ashwaganda

[Deleted member 14344]

im 16 yo, i take melatonin and im gonna take ashwaganda too? is it safe for me??

 

[Euclidd]

ive taken 1 pill of ashwaghanda everyday for a year im 19

 

[Deleted member 14344]

ive taken 1 pill of ashwaghanda everyday for a year im 19

any side effect? and was it worth it?

 

[Qwernity]

im 16 yo, i take melatonin and im gonna take ashwaganda too? is it safe for me??

melatonin for sleep?

 

[Deleted member 14344]

melatonin for sleep?

yep

 

[cumbutamoren]

around same age, have been on for a few weeks. Both are just supplements lol nothing to be worried about. Melatonin can make you drowsy the next day if you take too much tho

 

[Euclidd]

any side effect? and was it worth it?

i am rarely ever stressed by my situation. my stress is mostly self induced if that makes sense. might just be placebo though

 

[Deleted member 14344]

around same age, have been on for a few weeks. Both are just supplements lol nothing to be worried about. Melatonin can make you drowsy the next day if you take too much tho

yeah im taking it and no side effects honestly, i heard that it increase hgh too so

 

[St. Wristcel]

Yes lol it’s safe, just buy a well known brand and follow the instructions on the box

 

[Deleted member 14344]

Yes lol it’s safe, just buy a well known brand and follow the instructions on the box

thxx bro

 

[chadison]

Completely fine. Just buy some generic stuff on Amazon and take two a day. It boosts your sex drive a bit

 

[coolguy1]

im 16 yo, i take melatonin and im gonna take ashwaganda too? is it safe for me??

I would stop taking melatonin

 

[cumbutamoren]

yeah im taking it and no side effects honestly, i heard that it increase hgh too so

Melatonin is a light aromatase inhibitor, meaning it blocks estrogen. If you are heightmaxxing then this is very important and can delay growth plate closure.

A study found that it only acts as an AI for about 45 mins after absorption, but if you take it for a long time im sure it adds up.

 

[cumbutamoren]

I would stop taking melatonin

y?

 

[Deleted member 14344]

I would stop taking melatonin

why?

 

[evap0]

• Melatonin suppresses puberty and has negative effects on sex hormones

- Andrew Hubermann

 

[cumbutamoren]

• Melatonin suppresses puberty and has negative effects on sex hormones

- Andrew Hubermann

It suppresses estrogen... ik estrogen is necessary for brain development but there are teens on this site literally taking aromasin and other ais for height growth. Melatonin is nowhere near that extreme

 

[Deleted member 14344]

Melatonin is known to inhibit pubertal onset in normal children. At pubertal time, its level shows sharp decline (75% of its level). It is believed that this decline allows the surge of the hypothalamic GnRH and the start of cascade of pubertal changes. This means that melatonin acts as a gonadostat allowing puberty to occur in its proper time. There are reports of cases that showed precocious puberty with destructive pineal gland tumors causing low or absent melatonin, and on the contrary, cases of failed puberty owing to functioning pineal gland tumors secreting excess melatonin[7].

someone know wtf this means?

 

[evap0]

It suppresses estrogen... ik estrogen is necessary for brain development but there are teens on this site literally taking aromasin and other ais for height growth. Melatonin is nowhere near that extreme

Histological effects of zinc and melatonin on rat testes - PubMed

The obtained results suggest that 4-week treatment with melatonin leads to histological and physiological impairments of testis and that zinc supplementation might offset these damaging effects (Tab. 2, Fig. 4, Ref. 12).

pubmed.ncbi.nlm.nih.gov

Probably pretty bad to take when still in puberty, remember hearing Hubermann say the testes of rats who were given a generous dose of it shrunk massively

 

[Deleted member 14344]

Histological effects of zinc and melatonin on rat testes - PubMed

The obtained results suggest that 4-week treatment with melatonin leads to histological and physiological impairments of testis and that zinc supplementation might offset these damaging effects (Tab. 2, Fig. 4, Ref. 12).

pubmed.ncbi.nlm.nih.gov

Probably pretty bad to take when still in puberty, remember hearing Hubermann say the testes of rats who were given a generous dose of it shrunk massively

thx for the info

 

[evap0]

Melatonin is known to inhibit pubertal onset in normal children. At pubertal time, its level shows sharp decline (75% of its level). It is believed that this decline allows the surge of the hypothalamic GnRH and the start of cascade of pubertal changes. This means that melatonin acts as a gonadostat allowing puberty to occur in its proper time. There are reports of cases that showed precocious puberty with destructive pineal gland tumors causing low or absent melatonin, and on the contrary, cases of failed puberty owing to functioning pineal gland tumors secreting excess melatonin[7].

someone know wtf this means?

Children naturally have much higher melatonin levels than adults, these levels drop with puberty- and need to drop for you to get a complete and natural pubertal development

 

[cumbutamoren]

Melatonin is known to inhibit pubertal onset in normal children. At pubertal time, its level shows sharp decline (75% of its level). It is believed that this decline allows the surge of the hypothalamic GnRH and the start of cascade of pubertal changes. This means that melatonin acts as a gonadostat allowing puberty to occur in its proper time. There are reports of cases that showed precocious puberty with destructive pineal gland tumors causing low or absent melatonin, and on the contrary, cases of failed puberty owing to functioning pineal gland tumors secreting excess melatonin[7].

someone know wtf this means?

Causes a later puberty if taken as a kid. Kinda expected since its anti estrogenic. (This is why girls start growing earlier, and why they end up shorter).

The part about tumors doesnt refer to melatonin supplementation, its about endogenous serum melatonin being lowered

 

[Deleted member 6403]

it's serotonergic

 

[Deleted member 14344]

it's serotonergic

so its good or bad?

 

[Deleted member 6403]

melatonin for sleep?

melatonin is extremely estrogenic and may shrink your penis, serious

 

[Deleted member 6403]

so its good or bad?

bad, use intermittently if you insist on taking it

 

[cumbutamoren]

Histological effects of zinc and melatonin on rat testes - PubMed

The obtained results suggest that 4-week treatment with melatonin leads to histological and physiological impairments of testis and that zinc supplementation might offset these damaging effects (Tab. 2, Fig. 4, Ref. 12).

pubmed.ncbi.nlm.nih.gov

Probably pretty bad to take when still in puberty, remember hearing Hubermann say the testes of rats who were given a generous dose of it shrunk massively

interesting, but i do think that melatonin supplementation in humans at a dose lower than 10 mgs should be safe. Rat studies are often overdosed to get clear results. I will have to take a closer look at that study tho

 

[cumbutamoren]

melatonin is extremely estrogenic and may shrink your penis, serious

tf its an aromatase inhibitor what are you talking about

Melatonin as a selective estrogen enzyme modulator - PubMed

Melatonin exerts oncostatic effects on different kinds of tumors, especially on hormone-dependent breast cancer. The general conclusion is that melatonin, in vivo, reduces the incidence and growth of chemically-induced mammary tumors in rodents, and, in vitro, inhibits the proliferation and...

pubmed.ncbi.nlm.nih.gov

Melatonin decreases estrogen receptor binding to estrogen response elements sites on the OCT4 gene in human breast cancer stem cells

Cancer stem cells (CSCs) pose a challenge in cancer treatment, as these cells can drive tumor growth and are resistant to chemotherapy. Melatonin exerts its oncostatic effects through the estrogen receptor (ER) pathway in cancer cells, however its action ...

www.ncbi.nlm.nih.gov

 

[dnrd]

im 16 yo, i take melatonin and im gonna take ashwaganda too? is it safe for me??

 

[evap0]

interesting, but i do think that melatonin supplementation in humans at a dose lower than 10 mgs should be safe. Rat studies are often overdosed to get clear results. I will have to take a closer look at that study tho

Yeah true, but 1mm^3 of ball volume could still be the difference between Margot Robbie laughing at your puny balls or not and it's a risk I'm not willing to take

 

[Deleted member 6403]

tf its an aromatase inhibitor what are you talking about

Melatonin as a selective estrogen enzyme modulator - PubMed

Melatonin exerts oncostatic effects on different kinds of tumors, especially on hormone-dependent breast cancer. The general conclusion is that melatonin, in vivo, reduces the incidence and growth of chemically-induced mammary tumors in rodents, and, in vitro, inhibits the proliferation and...

pubmed.ncbi.nlm.nih.gov

Melatonin decreases estrogen receptor binding to estrogen response elements sites on the OCT4 gene in human breast cancer stem cells

Cancer stem cells (CSCs) pose a challenge in cancer treatment, as these cells can drive tumor growth and are resistant to chemotherapy. Melatonin exerts its oncostatic effects through the estrogen receptor (ER) pathway in cancer cells, however its action ...

www.ncbi.nlm.nih.gov

"Melatonin and prolactin are induced by stress, and darkness is a stress because it impairs mitochondrial energy production."

In our lab at the University of Oregon, our hamsters would try to hibernate, even though they were in temperature-controlled laboratories with regular cycles of artificial light. (The ceiling lights provided only dim illumination inside their cage boxes, so they were probably in a chronic state of light deprivation, which probably increased their sensitivity to the weak environmental cues that Frank Brown had investigated, possibly microwaves that easily penetrated the lab walls.) During the winter, when they were infertile, I found that their thymus glands practically disappeared. The mechanism seemed to include the increase of pineal gland activity (probably increasing melatonin synthesis) in the winter, under the intensified activity of the “sympathetic nervous system” (with increased activity of adrenalin and other catecholamines), and the melatonin was apparently a signal for suppressing fertility during the stressful winter. In some animals (Shvareva and Nevretdinova, 1989), estrogen is increased during hibernation, contributing to the reduction of body temperature."

In 1994 A.V. Sirotkin found that melatonin inhibits progesterone production but stimulates estrogen production, and it’s widely recognized that melatonin generally inhibits the thyroid hormones, creating an environment in which fertilization, implantation, and development of the embryo are not possible. This combination of high estrogen with low progesterone and low thyroid decreases the resistance of the organism, predisposing it to seizures and excitotoxic damage, and causing the thymus gland to atrophy."

Almost any kind of stress increases the formation of melatonin."

Am J Psychiatry 1976 Oct;133(10):1181-6.
Neuroendocrinol Lett 2001 Dec;22(6):432-4.
]Eur J Pharmacol 1990 Jul 3;182(2):313-25
Eksp Klin Farmakol 1999 Mar-Apr; 62(2):58-60
Eur J Endocrinol 1995 Dec;133(6):691-5.
J Pharmacol Exp Ther 1988 Sep;246(3):902-10

 

[cumbutamoren]

Yeah true, but 1mm^3 of ball volume could still be the difference between Margot Robbie laughing at your puny balls or not and it's a risk I'm not willing to take

True lol, but the real issue is the implication of smaller testes. This could mean lower endogenous testosterone production. But i did glance over the study, and I must say that their 3mg/kg dose, which is 1.5 mg assuming rats are half a kg, is much higher than that same dose given to a human. We are literally 100 times heavier and larger.

 

[cumbutamoren]

Melatonin and prolactin are induced by stress, and darkness is a stress because it impairs mitochondrial energy production."

In our lab at the University of Oregon, our hamsters would try to hibernate, even though they were in temperature-controlled laboratories with regular cycles of artificial light. (The ceiling lights provided only dim illumination inside their cage boxes, so they were probably in a chronic state of light deprivation, which probably increased their sensitivity to the weak environmental cues that Frank Brown had investigated, possibly microwaves that easily penetrated the lab walls.) During the winter, when they were infertile, I found that their thymus glands practically disappeared. The mechanism seemed to include the increase of pineal gland activity (probably increasing melatonin synthesis) in the winter, under the intensified activity of the “sympathetic nervous system” (with increased activity of adrenalin and other catecholamines), and the melatonin was apparently a signal for suppressing fertility during the stressful winter. In some animals (Shvareva and Nevretdinova, 1989), estrogen is increased during hibernation, contributing to the reduction of body temperature."

In 1994 A.V. Sirotkin found that melatonin inhibits progesterone production but stimulates estrogen production, and it’s widely recognized that melatonin generally inhibits the thyroid hormones, creating an environment in which fertilization, implantation, and development of the embryo are not possible. This combination of high estrogen with low progesterone and low thyroid decreases the resistance of the organism, predisposing it to seizures and excitotoxic damage, and causing the thymus gland to atrophy."

Almost any kind of stress increases the formation of melatonin."

Am J Psychiatry 1976 Oct;133(10):1181-6.
Neuroendocrinol Lett 2001 Dec;22(6):432-4.
]Eur J Pharmacol 1990 Jul 3;182(2):313-25
Eksp Klin Farmakol 1999 Mar-Apr; 62(2):58-60
Eur J Endocrinol 1995 Dec;133(6):691-5.
J Pharmacol Exp Ther 1988 Sep;246(3):902-10

stress apparently increases melatonin, but does melatonin increase stress? I do not think so. Regardless, melatonin’s SERM like qualities most likely outweigh the estrogenic effects of the stress melatonin supposedly causes downstream.

 

[Deleted member 6403]

does melatonin increase stress?

- lowers body temperature
- forms when the body is exposed to darkness
- doesn't actually promote sleep
- only signals darkness
- restricts blood flow to heart, brain and organs

 

[cumbutamoren]

- lowers body temperature
- forms when the body is exposed to darkness
- doesn't actually promote sleep
- only signals darkness
- restricts blood flow to heart, brain and organs

Ik you have researched a lot about stress, so I will assume that you are correct. But my point still stands that melatonin itself inhibits estrogen. This effect likely outweighs the estrogenic effects of stress.

 

[Deleted member 14344]

- lowers body temperature
- forms when the body is exposed to darkness
- doesn't actually promote sleep
- only signals darkness
- restricts blood flow to heart, brain and organs

u fucking hate melatonin , btw its helping me a lot, but idk if i will continue taking it

 

[Deleted member 13335]

any side effect? and was it worth it?

I am taking it currently and it has changed nothing at all. Maybe its bunk

 

[Qwernity]

melatonin generally inhibits the thyroid hormones

Holy crap!

 

[Chadakin]

copewaganda

 

[Qwernity]

@kjsbdfiusdf @cumbutamoren
I've been taking melatonin for few days now.....plz discuss more about it
@Wincel also made a heightmaxxing stack on melatonin,
@Henry_Gandy thoughts???

 

[Deleted member 6403]

@kjsbdfiusdf @cumbutamoren
I've been taking melatonin for few days now.....plz discuss more about it
@Wincel also made a heightmaxxing stack on melatonin,
@Henry_Gandy thoughts???

avoiding it is preferable but if you must, <1mg is ok

 

[Qwernity]

Or maybe like @189 said.. melatonin maybe a buildup AI like armidex and letrozole which BLOCKS E FOR A WHILE THEN CAUSES EXCESSIVE E PRODUCTION...
And only suicide AI is aromasin

@kjsbdfiusdf @Henry_Gandy @cumbutamoren thoughts???

 

[grimy]

Makes my pp harder srs

 

[cumbutamoren]

Or maybe like @189 said.. melatonin maybe a buildup AI like armidex and letrozole which BLOCKS E FOR A WHILE THEN CAUSES EXCESSIVE E PRODUCTION...
And only suicide AI is aromasin

@kjsbdfiusdf @Henry_Gandy @cumbutamoren thoughts???

Apparently, AIs prevents the “catalyzing the reaction that turns androstenedione and testosterone into estrone and estradiol.” In simple terms, it doesnt store estrogen somewhere it cant be used. Its just slowing down the conversion of T to E.
The buildup that you mention is just a buildup of testosterone waiting to be converted. When you stop taking the AI not all the stored T is converted to E immediately since it takes time. There might be a tiny spike after discontinuation since you have abnormally high t levels, but it shouldnt be significant.

Interesting topic, and I will definitely look further into it. These are just my thoughts as of now.

 

[Qwernity]

There might be a tiny spike after discontinuation since you have abnormally high t levels, but it shouldnt be significant.

@189 @extrachromosome 'n some others told that E RELEASE CAUSED BY BUILDUP OF ARMIDEX WHEN USED FOR 2 MONTHS ,IS ENOUGH TO CLOSE GROWTH PLATES IMMATURELY AND THAT E RELEASE IS SO HIGH THAT IT CAN MAKE U GAYY