ndos
6'4.5'',wide frame,acnecel,here to looksmax
- Joined
- Sep 14, 2022
- Posts
- 737
- Reputation
- 488
What is COX-2
The Leydig cells are where testosterone is produced. COX-2 is found in the Leydig cells and its expression increases with age.
This suggests that COX-2 is involved in age-related reductions in testosterone production. This is supported by the observation that long-term treatment of aged rats with COX-2 antagonists can partially reverse the drop in testosterone levels
Specifically, COX2 inhibits Leydig cell steroidogenesis and the expression of the steroidogenic acute regulatory protein (StAR; the rate-limited enzyme for transporting cholesterol into the mitochondria where it’s converted to pregnenolone).
This study found that in rats, the expression of COX-2 in the Leydig cells increase by 346% from the age of 3 to 30 months. This coincided with a decrease in StAR protein expression by 33% and a drop in blood testosterone concentration and testosterone synthesis in Leydig cells to 41 and 33%, respectively
In short: more COX-2 = less testosterone.
Aspirin works mainly by blocking the COX-2 enzyme, thus reducing the production of pro-inflammatory mediators (prostaglandins)
Aspirin has been shown to improve erectile function.
A recent 2020 meta-analysis found that people who took aspirin had a significant improvement in erectile function compared to non-users (R).
Aspirin helps improve erectile function by inhibiting platelet aggregation activity and stimulating the activity of endothelial NO synthase to increase the production of NO for smooth muscle relaxation.
They even concluded in the study that aspirin needs to be considered by practitioners when prescribing drugs for vasculogenic ED.
Aspirin can help to reduce excess cortisol and improve the testosterone-to-cortisol ratio
TLDR:
The Leydig cells are where testosterone is produced. COX-2 is found in the Leydig cells and its expression increases with age.
This suggests that COX-2 is involved in age-related reductions in testosterone production. This is supported by the observation that long-term treatment of aged rats with COX-2 antagonists can partially reverse the drop in testosterone levels
Specifically, COX2 inhibits Leydig cell steroidogenesis and the expression of the steroidogenic acute regulatory protein (StAR; the rate-limited enzyme for transporting cholesterol into the mitochondria where it’s converted to pregnenolone).
This study found that in rats, the expression of COX-2 in the Leydig cells increase by 346% from the age of 3 to 30 months. This coincided with a decrease in StAR protein expression by 33% and a drop in blood testosterone concentration and testosterone synthesis in Leydig cells to 41 and 33%, respectively
In short: more COX-2 = less testosterone.
Aspirin works mainly by blocking the COX-2 enzyme, thus reducing the production of pro-inflammatory mediators (prostaglandins)
Aspirin on sexual function
Aspirin has been shown to improve erectile function.
A recent 2020 meta-analysis found that people who took aspirin had a significant improvement in erectile function compared to non-users (R).
Aspirin helps improve erectile function by inhibiting platelet aggregation activity and stimulating the activity of endothelial NO synthase to increase the production of NO for smooth muscle relaxation.
They even concluded in the study that aspirin needs to be considered by practitioners when prescribing drugs for vasculogenic ED.
Aspirin can help to reduce excess cortisol and improve the testosterone-to-cortisol ratio
TLDR:
- Increase testosterone
- Increase dopamine
- Improve mood (R)
- Lower excess serotonin
- Lower elevated cortisol
- Lower excess estrogen
- Improve blood flow and erectile function
