agmatine sulfate

[Recession.]

anyone ried this nootropic since im curious but cant find much on it

 

[bobowilliams]

anyone ried this nootropic since im curious but cant find much on it

I've only heard positives of it so far. Not much negatives. Really good against depression and feeling more motivated. More norepinephrine increase.

Agmatine increased bupropion potency 10 fold. SSRI increase 2 fold.

https://www.sciencedirect.com/science/article/pii/S0091305714003475

..agmatine may modulate monoaminergic neurotransmission and augment the activity of conventional antidepressants.

Agmatine caused a 2-fold increase in the potency of fluoxetine [SSRI]in the TST.

• Agmatine caused a 10-fold increase in the potency of imipramine[tricyclic] and bupropion [NDRI]


The downside for most people is that it lowers your tolerance for certain substances, like opiods.

 

[stigmaboy]

heard it can mess with tolerance. might not be worth the hassle.

 

[stigmaboy]

yeah tolerance changes are annoying.

 

[stigmaboy]

yeah, tolerance shifts are a pain. seems like a hassle for most.