Aromatase Inhibitor Megathread

[Nosecel9000]

AI like aromasin are actually used for cancer. There are no scientifically studies that prove aromasin helps with growth.

The side effects however are risky

Please send some studies and articles

 

[Slyfex8]

Height Increment and Laboratory Profile of Boys Treated With Aromatase Inhibitors With or Without Growth Hormone - PubMed

Aromatase inhibitors (AIs) have been used to recover height loss due to their capacity to delay growth plate closure. Long-term studies describing final heights are needed to determine the efficacy and safety profiles of these drugs for the treatment of impaired growth. This study aims to...

www.ncbi.nlm.nih.gov

Aromatase inhibitors plus growth hormone may help short adolescent boys grow taller

Aromatase inhibitors, when used for up to three years in combination with growth hormone, may effectively and safely help very short adolescent boys grow taller, new research suggests.

www.sciencedaily.com

 

[dingodongo]

Height Increment and Laboratory Profile of Boys Treated With Aromatase Inhibitors With or Without Growth Hormone - PubMed

Aromatase inhibitors (AIs) have been used to recover height loss due to their capacity to delay growth plate closure. Long-term studies describing final heights are needed to determine the efficacy and safety profiles of these drugs for the treatment of impaired growth. This study aims to...

www.ncbi.nlm.nih.gov

Aromatase inhibitors plus growth hormone may help short adolescent boys grow taller

Aromatase inhibitors, when used for up to three years in combination with growth hormone, may effectively and safely help very short adolescent boys grow taller, new research suggests.

www.sciencedaily.com

Well they used growth hormone too.

So are kids really buying and self administering AIs nowadays lol. Low estrogen has a ton of bad effects.

 

[Slyfex8]

Well they used growth hormone too.

So are kids really buying and self administering AIs nowadays lol. Low estrogen has a ton of bad effects.

These are not long-term effects, so you might as well try to experiment with them and continue or stop depending on the side effects you are experimenting.

 

[middayshowers]

Height Increment and Laboratory Profile of Boys Treated With Aromatase Inhibitors With or Without Growth Hormone - PubMed

Aromatase inhibitors (AIs) have been used to recover height loss due to their capacity to delay growth plate closure. Long-term studies describing final heights are needed to determine the efficacy and safety profiles of these drugs for the treatment of impaired growth. This study aims to...

www.ncbi.nlm.nih.gov

Aromatase inhibitors plus growth hormone may help short adolescent boys grow taller

Aromatase inhibitors, when used for up to three years in combination with growth hormone, may effectively and safely help very short adolescent boys grow taller, new research suggests.

www.sciencedaily.com

>No significant side effects were observed. AI treatment, especially when used in association with GH was able to improve growth and the attainment of familial target height.

they had 96 adolescents on 2.5mg letrozole daily (or 1mg Anastrozole which i assume is equivalent), with half of them also on 0.05 mg/kg recombinant human growth hormone for 1-3.5 years and not a single patient had a significant side effect? that sounds really good tbh. How much did they actually grow on average though? the full text is $48 sadly
here are some other studies

NCBI | NLM | NIH

>Combination therapy with AI/GH increases height potential in pubertal boys with ISS more than GH and AI alone treated for 24-36 months with a strong safety profile.

NCBI | NLM | NIH

>Anastrozole increases adult height potential of adolescent boys on GH therapy while maintaining normal pubertal progression after 2-3 yr. This treatment offers an alternative in promoting growth in GH-deficient boys in puberty. Long-term follow up is needed to elucidate fully the safety and efficacy of this approach

NCBI | NLM | NIH

>The use of aromatase inhibitors (AI) in boys with short stature has showed its capability to improve the predicted final height.

 

[Slyfex8]

>No significant side effects were observed. AI treatment, especially when used in association with GH was able to improve growth and the attainment of familial target height.

they had 96 adolescents on 2.5mg letrozole daily (or 1mg Anastrozole which i assume is equivalent), with half of them also on 0.05 mg/kg recombinant human growth hormone for 1-3.5 years and not a single patient had a significant side effect? that sounds really good tbh. How much did they actually grow on average though? the full text is $48 sadly

I haven't tried AIs yet, so I'm not going to make a final judgment, but I think that right now some users around here, on this forum, abuse with the side effects of AIs, in reality, I doubt that the side effects of AIs are really significant for most people.

Otherwise logically I think they did not grow directly from the AI, it only helped to avoid the progress of plates fusion and thus allowed a more significant growth than if they had taken nothing.

 

[middayshowers]

This study is very interesting: https://www.endo.theclinics.com/article/S0889-8529(09)00051-6/fulltext

sci hub link: https://sci-hub.shop/https://www.ncbi.nlm.nih.gov/pubmed/19717007
> +4.5(1.2) cm and +6.7 (1.4) cm after 2 and 3 years respectively, as compared with +1cm at both time points in the placebo group

from just 2.5mg daily letrozole as a monotherapy in healthy pubertal males

>It is important to emphasize that it takes at least 2 to 3 years of daily treatment to observe positive effects in height prognosis.

 

[Jecht]

There's a brazilian heightmaxxer guy who says to take daily Letrozole 2.5g, Strontium ranelate 10g, Doxycycline 200mg and 0 Calcium for a year; and another year take Letrozole 2.5g, Doxycycline 200mg, HGH, Meclozine, Lead acetate and 0 Calcium. Afters those 2 year you take Letrozole and start consuming Calcium again.

According to him, doing this the growth plate would not close.

But my IQ is too low to understand half of the words in his sources.

EFFECT OF STRONTIUM ON THE EPIPHYSEAL CARTILAGE PLATE OF RAT TIBIAE—HISTOLOGICAL AND RADIOGRAPHIC STUDIES

Japan's largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies

www.jstage.jst.go.jp

https://www.sciencedirect.com/science/article/pii/S2213671114001994

Lead Induces Chondrogenesis and Alters Transforming Growth Factor-β and Bone Morphogenetic Protein Signaling in Mesenchymal Cell Populations on JSTOR

Michael J. Zuscik, Lin Ma, Taylor Buckley, J. Edward Puzas, Hicham Drissi, Edward M. Schwarz, Regis J. O'Keefe, Lead Induces Chondrogenesis and Alters Transforming Growth Factor-β and Bone Morphogenetic Protein Signaling in Mesenchymal Cell Populations, Environmental Health Perspectives, Vol...

www.jstor.org

Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia

Achondroplasia (ACH) is one of the most common skeletal dysplasias with short stature caused by gain-of-function mutations in FGFR3 encoding the fibroblast growth factor receptor 3. We used the drug repositioning strategy to identify an FDA-approved drug that suppresses abnormally activated...

journals.plos.org

 

[CarlSagan96]

Height Increment and Laboratory Profile of Boys Treated With Aromatase Inhibitors With or Without Growth Hormone - PubMed

Aromatase inhibitors (AIs) have been used to recover height loss due to their capacity to delay growth plate closure. Long-term studies describing final heights are needed to determine the efficacy and safety profiles of these drugs for the treatment of impaired growth. This study aims to...

www.ncbi.nlm.nih.gov

Aromatase inhibitors plus growth hormone may help short adolescent boys grow taller

Aromatase inhibitors, when used for up to three years in combination with growth hormone, may effectively and safely help very short adolescent boys grow taller, new research suggests.

www.sciencedaily.com

Thanks for the link I’ll be reading this later. Just from the abstract it looks like this was done on younger teenagers, I wonder how well it would work if at all with a more advanced bone age.

 

[SharpFaceButUgly]

So nobody is scared of bone density loss?

 

[Deleted member 15854]

There's a brazilian heightmaxxer guy who says to take daily Letrozole 2.5g, Strontium ranelate 10g, Doxycycline 200mg and 0 Calcium for a year; and another year take Letrozole 2.5g, Doxycycline 200mg, HGH, Meclozine, Lead acetate and 0 Calcium. Afters those 2 year you take Letrozole and start consuming Calcium again.

According to him, doing this the growth plate would not close.

But my IQ is too low to understand half of the words in his sources.

EFFECT OF STRONTIUM ON THE EPIPHYSEAL CARTILAGE PLATE OF RAT TIBIAE—HISTOLOGICAL AND RADIOGRAPHIC STUDIES

Japan's largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies

www.jstage.jst.go.jp

https://www.sciencedirect.com/science/article/pii/S2213671114001994

Lead Induces Chondrogenesis and Alters Transforming Growth Factor-β and Bone Morphogenetic Protein Signaling in Mesenchymal Cell Populations on JSTOR

Michael J. Zuscik, Lin Ma, Taylor Buckley, J. Edward Puzas, Hicham Drissi, Edward M. Schwarz, Regis J. O'Keefe, Lead Induces Chondrogenesis and Alters Transforming Growth Factor-β and Bone Morphogenetic Protein Signaling in Mesenchymal Cell Populations, Environmental Health Perspectives, Vol...

www.jstor.org

Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia

Achondroplasia (ACH) is one of the most common skeletal dysplasias with short stature caused by gain-of-function mutations in FGFR3 encoding the fibroblast growth factor receptor 3. We used the drug repositioning strategy to identify an FDA-approved drug that suppresses abnormally activated...

journals.plos.org

@FreakkForLife