Alternative skincare actives (has anyone actually experimented with them?)

[afkaik]

Fuhr mein, tazarotene and almost 2L of kefir everyday. Is anyone on this forum on actual spiro, clascoterone, or another promising topical drug ? Tired of seeing muh just use accutane (my liver enzymes are fucked and ill die if i use it). Drop your experiences, tazarotene had me under a mini breakout but quickly cleared up

And look at this:

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onlinelibrary.wiley.com

i think its pretty high iq, metformin gel for hormonal acne is quite promising, and i never see it discussed here of all places.