I see so many of you guys taking Accutane (Isotretinoin) like it’s just another supplement. It’s not. Before you swallow that next pill, you need to understand the pharmacology of what you’re actually doing to your body. Isotretinoin wasn't designed for acne, it was developed as a chemotherapy drug to treat high-risk cancers like neuroblastoma. When you take it you are essentially putting your body through a low dose chemotherapy-cycle.
Isotretinoin is lipophilic, meaning it crosses the blood-brain barrier no problem. Clinical PET scans have shown that it can nukes the metabolism in your orbitofrontal cortex by over 20%. This is the part of your brain that handles emotions and your will to live.
We aren't talking about "feeling a bit sad." We’re talking about a fundamental shift in who you are. It creates a state of Anhedonia—a complete loss of the ability to feel joy or motivation. You become a "new person," a hollowed-out version of yourself. This leads to what’s called "rational suicide." It’s not an emotional breakdown, it’s a cold, terrifyingly logical feeling that life no longer has value because your brain’s reward systems have been chemically dismantled. You don't even realize it’s the drug doing it while it's happening.
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Watch this video. This is a father talking about his son—a normal guy like us who just wanted to look better—who lost his life because Accutane changed his brain chemistry so deeply that he couldn't find his way back.
The pharmaceutical industry isn’t here to make you healthy; it’s here to create customers. These drugs aren't designed to "heal" you—they are designed to trade one symptom for a systemic disease that’s much harder to track.
Don't be fooled by a "clear" year. I’ve seen countless guys go through the hell of a cycle only to have their acne return two, three, or five years later. They nuked their internal organs for a temporary fix. You might feel fine now, but then the chronic fatigue, the joint degeneration, and the sexual dysfunction hit you years after you stopped taking the pills. By then, the damage is woven into your DNA.
Before you gamble with your life, maybe think about what you put in your body first and actually do some research instead of taking the advise from a random insecure kid on .org
Think about the long game. You ascend you marry a Stacy, you start a family, and you have kids. But then, the systemic toxicity finally catches up. You become a shell of a man, chronically ill and mentally absent, unable to be the father or the partner your family needs. In that moment, looking at your kids while you’re physically falling apart, you will wish you had never did what you have done.
As the saying goes: A healthy man has a thousand wishes, but a sick man has only one.
Don’t trade your health for a reflection in the mirror. You’ll regret it for the rest of your life.
Isotretinoin is lipophilic, meaning it crosses the blood-brain barrier no problem. Clinical PET scans have shown that it can nukes the metabolism in your orbitofrontal cortex by over 20%. This is the part of your brain that handles emotions and your will to live.
We aren't talking about "feeling a bit sad." We’re talking about a fundamental shift in who you are. It creates a state of Anhedonia—a complete loss of the ability to feel joy or motivation. You become a "new person," a hollowed-out version of yourself. This leads to what’s called "rational suicide." It’s not an emotional breakdown, it’s a cold, terrifyingly logical feeling that life no longer has value because your brain’s reward systems have been chemically dismantled. You don't even realize it’s the drug doing it while it's happening.
bump.
Watch this video. This is a father talking about his son—a normal guy like us who just wanted to look better—who lost his life because Accutane changed his brain chemistry so deeply that he couldn't find his way back.
The pharmaceutical industry isn’t here to make you healthy; it’s here to create customers. These drugs aren't designed to "heal" you—they are designed to trade one symptom for a systemic disease that’s much harder to track.
Don't be fooled by a "clear" year. I’ve seen countless guys go through the hell of a cycle only to have their acne return two, three, or five years later. They nuked their internal organs for a temporary fix. You might feel fine now, but then the chronic fatigue, the joint degeneration, and the sexual dysfunction hit you years after you stopped taking the pills. By then, the damage is woven into your DNA.
Before you gamble with your life, maybe think about what you put in your body first and actually do some research instead of taking the advise from a random insecure kid on .org
Think about the long game. You ascend you marry a Stacy, you start a family, and you have kids. But then, the systemic toxicity finally catches up. You become a shell of a man, chronically ill and mentally absent, unable to be the father or the partner your family needs. In that moment, looking at your kids while you’re physically falling apart, you will wish you had never did what you have done.
As the saying goes: A healthy man has a thousand wishes, but a sick man has only one.
Don’t trade your health for a reflection in the mirror. You’ll regret it for the rest of your life.
