ANTI ANDROGENS FULL GUIDE

[Askinov]

@AllMyExsLiveInTexas

 

[Askinov]

@mirinnnasal

 

[Askinov]

BUmp

 

[ThomasDeutsch]

dht is a useless hormone. u realistically dont need to nuke all scalp androgens w ru unless ur roiding or badly norwooding. 2.5+mg dut will be enough to preserve ur hair. once u nuke ur serum dht, there is no reason to not push up 4 more scalp.

Would daily 1mg finasteride be enough? Im Norwood 1.5 at 25 and couldnt get hands on dut in my country only fin

 

[Disturbed]

@Disturbed

Aight

 

[yasuoh]

@0 bone mass inb4 botb

 

[76.1]

wt happened to ur mod

what? i never had mod

 

[mirinnnasal]

LICATIONS OF ANTI ANDROGENS FOR LOOKSMAXING

GOAT IS BACK

ANY THOUGHTS ON TOPICAL ESTRONE, - DOES IT BEAT OUT RETINOIDS,

 

[Navity]

ANTI ANDROGENS

BY ASKINOV
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So i am making this thread by knowing that you know about androgens, androgen receptors, and effects of androgens in body already . so if you don't know watch other threads in this forum which has already discussed about it you can also view my thread . where i have talked about androgens and androgen receptors . and also view the thread by slayer jonas as for protocols don't get way excited . for protocols go to wiki or pubmed linked in our thread and gain your own knowledge

AN OVERVIEW OF AAS AND FACIAL CHANGES + INCREASING FACIAL BONES WITH AAS ? HOW LETS SEE . IS IT POSSIBLE ?+ OLD THREAD EDITED

READ EVERY MOLECULE DONT CONCLUDE ANYTHING BEFORE READING FULLY AS FOR THE PROTOCOL THERE ARE MANY IN THIS FORUM YOU CAN SEE YOURSELF CHAPTER 1: UNDERSTANDING AAS Anabolic steroids also known as anabolic androgenic steroids (AAS), are a class of drugs that are structurally related to...

looksmax.org

Roidmaxxing 101™ - How to get a physique halo

Natty lifting is cope. JFL at spending a decade training optimally to end up as looking like someone that has just ended his first cycle. If you're serious about Looksmaxing, you're going to take every shortcut to achieve your goal. Why should I give a shit about roiding? A body halo is...

looksmax.org

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APPLICATIONS OF ANTI ANDROGENS FOR LOOKSMAXING

There isn't much of use of anti androgens for male to looksmax expect it's best use cases will be for

1.Treating hormonal acne caused by high androgen activity

2.Treating hair loss caused by dht ( dihydro testosterone )
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WHAT ARE ANTI ANDROGENS
So this is not that hard to understand .Anti androgens are a class of medication that is use to minimize the androgenic effect caused by testosterone and its derivatives and synthetic derivatives like dihydro testosterone , nandrolone, oxandrolone , tren , type shit ...etc
so these comes in 3 forms

1. Androgen receptor inhibitors

2. 5 alpha reductase inhibitors

3. Total testosterone production inhibitors (meh no use )
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ANDROGENS RECEPTOR INHIBITORS


Mainly used for prostate cancer . Androgen receptor blockers (ARBs), also known as antiandrogens, are medications that prevent male hormones (androgens) from binding to androgen receptors. By blocking this interaction, these drugs stop androgens from fueling the growth of tissues and prostate cancer cells.

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NCI Dictionary of Cancer Terms​

A steroidal antiandrogen (SAA) : is an antiandrogen with a steroidal chemical structure They are typically antagonists of the androgen receptor (AR) and act both by blocking the effects of androgens like testosterone and dihydrotestosterone (DHT) and by suppressing gonadal androgen production. SAAs lower concentrations of testosterone through simulation of the negative feedback inhibition of the hypothalamus SAAs are used in the treatment of androgen-dependent conditions in men and women, and are also used in veterinary medicine for the same purpose.They are the converse of nonsteroidal antiandrogens (NSAAs), which are antiandrogens that are not steroids and are structurally unrelated to testosterone.

USAGES

Prostate cancer in men
Benign prostatic hyperplasia in men​

Benign prostatic hyperplasia (BPH) - Symptoms and causes​

Androgen-dependent skin and hair conditions like acne, hirsutismseborrhea, and pattern hair loss (androgenic alopecia) in women
other shit are done in women and fags ill link the wiki
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Steroidal antiandrogen - Wikipedia​

Cyproterone acetate (Androcur): A combined AR antagonist and progestogen/antigonadotropin. Also has weak glucocorticoid activity. Previously used widely in the treatment of prostate cancer, but since largely replaced by NSAAs. Also used for androgen-dependent indications in women and transgender women, precocious puberty in boys, and as a means of chemical castration for sexual deviation in men. Widely used in oral contraceptives as well (with ethinylestradiol under the brand names Diane and Diane-35). Not available in the United States. Uniquely among most SAAs, has a high risk of liver changes and hepatotoxicity. Also has a high incidence of psychiatric side effects such as depression, anxiety, and fatigue

this is also good at reducing sebum and hair growth


Spironolactone (Aldactone): An antimineralocorticoid (aldosterone antagonist) with additional/coincidental antiandrogen activity. Specifically acts as an AR antagonist, weak antigonadotropin, and weak steroidogenesis inhibitor. Used for androgen-dependent indications in women and transgender women, particularly in the United States where cyproterone acetate is unavailable. Studied in the treatment of benign prostatic hyperplasia but was found to be ineffective. Contraindicated in prostate cancer due to weak androgenic activity and stimulation of tumor growth. Most commonly used as a diuretic and antihypertensive for cardiovascular disease. Commonly associated with gynecomastia (breast development)

if you have hormonal acne you can go with spironolactone 500 to 200 mg daily

other drug ill link the wiki they have weak anti androgenic activity with weak glucocorticoid activity
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Steroidal antiandrogen - Wikipedia​

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7 Common Antiandrogen Drugs: Uses, Names, and Testosterone Blockers - Liv Hospital​

These drug i mentioned has some sides of making men feminine so ill be talking about fda approved 2 drugs brand named as winlevi and breezula one for acne and one for androgenic alopecia this both are clascoterone 1 % and 5 % respectively



Winlevi (clascoterone 1% solution ) : Clascoterone cream 1% is a prescription topical medicine for acne in people 12 and older. It is the first acne cream that targets sebum production. It blocks androgen receptor in the skin to stop breakouts. You apply a thin layer to clean, dry skin twice a day. it is just simple as it sounds luckily it is topical

hey this can be used for androgenic alopecia but the trail is on going its mostly designed for long term



Use about a small amount for your face.

Apply it in the morning and at night for 12 weeks .

men and female both can use it

don't put this on sun burned area . mild dryness irritation that is all the sides and if you apply it too much it can cause hormonal problem

before and after

View attachment 5335919

Winlevi: Dosage, side effects, uses, interactions, cost, and more

Winlevi (clascoterone) is a prescription infusion that treats acne in adults and children. Learn about dosage, side effects, and more.

www.medicalnewstoday.com

Clascoterone: Uses, Side-Effects and More — DermNet

Topical clascoterone cream 1% (Winlevi®) is a novel androgen receptor inhibitor used for the treatment of acne vulgaris in patients aged 12 years and older.

dermnetnz.org

Breezula ( Clascoterone 5 % solution ): As you know how clascoterone works but its not potent as 5-ar inhibitors as of a doctor view point . its on like phase 3 trials rn or already broke phase 3 trails and upcoming research is on going and they are telling that the sides effect is not like finasteride which gives whole on body but its really local it directly binds with hair follicle so may be this will be a good upcoming hair loss agent

Cosmo | Cosmo announces breakthrough Phase III Topline

Cosmo announces breakthrough Phase III Topline results from Scalp 1 and Scalp 2 for Clascoterone 5% Solution in male hair loss, showing up to 539% relative improvement in Target-Area Hair Count vs placebo; US and EU submissions are underway. 1,465 patients were randomized into the two...

www.cosmohealthconfidence.com

protocol 2 times a day 5 % to 7.5 % few drops and rub it around your scalp . 12 weeks too

a few points

1. it is not permanent need to apply time to time like minoxidil

2. can not revive dead follicle



A nonsteroidal antiandrogen (NSAA) is an antiandrogen with a nonsteroidal chemical structure. They are typically selective and full or silent antagonists of the androgen receptor (AR) and act by directly blocking the effects of androgens like testosterone and dihydrotestosterone (DHT). NSAAs are used in the treatment of androgen-dependent conditions in men and women They are the converse of steroidal antiandrogens (SAAs), which are antiandrogens that are steroids and are structurally related to testosterone
usages is same as steroidal

Flutamide (Eulexin): Marketed for the treatment of prostate cancer and also used in the treatment of acne, hirsutism, and hyperandrogenism in women. It has also been studied in the treatment of benign prostatic hyperplasia Now little-used due to high incidence of elevated liver enzymes and hepatotoxicity and the availability of safer agents.

RU-58841 (PSK-3841, HMR-3841): A first-generation NSAA related to nilutamide. It was under development as a topical medication for the treatment of acne and pattern hair loss but its development was discontinued during phase I clinical trials. its just block dht directly to not bind with androgen receptor

so this drug lost phase 1 trail . but the lore is it was actually because of commercial reason . the business that finasteride blew up so investors didn't had much a reason to spend money on this . not because it had crazy side

heard this on reddit

Reddit - Please wait for verification

www.reddit.com

Use RU58841 by applying 1 ml of a 5% liquid solution directly to clean, dry scalp once per day. Massage it into thinning areas and let it dry for 1 to 2 minutes.

as i spoke it is not permanent cause it doesn't stop the conversion of test into dht it just does not let dht to bind with hair follicle and it also does not have any side effect like finasteride apply it for like 12 week

and this has moderate to good binding affinity

irritation, chest tightness, heart palpitations, lightheadedness, and brain fog these are the sides

i say ask to @buccalfatremoval .com cause he is on this drug. flood his notification with dm's



this lacks human data at last ok

View attachment 5336056



KX -826 : has human data but this was giving same growth as the placebo trail .so ru wins no diff although the side effect is low and is clam cause human trails were done but meh .
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5α REDUCATSE INHIBTORS

As we know that 5alpha reductase enzyme is the main reason why test is converted into dht and then dht starts to show its side of male pattern baldness so 5-ar inhibitors works by directly blocking 5-ar enzyme to make it stop which will block conversion of test into dht

5α-Reductase Inhibitors - StatPearls - NCBI Bookshelf

Can be used for acne (hormonal ofc)

Mostly used for hair loss
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Finasteride vs. dutasteride ( i will use new claude model to format this part ) ​

Standard dosing​

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• Finasteride: 1 mg/day for androgenetic alopecia (AGA); FDA-approved for hair loss since 1997, at 5 mg/day for BPH. Interestingly, 1 mg was chosen because it gives comparable efficacy and safety to the 5 mg dose while minimizing systemic exposure.​
• Dutasteride: 0.5 mg/day is the standard dose for both AGA and BPH — unlike finasteride, the dose isn't scaled down between indications. It's approved specifically for AGA in Japan, South Korea, and Taiwan, but remains off-label for hair loss in the US and most other countries.​

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Head-to-head trials: dutasteride vs. finasteride for hair​

This comparison has more RCT data than almost any other 5ARI question:

Gubelin Harcha et al., 2014 (J Am Acad Dermatol) — the landmark dose-ranging trial. 917 men were randomized to dutasteride (0.02, 0.1, or 0.5 mg/day), finasteride 1 mg/day, or placebo for 24 weeks. Dutasteride 0.5 mg significantly outperformed finasteride on hair count, hair width, and photographic assessment (p=.003, .004, .002 respectively), with a dose-dependent effect across the dutasteride arms

Eun et al., 2010 (Korea) — an earlier RCT that similarly found dutasteride 0.5 mg significantly increased hair count versus placebo, one of the trials underpinning its Korean approval.

Head-to-head open-label RCT (2016, 90 men) — comparing 0.5 mg dutasteride vs. 1 mg finasteride daily for 24 weeks: total hair count rose from 223→246/cm² with dutasteride vs. 227→231/cm² with finasteride, a significantly larger gain for dutasteride.

2025 intermittent-dosing pilot (60 men) — tested whether dutasteride could be dosed less than daily: twice-weekly, thrice-weekly dutasteride (0.5 mg) vs. daily finasteride (1 mg) for 24 weeks. Thrice-weekly dutasteride actually beat daily finasteride on hair density/diameter and showed a higher rate of moderate-to-marked improvement (35% vs 21%), though it didn't significantly beat finasteride on raw hair count. This matters practically since it suggests dosing flexibility.

2022 Korean multicenter chart review (600 patients) — real-world (not trial) data likewise found dutasteride 0.5 mg/day superior to finasteride 1 mg/day, with a similar safety profile.

A 2024 systematic review pooling 9 studies concluded dutasteride is more effective than finasteride for both male and female AGA, with comparable adverse-event rates between the two drugs.

The mechanistic reason dutasteride keeps winning these trials: it lowers serum DHT to about 98%, versus roughly 70% for finasteride, and its longer half-life means more sustained suppression.

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Topical vs. oral​

This is a genuinely active research question, mainly because oral finasteride's rare-but-real sexual/psychiatric side effects have pushed both patients and researchers toward topical routes.


Topical finasteride spray — Piraccini et al., 2022, phase III RCT (the best-quality trial here): men with AGA were randomized to topical finasteride 0.25% spray, oral finasteride 1 mg, or placebo for 24 weeks.


Hair count improvement was numerically similar between topical and oral finasteride — both beat placebo significantly.

But systemic exposure differed sharply: peak plasma finasteride concentration was over 100-fold lower with topical vs. oral.

Serum DHT dropped 34.5% with topical vs. 55.6% with oral — meaningfully less systemic hormonal suppression with the topical route.

Sexual Dysfunction Questionnaire scores showed no significant difference between topical finasteride and placebo at 12 or 24 weeks, unlike oral finasteride's known (small) signal.

A separate proof-of-concept study looking specifically at scalp DHT (rather than hair counts) found a higher-dose topical formulation (2.5 mg) reduced scalp DHT by about 70%, versus roughly 50% for oral — suggesting topical delivery can concentrate drug locally more efficiently, though at that higher dose the serum DHT drop converged with oral, muddying the "topical = safer" story somewhat. The honest takeaway from the literature so far: topical and oral finasteride appear similarly effective for hair regrowth, but topical carries meaningfully lower systemic DHT suppression at standard doses — the tradeoff is mainly about systemic side-effect risk, not efficacy.


Topical dutasteride has less RCT data than topical finasteride, but there's a notable 2022 randomized, placebo-controlled trial combining microneedling with topical dutasteride solution (0.01%) for AGA, showing added benefit over microneedling alone — though this is a single trial and the combination-intervention design makes it hard to isolate dutasteride's independent topical effect.

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TLDR​

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Finasteride​	Dutasteride​
Isoform inhibited​	Type II (some III)​	Type I + II (dual)​
Serum DHT suppression​	~70%​	~98%​
Standard oral dose (hair)​	1 mg/day​	0.5 mg/day​
Regulatory status (hair)​	FDA-approved​	Off-label in US; approved in Japan/Korea/Taiwan​
Head-to-head hair trials​	Consistently outperformed by dutasteride​	Consistently superior in RCTs​
Topical option​	Well-studied phase III RCT, similar efficacy to oral, much lower systemic exposure​	Less-studied topically, mostly combination trials​
Acne evidence​	Weak/mixed ​	Weak, case-report level only​

YOU WILL NOT GET A OVER ALL TLDR READ



TAGS @Sycophant @Sayori @Hernan @Navity











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Bump, G

 

[imontheloose]

Would daily 1mg finasteride be enough? Im Norwood 1.5 at 25 and couldnt get hands on dut in my country only fin

i used fin b4 n i honestly didnt view it helpful enough. germany strict customs. i may be able to help sometime so u may wish 2 contact me in perhaps a month or so