aromatose inhibators+ hgh

[Kevla]

what is the best aromatase inhibitors with hgh

 

[tomacōck]

exemestane

 

[emogymmaxx]

just give yourself autism for 0.00001 inches theory
anyways arimidex

 

[Deleted member 271913]

Anastrozole (Arimidex) and Letrozole (Femara)

They have the highest estrogen inhibition rates.

Template:Pharmacodynamics of aromatase inhibitors - Wikipedia

en.wikipedia.org

There are sources under this template.

 

[narrator_313]

Yes bro give your self neurological problems for 0.67 inches of height

 

[emogymmaxx]

Anastrozole (Arimidex) and Letrozole (Femara)

They have the highest estrogen inhibition rates.

Template:Pharmacodynamics of aromatase inhibitors - Wikipedia

en.wikipedia.org

View attachment 4362621

There are sources under this template.

and insane rebound
know your doses people

 

[Deleted member 271913]

exemestane

That's misinformation.

Exemestane only has a mean inhibition rate of 97.9%.

In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients - PubMed

The effect of exemestane (6-methylenandrosta-1,4-diene-3,17-dione) 25 mg p.o. once daily on in vivo aromatization was studied in 10 postmenopausal women with advanced breast cancer. Aromatization was determined before treatment and after 6-8 weeks on therapy by administering a bolus injection of...

pubmed.ncbi.nlm.nih.gov

Treatment with exemestane suppressed whole body aromatization from a mean pretreatment value of 2.059% to 0.042% (mean suppression of 97.9%).

 

[Deleted member 271913]

Yes bro give your self neurological problems for 0.67 inches of height

You're a retard, men average 20-30 pg/mL of estradiol. We already have so little that going down to basically zero means nothing.

Send sources.

 

[narrator_313]

You're a retard, men average 20-30 pg/mL of estradiol. We already have so little that going down to basically zero means nothing.

Send sources.

Retards calling other retards retarded even a simple google search will show how wrong you are

 

[Deleted member 271913]

That's misinformation.

Exemestane only has a mean inhibition rate of 97.9%.

In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients - PubMed

The effect of exemestane (6-methylenandrosta-1,4-diene-3,17-dione) 25 mg p.o. once daily on in vivo aromatization was studied in 10 postmenopausal women with advanced breast cancer. Aromatization was determined before treatment and after 6-8 weeks on therapy by administering a bolus injection of...

pubmed.ncbi.nlm.nih.gov

Also I want to add more onto this.

Exemestane is irreversible, it binds permanently to the Aromatase enzymes. So if he ever wanted to go back to normal estrogen production, it would be impossible. This is dangerous misinformation that could harm the quality of his sperm, since estradiol does help prevent sperm death.

https://academic.oup.com/jcem/article-abstract/85/5/2057/2660648

Interestingly, both estrogen receptors α and β were found in early meiotic spermatocytes and elongating spermatids of the human testis. Furthermore, low concentrations of 17β-estradiol (10−9 and 10−10 mol/L) effectively inhibited male germ cell apoptosis, which was induced in vitro by incubating segments of human seminiferous tubules without survival factors (i.e. serum and hormones).

 

[Deleted member 271913]

Retards calling other retards retarded even a simple google search will show how wrong you are

Then show the source, you won't because you quite literally cannot.

I researched endocrinology extensively, I'm not wrong in the slightest.

 

[Deleted member 240816]

Also I want to add more onto this.

Exemestane is irreversible, it binds permanently to the Aromatase enzymes. So if he ever wanted to go back to normal estrogen production, it would be impossible. This is dangerous misinformation that could harm the quality of his sperm, since estradiol does help prevent sperm death.

https://academic.oup.com/jcem/article-abstract/85/5/2057/2660648

wdym??? yeah it binds permanently but ur body will still produce aromatese

 

[Deleted member 271913]

wdym??? yeah it binds permanently but ur body will still produce aromatese

Aromatase is not something the body produces, it's a process.

And this process cannot occur if the enzyme it being permanently binded to Exemestane.

 

[ltngymcell]

what is the best aromatase inhibitors with hgh

weak bones and neurological damage just for 2cm of height

 

[Deleted member 240816]

Aromatase is not something the body produces, it's a process.

And this process cannot occur if the enzyme it being permanently binded to Exemestane.

there is an enzyme called aromatase LMFAO which makes the aromatisation process. Yeah exemestane is an irreversible inhibitor but that doesnt mean it has irreversible effects on body JFL

 

[Deleted member 240816]

weak bones and neurological damage just for 2cm of height

just do bloodwork while taking it . U wont get anything bad if u dont go under 15 pg/mL (and 20 if ur high T naturally)

 

[tomacōck]

great info tysm

That's misinformation.

Exemestane only has a mean inhibition rate of 97.9%.

In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients - PubMed

The effect of exemestane (6-methylenandrosta-1,4-diene-3,17-dione) 25 mg p.o. once daily on in vivo aromatization was studied in 10 postmenopausal women with advanced breast cancer. Aromatization was determined before treatment and after 6-8 weeks on therapy by administering a bolus injection of...

pubmed.ncbi.nlm.nih.gov

 

[tomacōck]

there is an enzyme called aromatase LMFAO which makes the aromatisation process. Yeah exemestane is an irreversible inhibitor but that doesnt mean it has irreversible effects on body JFL

it does
how do you think AIs work?

 

[Deleted member 240816]

it does
how do you think AIs work?

exemestane binds to aromatase enzymes. And this will reduce the conversion of Testosterone obviously but ur body will still be able to create new aromatase enzymes. So when u quit aromasin ur E2 will probably be same as before within a week.

 

[ltngymcell]

just do bloodwork while taking it . U wont get anything bad if u dont go under 15 pg/mL (and 20 if ur high T naturally)

or just have 6'5 genes

 

[Deleted member 271913]

weak bones and neurological damage just for 2cm of height

"neurological damage" just from having undetectable levels of estrogen for like 2 years? Even though children all have undetectable levels of estrogen? By your logic, a 4yr not having puberty is causing brain damage. This is pure retardism.

there is an enzyme called aromatase LMFAO which makes the aromatisation process. Yeah exemestane is an irreversible inhibitor but that doesnt mean it has irreversible effects on body JFL

It's called suicide inhibition, also done by other steroidal sarms/serms. Here you can read that it's effects on the enzymes are literally irreversible.

Suicide inhibition - Wikipedia

en.wikipedia.org

 

[tomacōck]

exemestane binds to aromatase enzymes. And this will reduce the conversion of Testosterone obviously but ur body will still be able to create new aromatase enzymes. So when u quit aromasin ur E2 will probably be same as before within a week.

i wanted to input a giant essay-ish response on how youre wrong but e2 jumps back in 2-4 weeks anyway so pretty much nonsteroidal AIs are only really different if youre a female

 

[Deleted member 240816]

"neurological damage" just from having undetectable levels of estrogn for like 2 years? Even though children all have undetectable levels of estrogen? By your logic, a 4yr not having puberty is causing brain damage. This is pure retardism.

It's called suicide inhibition, also done by other steroidal sarms/serms. Here you can read that it's effects on the enzymes are literally irreversible.

Suicide inhibition - Wikipedia

en.wikipedia.org

The enzymes that exemestane binded wont be able to convert T to E2 anymore. but ur body will still be able to create new enzymes. and if u quit exemestane, exemestane wont bind to new enzymes so u will still be able to convert T to E2

 

[Deleted member 240816]

i wanted to input a giant essay-ish response on how youre wrong but e2 jumps back in 2-4 weeks anyway so pretty much nonsteroidal AIs are only really different if youre a female

im not saying that exemestane is reversible. its effects on the body is reversible. as u said e2 will jump back within 1 or 2 weeks.

 

[aids]

Also I want to add more onto this.

Exemestane is irreversible, it binds permanently to the Aromatase enzymes. So if he ever wanted to go back to normal estrogen production, it would be impossible. This is dangerous misinformation that could harm the quality of his sperm, since estradiol does help prevent sperm death.

https://academic.oup.com/jcem/article-abstract/85/5/2057/2660648

Please stop feigning intellectualism when you have no idea what you're talking about. The body makes more aromatase enzymes to compensate after Aromasin/any steroidal AI forms a covalent bond.
Is non-steroidal AI better for a height protocol? Yes, but NOT for the reasons you're mentioning.

 

[tomacōck]

"neurological damage" just from having undetectable levels of estrogen for like 2 years? Even though children all have undetectable levels of estrogen? By your logic, a 4yr not having puberty is causing brain damage. This is pure retardism.

It's called suicide inhibition, also done by other steroidal sarms/serms. Here you can read that it's effects on the enzymes are literally irreversible.

Suicide inhibition - Wikipedia

en.wikipedia.org

exemestane doesnt really fall into the suicide inhibitor territory although labeled so, since the producer of aromatase, the testes, still stay intact

 

[Deleted member 240816]

Please stop feigning intellectualism when you have no idea what you're talking about. The body makes more aromatase enzymes to compensate after Aromasin/any steroidal AI forms a covalent bond.
Is non-steroidal AI better for a height protocol? Yes, but NOT for the reasons you're mentioning.

fr LOL like why would we need to get exemestane regularly if it does reduce the E2 permanently.

btw why would u prefer non steroidal AI's over exemestane?

 

[Deleted member 240816]

exemestane doesnt really fall into the suicide inhibitor territory although labeled so, since the producer of aromatase, the testes, still stay intact

lmao then why did u wrote this:

i wanted to input a giant essay-ish response on how youre wrong but e2 jumps back in 2-4 weeks anyway so pretty much nonsteroidal AIs are only really different if youre a female

didnt i say the same thing?

 

[aids]

fr LOL like why would we need to get exemestane regularly if it does reduce the E2 permanently.

btw why would u prefer non steroidal AI's over exemestane?

Exemestane has an androgenic metabolite that can accelerate growth plate closure unlike non-steroidal AI.
Steroidal AI should be used ad hoc for if E2 is too high, not for prolonged use, since the dosing/effect is progressive, so it's easier to fuck yourself up and drop E2 too significantly.

 

[tomacōck]

lmao then why did u wrote this:

didnt i say the same thing?

almost the same
i wrote this in your support retard

 

[Deleted member 240816]

Exemestane has an androgenic metabolite that can accelerate growth plate closure unlike non-steroidal AI.
Steroidal AI should be used ad hoc for if E2 is too high, not for prolonged use, since the dosing/effect is progressive, so it's easier to fuck yourself up and drop E2 too significantly.

i took it for a week and half for eod (6.25 mg) and did a bloodwork. my T was doubled up and my E2 was the same as before and i think its caused bt mt naturally increased T levels. Should i switch to arimidrx?

 

[aids]

i took it for a week and half for eod (6.25 mg) and did a bloodwork. my T was doubled up and my E2 was the same as before and i think its caused bt mt naturally increased T levels. Should i switch to arimidrx?

Again, it depends entirely on your use case.

 

[Deleted member 240816]

almost the same
i wrote this in your support retard

"wanted to insert an essay bla bla on youre WRONG"

 

[tomacōck]

"wanted to insert an essay bla bla on youre WRONG"

"but" retard

 

[Deleted member 240816]

Again, it depends entirely on your use case.

my goal is to keep the plates open.
my e2 was 20 pg/mL and T was 500 ng/dL
now my T is 900 ng/dL and e2 is still the same

 

[aids]

my goal is to keep the plates open.
my e2 was 20 pg/mL and T was 500 ng/dL
now my T is 900 ng/dL and e2 is still the same

Then use non-steroidal.

 

[Deleted member 240816]

Then use non-steroidal.

i heard that the rebound might speed up plate closure (idk if thats true tho) i dont think so but i didnt want to risk it
is taking aromasin worse than taking nothing? i dont wanna switch up to arimidex before finishing all of my aromasins.

 

[aids]

i heard that the rebound might speed up plate closure (idk if thats true tho) i dont think so but i didnt want to risk it
is taking aromasin worse than taking nothing? i dont wanna switch up to arimidex before finishing all of my aromasins.

There is no rebound if you use it for a prolonged period, as aforementioned.

 

[Deleted member 240816]

There is no rebound if you use it for a prolonged period, as aforementioned.

ik but there might be cases that i need to stop taking it.

i just wanna know if taking aromasin is worse than nothing?

 

[shneckmax]

You're a retard, men average 20-30 pg/mL of estradiol. We already have so little that going down to basically zero means nothing.

Send sources.

zero neurons firing

only thing u know is how to screen shot and copy paste

 

[Deleted member 271913]

Please stop feigning intellectualism when you have no idea what you're talking about. The body makes more aromatase enzymes to compensate after Aromasin/any steroidal AI forms a covalent bond.
Is non-steroidal AI better for a height protocol? Yes, but NOT for the reasons you're mentioning.

We are assuming OP takes aromasin for years. If he takes aromasin for years, aromatase synthesis won't occur as naturally when he suddenly hops off. This will eventually lead to downregulation of the synthesis.

In fact I spent almost 20 minutes now trying to find results on the long term usage of aromasin in men, I couldn't find any. And studies on women won't work because they take gnrh analogues.

 

[Deleted member 271913]

There is no rebound if you use it for a prolonged period, as aforementioned.

Even then the rebound isn't severe (assuming you take a single dosage of 25mg)

Estradiol goes up about 10% for a day then goes back to baseline a day afterwards.

Sci-Hub. Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males / The Journal of Clinical Endocrinology & Metabolism, 2003

Also if you can, send studies on long term usage of aromasin.

 

[Deleted member 271913]

zero neurons firing

only thing u know is how to screen shot and copy paste

Still zero sources after a million years ahh.

Okay fine, I'll use google like the normies.

Nvm, even google doesn't know wtf yall are on.

 

[Greyascension]

Aromasin

 

[TheOsei]

Half the replies are fucking retarted.
If ur not sure if ur e2 is high start off with 6.25mg Aromasin EOD, this lowers e2 like 20-30% and wont cause any sides. Get some bloodwork and if e2 high up the dose to every day.
No you won’t become a retarted autistic nigger with down syndrome unless u take 12.5+ with normal e2

 

[aids]

Even then the rebound isn't severe (assuming you take a single dosage of 25mg)

Estradiol goes up about 10% for a day then goes back to baseline a day afterwards.

Sci-Hub. Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males / The Journal of Clinical Endocrinology & Metabolism, 2003

View attachment 4362783

Also if you can, send studies on long term usage of aromasin.

We're very obviously referencing non-steroidal AI... Aromasin doesn't have a rebound.

 

[aids]

We are assuming OP takes aromasin for years. If he takes aromasin for years, aromatase synthesis won't occur as naturally when he suddenly hops off. This will eventually lead to downregulation of the synthesis.

In fact I spent almost 20 minutes now trying to find results on the long term usage of aromasin in men, I couldn't find any. And studies on women won't work because they take gnrh analogues.

Stop shifting the goal posts. That nuance was not at all implied in your original posts, you're trying to add context to clarify why you're right when your blanket statements were definitively incorrect.

 

[Deleted member 271913]

We're very obviously referencing non-steroidal AI... Aromasin doesn't have a rebound.

This study shows Aromasin has an estrogen rebound, with a 10% increase in E2... Are you confused? Yes this is just for a single dosage but it still does have a rebound.

Stop shifting the goal posts. That nuance was not at all implied in your original posts, you're trying to add context to clarify why you're right when your blanket statements were definitively incorrect.

I said exactly this...

Exemestane is irreversible, it binds permanently to the Aromatase enzymes. So if he ever wanted to go back to normal estrogen production, it would be impossible. This is dangerous misinformation that could harm the quality of his sperm, since estradiol does help prevent sperm death.

It's entailed that enzyme synthesis would be significantly impacted if you're using a steroidal inhibitor for long periods of time. Do you want me to apologize for the fact you don't understand how implications work?

 

[aids]

This study shows Aromasin has an estrogen rebound, with a 10% increase in E2... Are you confused? Yes this is just for a single dosage but it still does have a rebound.


I said exactly this...

It's entailed that enzyme synthesis would be significantly impacted if you're using a steroidal inhibitor for long periods of time. Do you want me to apologize for the fact you don't understand how implications work?

I already stated that the nuance was not implied, not that your implications were hard to infer; your implications did not exist.
Regardless, you can continue trying to argue with me all you like, but you're an idiot that I won't consider debating because you will shift the goal posts every time I prove you wrong.
Your initial comments were wrong, and I said that... later you can add all the nuance you want, I'll just continue to disregard it.

 

[Trojanhorse1]

Then show the source, you won't because you quite literally cannot.

I researched endocrinology extensively, I'm not wrong in the slightest.

@Zagro share some of you wisdom