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MiroslavBulldosex
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Well for starters I want to say that accutane is a "miracle" drug and that everyone with medium to severe acne should take it once their growth plates are closed. I do not regret taking this drug at all.
I wanted to make this thread to talk about the mental side effects of this drug which I feel are not discussed enough.
People will usually only talk about the physical ones that almost everyone gets (dry lips, dry skin, some stiffness).
Basically what I've noticed is that I get way more sensitive whatever my emotion is.
For example if I get angry I might start punching walls and lose my shit from time to time which I rarely do when I'm off that drug unless I'm really fucking upset. If something makes me depressed I will feel more depressed than when I'm off the drug.
This study talks about it
www.ncbi.nlm.nih.gov
" RESULTS:
Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. There were no differences in the severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment.
CONCLUSIONS:
This study suggests that isotretinoin treatment is associated with changes in brain functioning."
en.wikipedia.org
The orbitofrontal cortex (OFC) is a prefrontal cortex region in the frontal lobes of the brain which is involved in the cognitive process of decision-making.
I wanted to make this thread to talk about the mental side effects of this drug which I feel are not discussed enough.
People will usually only talk about the physical ones that almost everyone gets (dry lips, dry skin, some stiffness).
Basically what I've noticed is that I get way more sensitive whatever my emotion is.
For example if I get angry I might start punching walls and lose my shit from time to time which I rarely do when I'm off that drug unless I'm really fucking upset. If something makes me depressed I will feel more depressed than when I'm off the drug.
This study talks about it
![www.ncbi.nlm.nih.gov](/proxy.php?image=https%3A%2F%2Fcdn.ncbi.nlm.nih.gov%2Fpubmed%2Fpersistent%2Fpubmed-meta-image-v2.jpg&hash=a1548116300a186a8bf3da49a5026dc1&return_error=1)
Functional brain imaging alterations in acne patients treated with isotretinoin - PubMed
This study suggests that isotretinoin treatment is associated with changes in brain functioning.
![www.ncbi.nlm.nih.gov](/proxy.php?image=https%3A%2F%2Fcdn.ncbi.nlm.nih.gov%2Fcoreutils%2Fnwds%2Fimg%2Ffavicons%2Ffavicon.png&hash=1ed167f576bf27f20bb138b271a9b7aa&return_error=1)
" RESULTS:
Isotretinoin but not antibiotic treatment was associated with decreased brain metabolism in the orbitofrontal cortex (-21% change versus 2% change for antibiotic), a brain area known to mediate symptoms of depression. There were no differences in the severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment.
CONCLUSIONS:
This study suggests that isotretinoin treatment is associated with changes in brain functioning."
![en.wikipedia.org](/proxy.php?image=https%3A%2F%2Fupload.wikimedia.org%2Fwikipedia%2Fcommons%2Ff%2Ff6%2FMRI_of_orbitofrontal_cortex.jpg&hash=fd9fd1bc67c43ea345a2b7f95ca5ef4d&return_error=1)
Orbitofrontal cortex - Wikipedia
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