@iloveboobs why no react?
Effect of growth hormone therapy on height in children with idiopathic short stature: a meta-analysis - PubMed
Treatment with GH results in short-term increases in growth for children with idiopathic short stature, and long-term GH can increase adult height. These results are fundamental to decisions about GH use and raise questions about the goals of treatment. Use of GH for idiopathic short stature in...pubmed.ncbi.nlm.nih.gov
nigga gh therapy causes increase growth in children with ISS who have normal gh levels
In other words there ISS was caused by the lack of sensitivity to gh not low gh itself
So what makes you think that injecting hgh to someone who has a higher sensitivity to gh won’t make them grow when it works on people with a lower gh sensitivity
Bruh hgh causes height growth in children with normal gh levels but low sensitivity
Growth hormone is actually not the only factor controlling igf-1 secretion in the circulation Insulin, thyroid hormone and androgens all stimulate igf-1 release
because the gh does not turn into igf-1 which actually makes the kid taller. If it did work, there would be tons and tons of teen manlets making posts on org showing their height growth, and to date, there's none currently. There was one by a kid who was 4'8 at 14 and he only grew to 5'6 which obviously shows he was gh deficient. I'm not saying hgh doesn't work on gh deficient kids because it does, but it won't work for your typical teen manlet. Also for igf-1 to even be produced, you need tons of different hormones like the thyroid, and androgen receptors. Factoring all of this in, makes it impossible for a child with normal gh level to grow taller just by hgh alone
Nigger even in the kids with a genetic predisposition to having less gh turn into igf-1 it still caused them to grow
You are forgetting the other hormones which stimulate igf-1 as well. The best thing a teen manlet can do is use an ai which makes their plates open for longerNigger even in the kids with a genetic predisposition to having less gh turn into igf-1 it still caused them to grow
So if a kid with a normal gh to igf-1 conversion takes hgh it won’t cause him to grow?
Mirin logic
No it doesn’t work that way. It’s not like every tall men has had abnormal growth hormone levels during development.No it can’t it just causes you to grow, a kid with low hgh levels will grow less than a kid with average hgh levels and a kid with high hgh will grow more than a kid with average hgh levels
Where are you getting the idea that hgh injections won’t do anything if you already have normal high levels. If that were the case acromegaly wouldn’t be a thing
Acromegaly - Symptoms and causes
www.mayoclinic.org
Yeah significantly higher baseline testosterone levels were a reason for this.
The kids had a normal hormone profile and that’s why we have control groups lol
Nigga I’m talking abt in general which it is true
yeah, i believe in the future, kids will start to hit puberty at 16,17 or even 18 and finish development maybe in their early-mid 20s because of how low testosterone is becoming. If we still had the enviroment, our ancestors had, we would've probably already finished puberty at like 12 and had kids during our mid teens.
Hunter gatherers were taller
It is uncertain whether insulin stimulates bone directly or indirectly by increasing muscle work and secreting igf-1
if they need gh therapy then they dont have a normal hormonal profile but ok
I think it works by providing nutrients directly to the bones rather than increasing IGF. I'm trying to think simple
Nigga it could be that they have a lower sensitive to certain horomones which is what caused them to not grow but their hormone levels themselves are fine
It's a really interesting topic if you were to dive deep into it but research is yet uncertain to the direct functions of insulin on longitudinal bone growth
thing with having gh defiency is that, it also means other hormones are fucked, especially since gh is such an important hormone in the body. My theory is that the children grew because as you said their other hormones are normal meaning that igf-1 was produced as normal causing them to grow, whereas the other children might also suffer with other hormones being fucked, meaning that igf-1 levels were inhibited causing them to not grow as much.
Most of them weren’t taller than modern human societies.
they excluded such cases from the study? did you read it? These are otherwise normal children its just they have ISS also the growth velocities were equivalent at baseline
or you can just go with the researchers theory which is that the gh caused them to grow
People with growth hormone insensitivity even at slight which is not rare are not responsive to growth hormone therapy, but usually responsive to treatment with igf-1. However, the response of people with insensitivity, igf-1 therapy is variable and substantially less than that of a GH deficient person treated with growth hormone. Recombinant igf-1 has been used in children with insensitivity to growth hormone. In one study the height velocity increased from 2.7 cm/year to a crazy of 8 cms/year during the first year of treatment and the height velocity remained above baseline for up to eight years following initiation of igf-1 therapy.
I'll be honest I couldn't be asked reading the study. Not my fault your pajeet ass didn't state that.
Nigger it’s like the first few lines in mirin attention span
so why not inject igf-1
Because it costs 80k retard
My brain is melting from the retardation
I cant find anything about igf-1 injectiosn on the internet but in theory if you inject igf-1 instead of gh which would be better
lol this forum has gotten even dumber since last time i was here
thats not true at all, actually. The average age where puberty begins is getting earlier and earlier. Puberty beggining a little bit later is actually a GOOD thing + will make you taller than expected. Early puberty IS the bad thing.
