonist medication used to treat type 2 diabetes and obesity. It works by mimicking the natural hormone GLP-1. Semaglutide is a single agonist. It only effects GLP-1R (GLP-1 receptors). It has the highest affinity for its target site. Semaglutide is about 94% identical to human produced GLP-1. GLP-1 has multiple effects. To mention a few it decreased hunger and food noise, delayed gastric emptying, increased satiety, decreased glucagon secretion, increased pancreatic beta cell function.



Effects on muscle mass

Out of the 3 main GLP-1 Agonists, Semaglutide has the worst muscle wastage to fat loss ratio compared to the other agonists. This is because it doesn't have the other methods of action that will help to relieve side effects and improve nutrient partitioning (amongst other things) to preserve lean mass. The muscle mass loss can be mitigated to a large degree by making sure you continue to have a high protein diet (which may be hard if you want to puke every time you eat), and continue weight training. The drug itself is not muscle wasting like some people seem to believe. The muscle loss is a direct cause of the aggressive deficit.



The side effects of Semaglutide

The most common would be Nausea which is experienced by around 43.9% of users on this highest dosage of Semaglutide (2.4mg). Vomiting, Diarrhoea, Abdominal pain and constipation are amongst the most common side effects. You may feel sick every time you think about eating, which is a large reason why it works, but obviously this is not ideal. Semaglutide has the harshest side effects out of the 3
What is it?

Tirzepatide isn’t actually GLP-1. It’s actually a 39 amino acid modified GIP molecule that has GLP-1 activity added to the molecule. That is why we call it a dual agonist. It’s having an effect on two incretin receptors. That means Tirzepatide is binding to the native GIP-R (GIP receptor) with essentially equal affinity as our body’s own GIP molecule. However, the GLP-1 binding is about 5 times weaker than what our body creates. It is an imbalanced dual agonist with preferential activity at GIP over GLP-1. This means that mg for mg, compared to Semaglutide, it will reduce apatite to a much greater degree than Tirzepatide since the drug is a full agonist of GIP-R, and only a partial agonist of GLP-1R. That partial agonist effect means you’re not fully saturating the receptor site, which means you don’t get the full effect.



The benefits of being a GIP Agonist

There are multiple benefits to GIP (glucose-dependent insulinotropic polypeptide) Agonism that Semaglutide don't produce. GIP is another hormone involved in glucose metabolism. It has an anti-emetic/anti-nausea effect which explain why some people experience less side effects. Like GLP-1, it promotes insulin secretion in response to high blood glucose levels. However, GIP has also been shown to have effects on fat metabolism and energy balance. It also has other effects, it is neuroprotective, increases bone formation, decreases stomach acid secretion, increases insulin release.



Effects on muscle mass and bodyweight

In a study comparing the weight loss effects of Semaglutide and Tirzepatide, it was found that a larger proportion of patients on Tirzepatide achieved significant weight loss.

Spoiler

In terms of lean mass preservation Tirzepatide does seem to preserve more than Semaglutide users.



The side effect of Tirzepatide

The side effect profile is very much the same as Semaglutide. The side effects are typically less severe than Semaglutide allowing it to be a much more sustainable to run long term. The main side effects still are Nausea, Vomiting, Diarrhoea, Abdominal pain and constipation.



Who should run Tirzepatide?

Well, in my opinion no one, due to the existence of Retatutide (which I will explain next) which makes Tirzepatide redundant. There is a reason I do not say that Semaglutide is redundant which I will get into later on in this thread, since it can be utilised well in specific scenarios. The only reason one could consider retatrutide is due to cost issues and it being less costly than Retatrutide. But with proper sourcing you can a year supply of the superior drug for very cheap. If your are going to a run a GLP-1 year round and you cannot get your hands on retatrutide for whatever reason, Tirzepatide is your best bet.



Tirzepatide dosage protocol

View attachment 4121925
What is it?

Retatrutide's a triple agonist, acting on GLP-1R, GIP-R and glucagon receptors (GCGR). Structurally, it is nearly identical to Tirzepatide. It is also a 39 amino acid modified GIP molecule but with changes to the amino acid structure to allow for activity at the GCGR site as well. It is also an imbalanced agonist. It is 8.9 fold more potent at GIP-R than human GIP. So this drug is way more potent than Tirzepatide at GIP-R agonism which means it further enhances any of the GIP-R effects and the GLP-1 effects in a synergistic manner.



Who should use Retatrutide?

Everyone. Everyone should use it. Even if you have already reached your goal body fat I would (and am currently) run Retatrutide year round to improve lipids and all your healthy blood markers and allow you to effortlessly maintain your current level of leanness.



Retatrutide dosage protocol

I would recommend starting at 1mg and titrating your way up as necessary. High dose Retatrutide can have it's benefits such as burning a few extra hundred calories through other mechanisms of lipolysis. If you want to use high dose Retatrutide, I would recommend between 5-10mg every week.
How DNP works

DNP works by increasing metabolism through inhibiting the mitochondria from making adenosine triphosphate (ATP), which results in heat being produced instead of ATP. So put that simply in the most basic way possible, it prevents energy from being stored as fat burning it as heat instead.



DNP side effect profile

You will be sweating.

You will experience facial bloating on cycle that will resolve 1 week after your cycle ends.

You may experience a slight rash on cycle. Sometimes you'll get it, sometimes you won't. It is harmless. Use anti-histamine if you want.

Your thyroid will be tanked for 1-2 weeks after your cycle, so keep calories low for those 2 weeks to not regain fat is a good idea. (T3 replacement can also be run with the cycle).

Your apatite will go crazy, and you will mainly crave carbohydrates (solution below)



DNP effects on muscle mass

DNP is protein sparing. It only uses fats and carbs for energy. Your strength will decrease on cycle, that is because you are completely glycogen depleted and your cells are essential in overdrive. Once you carb up and DNP leaves your system you will regain your strength.



How much does DNP increase your TDEE?

DNP increases your TDEE, not your BMR. This means it acts as a multiplicator for any activity that you do. DNP powder will increase your TDEE by ~15% and crystal will increase your TDEE by ~11% for every 100mg consumed after the DNP has built up in your system which is after about 5-6 days unless you front load it, which I would not recommend due to the fact that dealers may miss dose the DNP and you could be consuming more than you think, which can be fatal if you are at high dosages.



DNP dosage protocol

Always start low and titrate DNP up for the reason I just mentioned. 200mg will give help you out, but 400mg mogs everything to oblivion. Do not exceed 600mg, ESPECIALLY after you have reached peak DNP concentration of a certain dose at around day 5. If you are looking for good steady weight loss 200mg is a perfect dosage that will give you all the benefits with minimal heat and side effects.



The best way to run DNP

DNP solo is great, it does what it says. The only problem is that DNP will ramp up your apatite to another level. You will feel orgasmic whilst eating an apple. This can lead to you uncountably eating. To combat this using a GLP-1 Agonist is ideal. The GLP-1 Agonist as discussed above will nuke your apatite and the DNP will ramp up your metabolism. I would recommend using either Semaglutide or Tirzepatide due to the fact they are just more potent apatite suppressors than Retatutide. We do not really care for the increased metabolic effects that Retatutude would give, since we have given that job to DNP, we just need the apatite to be gone.



Benefits of running DNP

At the end of the cycle, with DNP and GLP-1 Agonists you will be left disgustingly insulin sensitive since DNP sensitizes insulin

Obviously you will become dick skin shredded

DNP releases releases a tonne of PUFA

DNP is neurogenic

DNP is anti-catabolic

DNP removes visceral fat first

Some DNP studies show that is may have protective effects on mitochondria
Run DNP with either Tirzepatide or Semaglutide and run Reta for once you reach your ideal bf (<10%)

Do a sarms cycle as your first cycle,

Then do a AAS cycle for the rest

Remember to add HGH, Reta, Epleronone, Dutasteride and Accutane for best results

And run DNP with either Tirzepatide or Semaglutide if you’re cutting

And then just do TRT and chill

@edodalic29 @Copercel @SlayerJonas @chadisbeingmade @Iplamephiltrum @Orc
@enchanted_elixir @Gengar @Stacyslayerᛉ @FlotPSL @iblamegenetics7681 @BigBallsLarry @Lars2 @FutureExoticChad @MaracasMogs
Mirin wanted to get tag but alright :owo:
 
  • +1
Reactions: Luca_., Zagro and Aryan Incel
Good thread is this your first long one?
Your first cycle guide. A deep dive into roids, sarms, HGH and more. The truth about how to start your first guide

View attachment 4121947
This thread will go over the best way to do a cycle and will go over copes, sarms, AAS and more.

Most of the info has been found through lurking through @Zagro @SlayerJonas @chadisbeingmade threads

In 1998, researchers discovered a new class of non-steroidal compounds, the SARMs. These compounds selectively stimulate the androgen receptor, offering potent effects on bone and muscle to increase bone density and lean body mass while having minimal impact on reproductive tissues.
View attachment 4121892

Rad 140



Dosing 10mg per day



Rating (as a SARM) 5/10



How it works:

It specifically affects ARs in muscles and bones, activating them for muscle protein synthesis and cell growth. Its structure optimizes interactions, ends up leading to positive changes in gene expression related to muscle development and satellite cell proliferation.



A strong sarm with very good muscle gaining ability. And giving mostly dry muscle gains.



However Very strong hair loss is common with it putting big strain on your cardiovascular system and liver.



All in all rad 140 upsides do not outweigh the downsides, as many other sarms have similar upsides with nowhere near as bad downsides



S23



How it works:

S-23 activates ARs in muscles, stimulating protein synthesis and satellite cell activation, with some androgenic effects on reproductive tissues.



Dosing 10 mg per day



Rating 6/10



It’s the most powerful sarm

And you get the most amount of gains on this sarm. However it completely test shutdown you’ll need to get a proper test base and probably TRT. It also will fuck up your liver and your hair



I would not recommend S23 especially for beginners as there aren’t really much more benefits than the others and at this point you’d be better to do AAS instead



Lgd 4033



Its targeting of ARs in muscles and bones is caused by its molecular structure. This interaction prompts changes in the receptor, influencing gene expression for muscle growth and bons .



Dosing 10mg every day



Rating 9/10



My personal favorite sarm, and the one I think mogs all the others



Muscle gains are similar to rad but usually not full dry mass (some water weight)



Only 1-2% experience balding on this sarm(dut should be taken as well for preventative measures)



https://muscleandbrawn.com/sarms/sarms-hair-loss/



However it is toxic to the liver but less so than Rad 140 and you can get a LGD flu but it passes after a week



To conclude I’d recommend Lgd 4033 to all beginners or people doing a Sarms cycle



MK677 (not a sarm but I’m including anyway as people might use them)



Rating 0/10



How it works

it stimulates the growth hormone secretagogue receptor (GHSR), releasing growth hormone (GH) and insulin-like growth factor 1



Very mid gains and it will basically only make you bloated.
Your SARM cycle should last 8 weeks with a PCT of Enclo ED (12.5 mg) starting for 2 weeks before (boost to 25 mg for the days prior) and 2 weeks after. Remember to take 20 mg of accutane and 2.5 mg of Dutasteride while on the cycle.
Some sarms are useful and should be used as a stepping stone to AAS, but they get brutally mogged by AAS and shouldn’t be anymore than just your first cycle

Testosterone was isolated in the 1930s, and numerous synthetic androgens were quickly developed thereafter. Athletes soon discovered the dramatic anabolic effects of these hormones, and AAS spread rapidly through elite athletics and bodybuilding from the 1950s through the 1970s
Anavar



Dosing 20 mg every day



Rating (as a AAS) 4/10



How it works



is a synthetic anabolic steroid that works primarily by binding to androgen receptors inside muscle cells. Once activated, these receptors increase protein synthesis, promote lean muscle growth, and enhance nitrogen retention.



Some positives are you take pill so no injection which some can be scared of jfl. decent muscle growth mogs SARMS but not as good as test. The downside is it pretty much has the same downsides as test but is worse at muscle gains.



Test E



Dosing 500mg- 1g per week



Rating 8/10



How it works



works by acting as a long-lasting reservoir of testosterone in the body. When injected, the enanthate ester is slowly released from an oil depot, then broken down by enzymes to release free testosterone. This restores the body's testosterone levels, producing anabolic effects like increased muscle mass and bone density.



Mogger AAS and the best imo. Extremely good muscle gain with a very good rep. However bloat on it is fairly common so make sure to use over 200 mg of Epleronone to counter it. Some downsides are lower fertility, hairloss and acne. But all can be easily countered if done correctly.


Masterone



Rating 0/10



How it works



It Binds Strongly to Androgen Receptors (AR), Masteron is a highly androgenic compound, meaning it directly activates androgen receptors in muscle tissue and fat cells.



Some positives are it Hardens Muscles & Reduces Softness, Masteron’s DHT-like effects make muscles feel solid, dense, and dry. It pulls water from under the skin, which makes veins pop more and muscle striations stand out.



However it should never be taken under any circumstance as it heavily ages you
First have your estrogen checked and if youre estrogen is too high use an Aromatase inhibitor.

Next your cycle should last 20 weeks and look like this-



AAS of choice

5 IU’s of HGH (I’ll explain in the HGH section)

20 mg of accutane

2.5 mg of Dutasteride

AI of your choice if needed



After the cycle you should go on TRT use test e and dose 100 mg 2 times a week (e.g Wednesday and Sunday)

Most of the info about this section came from @Zagro thread
Human growth hormone (HGH) is a peptide hormone crucial for growth and metabolism in humans. Its discovery traces back to the 1920s, with significant advancements made in the mid-20th century when researchers like Choh Hao Li isolated growth hormones from various species, including humans.
Biggest reason why you should take it from a roiders perspective is it allows more lean mass to be gained on bulls rather than fat



Some cons are:



Bloat : Bloat on HGH happens mainly because HGH increases water retention by boosting sodium retention and raising levels of a hormone called aldosterone, leading to fluid buildup in the skin and tissues.

Study: https://pubmed.ncbi.nlm.nih.gov/11932310/



Cartilage Growth : This happens because of higher IGF-1 levels and cartilage in for example the nose and the ears are very sensitive to IGF-1 and are the first bones to show noticeable effect this and grow in size due to this.



Drains Thyroid : HGH increases the conversion of T4 to T3, making the thyroid work harder and eventually causing it to slow down if not supported.

Study: https://pubmed.ncbi.nlm.nih.gov/34012834/



Hyperglycemia : HGH lowers insulin sensitivity, so you need carbs to prevent low blood sugar. 10-15 grams of carbs per IU keeps your blood sugar stableand avoids symptoms like shakiness and dizziness.



But they are really very rare on lowish doses (<10 IU).
6-8 IU every day
Taking HGH will real help you gym maxxing as it’s not risky and has great benefits

Contrary to popular belief it isnt quite a simple as calories in calories out and there’s much simpler ways. I got most of this section from @chadisbeingmade
What is it?

To put it as simply as possible, it's just an apatite suppressant. It is a GLP-1 receptor agonist medication used to treat type 2 diabetes and obesity. It works by mimicking the natural hormone GLP-1. Semaglutide is a single agonist. It only effects GLP-1R (GLP-1 receptors). It has the highest affinity for its target site. Semaglutide is about 94% identical to human produced GLP-1. GLP-1 has multiple effects. To mention a few it decreased hunger and food noise, delayed gastric emptying, increased satiety, decreased glucagon secretion, increased pancreatic beta cell function.



Effects on muscle mass

Out of the 3 main GLP-1 Agonists, Semaglutide has the worst muscle wastage to fat loss ratio compared to the other agonists. This is because it doesn't have the other methods of action that will help to relieve side effects and improve nutrient partitioning (amongst other things) to preserve lean mass. The muscle mass loss can be mitigated to a large degree by making sure you continue to have a high protein diet (which may be hard if you want to puke every time you eat), and continue weight training. The drug itself is not muscle wasting like some people seem to believe. The muscle loss is a direct cause of the aggressive deficit.



The side effects of Semaglutide

The most common would be Nausea which is experienced by around 43.9% of users on this highest dosage of Semaglutide (2.4mg). Vomiting, Diarrhoea, Abdominal pain and constipation are amongst the most common side effects. You may feel sick every time you think about eating, which is a large reason why it works, but obviously this is not ideal. Semaglutide has the harshest side effects out of the 3
What is it?

Tirzepatide isn’t actually GLP-1. It’s actually a 39 amino acid modified GIP molecule that has GLP-1 activity added to the molecule. That is why we call it a dual agonist. It’s having an effect on two incretin receptors. That means Tirzepatide is binding to the native GIP-R (GIP receptor) with essentially equal affinity as our body’s own GIP molecule. However, the GLP-1 binding is about 5 times weaker than what our body creates. It is an imbalanced dual agonist with preferential activity at GIP over GLP-1. This means that mg for mg, compared to Semaglutide, it will reduce apatite to a much greater degree than Tirzepatide since the drug is a full agonist of GIP-R, and only a partial agonist of GLP-1R. That partial agonist effect means you’re not fully saturating the receptor site, which means you don’t get the full effect.



The benefits of being a GIP Agonist

There are multiple benefits to GIP (glucose-dependent insulinotropic polypeptide) Agonism that Semaglutide don't produce. GIP is another hormone involved in glucose metabolism. It has an anti-emetic/anti-nausea effect which explain why some people experience less side effects. Like GLP-1, it promotes insulin secretion in response to high blood glucose levels. However, GIP has also been shown to have effects on fat metabolism and energy balance. It also has other effects, it is neuroprotective, increases bone formation, decreases stomach acid secretion, increases insulin release.



Effects on muscle mass and bodyweight

In a study comparing the weight loss effects of Semaglutide and Tirzepatide, it was found that a larger proportion of patients on Tirzepatide achieved significant weight loss.

Spoiler

In terms of lean mass preservation Tirzepatide does seem to preserve more than Semaglutide users.



The side effect of Tirzepatide

The side effect profile is very much the same as Semaglutide. The side effects are typically less severe than Semaglutide allowing it to be a much more sustainable to run long term. The main side effects still are Nausea, Vomiting, Diarrhoea, Abdominal pain and constipation.



Who should run Tirzepatide?

Well, in my opinion no one, due to the existence of Retatutide (which I will explain next) which makes Tirzepatide redundant. There is a reason I do not say that Semaglutide is redundant which I will get into later on in this thread, since it can be utilised well in specific scenarios. The only reason one could consider retatrutide is due to cost issues and it being less costly than Retatrutide. But with proper sourcing you can a year supply of the superior drug for very cheap. If your are going to a run a GLP-1 year round and you cannot get your hands on retatrutide for whatever reason, Tirzepatide is your best bet.



Tirzepatide dosage protocol

View attachment 4121925
What is it?

Retatrutide's a triple agonist, acting on GLP-1R, GIP-R and glucagon receptors (GCGR). Structurally, it is nearly identical to Tirzepatide. It is also a 39 amino acid modified GIP molecule but with changes to the amino acid structure to allow for activity at the GCGR site as well. It is also an imbalanced agonist. It is 8.9 fold more potent at GIP-R than human GIP. So this drug is way more potent than Tirzepatide at GIP-R agonism which means it further enhances any of the GIP-R effects and the GLP-1 effects in a synergistic manner.



Who should use Retatrutide?

Everyone. Everyone should use it. Even if you have already reached your goal body fat I would (and am currently) run Retatrutide year round to improve lipids and all your healthy blood markers and allow you to effortlessly maintain your current level of leanness.



Retatrutide dosage protocol

I would recommend starting at 1mg and titrating your way up as necessary. High dose Retatrutide can have it's benefits such as burning a few extra hundred calories through other mechanisms of lipolysis. If you want to use high dose Retatrutide, I would recommend between 5-10mg every week.
How DNP works

DNP works by increasing metabolism through inhibiting the mitochondria from making adenosine triphosphate (ATP), which results in heat being produced instead of ATP. So put that simply in the most basic way possible, it prevents energy from being stored as fat burning it as heat instead.



DNP side effect profile

You will be sweating.

You will experience facial bloating on cycle that will resolve 1 week after your cycle ends.

You may experience a slight rash on cycle. Sometimes you'll get it, sometimes you won't. It is harmless. Use anti-histamine if you want.

Your thyroid will be tanked for 1-2 weeks after your cycle, so keep calories low for those 2 weeks to not regain fat is a good idea. (T3 replacement can also be run with the cycle).

Your apatite will go crazy, and you will mainly crave carbohydrates (solution below)



DNP effects on muscle mass

DNP is protein sparing. It only uses fats and carbs for energy. Your strength will decrease on cycle, that is because you are completely glycogen depleted and your cells are essential in overdrive. Once you carb up and DNP leaves your system you will regain your strength.



How much does DNP increase your TDEE?

DNP increases your TDEE, not your BMR. This means it acts as a multiplicator for any activity that you do. DNP powder will increase your TDEE by ~15% and crystal will increase your TDEE by ~11% for every 100mg consumed after the DNP has built up in your system which is after about 5-6 days unless you front load it, which I would not recommend due to the fact that dealers may miss dose the DNP and you could be consuming more than you think, which can be fatal if you are at high dosages.



DNP dosage protocol

Always start low and titrate DNP up for the reason I just mentioned. 200mg will give help you out, but 400mg mogs everything to oblivion. Do not exceed 600mg, ESPECIALLY after you have reached peak DNP concentration of a certain dose at around day 5. If you are looking for good steady weight loss 200mg is a perfect dosage that will give you all the benefits with minimal heat and side effects.



The best way to run DNP

DNP solo is great, it does what it says. The only problem is that DNP will ramp up your apatite to another level. You will feel orgasmic whilst eating an apple. This can lead to you uncountably eating. To combat this using a GLP-1 Agonist is ideal. The GLP-1 Agonist as discussed above will nuke your apatite and the DNP will ramp up your metabolism. I would recommend using either Semaglutide or Tirzepatide due to the fact they are just more potent apatite suppressors than Retatutide. We do not really care for the increased metabolic effects that Retatutude would give, since we have given that job to DNP, we just need the apatite to be gone.



Benefits of running DNP

At the end of the cycle, with DNP and GLP-1 Agonists you will be left disgustingly insulin sensitive since DNP sensitizes insulin

Obviously you will become dick skin shredded

DNP releases releases a tonne of PUFA

DNP is neurogenic

DNP is anti-catabolic

DNP removes visceral fat first

Some DNP studies show that is may have protective effects on mitochondria
Run DNP with either Tirzepatide or Semaglutide and run Reta for once you reach your ideal bf (<10%)

Do a sarms cycle as your first cycle,

Then do a AAS cycle for the rest

Remember to add HGH, Reta, Epleronone, Dutasteride and Accutane for best results

And run DNP with either Tirzepatide or Semaglutide if you’re cutting

And then just do TRT and chill

@edodalic29 @Copercel @SlayerJonas @chadisbeingmade @Iplamephiltrum @Orc
@enchanted_elixir @Gengar @Stacyslayerᛉ @FlotPSL @iblamegenetics7681 @BigBallsLarry @Lars2 @FutureExoticChad @MaracasMogs
 
  • +1
Reactions: Luca_. and Zagro
ah so you recycled other people's threads except that you were kind enough to include some misinformation? Make something original and insightful if you're going to bother making structured threads. Nobody gained a thing from this.
 
Last edited:
  • +1
Reactions: Mike456, Luca_. and m0ss26
Nice thread bhai:Comfy: love it
 
  • Love it
Reactions: Aryan Incel
Stop recommend the 2x a week pin shit its so fucking ass
If you actually want to be optimal you stop being a pussy and pin your gear daily, less sides and more stable blood levels
And masteron is the safest injectable after test (no it doesnt rape your hair)
I’m not biased i dont even run mast
lol masterone will age you like crazy good luck with that
 
  • +1
Reactions: MaracasMogs
lol masterone will age you like crazy good luck with that
Show evidence it ages you more than other anabolics

nigga also said good luck with that when I specified I don’t even use the substance jfl
 
ah so you recycled other people's threads except that you were kind enough to include some misinformation? Make something original and insightful if you're going to bother making structured threads. Nobody gained a thing from this.
Yea kinda shitty ngl but he tried I guess
There are only like 3 -5 threads about gear on here worth reading
 
  • +1
Reactions: m0ss26
Show evidence
it'll take him a few days to find the info by looking through every post @chadisbeingmade has ever written
 
  • +1
Reactions: m0ss26
Your first cycle guide. A deep dive into roids, sarms, HGH and more. The truth about how to start your first guide

View attachment 4121947
This thread will go over the best way to do a cycle and will go over copes, sarms, AAS and more.

Most of the info has been found through lurking through @Zagro @SlayerJonas @chadisbeingmade threads

In 1998, researchers discovered a new class of non-steroidal compounds, the SARMs. These compounds selectively stimulate the androgen receptor, offering potent effects on bone and muscle to increase bone density and lean body mass while having minimal impact on reproductive tissues.
View attachment 4121892

Rad 140



Dosing 10mg per day



Rating (as a SARM) 5/10



How it works:

It specifically affects ARs in muscles and bones, activating them for muscle protein synthesis and cell growth. Its structure optimizes interactions, ends up leading to positive changes in gene expression related to muscle development and satellite cell proliferation.



A strong sarm with very good muscle gaining ability. And giving mostly dry muscle gains.



However Very strong hair loss is common with it putting big strain on your cardiovascular system and liver.



All in all rad 140 upsides do not outweigh the downsides, as many other sarms have similar upsides with nowhere near as bad downsides



S23



How it works:

S-23 activates ARs in muscles, stimulating protein synthesis and satellite cell activation, with some androgenic effects on reproductive tissues.



Dosing 10 mg per day



Rating 6/10



It’s the most powerful sarm

And you get the most amount of gains on this sarm. However it completely test shutdown you’ll need to get a proper test base and probably TRT. It also will fuck up your liver and your hair



I would not recommend S23 especially for beginners as there aren’t really much more benefits than the others and at this point you’d be better to do AAS instead



Lgd 4033



Its targeting of ARs in muscles and bones is caused by its molecular structure. This interaction prompts changes in the receptor, influencing gene expression for muscle growth and bons .



Dosing 10mg every day



Rating 9/10



My personal favorite sarm, and the one I think mogs all the others



Muscle gains are similar to rad but usually not full dry mass (some water weight)



Only 1-2% experience balding on this sarm(dut should be taken as well for preventative measures)



https://muscleandbrawn.com/sarms/sarms-hair-loss/



However it is toxic to the liver but less so than Rad 140 and you can get a LGD flu but it passes after a week



To conclude I’d recommend Lgd 4033 to all beginners or people doing a Sarms cycle



MK677 (not a sarm but I’m including anyway as people might use them)



Rating 0/10



How it works

it stimulates the growth hormone secretagogue receptor (GHSR), releasing growth hormone (GH) and insulin-like growth factor 1



Very mid gains and it will basically only make you bloated.
Your SARM cycle should last 8 weeks with a PCT of Enclo ED (12.5 mg) starting for 2 weeks before (boost to 25 mg for the days prior) and 2 weeks after. Remember to take 20 mg of accutane and 2.5 mg of Dutasteride while on the cycle.
Some sarms are useful and should be used as a stepping stone to AAS, but they get brutally mogged by AAS and shouldn’t be anymore than just your first cycle

Testosterone was isolated in the 1930s, and numerous synthetic androgens were quickly developed thereafter. Athletes soon discovered the dramatic anabolic effects of these hormones, and AAS spread rapidly through elite athletics and bodybuilding from the 1950s through the 1970s
Anavar



Dosing 20 mg every day



Rating (as a AAS) 4/10



How it works



is a synthetic anabolic steroid that works primarily by binding to androgen receptors inside muscle cells. Once activated, these receptors increase protein synthesis, promote lean muscle growth, and enhance nitrogen retention.



Some positives are you take pill so no injection which some can be scared of jfl. decent muscle growth mogs SARMS but not as good as test. The downside is it pretty much has the same downsides as test but is worse at muscle gains.



Test E



Dosing 500mg- 1g per week



Rating 8/10



How it works



works by acting as a long-lasting reservoir of testosterone in the body. When injected, the enanthate ester is slowly released from an oil depot, then broken down by enzymes to release free testosterone. This restores the body's testosterone levels, producing anabolic effects like increased muscle mass and bone density.



Mogger AAS and the best imo. Extremely good muscle gain with a very good rep. However bloat on it is fairly common so make sure to use over 200 mg of Epleronone to counter it. Some downsides are lower fertility, hairloss and acne. But all can be easily countered if done correctly.


Masterone



Rating 0/10



How it works



It Binds Strongly to Androgen Receptors (AR), Masteron is a highly androgenic compound, meaning it directly activates androgen receptors in muscle tissue and fat cells.



Some positives are it Hardens Muscles & Reduces Softness, Masteron’s DHT-like effects make muscles feel solid, dense, and dry. It pulls water from under the skin, which makes veins pop more and muscle striations stand out.



However it should never be taken under any circumstance as it heavily ages you
First have your estrogen checked and if youre estrogen is too high use an Aromatase inhibitor.

Next your cycle should last 20 weeks and look like this-



AAS of choice

5 IU’s of HGH (I’ll explain in the HGH section)

20 mg of accutane

2.5 mg of Dutasteride

AI of your choice if needed



After the cycle you should go on TRT use test e and dose 100 mg 2 times a week (e.g Wednesday and Sunday)

Most of the info about this section came from @Zagro thread
Human growth hormone (HGH) is a peptide hormone crucial for growth and metabolism in humans. Its discovery traces back to the 1920s, with significant advancements made in the mid-20th century when researchers like Choh Hao Li isolated growth hormones from various species, including humans.
Biggest reason why you should take it from a roiders perspective is it allows more lean mass to be gained on bulls rather than fat



Some cons are:



Bloat : Bloat on HGH happens mainly because HGH increases water retention by boosting sodium retention and raising levels of a hormone called aldosterone, leading to fluid buildup in the skin and tissues.

Study: https://pubmed.ncbi.nlm.nih.gov/11932310/



Cartilage Growth : This happens because of higher IGF-1 levels and cartilage in for example the nose and the ears are very sensitive to IGF-1 and are the first bones to show noticeable effect this and grow in size due to this.



Drains Thyroid : HGH increases the conversion of T4 to T3, making the thyroid work harder and eventually causing it to slow down if not supported.

Study: https://pubmed.ncbi.nlm.nih.gov/34012834/



Hyperglycemia : HGH lowers insulin sensitivity, so you need carbs to prevent low blood sugar. 10-15 grams of carbs per IU keeps your blood sugar stableand avoids symptoms like shakiness and dizziness.



But they are really very rare on lowish doses (<10 IU).
6-8 IU every day
Taking HGH will real help you gym maxxing as it’s not risky and has great benefits

Contrary to popular belief it isnt quite a simple as calories in calories out and there’s much simpler ways. I got most of this section from @chadisbeingmade
What is it?

To put it as simply as possible, it's just an apatite suppressant. It is a GLP-1 receptor agonist medication used to treat type 2 diabetes and obesity. It works by mimicking the natural hormone GLP-1. Semaglutide is a single agonist. It only effects GLP-1R (GLP-1 receptors). It has the highest affinity for its target site. Semaglutide is about 94% identical to human produced GLP-1. GLP-1 has multiple effects. To mention a few it decreased hunger and food noise, delayed gastric emptying, increased satiety, decreased glucagon secretion, increased pancreatic beta cell function.



Effects on muscle mass

Out of the 3 main GLP-1 Agonists, Semaglutide has the worst muscle wastage to fat loss ratio compared to the other agonists. This is because it doesn't have the other methods of action that will help to relieve side effects and improve nutrient partitioning (amongst other things) to preserve lean mass. The muscle mass loss can be mitigated to a large degree by making sure you continue to have a high protein diet (which may be hard if you want to puke every time you eat), and continue weight training. The drug itself is not muscle wasting like some people seem to believe. The muscle loss is a direct cause of the aggressive deficit.



The side effects of Semaglutide

The most common would be Nausea which is experienced by around 43.9% of users on this highest dosage of Semaglutide (2.4mg). Vomiting, Diarrhoea, Abdominal pain and constipation are amongst the most common side effects. You may feel sick every time you think about eating, which is a large reason why it works, but obviously this is not ideal. Semaglutide has the harshest side effects out of the 3
What is it?

Tirzepatide isn’t actually GLP-1. It’s actually a 39 amino acid modified GIP molecule that has GLP-1 activity added to the molecule. That is why we call it a dual agonist. It’s having an effect on two incretin receptors. That means Tirzepatide is binding to the native GIP-R (GIP receptor) with essentially equal affinity as our body’s own GIP molecule. However, the GLP-1 binding is about 5 times weaker than what our body creates. It is an imbalanced dual agonist with preferential activity at GIP over GLP-1. This means that mg for mg, compared to Semaglutide, it will reduce apatite to a much greater degree than Tirzepatide since the drug is a full agonist of GIP-R, and only a partial agonist of GLP-1R. That partial agonist effect means you’re not fully saturating the receptor site, which means you don’t get the full effect.



The benefits of being a GIP Agonist

There are multiple benefits to GIP (glucose-dependent insulinotropic polypeptide) Agonism that Semaglutide don't produce. GIP is another hormone involved in glucose metabolism. It has an anti-emetic/anti-nausea effect which explain why some people experience less side effects. Like GLP-1, it promotes insulin secretion in response to high blood glucose levels. However, GIP has also been shown to have effects on fat metabolism and energy balance. It also has other effects, it is neuroprotective, increases bone formation, decreases stomach acid secretion, increases insulin release.



Effects on muscle mass and bodyweight

In a study comparing the weight loss effects of Semaglutide and Tirzepatide, it was found that a larger proportion of patients on Tirzepatide achieved significant weight loss.

Spoiler

In terms of lean mass preservation Tirzepatide does seem to preserve more than Semaglutide users.



The side effect of Tirzepatide

The side effect profile is very much the same as Semaglutide. The side effects are typically less severe than Semaglutide allowing it to be a much more sustainable to run long term. The main side effects still are Nausea, Vomiting, Diarrhoea, Abdominal pain and constipation.



Who should run Tirzepatide?

Well, in my opinion no one, due to the existence of Retatutide (which I will explain next) which makes Tirzepatide redundant. There is a reason I do not say that Semaglutide is redundant which I will get into later on in this thread, since it can be utilised well in specific scenarios. The only reason one could consider retatrutide is due to cost issues and it being less costly than Retatrutide. But with proper sourcing you can a year supply of the superior drug for very cheap. If your are going to a run a GLP-1 year round and you cannot get your hands on retatrutide for whatever reason, Tirzepatide is your best bet.



Tirzepatide dosage protocol

View attachment 4121925
What is it?

Retatrutide's a triple agonist, acting on GLP-1R, GIP-R and glucagon receptors (GCGR). Structurally, it is nearly identical to Tirzepatide. It is also a 39 amino acid modified GIP molecule but with changes to the amino acid structure to allow for activity at the GCGR site as well. It is also an imbalanced agonist. It is 8.9 fold more potent at GIP-R than human GIP. So this drug is way more potent than Tirzepatide at GIP-R agonism which means it further enhances any of the GIP-R effects and the GLP-1 effects in a synergistic manner.



Who should use Retatrutide?

Everyone. Everyone should use it. Even if you have already reached your goal body fat I would (and am currently) run Retatrutide year round to improve lipids and all your healthy blood markers and allow you to effortlessly maintain your current level of leanness.



Retatrutide dosage protocol

I would recommend starting at 1mg and titrating your way up as necessary. High dose Retatrutide can have it's benefits such as burning a few extra hundred calories through other mechanisms of lipolysis. If you want to use high dose Retatrutide, I would recommend between 5-10mg every week.
How DNP works

DNP works by increasing metabolism through inhibiting the mitochondria from making adenosine triphosphate (ATP), which results in heat being produced instead of ATP. So put that simply in the most basic way possible, it prevents energy from being stored as fat burning it as heat instead.



DNP side effect profile

You will be sweating.

You will experience facial bloating on cycle that will resolve 1 week after your cycle ends.

You may experience a slight rash on cycle. Sometimes you'll get it, sometimes you won't. It is harmless. Use anti-histamine if you want.

Your thyroid will be tanked for 1-2 weeks after your cycle, so keep calories low for those 2 weeks to not regain fat is a good idea. (T3 replacement can also be run with the cycle).

Your apatite will go crazy, and you will mainly crave carbohydrates (solution below)



DNP effects on muscle mass

DNP is protein sparing. It only uses fats and carbs for energy. Your strength will decrease on cycle, that is because you are completely glycogen depleted and your cells are essential in overdrive. Once you carb up and DNP leaves your system you will regain your strength.



How much does DNP increase your TDEE?

DNP increases your TDEE, not your BMR. This means it acts as a multiplicator for any activity that you do. DNP powder will increase your TDEE by ~15% and crystal will increase your TDEE by ~11% for every 100mg consumed after the DNP has built up in your system which is after about 5-6 days unless you front load it, which I would not recommend due to the fact that dealers may miss dose the DNP and you could be consuming more than you think, which can be fatal if you are at high dosages.



DNP dosage protocol

Always start low and titrate DNP up for the reason I just mentioned. 200mg will give help you out, but 400mg mogs everything to oblivion. Do not exceed 600mg, ESPECIALLY after you have reached peak DNP concentration of a certain dose at around day 5. If you are looking for good steady weight loss 200mg is a perfect dosage that will give you all the benefits with minimal heat and side effects.



The best way to run DNP

DNP solo is great, it does what it says. The only problem is that DNP will ramp up your apatite to another level. You will feel orgasmic whilst eating an apple. This can lead to you uncountably eating. To combat this using a GLP-1 Agonist is ideal. The GLP-1 Agonist as discussed above will nuke your apatite and the DNP will ramp up your metabolism. I would recommend using either Semaglutide or Tirzepatide due to the fact they are just more potent apatite suppressors than Retatutide. We do not really care for the increased metabolic effects that Retatutude would give, since we have given that job to DNP, we just need the apatite to be gone.



Benefits of running DNP

At the end of the cycle, with DNP and GLP-1 Agonists you will be left disgustingly insulin sensitive since DNP sensitizes insulin

Obviously you will become dick skin shredded

DNP releases releases a tonne of PUFA

DNP is neurogenic

DNP is anti-catabolic

DNP removes visceral fat first

Some DNP studies show that is may have protective effects on mitochondria
Run DNP with either Tirzepatide or Semaglutide and run Reta for once you reach your ideal bf (<10%)

Do a sarms cycle as your first cycle,

Then do a AAS cycle for the rest

Remember to add HGH, Reta, Epleronone, Dutasteride and Accutane for best results

And run DNP with either Tirzepatide or Semaglutide if you’re cutting

And then just do TRT and chill

@edodalic29 @Copercel @SlayerJonas @chadisbeingmade @Iplamephiltrum @Orc
@enchanted_elixir @Gengar @Stacyslayerᛉ @FlotPSL @iblamegenetics7681 @BigBallsLarry @Lars2 @FutureExoticChad @MaracasMogs
Comical that you even mentioned SARMs JFL, worst PEDs ever
 
Your first cycle guide. A deep dive into roids, sarms, HGH and more. The truth about how to start your first guide

View attachment 4121947
This thread will go over the best way to do a cycle and will go over copes, sarms, AAS and more.

Most of the info has been found through lurking through @Zagro @SlayerJonas @chadisbeingmade threads

In 1998, researchers discovered a new class of non-steroidal compounds, the SARMs. These compounds selectively stimulate the androgen receptor, offering potent effects on bone and muscle to increase bone density and lean body mass while having minimal impact on reproductive tissues.
View attachment 4121892

Rad 140



Dosing 10mg per day



Rating (as a SARM) 5/10



How it works:

It specifically affects ARs in muscles and bones, activating them for muscle protein synthesis and cell growth. Its structure optimizes interactions, ends up leading to positive changes in gene expression related to muscle development and satellite cell proliferation.



A strong sarm with very good muscle gaining ability. And giving mostly dry muscle gains.



However Very strong hair loss is common with it putting big strain on your cardiovascular system and liver.



All in all rad 140 upsides do not outweigh the downsides, as many other sarms have similar upsides with nowhere near as bad downsides



S23



How it works:

S-23 activates ARs in muscles, stimulating protein synthesis and satellite cell activation, with some androgenic effects on reproductive tissues.



Dosing 10 mg per day



Rating 6/10



It’s the most powerful sarm

And you get the most amount of gains on this sarm. However it completely test shutdown you’ll need to get a proper test base and probably TRT. It also will fuck up your liver and your hair



I would not recommend S23 especially for beginners as there aren’t really much more benefits than the others and at this point you’d be better to do AAS instead



Lgd 4033



Its targeting of ARs in muscles and bones is caused by its molecular structure. This interaction prompts changes in the receptor, influencing gene expression for muscle growth and bons .



Dosing 10mg every day



Rating 9/10



My personal favorite sarm, and the one I think mogs all the others



Muscle gains are similar to rad but usually not full dry mass (some water weight)



Only 1-2% experience balding on this sarm(dut should be taken as well for preventative measures)



https://muscleandbrawn.com/sarms/sarms-hair-loss/



However it is toxic to the liver but less so than Rad 140 and you can get a LGD flu but it passes after a week



To conclude I’d recommend Lgd 4033 to all beginners or people doing a Sarms cycle



MK677 (not a sarm but I’m including anyway as people might use them)



Rating 0/10



How it works

it stimulates the growth hormone secretagogue receptor (GHSR), releasing growth hormone (GH) and insulin-like growth factor 1



Very mid gains and it will basically only make you bloated.
Your SARM cycle should last 8 weeks with a PCT of Enclo ED (12.5 mg) starting for 2 weeks before (boost to 25 mg for the days prior) and 2 weeks after. Remember to take 20 mg of accutane and 2.5 mg of Dutasteride while on the cycle.
Some sarms are useful and should be used as a stepping stone to AAS, but they get brutally mogged by AAS and shouldn’t be anymore than just your first cycle

Testosterone was isolated in the 1930s, and numerous synthetic androgens were quickly developed thereafter. Athletes soon discovered the dramatic anabolic effects of these hormones, and AAS spread rapidly through elite athletics and bodybuilding from the 1950s through the 1970s
Anavar



Dosing 20 mg every day



Rating (as a AAS) 4/10



How it works



is a synthetic anabolic steroid that works primarily by binding to androgen receptors inside muscle cells. Once activated, these receptors increase protein synthesis, promote lean muscle growth, and enhance nitrogen retention.



Some positives are you take pill so no injection which some can be scared of jfl. decent muscle growth mogs SARMS but not as good as test. The downside is it pretty much has the same downsides as test but is worse at muscle gains.



Test E



Dosing 500mg- 1g per week



Rating 8/10



How it works



works by acting as a long-lasting reservoir of testosterone in the body. When injected, the enanthate ester is slowly released from an oil depot, then broken down by enzymes to release free testosterone. This restores the body's testosterone levels, producing anabolic effects like increased muscle mass and bone density.



Mogger AAS and the best imo. Extremely good muscle gain with a very good rep. However bloat on it is fairly common so make sure to use over 200 mg of Epleronone to counter it. Some downsides are lower fertility, hairloss and acne. But all can be easily countered if done correctly.


Masterone



Rating 0/10



How it works



It Binds Strongly to Androgen Receptors (AR), Masteron is a highly androgenic compound, meaning it directly activates androgen receptors in muscle tissue and fat cells.



Some positives are it Hardens Muscles & Reduces Softness, Masteron’s DHT-like effects make muscles feel solid, dense, and dry. It pulls water from under the skin, which makes veins pop more and muscle striations stand out.



However it should never be taken under any circumstance as it heavily ages you
First have your estrogen checked and if youre estrogen is too high use an Aromatase inhibitor.

Next your cycle should last 20 weeks and look like this-



AAS of choice

5 IU’s of HGH (I’ll explain in the HGH section)

20 mg of accutane

2.5 mg of Dutasteride

AI of your choice if needed



After the cycle you should go on TRT use test e and dose 100 mg 2 times a week (e.g Wednesday and Sunday)

Most of the info about this section came from @Zagro thread
Human growth hormone (HGH) is a peptide hormone crucial for growth and metabolism in humans. Its discovery traces back to the 1920s, with significant advancements made in the mid-20th century when researchers like Choh Hao Li isolated growth hormones from various species, including humans.
Biggest reason why you should take it from a roiders perspective is it allows more lean mass to be gained on bulls rather than fat



Some cons are:



Bloat : Bloat on HGH happens mainly because HGH increases water retention by boosting sodium retention and raising levels of a hormone called aldosterone, leading to fluid buildup in the skin and tissues.

Study: https://pubmed.ncbi.nlm.nih.gov/11932310/



Cartilage Growth : This happens because of higher IGF-1 levels and cartilage in for example the nose and the ears are very sensitive to IGF-1 and are the first bones to show noticeable effect this and grow in size due to this.



Drains Thyroid : HGH increases the conversion of T4 to T3, making the thyroid work harder and eventually causing it to slow down if not supported.

Study: https://pubmed.ncbi.nlm.nih.gov/34012834/



Hyperglycemia : HGH lowers insulin sensitivity, so you need carbs to prevent low blood sugar. 10-15 grams of carbs per IU keeps your blood sugar stableand avoids symptoms like shakiness and dizziness.



But they are really very rare on lowish doses (<10 IU).
6-8 IU every day
Taking HGH will real help you gym maxxing as it’s not risky and has great benefits

Contrary to popular belief it isnt quite a simple as calories in calories out and there’s much simpler ways. I got most of this section from @chadisbeingmade
What is it?

To put it as simply as possible, it's just an apatite suppressant. It is a GLP-1 receptor agonist medication used to treat type 2 diabetes and obesity. It works by mimicking the natural hormone GLP-1. Semaglutide is a single agonist. It only effects GLP-1R (GLP-1 receptors). It has the highest affinity for its target site. Semaglutide is about 94% identical to human produced GLP-1. GLP-1 has multiple effects. To mention a few it decreased hunger and food noise, delayed gastric emptying, increased satiety, decreased glucagon secretion, increased pancreatic beta cell function.



Effects on muscle mass

Out of the 3 main GLP-1 Agonists, Semaglutide has the worst muscle wastage to fat loss ratio compared to the other agonists. This is because it doesn't have the other methods of action that will help to relieve side effects and improve nutrient partitioning (amongst other things) to preserve lean mass. The muscle mass loss can be mitigated to a large degree by making sure you continue to have a high protein diet (which may be hard if you want to puke every time you eat), and continue weight training. The drug itself is not muscle wasting like some people seem to believe. The muscle loss is a direct cause of the aggressive deficit.



The side effects of Semaglutide

The most common would be Nausea which is experienced by around 43.9% of users on this highest dosage of Semaglutide (2.4mg). Vomiting, Diarrhoea, Abdominal pain and constipation are amongst the most common side effects. You may feel sick every time you think about eating, which is a large reason why it works, but obviously this is not ideal. Semaglutide has the harshest side effects out of the 3
What is it?

Tirzepatide isn’t actually GLP-1. It’s actually a 39 amino acid modified GIP molecule that has GLP-1 activity added to the molecule. That is why we call it a dual agonist. It’s having an effect on two incretin receptors. That means Tirzepatide is binding to the native GIP-R (GIP receptor) with essentially equal affinity as our body’s own GIP molecule. However, the GLP-1 binding is about 5 times weaker than what our body creates. It is an imbalanced dual agonist with preferential activity at GIP over GLP-1. This means that mg for mg, compared to Semaglutide, it will reduce apatite to a much greater degree than Tirzepatide since the drug is a full agonist of GIP-R, and only a partial agonist of GLP-1R. That partial agonist effect means you’re not fully saturating the receptor site, which means you don’t get the full effect.



The benefits of being a GIP Agonist

There are multiple benefits to GIP (glucose-dependent insulinotropic polypeptide) Agonism that Semaglutide don't produce. GIP is another hormone involved in glucose metabolism. It has an anti-emetic/anti-nausea effect which explain why some people experience less side effects. Like GLP-1, it promotes insulin secretion in response to high blood glucose levels. However, GIP has also been shown to have effects on fat metabolism and energy balance. It also has other effects, it is neuroprotective, increases bone formation, decreases stomach acid secretion, increases insulin release.



Effects on muscle mass and bodyweight

In a study comparing the weight loss effects of Semaglutide and Tirzepatide, it was found that a larger proportion of patients on Tirzepatide achieved significant weight loss.

Spoiler

In terms of lean mass preservation Tirzepatide does seem to preserve more than Semaglutide users.



The side effect of Tirzepatide

The side effect profile is very much the same as Semaglutide. The side effects are typically less severe than Semaglutide allowing it to be a much more sustainable to run long term. The main side effects still are Nausea, Vomiting, Diarrhoea, Abdominal pain and constipation.



Who should run Tirzepatide?

Well, in my opinion no one, due to the existence of Retatutide (which I will explain next) which makes Tirzepatide redundant. There is a reason I do not say that Semaglutide is redundant which I will get into later on in this thread, since it can be utilised well in specific scenarios. The only reason one could consider retatrutide is due to cost issues and it being less costly than Retatrutide. But with proper sourcing you can a year supply of the superior drug for very cheap. If your are going to a run a GLP-1 year round and you cannot get your hands on retatrutide for whatever reason, Tirzepatide is your best bet.



Tirzepatide dosage protocol

View attachment 4121925
What is it?

Retatrutide's a triple agonist, acting on GLP-1R, GIP-R and glucagon receptors (GCGR). Structurally, it is nearly identical to Tirzepatide. It is also a 39 amino acid modified GIP molecule but with changes to the amino acid structure to allow for activity at the GCGR site as well. It is also an imbalanced agonist. It is 8.9 fold more potent at GIP-R than human GIP. So this drug is way more potent than Tirzepatide at GIP-R agonism which means it further enhances any of the GIP-R effects and the GLP-1 effects in a synergistic manner.



Who should use Retatrutide?

Everyone. Everyone should use it. Even if you have already reached your goal body fat I would (and am currently) run Retatrutide year round to improve lipids and all your healthy blood markers and allow you to effortlessly maintain your current level of leanness.



Retatrutide dosage protocol

I would recommend starting at 1mg and titrating your way up as necessary. High dose Retatrutide can have it's benefits such as burning a few extra hundred calories through other mechanisms of lipolysis. If you want to use high dose Retatrutide, I would recommend between 5-10mg every week.
How DNP works

DNP works by increasing metabolism through inhibiting the mitochondria from making adenosine triphosphate (ATP), which results in heat being produced instead of ATP. So put that simply in the most basic way possible, it prevents energy from being stored as fat burning it as heat instead.



DNP side effect profile

You will be sweating.

You will experience facial bloating on cycle that will resolve 1 week after your cycle ends.

You may experience a slight rash on cycle. Sometimes you'll get it, sometimes you won't. It is harmless. Use anti-histamine if you want.

Your thyroid will be tanked for 1-2 weeks after your cycle, so keep calories low for those 2 weeks to not regain fat is a good idea. (T3 replacement can also be run with the cycle).

Your apatite will go crazy, and you will mainly crave carbohydrates (solution below)



DNP effects on muscle mass

DNP is protein sparing. It only uses fats and carbs for energy. Your strength will decrease on cycle, that is because you are completely glycogen depleted and your cells are essential in overdrive. Once you carb up and DNP leaves your system you will regain your strength.



How much does DNP increase your TDEE?

DNP increases your TDEE, not your BMR. This means it acts as a multiplicator for any activity that you do. DNP powder will increase your TDEE by ~15% and crystal will increase your TDEE by ~11% for every 100mg consumed after the DNP has built up in your system which is after about 5-6 days unless you front load it, which I would not recommend due to the fact that dealers may miss dose the DNP and you could be consuming more than you think, which can be fatal if you are at high dosages.



DNP dosage protocol

Always start low and titrate DNP up for the reason I just mentioned. 200mg will give help you out, but 400mg mogs everything to oblivion. Do not exceed 600mg, ESPECIALLY after you have reached peak DNP concentration of a certain dose at around day 5. If you are looking for good steady weight loss 200mg is a perfect dosage that will give you all the benefits with minimal heat and side effects.



The best way to run DNP

DNP solo is great, it does what it says. The only problem is that DNP will ramp up your apatite to another level. You will feel orgasmic whilst eating an apple. This can lead to you uncountably eating. To combat this using a GLP-1 Agonist is ideal. The GLP-1 Agonist as discussed above will nuke your apatite and the DNP will ramp up your metabolism. I would recommend using either Semaglutide or Tirzepatide due to the fact they are just more potent apatite suppressors than Retatutide. We do not really care for the increased metabolic effects that Retatutude would give, since we have given that job to DNP, we just need the apatite to be gone.



Benefits of running DNP

At the end of the cycle, with DNP and GLP-1 Agonists you will be left disgustingly insulin sensitive since DNP sensitizes insulin

Obviously you will become dick skin shredded

DNP releases releases a tonne of PUFA

DNP is neurogenic

DNP is anti-catabolic

DNP removes visceral fat first

Some DNP studies show that is may have protective effects on mitochondria
Run DNP with either Tirzepatide or Semaglutide and run Reta for once you reach your ideal bf (<10%)

Do a sarms cycle as your first cycle,

Then do a AAS cycle for the rest

Remember to add HGH, Reta, Epleronone, Dutasteride and Accutane for best results

And run DNP with either Tirzepatide or Semaglutide if you’re cutting

And then just do TRT and chill

@edodalic29 @Copercel @SlayerJonas @chadisbeingmade @Iplamephiltrum @Orc
@enchanted_elixir @Gengar @Stacyslayerᛉ @FlotPSL @iblamegenetics7681 @BigBallsLarry @Lars2 @FutureExoticChad @MaracasMogs
For my first sarm cycle my goal is facial remodeling/construction in the same way as just high androgen exposure I can’t pin test so I was thinking S4 andarine with high dose mk and enclo for pct
 
Your first cycle guide. A deep dive into roids, sarms, HGH and more. The truth about how to start your first guide

View attachment 4121947
This thread will go over the best way to do a cycle and will go over copes, sarms, AAS and more.

Most of the info has been found through lurking through @Zagro @SlayerJonas @chadisbeingmade threads

In 1998, researchers discovered a new class of non-steroidal compounds, the SARMs. These compounds selectively stimulate the androgen receptor, offering potent effects on bone and muscle to increase bone density and lean body mass while having minimal impact on reproductive tissues.
View attachment 4121892

Rad 140



Dosing 10mg per day



Rating (as a SARM) 5/10



How it works:

It specifically affects ARs in muscles and bones, activating them for muscle protein synthesis and cell growth. Its structure optimizes interactions, ends up leading to positive changes in gene expression related to muscle development and satellite cell proliferation.



A strong sarm with very good muscle gaining ability. And giving mostly dry muscle gains.



However Very strong hair loss is common with it putting big strain on your cardiovascular system and liver.



All in all rad 140 upsides do not outweigh the downsides, as many other sarms have similar upsides with nowhere near as bad downsides



S23



How it works:

S-23 activates ARs in muscles, stimulating protein synthesis and satellite cell activation, with some androgenic effects on reproductive tissues.



Dosing 10 mg per day



Rating 6/10



It’s the most powerful sarm

And you get the most amount of gains on this sarm. However it completely test shutdown you’ll need to get a proper test base and probably TRT. It also will fuck up your liver and your hair



I would not recommend S23 especially for beginners as there aren’t really much more benefits than the others and at this point you’d be better to do AAS instead



Lgd 4033



Its targeting of ARs in muscles and bones is caused by its molecular structure. This interaction prompts changes in the receptor, influencing gene expression for muscle growth and bons .



Dosing 10mg every day



Rating 9/10



My personal favorite sarm, and the one I think mogs all the others



Muscle gains are similar to rad but usually not full dry mass (some water weight)



Only 1-2% experience balding on this sarm(dut should be taken as well for preventative measures)



https://muscleandbrawn.com/sarms/sarms-hair-loss/



However it is toxic to the liver but less so than Rad 140 and you can get a LGD flu but it passes after a week



To conclude I’d recommend Lgd 4033 to all beginners or people doing a Sarms cycle



MK677 (not a sarm but I’m including anyway as people might use them)



Rating 0/10



How it works

it stimulates the growth hormone secretagogue receptor (GHSR), releasing growth hormone (GH) and insulin-like growth factor 1



Very mid gains and it will basically only make you bloated.
Your SARM cycle should last 8 weeks with a PCT of Enclo ED (12.5 mg) starting for 2 weeks before (boost to 25 mg for the days prior) and 2 weeks after. Remember to take 20 mg of accutane and 2.5 mg of Dutasteride while on the cycle.
Some sarms are useful and should be used as a stepping stone to AAS, but they get brutally mogged by AAS and shouldn’t be anymore than just your first cycle

Testosterone was isolated in the 1930s, and numerous synthetic androgens were quickly developed thereafter. Athletes soon discovered the dramatic anabolic effects of these hormones, and AAS spread rapidly through elite athletics and bodybuilding from the 1950s through the 1970s
Anavar



Dosing 20 mg every day



Rating (as a AAS) 4/10



How it works



is a synthetic anabolic steroid that works primarily by binding to androgen receptors inside muscle cells. Once activated, these receptors increase protein synthesis, promote lean muscle growth, and enhance nitrogen retention.



Some positives are you take pill so no injection which some can be scared of jfl. decent muscle growth mogs SARMS but not as good as test. The downside is it pretty much has the same downsides as test but is worse at muscle gains.



Test E



Dosing 500mg- 1g per week



Rating 8/10



How it works



works by acting as a long-lasting reservoir of testosterone in the body. When injected, the enanthate ester is slowly released from an oil depot, then broken down by enzymes to release free testosterone. This restores the body's testosterone levels, producing anabolic effects like increased muscle mass and bone density.



Mogger AAS and the best imo. Extremely good muscle gain with a very good rep. However bloat on it is fairly common so make sure to use over 200 mg of Epleronone to counter it. Some downsides are lower fertility, hairloss and acne. But all can be easily countered if done correctly.


Masterone



Rating 0/10



How it works



It Binds Strongly to Androgen Receptors (AR), Masteron is a highly androgenic compound, meaning it directly activates androgen receptors in muscle tissue and fat cells.



Some positives are it Hardens Muscles & Reduces Softness, Masteron’s DHT-like effects make muscles feel solid, dense, and dry. It pulls water from under the skin, which makes veins pop more and muscle striations stand out.



However it should never be taken under any circumstance as it heavily ages you
First have your estrogen checked and if youre estrogen is too high use an Aromatase inhibitor.

Next your cycle should last 20 weeks and look like this-



AAS of choice

5 IU’s of HGH (I’ll explain in the HGH section)

20 mg of accutane

2.5 mg of Dutasteride

AI of your choice if needed



After the cycle you should go on TRT use test e and dose 100 mg 2 times a week (e.g Wednesday and Sunday)

Most of the info about this section came from @Zagro thread
Human growth hormone (HGH) is a peptide hormone crucial for growth and metabolism in humans. Its discovery traces back to the 1920s, with significant advancements made in the mid-20th century when researchers like Choh Hao Li isolated growth hormones from various species, including humans.
Biggest reason why you should take it from a roiders perspective is it allows more lean mass to be gained on bulls rather than fat



Some cons are:



Bloat : Bloat on HGH happens mainly because HGH increases water retention by boosting sodium retention and raising levels of a hormone called aldosterone, leading to fluid buildup in the skin and tissues.

Study: https://pubmed.ncbi.nlm.nih.gov/11932310/



Cartilage Growth : This happens because of higher IGF-1 levels and cartilage in for example the nose and the ears are very sensitive to IGF-1 and are the first bones to show noticeable effect this and grow in size due to this.



Drains Thyroid : HGH increases the conversion of T4 to T3, making the thyroid work harder and eventually causing it to slow down if not supported.

Study: https://pubmed.ncbi.nlm.nih.gov/34012834/



Hyperglycemia : HGH lowers insulin sensitivity, so you need carbs to prevent low blood sugar. 10-15 grams of carbs per IU keeps your blood sugar stableand avoids symptoms like shakiness and dizziness.



But they are really very rare on lowish doses (<10 IU).
6-8 IU every day
Taking HGH will real help you gym maxxing as it’s not risky and has great benefits

Contrary to popular belief it isnt quite a simple as calories in calories out and there’s much simpler ways. I got most of this section from @chadisbeingmade
What is it?

To put it as simply as possible, it's just an apatite suppressant. It is a GLP-1 receptor agonist medication used to treat type 2 diabetes and obesity. It works by mimicking the natural hormone GLP-1. Semaglutide is a single agonist. It only effects GLP-1R (GLP-1 receptors). It has the highest affinity for its target site. Semaglutide is about 94% identical to human produced GLP-1. GLP-1 has multiple effects. To mention a few it decreased hunger and food noise, delayed gastric emptying, increased satiety, decreased glucagon secretion, increased pancreatic beta cell function.



Effects on muscle mass

Out of the 3 main GLP-1 Agonists, Semaglutide has the worst muscle wastage to fat loss ratio compared to the other agonists. This is because it doesn't have the other methods of action that will help to relieve side effects and improve nutrient partitioning (amongst other things) to preserve lean mass. The muscle mass loss can be mitigated to a large degree by making sure you continue to have a high protein diet (which may be hard if you want to puke every time you eat), and continue weight training. The drug itself is not muscle wasting like some people seem to believe. The muscle loss is a direct cause of the aggressive deficit.



The side effects of Semaglutide

The most common would be Nausea which is experienced by around 43.9% of users on this highest dosage of Semaglutide (2.4mg). Vomiting, Diarrhoea, Abdominal pain and constipation are amongst the most common side effects. You may feel sick every time you think about eating, which is a large reason why it works, but obviously this is not ideal. Semaglutide has the harshest side effects out of the 3
What is it?

Tirzepatide isn’t actually GLP-1. It’s actually a 39 amino acid modified GIP molecule that has GLP-1 activity added to the molecule. That is why we call it a dual agonist. It’s having an effect on two incretin receptors. That means Tirzepatide is binding to the native GIP-R (GIP receptor) with essentially equal affinity as our body’s own GIP molecule. However, the GLP-1 binding is about 5 times weaker than what our body creates. It is an imbalanced dual agonist with preferential activity at GIP over GLP-1. This means that mg for mg, compared to Semaglutide, it will reduce apatite to a much greater degree than Tirzepatide since the drug is a full agonist of GIP-R, and only a partial agonist of GLP-1R. That partial agonist effect means you’re not fully saturating the receptor site, which means you don’t get the full effect.



The benefits of being a GIP Agonist

There are multiple benefits to GIP (glucose-dependent insulinotropic polypeptide) Agonism that Semaglutide don't produce. GIP is another hormone involved in glucose metabolism. It has an anti-emetic/anti-nausea effect which explain why some people experience less side effects. Like GLP-1, it promotes insulin secretion in response to high blood glucose levels. However, GIP has also been shown to have effects on fat metabolism and energy balance. It also has other effects, it is neuroprotective, increases bone formation, decreases stomach acid secretion, increases insulin release.



Effects on muscle mass and bodyweight

In a study comparing the weight loss effects of Semaglutide and Tirzepatide, it was found that a larger proportion of patients on Tirzepatide achieved significant weight loss.

Spoiler

In terms of lean mass preservation Tirzepatide does seem to preserve more than Semaglutide users.



The side effect of Tirzepatide

The side effect profile is very much the same as Semaglutide. The side effects are typically less severe than Semaglutide allowing it to be a much more sustainable to run long term. The main side effects still are Nausea, Vomiting, Diarrhoea, Abdominal pain and constipation.



Who should run Tirzepatide?

Well, in my opinion no one, due to the existence of Retatutide (which I will explain next) which makes Tirzepatide redundant. There is a reason I do not say that Semaglutide is redundant which I will get into later on in this thread, since it can be utilised well in specific scenarios. The only reason one could consider retatrutide is due to cost issues and it being less costly than Retatrutide. But with proper sourcing you can a year supply of the superior drug for very cheap. If your are going to a run a GLP-1 year round and you cannot get your hands on retatrutide for whatever reason, Tirzepatide is your best bet.



Tirzepatide dosage protocol

View attachment 4121925
What is it?

Retatrutide's a triple agonist, acting on GLP-1R, GIP-R and glucagon receptors (GCGR). Structurally, it is nearly identical to Tirzepatide. It is also a 39 amino acid modified GIP molecule but with changes to the amino acid structure to allow for activity at the GCGR site as well. It is also an imbalanced agonist. It is 8.9 fold more potent at GIP-R than human GIP. So this drug is way more potent than Tirzepatide at GIP-R agonism which means it further enhances any of the GIP-R effects and the GLP-1 effects in a synergistic manner.



Who should use Retatrutide?

Everyone. Everyone should use it. Even if you have already reached your goal body fat I would (and am currently) run Retatrutide year round to improve lipids and all your healthy blood markers and allow you to effortlessly maintain your current level of leanness.



Retatrutide dosage protocol

I would recommend starting at 1mg and titrating your way up as necessary. High dose Retatrutide can have it's benefits such as burning a few extra hundred calories through other mechanisms of lipolysis. If you want to use high dose Retatrutide, I would recommend between 5-10mg every week.
How DNP works

DNP works by increasing metabolism through inhibiting the mitochondria from making adenosine triphosphate (ATP), which results in heat being produced instead of ATP. So put that simply in the most basic way possible, it prevents energy from being stored as fat burning it as heat instead.



DNP side effect profile

You will be sweating.

You will experience facial bloating on cycle that will resolve 1 week after your cycle ends.

You may experience a slight rash on cycle. Sometimes you'll get it, sometimes you won't. It is harmless. Use anti-histamine if you want.

Your thyroid will be tanked for 1-2 weeks after your cycle, so keep calories low for those 2 weeks to not regain fat is a good idea. (T3 replacement can also be run with the cycle).

Your apatite will go crazy, and you will mainly crave carbohydrates (solution below)



DNP effects on muscle mass

DNP is protein sparing. It only uses fats and carbs for energy. Your strength will decrease on cycle, that is because you are completely glycogen depleted and your cells are essential in overdrive. Once you carb up and DNP leaves your system you will regain your strength.



How much does DNP increase your TDEE?

DNP increases your TDEE, not your BMR. This means it acts as a multiplicator for any activity that you do. DNP powder will increase your TDEE by ~15% and crystal will increase your TDEE by ~11% for every 100mg consumed after the DNP has built up in your system which is after about 5-6 days unless you front load it, which I would not recommend due to the fact that dealers may miss dose the DNP and you could be consuming more than you think, which can be fatal if you are at high dosages.



DNP dosage protocol

Always start low and titrate DNP up for the reason I just mentioned. 200mg will give help you out, but 400mg mogs everything to oblivion. Do not exceed 600mg, ESPECIALLY after you have reached peak DNP concentration of a certain dose at around day 5. If you are looking for good steady weight loss 200mg is a perfect dosage that will give you all the benefits with minimal heat and side effects.



The best way to run DNP

DNP solo is great, it does what it says. The only problem is that DNP will ramp up your apatite to another level. You will feel orgasmic whilst eating an apple. This can lead to you uncountably eating. To combat this using a GLP-1 Agonist is ideal. The GLP-1 Agonist as discussed above will nuke your apatite and the DNP will ramp up your metabolism. I would recommend using either Semaglutide or Tirzepatide due to the fact they are just more potent apatite suppressors than Retatutide. We do not really care for the increased metabolic effects that Retatutude would give, since we have given that job to DNP, we just need the apatite to be gone.



Benefits of running DNP

At the end of the cycle, with DNP and GLP-1 Agonists you will be left disgustingly insulin sensitive since DNP sensitizes insulin

Obviously you will become dick skin shredded

DNP releases releases a tonne of PUFA

DNP is neurogenic

DNP is anti-catabolic

DNP removes visceral fat first

Some DNP studies show that is may have protective effects on mitochondria
Run DNP with either Tirzepatide or Semaglutide and run Reta for once you reach your ideal bf (<10%)

Do a sarms cycle as your first cycle,

Then do a AAS cycle for the rest

Remember to add HGH, Reta, Epleronone, Dutasteride and Accutane for best results

And run DNP with either Tirzepatide or Semaglutide if you’re cutting

And then just do TRT and chill

@edodalic29 @Copercel @SlayerJonas @chadisbeingmade @Iplamephiltrum @Orc
@enchanted_elixir @Gengar @Stacyslayerᛉ @FlotPSL @iblamegenetics7681 @BigBallsLarry @Lars2 @FutureExoticChad @MaracasMogs
what your opinion on PCT for reforming your test production
 
For my first sarm cycle my goal is facial remodeling/construction in the same way as just high androgen exposure I can’t pin test so I was thinking S4 andarine with high dose mk and enclo for pct
🤣
 
  • +1
Reactions: Aryan Incel
For my first sarm cycle my goal is facial remodeling/construction in the same way as just high androgen exposure I can’t pin test so I was thinking S4 andarine with high dose mk and enclo for pct
Mk677 upregulates somatostatin which inhibits igf1 🤣, also pct is a meme it's useless, run enclo on cycle but this stack is shit anyways, pin or stay natural
 
Mk677 upregulates somatostatin which inhibits igf1 🤣, also pct is a meme it's useless, run enclo on cycle but this stack is shit anyways, pin or stay natural
Well I can’t pin would u recommend anavar? Also I can bet u the amount of somatostatin would be pretty low from the mk prolly would barely make a differance in actual igf1 levels it will still increase at least more then 1.5x at 25mg daily
 
"Cartilage Growth : This happens because of higher IGF-1 levels and cartilage in for example the nose and the ears are very sensitive to IGF-1 and are the first bones to show noticeable effect this and grow in size due to this."

So if I have big ears and nose HGH has a chance of descending me even further?
 
Well I can’t pin would u recommend anavar? Also I can bet u the amount of somatostatin would be pretty low from the mk prolly would barely make a differance in actual igf1 levels it will still increase at least more then 1.5x at 25mg daily
Well I can’t pin would u recommend anavar? Also I can bet u the amount of somatostatin would be pretty low from the mk prolly would barely make a differance in actual igf1 levels it will still increase at least more then 1.5x at 25mg daily
Secretagauges are utter dogshit anyways, capped by pituitary output limit. Pin or nothing, and Anavar you need a test base or you'll feel like shit. Why can't you pin?
 
Secretagauges are utter dogshit anyways, capped by pituitary output limit. Pin or nothing, and Anavar you need a test base or you'll feel like shit. Why can't you pin?
Parents, they r fine with me taking orals cuz they know I’ll be smart wit it I’ve talked to them for ages they won’t let me pin
 

Similar threads

eon
Replies
77
Views
2K
eon
eon
Edopsl
Replies
10
Views
687
Edopsl
Edopsl
vision_n
Replies
8
Views
359
Bitchwhipper2
Bitchwhipper2
iblamemyself!
Replies
8
Views
495
Sub5kang
Sub5kang

Users who are viewing this thread

Back
Top