aspirin & other COX-2 inhibitors potentially anti toxoplasma

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Frontiers | Cyclooxygenase (COX)-2 Inhibitors Reduce Toxoplasma gondii Infection and Upregulate the Pro-inflammatory Immune Response in Calomys callosus Rodents and Human Monocyte Cell Line

Toxoplasma gondii is able to infect a wide range of vertebrates, including humans. Studies show that cyclooxygenase-2 (COX-2) is a modulator of immune respon...

www.frontiersin.org

the study used the COX-2 inhibitors meloxicam and celecoxib not aspirin , but aspirin also inhibits COX-2

"Parasite burden and COX-2 expression in C. callosus after infection with T. gondii and treatment with COX-2 inhibitors. Females were infected orally with 50 cysts of T. gondii (ME49 strain), treated or untreated with meloxicam (0.5 mg/kg) or celecoxib (5 mg/kg) daily, euthanized after 40 days of infection and treatment, and the brains collected and analyzed by real-time PCR to quantify the parasite burden"
"The data are shown as T. gondii DNA (TgDNA) concentration in 100 ng/μL total DNA"

 

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"Our studies demonstrated that T. gondii developed mechanisms to evade of the host immune response, such as cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) induction, and these mediators can be produced/stored in lipid droplets (LDs). The aim of this study was to evaluate the role of COX-2 and LDs during T. gondii infection in human trophoblast cells and villous explants. Our data demonstrated that COX-2 inhibitors decreased T. gondii replication in trophoblast cells and villous."

Cyclooxygenase (COX)-2 modulates Toxoplasma gondii infection, immune response and lipid droplets formation in human trophoblast cells and villous explants - Scientific Reports

Congenital toxoplasmosis is represented by the transplacental passage of Toxoplasma gondii from the mother to the fetus. Our studies demonstrated that T. gondii developed mechanisms to evade of the host immune response, such as cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) induction, and...

www.nature.com

 

[copamine]

Autistic ramblings

 

[Youㅤ]

Autistic ramblings

more like actual quality info unlike 99% of posts

 

[Youㅤ]

@5'7 zoomer

 

[Achilles]

aspirin is based