AI and GH Will NOT Make You Grow Taller

[truecel12]

Nigga are you slow no way ur saying GH and AI dont work...

First off, e2.... No way u think it's as simple as "estrogen closes growth plates" muh muhh nigga. Estrogen interacts with ERa and ERB on chondrocytes, which triggers MAPK/ERK, PI3K/Akt, and Wnt/B-catenin pathways they regulate chondrocyte proliferation and hypertrophy. E2 also upregulates MMPs and VEGF for remodeling plates and boosting blood vessel formation. This isnt "muh e2 simpleee" it's a process that you clearly don’t get

Now Ai your saying they don’t work because reducing estrogen isn’t enough??? lmao what nigga, it stops the conversion of androgens to estrogens... This slows down EVERY estrogen mediated process. this isnt a fucking theory it’s how these drugs work nigga

More e2 = more test/dht doesnt mean plates will close faster... they interact with androgen receptors on chondrocytes, which activatees paths that PROMOTE growth the Wnt/B-catenin path is involved here too higher androgen receptor expression means chondrocytes are more responsive to androgens supports continued growth even when e2 levels are changes

Abt telomeres, E2 affects telomerase activity + TRF1 and TRF2 which MAINTAINS telomere integrity lowering estrogen delays telomere attrition which would increase chondrocyte proliferative capacity + epigenetic changes, DNA methylation and histone modifications change gene expression patterns for growth epigenetic drugs can reverse this, reactivating growth genes youre ignoring a whole field of science

also localized deliver like nanoparticle carriers boosts GH and IGF-1 u could also combine this with telomerase activators and epigenetic modulators could boost chondrocyte proliferation and delay senescence

"insulin resistance"
nigga even ur avg steroid gymbro knows how to counter this side

TLDR: hes on copius amounts of weed

i dont even know why you responded to threads like this. chondrocytes becoming less responsive and active as you age may be true, but i disregarded this thread as soon as this guy tried to claim that aromatase inhibitors dont slow boneage dramatically and that it makes you shorter (which has been directly disproven in clinical trials).

sources:

Aromatase inhibitors: a useful additional therapeutic option for slowing down advanced bone age in boys with growth hormone deficiency - Journal of Endocrinological Investigation

Introduction Aromatase inhibitors (AIs) have been used to slow down estrogen-dependent skeletal maturation in pubertal boys with short stature. In the literature, few data evaluate the effectiveness and safety of AIs in boys with growth hormone deficiency (GHD). This study aimed to evaluate the...

link.springer.com

Aromatase Inhibitor as Treatment for Severely Advanced Bone Age in Congenital Adrenal Hyperplasia: A Case Report - PMC

Treatment with aromatase inhibitors (AI) is a potential novel treatment in patients with congenital adrenal hyperplasia (CAH) and advanced bone age (BA), to increase near adult height (NAH). Not much is known about the efficacy of AI treatment in ...

www.ncbi.nlm.nih.gov

 

[truecel12]

and something that other people dont realize is that if your injecting chinese drugs and taking indian pills it was already over to begin with. you actually have autism if you made such a drastic choice based off niggas on an indian forum.

nt is law, if you take this shit DONT FUCKING TELL ANYBODY. NOT EVEN YOUR CLOSEST FRIENDS. i fucked up by telling my close friend, and he said it loud as fuck in class about how my 250 bench didnt count because i was on "peds".

instead of spending your time researching sperg shit, study hard in school and become a fucking doctor, at least betabuxxing will save your 5'4 indian ass.

 

[Rigged]

i dont even know why you responded to threads like this. chondrocytes becoming less responsive and active as you age may be true, but i disregarded this thread as soon as this guy tried to claim that aromatase inhibitors dont slow boneage dramatically and that it makes you shorter (which has been directly disproven in clinical trials).

sources:

Aromatase inhibitors: a useful additional therapeutic option for slowing down advanced bone age in boys with growth hormone deficiency - Journal of Endocrinological Investigation

Introduction Aromatase inhibitors (AIs) have been used to slow down estrogen-dependent skeletal maturation in pubertal boys with short stature. In the literature, few data evaluate the effectiveness and safety of AIs in boys with growth hormone deficiency (GHD). This study aimed to evaluate the...

link.springer.com

Aromatase Inhibitor as Treatment for Severely Advanced Bone Age in Congenital Adrenal Hyperplasia: A Case Report - PMC

Treatment with aromatase inhibitors (AI) is a potential novel treatment in patients with congenital adrenal hyperplasia (CAH) and advanced bone age (BA), to increase near adult height (NAH). Not much is known about the efficacy of AI treatment in ...

www.ncbi.nlm.nih.gov

I replied for the rep i want positive

 

[Rigged]

and something that other people dont realize is that if your injecting chinese drugs and taking indian pills it was already over to begin with. you actually have autism if you made such a drastic choice based off niggas on an indian forum.

nt is law, if you take this shit DONT FUCKING TELL ANYBODY. NOT EVEN YOUR CLOSEST FRIENDS. i fucked up by telling my close friend, and he said it loud as fuck in class about how my 250 bench didnt count because i was on "peds".

instead of spending your time researching sperg shit, study hard in school and become a fucking doctor, at least betabuxxing will save your 5'4 indian ass.

my friend yelled “are u on looksmax again” when i was on insta, hate niggas

 

[truecel12]

my friend yelled “are u on looksmax again” when i was on insta, hate niggas

never use this forum in public. normies will always try to drag you.

 

[ceez]

I went extrmely hard as well and was too late, 17 bone age is too late to spend hundreds of dollars, you won't get much past your growth chart snd prediction if you don't start at like 15

I'm freshly 15, could I?

 

[pinterest]

it's fine as long as the information is accurate.

something that's often overlooked here is that the average age of the participants in hgh trials is around 10 years of age, they're pre-puberty, not nearing the end of it like most posters here.

what if im 14