Androgen Receptor Modulation + TEST and IGF secretagogue peptides have the potential to actually increase facial bone mass.

[ThugggButt]

(High IQ responses only, I've done a lot of research)

Water:
Testosterone by itself has no effect on facial bone mass and only extremely minor effects on soft tissue.
Examples of testosterone doing nothing to the face besides decreasing body fat:

Spoiler

Spoiler

Spoiler

However, the introduction of SARMs (Selective androgen receptor modulators) could allow your facial bones (which contain permanent-acting androgen receptors unlike muscle which does not contain those and will change regularly) to react to free testosterone and IGF which will actually cause osteoplasts to grow facial bones at any age.)
Examples of PED-related facial growth actually working:

Spoiler: Before

Spoiler: After

Conclusion:
A PED stack containing SARMs such as S-4 or Ostarine, along with peptides such as CJC, or Gonadorelin, or with TRT instead of peptides could have the potential to actually increase facial bone mass permanently in areas besides the mandible.

Reply if you think this could work or if you have better ideas for peptides or SARMs because I will try this.

 

[StarvedEpi]

DNR(yet)

 

[appealmaxed]

what about s4 vision sides.
what dose of osta u talking of?
cjc causes bloating

 

[ThugggButt]

DNR(yet)

The point of it is that it could work for adults by manually activating and producing androgen receptors like when you were in early puberty.

 

[StarvedEpi]

The point of it is that it could work for adults by manually activating and producing androgen receptors like when you were in early puberty.

ok that answered my question that i was going to ask

 

[ThugggButt]

what about s4 vision sides.
what dose of osta u talking of?
cjc causes bloating

what about s4 vision sides.
I'll go blind to be chad

what dose of osta u talking of?
Not the regular since I'd be combining it with other PEDs

cjc causes bloating
This is where you could substitute TRT or HCG

 

[Maalik]

Cope

 

[ThugggButt]

Cope

tard

 

[Maalik]

tard

Yes you are.

 

[ThugggButt]

Yes you are.

youve been uselessmaxxing since Oct 29th 2022

 

[Maalik]

youve been uselessmaxxing since Oct 29th 2022

you've been uselessmaxxing for one year too
and with subzero post rep ratio to show for it.

Ultimate sign of a LowIQ dog.

 

[ThugggButt]

you've been uselessmaxxing for one year too
and with subzero post rep ratio to show for it.

Ultimate sign of a LowIQ dog.

added to my rape list lil bro

 

[FutureChadronelite]

added to my rape list lil bro

 

[mfk]

Your evidence of PED related bone growth was a before and after picture of young vs old Greg Doucette??

 

[MA_ascender]

stopped reading when u showed pics of adults


blast T at 12 or cope


i wont read

 

[ThugggButt]

stopped reading when u showed pics of adults


blast T at 12 or cope


i wont read

the whole point of the article is for it to work on adults

 

[DR. NICKGA]

All cope

Its all genetics

 

[ThugggButt]

Your evidence of PED related bone growth was a before and after picture of young vs old Greg Doucette??

yes hes a fucking mogger now when before he looked average at the same bf

 

[ArdaxHG]

Sarms are literally less androgenic Testosterone and even some are much less anabolic than it. Bone growth is mainly modulated by growth factors such as igf1 but androgenic hormones like dht and test grow male specific bones such as browridge, shoulder gridle etc. So you gain nothing by using sarms but losing the androgenic effects of steroids

 

[ThugggButt]

Sarms are literally less androgenic Testosterone and even some are much less anabolic than it. Bone growth is mainly modulated by growth factors such as igf1 but androgenic hormones like dht and test grow male specific bones such as browridge, shoulder gridle etc. So you gain nothing by using sarms but losing the androgenic effects of steroids

Androgen receptors are attached to cells and they react to androgens such as testosterone. When they do this they tell the cell to perform actions based on the androgen.

Of course SARMs are less androgenic than testosterone because a SARM is not an androgen. It causes the body to produce more of and activate androgen receptors to react to testosterone.

This is the reason combining a sarm with an androgen or androgen secretagogue would be effective and bypass the closing of androgen receptors from age.

also I don't think you know what androgenic or anabolic means

 

[mfk]

yes hes a fucking mogger now when before he looked average at the same bf

facial fat is lost as you age

 

[ArdaxHG]

Androgen receptors are attached to cells and they react to androgens such as testosterone. When they do this they tell the cell to perform actions based on the androgen.

Of course SARMs are less androgenic than testosterone because a SARM is not an androgen. It causes the body to produce more of and activate androgen receptors to react to testosterone.

This is the reason combining a sarm with an androgen or androgen secretagogue would be effective and bypass the closing of androgen receptors from age.

also I don't think you know what androgenic or anabolic means

Lol. How come something which is not androgenic result in androen receptors upregulation. Sarms bind to ar in muscle only.

 

[LooksmaxAutist]

The whole reason SARM's / Steroids were made was to NOT HAVE less masculinizing effects milligram for milligram compared to testosterone so that we could give these drugs to women and children. If your goal is masculinization of the face (or really any area of the body) you would want the most masculinizing hormone we make which is DHT. You can get DHT cream Andractim from an online pharmacy and rub that on your face if your goal was androgenicity however you will halt your own testosterone production so I would recommend also pinning TRT during the experiment.

 

[20/04/2008]

(High IQ responses only, I've done a lot of research)

Water:
Testosterone by itself has no effect on facial bone mass and only extremely minor effects on soft tissue.
Examples of testosterone doing nothing to the face besides decreasing body fat:

Spoiler

View attachment 3207958

Spoiler

View attachment 3207965

Spoiler

View attachment 3207962

However, the introduction of SARMs (Selective androgen receptor modulators) could allow your facial bones (which contain permanent-acting androgen receptors unlike muscle which does not contain those and will change regularly) to react to free testosterone and IGF which will actually cause osteoplasts to grow facial bones at any age.)
Examples of PED-related facial growth actually working:

Spoiler: Before

View attachment 3207972View attachment 3207973

Spoiler: After

View attachment 3207976

Conclusion:
A PED stack containing SARMs such as S-4 or Ostarine, along with peptides such as CJC, or Gonadorelin, or with TRT instead of peptides could have the potential to actually increase facial bone mass permanently in areas besides the mandible.

Reply if you think this could work or if you have better ideas for peptides or SARMs because I will try this.

nigga jay cutler jaw grw in his 20s
because of the stress he put on his jaw by eating pounds and pounds of hard food
and the 10s to 20s iu of hgh and the grams of test deca equip tren primo he was on
and dont let me started on people who started gear early for me i think this is the most gatekept thing in this forum

 

[ThugggButt]

Lol. How come something which is not androgenic result in androen receptors upregulation. Sarms bind to ar in muscle only.

Ever heard of ostarine or S-4 did you even read what I said, you genuinely do not know what a SARM is, it is literally an acronym for SELECTIVE ANDROGEN RECEPTOR MODULATOR

The whole reason SARM's / Steroids were made was to NOT HAVE less masculinizing effects milligram for milligram compared to testosterone so that we could give these drugs to women and children. If your goal is masculinization of the face (or really any area of the body) you would want the most masculinizing hormone we make which is DHT. You can get DHT cream Andractim from an online pharmacy and rub that on your face if your goal was androgenicity however you will halt your own testosterone production so I would recommend also pinning TRT during the experiment.

DHT cream does not grow facial bones in adults, however, the combination of it with SARMs could grow them mimicking an effect of an extended puberty. That's what the whole post is about, obviously I know what DHT is I'm not a retard.

 

[LooksmaxAutist]

DHT cream does not grow facial bones in adults, however, the combination of it with SARMs could grow them mimicking an effect of an extended puberty. That's what the whole post is about, obviously I know what DHT is I'm not a retard.

Then I am confused as to what you are postulating, you realize that SARMs and DHT are both targets for androgen receptor, what do you believe will occur if the ligand for the receptor is a SARM vs DHT? SARMs are translocated into the nucleus the same way DHT is and as a result the only difference would be in the resulted transcription. You need to link articles if SARMs are in fact able to cause bone formation whereas DHT is not because I have never seen any evidence to suggest this.

 

[ThugggButt]

Then I am confused as to what you are postulating, you realize that SARMs and DHT are both targets for androgen receptor, what do you believe will occur if the ligand for the receptor is a SARM vs DHT? SARMs are translocated into the nucleus the same way DHT is and as a result the only difference would be in the resulted transcription. You need to link articles if SARMs are in fact able to cause bone formation whereas DHT is not because I have never seen any evidence to suggest this.

I'm not gonna bother sourcing just search for it,

SARMs increase the amount of androgen receptors in certain areas of the body, DHT is an androgen, so when SARMs increase androgen receptors and you combine it with any other androgen such as test or GH from peptides it would have an increased effect.

 

[LooksmaxAutist]

I'm not gonna bother sourcing just search for it,

SARMs increase the amount of androgen receptors in certain areas of the body, DHT is an androgen, so when SARMs increase androgen receptors and you combine it with any other androgen such as test or GH from peptides it would have an increased effect.

I think you misunderstand why SARMs are called SARMs, the reason for the name isn't because it causes recruitment of androgen receptors but rather because it can both exhort an agonistic effects in some tissues and an antagonistic effect it others, the goal for the drug development was to refine SARMs to a point they only caused agonism in skeletal muscle. Also GH is not an androgen. I can't find any data to back up what you say.

 

[20/04/2008]

I think you misunderstand why SARMs are called SARMs, the reason for the name isn't because it causes recruitment of androgen receptors but rather because it can both exhort an agonistic effects in some tissues and an antagonistic effect it others, the goal for the drug development was to refine SARMs to a point they only caused agonism in skeletal muscle. Also GH is not an androgen. I can't find any data to back up what you say.

Sarms are 0 androgenic and suppress your natural hormones (but they still technically are slightly androgenic) (and for the suppression its mild and you recover fast especially compared to injectables and especially 19 Nooooorsss)
The main result they invinted Sarms was to cure breast cancer so they have to find an androgen like dht gel who would reduce gynocomastia without causing androgenic side effects

 

[LooksmaxAutist]

Sarms are 0 androgenic and suppress your natural hormones (but they still technically are slightly androgenic) (and for the suppression its mild and you recover fast especially compared to injectables and especially 19 Nooooorsss)
The main result they invinted Sarms was to cure breast cancer so they have to find an androgen like dht gel who would reduce gynocomastia without causing androgenic side effects

No, no to everything you said.

1. Because Sarms are not an oral they aren't esterified meaning they will act quicker than there esterfied steroid counterparts, while I am not saying the amount of suppression is equal to a 19-nor the onset of action of the drug is quicker and thus will work on receptors within the HPTA quicker.

2. Sarms were not meant to "cure breast cancer" Sarms were invented as a successor to steroids and used in treating muscle wasting conditions such as cancer, this is why any steroid or sarm in clinical trials is tested on people who have sarcopenia, or are currently in chemotherapy.

3. as an adjunct to part 2 I think you mean SERMs which ARE used in the treatment of breast cancer.

 

[20/04/2008]

No, no to everything you said.

1. Because Sarms are not an oral they aren't esterified meaning they will act quicker than there esterfied steroid counterparts, while I am not saying the amount of suppression is equal to a 19-nor the onset of action of the drug is quicker and thus will work on receptors within the HPTA quicker.

2. Sarms were not meant to "cure breast cancer" Sarms were invented as a successor to steroids and used in treating muscle wasting conditions such as cancer, this is why any steroid or sarm in clinical trials is tested on people who have sarcopenia, or are currently in chemotherapy.

3. as an adjunct to part 2 I think you mean SERMs which ARE used in the treatment of breast cancer.

1)Nigga Rad 140 and lgd were made to cure breast cancer im 100% sure
2)No steroid or sarm has ever been created for performing enhancing purposes the only exeption is turinabol
3)i would fuck you in the ass for thinking i was dumb enough to think serms (clomid,nolva,ralox) and Sarms (rad osta lgd S23) are the same what fo you think i use fucking chat gpt like you
4)Wtf did you just wright at the beginning of your reply do you just write some mubha bumhai to seem smart
Like if someone has basic knowledge in pharmacology he would come out of the screen or your phone and slap your ass for writing that like wtf did you just even write what does that have to do with everything im sure you just googled 19 nor 5 min ago im really now suspecting your using some kind of ai for your replies

 

[20/04/2008]

• PMID: 28974548 (study of rad 140)
• PMCID: PMC4114483
  PMID: 25072326 (study showing that Sarms have breast cancer onhibbiting effects)

 

[bpow321]

(High IQ responses only, I've done a lot of research)

Water:
Testosterone by itself has no effect on facial bone mass and only extremely minor effects on soft tissue.
Examples of testosterone doing nothing to the face besides decreasing body fat:

Spoiler

View attachment 3207958

Spoiler

View attachment 3207965

Spoiler

View attachment 3207962

However, the introduction of SARMs (Selective androgen receptor modulators) could allow your facial bones (which contain permanent-acting androgen receptors unlike muscle which does not contain those and will change regularly) to react to free testosterone and IGF which will actually cause osteoplasts to grow facial bones at any age.)
Examples of PED-related facial growth actually working:

Spoiler: Before

View attachment 3207972View attachment 3207973

Spoiler: After

View attachment 3207976

Conclusion:
A PED stack containing SARMs such as S-4 or Ostarine, along with peptides such as CJC, or Gonadorelin, or with TRT instead of peptides could have the potential to actually increase facial bone mass permanently in areas besides the mandible.

Reply if you think this could work or if you have better ideas for peptides or SARMs because I will try this.

Was expecting evidence beyond some random screenshots of dudes

 

[elemanzelvadre]

test better

 

[LooksmaxAutist]

1)Nigga Rad 140 and lgd were made to cure breast cancer im 100% sure
2)No steroid or sarm has ever been created for performing enhancing purposes the only exeption is turinabol
3)i would fuck you in the ass for thinking i was dumb enough to think serms (clomid,nolva,ralox) and Sarms (rad osta lgd S23) are the same what fo you think i use fucking chat gpt like you
4)Wtf did you just wright at the beginning of your reply do you just write some mubha bumhai to seem smart
Like if someone has basic knowledge in pharmacology he would come out of the screen or your phone and slap your ass for writing that like wtf did you just even write what does that have to do with everything im sure you just googled 19 nor 5 min ago im really now suspecting your using some kind of ai for your replies

1) They weren't "made" to cure breast cancer, when I say SARM's weren't developed to cure breast cancer I meant that the intended reasons SARM's were researched in the first place was originally because in rodent models we saw castrated rats able to exhibit the same level of muscle tissue retention as rats who were not castrated with the use of arylpropionamide SARMs while at the same time leading to relative lack of growth of the prostate which would lead researchers to believe SARM's could target skeletal tissue in humans aka work in treating patients with ANY MUSCLE WASTING CONDITIONS NOT NECESSARILY TO CURE BREAST CANCER. The reason you think breast cancer with RAD140 for example is because radius health, the company who developed rad, sold the rights to the molecule after clinical testing showed promise in the treatment of breast cancer https://ellipses.life/wp-content/up...ivests-RAD-140-Program-to-Ellipses-Pharma.pdf

we have also seen SARMs like LGD2941 go through the drug development pipeline and reach phase 1 for the treatment of frailty and osteoporosis (way before RAD140 ever entered phase 1 clinical testing) but then fall off the face of the planet once they can't get any further in the drug development process because the drug is not refined enough. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896569/

Sarms were intended to treat a variety of muscle wasting conditions, what conditions are ethical for its use in a clinical setting need to be determined by companies looking to get the drug on the market and the FDA.

2) I never claimed sarms were made for this reason

3) from the way you speak it's obvious you know a bit about gear but not enough to act the way you do

4) let me explain some concepts to you, esterfied steroids are steroids that have an ester attached that when acted upon by esterease enzymes frees the parent hormone to bind on the AR. HPTA is the negative feedback loop used for regulating sex hormone production. Onset of action is how long it takes for the drug to exhort its effects

also no I don't use chatGPT I actually understand this stuff, 19-nor refers to the fact that at the 19th carbon atom in the structure of testosterone a functional group was removed.

 

[LooksmaxAutist]

Was expecting evidence beyond some random screenshots of dudes

theese eese org bro don't expect much

 

[Deleted member 96505]

This has been said a million times already. The problem is that androgens make u bald and growth factors give u enlarged nose and ears.

 

[20/04/2008]

Then I am confused as to what you are postulating, you realize that SARMs and DHT are both targets for androgen receptor, what do you believe will occur if the ligand for the receptor is a SARM vs DHT? SARMs are translocated into the nucleus the same way DHT is and as a result the only difference would be in the resulted transcription. You need to link articles if SARMs are in fact able to cause bone formation whereas DHT is not because I have never seen any evidence to suggest this.

Nigga Sarms are not androgenic it just have indirect effects

1) They weren't "made" to cure breast cancer, when I say SARM's weren't developed to cure breast cancer I meant that the intended reasons SARM's were researched in the first place was originally because in rodent models we saw castrated rats able to exhibit the same level of muscle tissue retention as rats who were not castrated with the use of arylpropionamide SARMs while at the same time leading to relative lack of growth of the prostate which would lead researchers to believe SARM's could target skeletal tissue in humans aka work in treating patients with ANY MUSCLE WASTING CONDITIONS NOT NECESSARILY TO CURE BREAST CANCER. The reason you think breast cancer with RAD140 for example is because radius health, the company who developed rad, sold the rights to the molecule after clinical testing showed promise in the treatment of breast cancer https://ellipses.life/wp-content/up...ivests-RAD-140-Program-to-Ellipses-Pharma.pdf

we have also seen SARMs like LGD2941 go through the drug development pipeline and reach phase 1 for the treatment of frailty and osteoporosis (way before RAD140 ever entered phase 1 clinical testing) but then fall off the face of the planet once they can't get any further in the drug development process because the drug is not refined enough. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896569/

Sarms were intended to treat a variety of muscle wasting conditions, what conditions are ethical for its use in a clinical setting need to be determined by companies looking to get the drug on the market and the FDA.

2) I never claimed sarms were made for this reason

3) from the way you speak it's obvious you know a bit about gear but not enough to act the way you do

4) let me explain some concepts to you, esterfied steroids are steroids that have an ester attached that when acted upon by esterease enzymes frees the parent hormone to bind on the AR. HPTA is the negative feedback loop used for regulating sex hormone production. Onset of action is how long it takes for the drug to exhort its effects

also no I don't use chatGPT I actually understand this stuff, 19-nor refers to the fact that at the 19th carbon atom in the structure of testosterone a functional group was removed.

what does ester has to do with anything why tf do you explain that to me and what does it have to do anything eith what i writed its just like you write just fir the sake for seeming smart stop frauding
And also i knew about the prostate i just forgot

 

[20/04/2008]

This has been said a million times already. The problem is that androgens make u bald and growth factors give u enlarged nose and ears.

Even rad 140 can have balding effects

 

[AySab]

(High IQ responses only, I've done a lot of research)

Water:
Testosterone by itself has no effect on facial bone mass and only extremely minor effects on soft tissue.
Examples of testosterone doing nothing to the face besides decreasing body fat:

Spoiler

View attachment 3207958

Spoiler

View attachment 3207965

Spoiler

View attachment 3207962

However, the introduction of SARMs (Selective androgen receptor modulators) could allow your facial bones (which contain permanent-acting androgen receptors unlike muscle which does not contain those and will change regularly) to react to free testosterone and IGF which will actually cause osteoplasts to grow facial bones at any age.)
Examples of PED-related facial growth actually working:

Spoiler: Before

View attachment 3207972View attachment 3207973

Spoiler: After

View attachment 3207976

Conclusion:
A PED stack containing SARMs such as S-4 or Ostarine, along with peptides such as CJC, or Gonadorelin, or with TRT instead of peptides could have the potential to actually increase facial bone mass permanently in areas besides the mandible.

Reply if you think this could work or if you have better ideas for peptides or SARMs because I will try this.

stupid shit found out what BMD means. congrats fucking asian chink faggot bitch.

 

[LooksmaxAutist]

Nigga Sarms are not androgenic it just have indirect effects

what does ester has to do with anything why tf do you explain that to me and what does it have to do anything eith what i writed its just like you write just fir the sake for seeming smart stop frauding
And also i knew about the prostate i just forgot

SARMs ARE androgenic, if they were not they would have passed clinical testing by now, the way that RAD140 has been useful in the treatment of breast cancer is because androgens are able to prevent transcription after the binding of estrogens to the ER, as a result in breast tissue you would be able to prevent tumor growth by inhibiting cell proliferation via the ER if you have adequate androgenic activity. We see this same concept play out when taking androgenic steroids such as Masteron which allows people who run high doses of test to not need an AI because Masteron is able to prevent transcription of estradiol. This does seem to just be molecules that are androgenic in general rather than specifically steroids or sarms because we see this also play out with DHT https://pubmed.ncbi.nlm.nih.gov/6645492/
" These findings suggest that the mechanism of DHT antagonism of estrogen effect in this organ system does not involve inhibition of synthesis of estrogen receptor as has been shown for progesterone, but appears to occur by decreasing estrogen-induced RNA transcription at a point subsequent to estrogen receptor binding."

Even rad 140 can have balding effects

You even say here Rad has balding effects, guess what androgenicity does? It causes hair loss which is what is being done in the case of RAD.


You talked about how I was using terms that were mumba jumba to seem smart, I explained the terms so you could understand them and it doesn't seem like mumba jumba

I am not frauding, the idea of having enzymes in the body that cleave off parts of a molecule to release the hormone seems like you would need to be a genius to understand it to the average person but in reality it isn't. A person with below average IQ can understand this, the reason I worded it the way I did is that is as simple as I can make it.

 

[20/04/2008]

SARMs ARE androgenic, if they were not they would have passed clinical testing by now, the way that RAD140 has been useful in the treatment of breast cancer is because androgens are able to prevent transcription after the binding of estrogens to the ER, as a result in breast tissue you would be able to prevent tumor growth by inhibiting cell proliferation via the ER if you have adequate androgenic activity. We see this same concept play out when taking androgenic steroids such as Masteron which allows people who run high doses of test to not need an AI because Masteron is able to prevent transcription of estradiol. This does seem to just be molecules that are androgenic in general rather than specifically steroids or sarms because we see this also play out with DHT https://pubmed.ncbi.nlm.nih.gov/6645492/
" These findings suggest that the mechanism of DHT antagonism of estrogen effect in this organ system does not involve inhibition of synthesis of estrogen receptor as has been shown for progesterone, but appears to occur by decreasing estrogen-induced RNA transcription at a point subsequent to estrogen receptor binding."


You even say here Rad has balding effects, guess what androgenicity does? It causes hair loss which is what is being done in the case of RAD.


You talked about how I was using terms that were mumba jumba to seem smart, I explained the terms so you could understand them and it doesn't seem like mumba jumba

I am not frauding, the idea of having enzymes in the body that cleave off parts of a molecule to release the hormone seems like you would need to be a genius to understand it to the average person but in reality it isn't. A person with below average IQ can understand this, the reason I worded it the way I did is that is as simple as I can make it.

nigga why do you repeat what i say your making me mad i already knew that wtf are you on

 

[LooksmaxAutist]

nigga why do you repaet what i say your making me mad i alreafy knew that wtd are you on

Because you keep contradicting yourself, if you are claiming rad140 has no androgenicity but it also causes hairloss then one of your statements is wrong as androgens are responsible for the majority of hairloss in men. Unless you are suggesting some other mechanism of hairloss outside of the AR such as estrogen deprivation then I'm lost as to what your position is, Does rad140 have androgenic effects yes or no?

 

[20/04/2008]

Because you keep contradicting yourself, if you are claiming rad140 has no androgenicity but it also causes hairloss then one of your statements is wrong as androgens are responsible for the majority of hairloss in men. Unless you are suggesting some other mechanism of hairloss outside of the AR such as estrogen deprivation then I'm lost as to what your position is, Does rad140 have androgenic effects yes or no?

No go reread my messages
I said it’s technically 0 androgenic im talking about the anabolic to androgenic ratio
Then i say after that indeed have some androgenic sides like for example hairloss

 

[LooksmaxAutist]

No go reread my messages
I said it’s technically 0 androgenic im talking about the anabolic to androgenic ratio
Then i say after that indeed have some androgenic sides like for example hairloss

the anabolic to androgenic ratio is sort of a bad way to look at drugs. The hershberger assay which dictates that ratio is determined by looking at castrated vs uncastrated rats and tends to not play out in real world applications. A good example of this is superdrol with a 400/20 anabolic to androgenic ratio, we see this doesn't end up playing out in real life and as a result superdrol is not used in the treatment of muscle wasting conditions or in an offseason context in bodybuilding. A hershberger assay can be useful in getting an idea of how a drug might perform but we have to keep in mind when looking at this number it's pulled from rodent models.

 

[mfk]

1) They weren't "made" to cure breast cancer, when I say SARM's weren't developed to cure breast cancer I meant that the intended reasons SARM's were researched in the first place was originally because in rodent models we saw castrated rats able to exhibit the same level of muscle tissue retention as rats who were not castrated with the use of arylpropionamide SARMs while at the same time leading to relative lack of growth of the prostate which would lead researchers to believe SARM's could target skeletal tissue in humans aka work in treating patients with ANY MUSCLE WASTING CONDITIONS NOT NECESSARILY TO CURE BREAST CANCER. The reason you think breast cancer with RAD140 for example is because radius health, the company who developed rad, sold the rights to the molecule after clinical testing showed promise in the treatment of breast cancer https://ellipses.life/wp-content/up...ivests-RAD-140-Program-to-Ellipses-Pharma.pdf

we have also seen SARMs like LGD2941 go through the drug development pipeline and reach phase 1 for the treatment of frailty and osteoporosis (way before RAD140 ever entered phase 1 clinical testing) but then fall off the face of the planet once they can't get any further in the drug development process because the drug is not refined enough. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896569/

Sarms were intended to treat a variety of muscle wasting conditions, what conditions are ethical for its use in a clinical setting need to be determined by companies looking to get the drug on the market and the FDA.

2) I never claimed sarms were made for this reason

3) from the way you speak it's obvious you know a bit about gear but not enough to act the way you do

4) let me explain some concepts to you, esterfied steroids are steroids that have an ester attached that when acted upon by esterease enzymes frees the parent hormone to bind on the AR. HPTA is the negative feedback loop used for regulating sex hormone production. Onset of action is how long it takes for the drug to exhort its effects

also no I don't use chatGPT I actually understand this stuff, 19-nor refers to the fact that at the 19th carbon atom in the structure of testosterone a functional group was removed.

You’re right in this argument. Possibly the highest IQ greycel I’ve seen in this forum for a while.

Other guy really said SARMs have zero androgenicity

 

[LooksmaxAutist]

You’re right in this argument. Possibly the highest IQ greycel I’ve seen in this forum for a while.

Thank you my brotha, I shall print this out and put it on my fridge

 

[20/04/2008]

the anabolic to androgenic ratio is sort of a bad way to look at drugs. The hershberger assay which dictates that ratio is determined by looking at castrated vs uncastrated rats and tends to not play out in real world applications. A good example of this is superdrol with a 400/20 anabolic to androgenic ratio, we see this doesn't end up playing out in real life and as a result superdrol is not used in the treatment of muscle wasting conditions or in an offseason context in bodybuilding. A hershberger assay can be useful in getting an idea of how a drug might perform but we have to keep in mind when looking at this number it's pulled from rodent models.

You’re right in this argument. Possibly the highest IQ greycel I’ve seen in this forum for a while.

Other guy really said SARMs have zero androgenicity

No look what i writed

 

[20/04/2008]

Sarms are 0 androgenic and suppress your natural hormones (but they still technically are slightly androgenic) (and for the suppression its mild and you recover fast especially compared to injectables and especially 19 Nooooorsss)
The main result they invinted Sarms was to cure breast cancer so they have to find an androgen like dht gel who would reduce gynocomastia without causing androgenic side effects

.

 

[20/04/2008]

Even rad 140 can have balding effects

.