PharmaPhaggot
Hedonism final boss
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So when we for example try to mitigate roid induced aging with ru58841 for example what is done is basically a hard stop. Now this makes sense as its very reliable method to do this but it comes with some limitations. In this case it's that the application cannot be too frequent or with a too high % solution. Now im of course not shitting on ru its a gift from god but those limitations atleast seem like they should too some degree lower its efficacy. So I think at least in theory it seems like a good idea to also go a step further and also more specifically suppress the genes that are detrimental to our progress as a second line of defense against those androgen receptors that were missed when you applied RU.
hair safety
dkk1 is a gene that was made by the devil himself, it's the main reason anabolics cause hair miniaturization so we wanna minimize it at all costs
Piperonylic acid
So this paper https://www.mdpi.com/1422-0067/25/19/10774 actually both tested it on people and it helped hair density significantly indicating that its not just a slight theoretical effect but actually applicable to us. They also put dht on skin cells and piperonylic acid was actually able to reduce dkk1 expression
this when i looked it up quickly seemed cheap and available so it might be good to put this into consideration
elastin and collagen
the main reason almost all transformations or users of other androgenic compounds almost always show horrible skin quality, like exaggerated nasolabial folds and such like mike isratel is due to anabolics horribly upregulating mmp’s which are enzymes that break down collagen and elastin.
t-5224
in this study https://pubmed.ncbi.nlm.nih.gov/29476740/ t-5224 was able to reduce expression of mmp 1,3 and 13 with 1 being the one were most focussed on as its the one that destroys most collagen and will therefore agepill you the most
short thread but idgaf, do more research if it seems interesting
Feel free to debunk ofc
hair safety
dkk1 is a gene that was made by the devil himself, it's the main reason anabolics cause hair miniaturization so we wanna minimize it at all costs
Piperonylic acid
So this paper https://www.mdpi.com/1422-0067/25/19/10774 actually both tested it on people and it helped hair density significantly indicating that its not just a slight theoretical effect but actually applicable to us. They also put dht on skin cells and piperonylic acid was actually able to reduce dkk1 expression
this when i looked it up quickly seemed cheap and available so it might be good to put this into consideration
elastin and collagen
the main reason almost all transformations or users of other androgenic compounds almost always show horrible skin quality, like exaggerated nasolabial folds and such like mike isratel is due to anabolics horribly upregulating mmp’s which are enzymes that break down collagen and elastin.
t-5224
in this study https://pubmed.ncbi.nlm.nih.gov/29476740/ t-5224 was able to reduce expression of mmp 1,3 and 13 with 1 being the one were most focussed on as its the one that destroys most collagen and will therefore agepill you the most
short thread but idgaf, do more research if it seems interesting
Feel free to debunk ofc