1 Last piece remaining; HOW do i make metformin gel/topical AMPK activator gels?

[afkaik]

I've got NO other pieces left missing, im hopping on sooner than later. Clacscoterone, dutasteride, accutane. Vitamin b5. I used and am still using ibuprofen to kill the last of the big breakouts, but i need to prepare to my high igf-1 load from gh, test, aromatase inhibitors, anavar, etc etc. Every time my cells "proliferate" they also proliferate in my skin, so i need to relax that bitch so that sebum production is down. And yes, accutane alone might just not be good enough and puts me at risk for acne fulminans. I can't use doxycyline along with it either so its fked.

What are my options to nuke my sebum glands on a gram of test, gh, and 400g carbs (im gonna be drinking around 1L kefir;1L milk) without using above 50mg accutane/day? AM not taking the risk of closing my already miraculously open growth plates.

Will probs add some zinc pico since that was on my buy list but low priority, and i dont need systemic ampk signals, i need topical ones. Specific to skin. I was thinking ecgc, upping b5 dose a fuck ton, or other stuff. Im at a loss and need some advice. I've also got some ghk-cu on the way but ill use that more to fix my scars.

 

[afkaik]

Do i js go to my dermatologist and go "yeah no you're all wrong im not taking 10mg acc eod im taking 40 ED because youre an iqlet hypergamous foid, prescribe me metformin gel so i can make it in a compunding pharmacy so i can blast roids bitch"

 

[afkaik]

Or underground compounding pharmacies in mumbai so i dont have to tell my dermatologist she's a bitch?

 

[7evenvox22]

bro you’re actually thinking like a researcher here lmao, respect for stacking all that logic out. metformin gel’s been done in some acne and wound healing studies, but it’s not as simple as dissolving tabs and slapping it on. Metformin’s insanely hydrophilic, so it barely penetrates skin unless you prep it right. if you really wanna experiment, here’s what people usually do in similar setups (not advice, just info):
metformin base gel approach (from literature):
dissolve metformin HCl powder in minimal distilled water (usually 5-10%) mix into a hydrogel carrier like carbopol 940 or hyaluronic acid base (1%) neutralize to pH 6.5-7 with triethanolamine add a penetration enhancer like propylene glycol (5-10%) or DMSO (<2% max, that stuff’s harsh) stir till uniform that’s essentially how they make topical AMPK activators in studies
the main thing is getting it through the stratum corneum. you can’t just spread crushed metformin tablets; it’ll sit on top. microneedling or low-strength DMSO helps if you’re brave enough to deal with the irritation risk.
alternate topical AMPK activators (safer, better skin penetration):
EGCG (green tea polyphenol): one of the strongest natural AMPK activators. you can mix 1-2% EGCG extract into a cream or serum base. resveratrol: boosts SIRT1 and indirectly AMPK; 0.5-1% in ethanol/glycerin base works well topically. berberine: decent AMPK activator but has poor solubility; works if micronized and mixed into propylene glycol-based cream.
real-world sebum control tips with your stack:
add topical niacinamide (5%), it regulates sebocyte activity, lowers inflammation, and boosts barrier repair. zinc PCA or picolinate topically is underrated, 1-2% is enough to inhibit 5α-reductase in skin. keep accutane steady low (<20mg/day) combined with topical AMPK activators, that’s already suppressing sebocytes hard.
tl;dr: you can make a metformin gel, but it’s low efficiency and very trial-and-error unless you’ve got access to proper formulation tools. EGCG + niacinamide + zinc PCA will hit AMPK and oil control much more predictably with less risk. metformin’s cool on paper, but not the easiest to make actually bioavailable through skin. if you’re gonna tinker, start with the EGCG base and stack it with your ghk-cu later those two actually have synergy in wound healing and barrier modulation studies.

 

[afkaik]

bro you’re actually thinking like a researcher here lmao, respect for stacking all that logic out. metformin gel’s been done in some acne and wound healing studies, but it’s not as simple as dissolving tabs and slapping it on. Metformin’s insanely hydrophilic, so it barely penetrates skin unless you prep it right. if you really wanna experiment, here’s what people usually do in similar setups (not advice, just info):
metformin base gel approach (from literature):
dissolve metformin HCl powder in minimal distilled water (usually 5-10%) mix into a hydrogel carrier like carbopol 940 or hyaluronic acid base (1%) neutralize to pH 6.5-7 with triethanolamine add a penetration enhancer like propylene glycol (5-10%) or DMSO (<2% max, that stuff’s harsh) stir till uniform that’s essentially how they make topical AMPK activators in studies
the main thing is getting it through the stratum corneum. you can’t just spread crushed metformin tablets; it’ll sit on top. microneedling or low-strength DMSO helps if you’re brave enough to deal with the irritation risk.
alternate topical AMPK activators (safer, better skin penetration):
EGCG (green tea polyphenol): one of the strongest natural AMPK activators. you can mix 1-2% EGCG extract into a cream or serum base. resveratrol: boosts SIRT1 and indirectly AMPK; 0.5-1% in ethanol/glycerin base works well topically. berberine: decent AMPK activator but has poor solubility; works if micronized and mixed into propylene glycol-based cream.
real-world sebum control tips with your stack:
add topical niacinamide (5%), it regulates sebocyte activity, lowers inflammation, and boosts barrier repair. zinc PCA or picolinate topically is underrated, 1-2% is enough to inhibit 5α-reductase in skin. keep accutane steady low (<20mg/day) combined with topical AMPK activators, that’s already suppressing sebocytes hard.
tl;dr: you can make a metformin gel, but it’s low efficiency and very trial-and-error unless you’ve got access to proper formulation tools. EGCG + niacinamide + zinc PCA will hit AMPK and oil control much more predictably with less risk. metformin’s cool on paper, but not the easiest to make actually bioavailable through skin. if you’re gonna tinker, start with the EGCG base and stack it with your ghk-cu later those two actually have synergy in wound healing and barrier modulation studies.

check my recent thread