T
truecel12
hgh at 5'10 14
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i dont even know why you responded to threads like this. chondrocytes becoming less responsive and active as you age may be true, but i disregarded this thread as soon as this guy tried to claim that aromatase inhibitors dont slow boneage dramatically and that it makes you shorter (which has been directly disproven in clinical trials).Nigga are you slow no way ur saying GH and AI dont work...
First off, e2.... No way u think it's as simple as "estrogen closes growth plates" muh muhh nigga. Estrogen interacts with ERa and ERB on chondrocytes, which triggers MAPK/ERK, PI3K/Akt, and Wnt/B-catenin pathways they regulate chondrocyte proliferation and hypertrophy. E2 also upregulates MMPs and VEGF for remodeling plates and boosting blood vessel formation. This isnt "muh e2 simpleee" it's a process that you clearly don’t get
Now Ai your saying they don’t work because reducing estrogen isn’t enough??? lmao what nigga, it stops the conversion of androgens to estrogens... This slows down EVERY estrogen mediated process. this isnt a fucking theory it’s how these drugs work nigga
More e2 = more test/dht doesnt mean plates will close faster... they interact with androgen receptors on chondrocytes, which activatees paths that PROMOTE growth the Wnt/B-catenin path is involved here too higher androgen receptor expression means chondrocytes are more responsive to androgens supports continued growth even when e2 levels are changes
Abt telomeres, E2 affects telomerase activity + TRF1 and TRF2 which MAINTAINS telomere integrity lowering estrogen delays telomere attrition which would increase chondrocyte proliferative capacity + epigenetic changes, DNA methylation and histone modifications change gene expression patterns for growth epigenetic drugs can reverse this, reactivating growth genes youre ignoring a whole field of science
also localized deliver like nanoparticle carriers boosts GH and IGF-1 u could also combine this with telomerase activators and epigenetic modulators could boost chondrocyte proliferation and delay senescence
"insulin resistance"
nigga even ur avg steroid gymbro knows how to counter this side
TLDR: hes on copius amounts of weed
sources:
![link.springer.com](/proxy.php?image=https%3A%2F%2Fstatic-content.springer.com%2Fimage%2Fart%253A10.1007%252Fs40618-023-02242-w%2FMediaObjects%2F40618_2023_2242_Fig1_HTML.png&hash=3ca504ceb980440a8769b83b0f20d9d9&return_error=1)
Aromatase inhibitors: a useful additional therapeutic option for slowing down advanced bone age in boys with growth hormone deficiency - Journal of Endocrinological Investigation
Introduction Aromatase inhibitors (AIs) have been used to slow down estrogen-dependent skeletal maturation in pubertal boys with short stature. In the literature, few data evaluate the effectiveness and safety of AIs in boys with growth hormone deficiency (GHD). This study aimed to evaluate the...
![link.springer.com](/proxy.php?image=https%3A%2F%2Flink.springer.com%2Foscar-static%2Fimg%2Ffavicons%2Fdarwin%2Fandroid-chrome-192x192-6f081ca7e5.png&hash=5d3a0bb776905d3fda559adf35647578&return_error=1)